PT3565905T - Sequenciação de ácidos nucleicos utilizando reagentes de afinidade - Google Patents
Sequenciação de ácidos nucleicos utilizando reagentes de afinidadeInfo
- Publication number
- PT3565905T PT3565905T PT187361712T PT18736171T PT3565905T PT 3565905 T PT3565905 T PT 3565905T PT 187361712 T PT187361712 T PT 187361712T PT 18736171 T PT18736171 T PT 18736171T PT 3565905 T PT3565905 T PT 3565905T
- Authority
- PT
- Portugal
- Prior art keywords
- natural nucleotides
- reversible terminators
- labeled reversible
- stepwise sequencing
- stepwise
- Prior art date
Links
- 239000002773 nucleotide Substances 0.000 title 1
- 125000003729 nucleotide group Chemical group 0.000 title 1
- 230000002441 reversible effect Effects 0.000 title 1
- 238000012163 sequencing technique Methods 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762442263P | 2017-01-04 | 2017-01-04 | |
US201762490511P | 2017-04-26 | 2017-04-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT3565905T true PT3565905T (pt) | 2022-08-02 |
Family
ID=62791177
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT187361712T PT3565905T (pt) | 2017-01-04 | 2018-01-04 | Sequenciação de ácidos nucleicos utilizando reagentes de afinidade |
Country Status (17)
Country | Link |
---|---|
US (3) | US10851410B2 (pt) |
EP (2) | EP3565905B1 (pt) |
JP (2) | JP2020508037A (pt) |
KR (1) | KR102349259B1 (pt) |
CN (1) | CN110418847A (pt) |
AU (2) | AU2018205472B2 (pt) |
BR (1) | BR112019013715B1 (pt) |
CA (1) | CA3048486A1 (pt) |
DK (1) | DK3565905T3 (pt) |
ES (1) | ES2924223T3 (pt) |
HU (1) | HUE059673T2 (pt) |
IL (1) | IL267836B2 (pt) |
MX (1) | MX2019008016A (pt) |
PL (1) | PL3565905T3 (pt) |
PT (1) | PT3565905T (pt) |
RS (1) | RS63419B1 (pt) |
WO (1) | WO2018129214A1 (pt) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT3565905T (pt) | 2017-01-04 | 2022-08-02 | Mgi Tech Co Ltd | Sequenciação de ácidos nucleicos utilizando reagentes de afinidade |
CN112840035B (zh) * | 2018-11-07 | 2024-01-30 | 青岛华大智造科技有限责任公司 | 对多核苷酸进行测序的方法 |
CN113272448A (zh) * | 2018-11-09 | 2021-08-17 | 深圳华大智造科技股份有限公司 | 使用未标记的核苷酸进行大规模平行测序 |
CA3122127C (en) | 2018-12-05 | 2023-05-16 | Egi Tech (Shen Zhen) Co, Limited | Rolling circle amplification method, method for preparing sequencing library, and dna nanosphere prepared therefrom |
EP3702474A1 (en) * | 2019-02-26 | 2020-09-02 | QIAGEN GmbH | Sequencing method and kit |
KR20220009992A (ko) * | 2019-05-15 | 2022-01-25 | 이지아이 테크 (센젠) 컴퍼니 리미티드 | 자가-발광을 기초로 하는 단일-채널 시퀀싱 방법 |
KR20220115857A (ko) * | 2019-12-16 | 2022-08-19 | 일루미나, 인코포레이티드 | 키트 및 플로우 셀 |
US20210189483A1 (en) | 2019-12-23 | 2021-06-24 | Mgi Tech Co. Ltd. | Controlled strand-displacement for paired end sequencing |
CN113795595B (zh) | 2020-04-20 | 2023-02-28 | 深圳华大智造科技股份有限公司 | Dna成像缓冲液中的dna保护试剂 |
CN115997030A (zh) | 2020-04-30 | 2023-04-21 | 德迈逊科技有限公司 | 用于大分子操作的装置和方法 |
US20220033900A1 (en) | 2020-07-28 | 2022-02-03 | Illumina Cambridge Limited | Substituted coumarin dyes and uses as fluorescent labels |
GB2599729A (en) * | 2020-10-12 | 2022-04-13 | Sumitomo Chemical Co | Method comprising light emitting marker |
