CN115667270A - 稠环衍生物及其在药学上的应用 - Google Patents

稠环衍生物及其在药学上的应用 Download PDF

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Publication number
CN115667270A
CN115667270A CN202180036796.4A CN202180036796A CN115667270A CN 115667270 A CN115667270 A CN 115667270A CN 202180036796 A CN202180036796 A CN 202180036796A CN 115667270 A CN115667270 A CN 115667270A
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compound
added
crude product
reaction
synthesis
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CN115667270B (zh
Inventor
陈曙辉
冯嘉杰
魏巍
李鹏
贺海鹰
刘金鑫
黎健
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Cisen Pharmaceutical Co ltd
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Cisen Pharmaceutical Co ltd
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

本发明公开了一类稠环衍生物,具体公开了式(I)所示化合物及其药学上可接受的盐。

Description

PCT国内申请,说明书已公开。

Claims (16)

  1. PCT国内申请,权利要求书已公开。
CN202180036796.4A 2020-05-21 2021-05-18 稠环衍生物及其在药学上的应用 Active CN115667270B (zh)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
CN202010435705 2020-05-21
CN2020104357051 2020-05-21
CN2020106993028 2020-07-20
CN202010699302 2020-07-20
CN202010941000 2020-09-09
CN2020109410007 2020-09-09
CN2020112577706 2020-11-11
CN202011257770 2020-11-11
CN202110059299 2021-01-14
CN2021100592998 2021-01-14
PCT/CN2021/094384 WO2021233302A1 (zh) 2020-05-21 2021-05-18 稠环衍生物及其在药学上的应用

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CN115667270A true CN115667270A (zh) 2023-01-31
CN115667270B CN115667270B (zh) 2024-06-04

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US (1) US20230212187A1 (zh)
EP (1) EP4155312A4 (zh)
JP (1) JP7407976B2 (zh)
CN (1) CN115667270B (zh)
WO (1) WO2021233302A1 (zh)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016175224A1 (ja) * 2015-04-28 2016-11-03 塩野義製薬株式会社 置換された多環性ピリドン誘導体およびそのプロドラッグ
WO2019230857A1 (ja) * 2018-05-31 2019-12-05 塩野義製薬株式会社 多環性ピリドン誘導体
WO2019230858A1 (ja) * 2018-05-31 2019-12-05 塩野義製薬株式会社 多環性カルバモイルピリドン誘導体

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2608519C2 (ru) 2010-09-24 2017-01-19 Шионоги энд Ко. Лтд. Пролекарственная форма замещенного полициклического производного карбамоилпиридона
AU2019359539A1 (en) * 2018-10-10 2021-04-29 Janssen Biopharma, Inc. Macrocyclic flu endonuclease inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016175224A1 (ja) * 2015-04-28 2016-11-03 塩野義製薬株式会社 置換された多環性ピリドン誘導体およびそのプロドラッグ
WO2019230857A1 (ja) * 2018-05-31 2019-12-05 塩野義製薬株式会社 多環性ピリドン誘導体
WO2019230858A1 (ja) * 2018-05-31 2019-12-05 塩野義製薬株式会社 多環性カルバモイルピリドン誘導体

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WO2021233302A1 (zh) 2021-11-25
EP4155312A1 (en) 2023-03-29
JP2023529295A (ja) 2023-07-10
EP4155312A4 (en) 2024-06-19
CN115667270B (zh) 2024-06-04
JP7407976B2 (ja) 2024-01-04
US20230212187A1 (en) 2023-07-06

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