WO2022078319A1 (en) * | 2020-10-12 | 2022-04-21 | Mgi Tech Co., Ltd. | Protein detection and tracking using nucleoside tags |
EP4234566A1 (en) | 2020-10-21 | 2023-08-30 | BGI Shenzhen | Modified nucleoside or nucleotide |
US20220195517A1 (en) | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Long stokes shift chromenoquinoline dyes and uses in sequencing applications |
US20220195196A1 (en) | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Alkylpyridinium coumarin dyes and uses in sequencing applications |
US20220195516A1 (en) | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Methods, systems and compositions for nucleic acid sequencing |
US20220195518A1 (en) * | 2020-12-22 | 2022-06-23 | Illumina Cambridge Limited | Methods and compositions for nucleic acid sequencing |
WO2022197589A1 (en) | 2021-03-15 | 2022-09-22 | President And Fellows Of Harvard College | Methods for in situ sequencing |
CN115197291A (zh) | 2021-04-01 | 2022-10-18 | 深圳华大生命科学研究院 | 用于测序的核苷酸类似物 |
EP4334327A1 (en) | 2021-05-05 | 2024-03-13 | Illumina Cambridge Limited | Fluorescent dyes containing bis-boron fused heterocycles and uses in sequencing |
CN113372402A (zh) * | 2021-06-15 | 2021-09-10 | 中国人民解放军军事科学院军事医学研究院 | 3’-o-可逆封闭的核苷酸及其在无模板酶促核酸合成中的应用 |
WO2023114896A1 (en) | 2021-12-16 | 2023-06-22 | Illumina Cambridge Limited | Methods for metal directed cleavage of surface-bound polynucleotides |
CA3222842A1 (en) | 2021-12-20 | 2023-06-29 | Oliver MILLER | Periodate compositions and methods for chemical cleavage of surface-bound polynucleotides |
WO2023122491A1 (en) | 2021-12-20 | 2023-06-29 | Illumina Cambridge Limited | Periodate compositions and methods for chemical cleavage of surface-bound polynucleotides |
US20230313292A1 (en) | 2022-03-29 | 2023-10-05 | Illumina Cambridge Limited | Chromenoquinoline dyes and uses in sequencing |
AU2023246691A1 (en) | 2022-03-30 | 2024-01-18 | Illumina, Inc. | Methods for chemical cleavage of surface-bound polynucleotides |
WO2023192900A1 (en) * | 2022-03-31 | 2023-10-05 | Illumina Singapore Pte. Ltd. | Nucleosides and nucleotides with 3' vinyl blocking group useful in sequencing by synthesis |
CA3223128A1 (en) | 2022-03-31 | 2023-10-05 | Illumina, Inc. | Compositions and methods for improving sequencing signals |
WO2024003087A1 (en) | 2022-06-28 | 2024-01-04 | Illumina, Inc. | Fluorescent dyes containing fused tetracyclic bis-boron heterocycle and uses in sequencing |
WO2024068889A2 (en) | 2022-09-30 | 2024-04-04 | Illumina, Inc. | Compositions and methods for reducing photo damage during sequencing |
CN116536399A (zh) * | 2023-07-07 | 2023-08-04 | 之江实验室 | 一种基于微珠测序的基因芯片编解码方法及基因芯片 |
Family Cites Families (88)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2713102A (en) | 1952-06-25 | 1955-07-12 | Railroad Accessories Corp | Test terminal |
US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
US4351760A (en) | 1979-09-07 | 1982-09-28 | Syva Company | Novel alkyl substituted fluorescent compounds and polyamino acid conjugates |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
CA2020958C (en) | 1989-07-11 | 2005-01-11 | Daniel L. Kacian | Nucleic acid sequence amplification methods |
US5053336A (en) * | 1989-07-17 | 1991-10-01 | Regents Of The University Of California | Monoclonal antibodies for the separate detection of halodeoxyuridines and method for their use |
US5188934A (en) | 1989-11-14 | 1993-02-23 | Applied Biosystems, Inc. | 4,7-dichlorofluorescein dyes as molecular probes |
US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
US6401267B1 (en) | 1993-09-27 | 2002-06-11 | Radoje Drmanac | Methods and compositions for efficient nucleic acid sequencing |
US6232465B1 (en) | 1994-09-02 | 2001-05-15 | Andrew C. Hiatt | Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides |
US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
ATE428801T1 (de) | 1996-06-04 | 2009-05-15 | Univ Utah Res Found | Überwachung der hybridisierung während pcr |
GB9620209D0 (en) | 1996-09-27 | 1996-11-13 | Cemu Bioteknik Ab | Method of sequencing DNA |
GB9626815D0 (en) | 1996-12-23 | 1997-02-12 | Cemu Bioteknik Ab | Method of sequencing DNA |
US6969488B2 (en) | 1998-05-22 | 2005-11-29 | Solexa, Inc. | System and apparatus for sequential processing of analytes |
AU737174B2 (en) | 1997-10-10 | 2001-08-09 | President & Fellows Of Harvard College | Replica amplification of nucleic acid arrays |
US6743605B1 (en) | 1998-06-24 | 2004-06-01 | Enzo Life Sciences, Inc. | Linear amplification of specific nucleic acid sequences |
US6787308B2 (en) | 1998-07-30 | 2004-09-07 | Solexa Ltd. | Arrayed biomolecules and their use in sequencing |
US20030022207A1 (en) | 1998-10-16 | 2003-01-30 | Solexa, Ltd. | Arrayed polynucleotides and their use in genome analysis |
US6287824B1 (en) | 1998-09-15 | 2001-09-11 | Yale University | Molecular cloning using rolling circle amplification |
AR021833A1 (es) | 1998-09-30 | 2002-08-07 | Applied Research Systems | Metodos de amplificacion y secuenciacion de acido nucleico |
GB9901475D0 (en) | 1999-01-22 | 1999-03-17 | Pyrosequencing Ab | A method of DNA sequencing |
US20050191698A1 (en) | 1999-04-20 | 2005-09-01 | Illumina, Inc. | Nucleic acid sequencing using microsphere arrays |
CA2374596A1 (en) | 1999-05-20 | 2000-11-30 | Illumina, Inc. | Method and apparatus for retaining and presenting at least one microsphere array to solutions and/or to optical imaging systems |
US6544732B1 (en) | 1999-05-20 | 2003-04-08 | Illumina, Inc. | Encoding and decoding of array sensors utilizing nanocrystals |
US6818395B1 (en) | 1999-06-28 | 2004-11-16 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
US7244559B2 (en) | 1999-09-16 | 2007-07-17 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
US6274320B1 (en) | 1999-09-16 | 2001-08-14 | Curagen Corporation | Method of sequencing a nucleic acid |
EP1218543A2 (en) | 1999-09-29 | 2002-07-03 | Solexa Ltd. | Polynucleotide sequencing |
JP2001245698A (ja) * | 1999-11-22 | 2001-09-11 | Xiao Bing Wang | 核酸検出法 |
GB0002389D0 (en) | 2000-02-02 | 2000-03-22 | Solexa Ltd | Molecular arrays |
JP3852555B2 (ja) | 2000-09-01 | 2006-11-29 | 三菱電機株式会社 | 熱制御装置、宇宙機および熱制御方法 |
WO2002027029A2 (en) | 2000-09-27 | 2002-04-04 | Lynx Therapeutics, Inc. | Method for determining relative abundance of nucleic acid sequences |
EP3034627B1 (en) | 2000-10-06 | 2019-01-30 | The Trustees of Columbia University in the City of New York | Massive parallel method for decoding dna and rna |
GB0105831D0 (en) * | 2001-03-09 | 2001-04-25 | Toumaz Technology Ltd | Method for dna sequencing utilising enzyme linked field effect transistors |
US20030124560A1 (en) | 2001-06-14 | 2003-07-03 | Yoshihiko Makino | Method for analyzing a target nucleic acid fragment and a kit for analyzing a target nucleic acid fragment |
WO2002103039A1 (en) * | 2001-06-14 | 2002-12-27 | Cavidi Tech Ab | A method for measuring dna polymerization and applications of the method |
JP4500540B2 (ja) * | 2001-06-29 | 2010-07-14 | ヴェリ‐キュー,インコーポレイテッド | 化学的に合成された核酸の純度を決定し、かつ化学的に合成された核酸を精製するための方法および組成物 |
FR2836995B1 (fr) * | 2002-03-05 | 2006-09-22 | Centre Nat Rech Scient | Utilisation de derives de nucleosides comportant un groupement citrate pour la production d'anticorps ayant une affinite pour des nucleosides triphosphorylees et leurs applications |
US7595883B1 (en) | 2002-09-16 | 2009-09-29 | The Board Of Trustees Of The Leland Stanford Junior University | Biological analysis arrangement and approach therefor |
ES2338654T5 (es) * | 2003-01-29 | 2017-12-11 | 454 Life Sciences Corporation | Amplificación de ácidos nucleicos en emulsión de perlas |
US8399196B2 (en) | 2003-02-21 | 2013-03-19 | Geneform Technologies Limited | Nucleic acid sequencing methods, kits and reagents |
CN103397082B (zh) | 2003-02-26 | 2017-05-31 | 考利达基因组股份有限公司 | 通过杂交进行的随机阵列dna分析 |
GB0321306D0 (en) | 2003-09-11 | 2003-10-15 | Solexa Ltd | Modified polymerases for improved incorporation of nucleotide analogues |
WO2005082098A2 (en) | 2004-02-27 | 2005-09-09 | President And Fellows Of Harvard College | Polony fluorescent in situ sequencing beads |
US20060024711A1 (en) | 2004-07-02 | 2006-02-02 | Helicos Biosciences Corporation | Methods for nucleic acid amplification and sequence determination |
WO2006073504A2 (en) | 2004-08-04 | 2006-07-13 | President And Fellows Of Harvard College | Wobble sequencing |
JP4990886B2 (ja) | 2005-05-10 | 2012-08-01 | ソレックサ リミテッド | 改良ポリメラーゼ |
WO2006131749A2 (en) | 2005-06-10 | 2006-12-14 | Medical Research Council | Scaffold |
JP5331476B2 (ja) | 2005-06-15 | 2013-10-30 | カリダ・ジェノミックス・インコーポレイテッド | 遺伝子解析および化学解析用の単分子アレイ |
US7960104B2 (en) | 2005-10-07 | 2011-06-14 | Callida Genomics, Inc. | Self-assembled single molecule arrays and uses thereof |
WO2007120208A2 (en) | 2005-11-14 | 2007-10-25 | President And Fellows Of Harvard College | Nanogrid rolling circle dna sequencing |
EP1994180A4 (en) | 2006-02-24 | 2009-11-25 | Callida Genomics Inc | GENOME SEQUENCING ON DNA ARRAYS WITH HIGH THROUGHPUT |
SG10201405158QA (en) | 2006-02-24 | 2014-10-30 | Callida Genomics Inc | High throughput genome sequencing on dna arrays |
WO2008045575A2 (en) | 2006-10-13 | 2008-04-17 | J. Craig Venter Institute, Inc. | Sequencing method |
US7910302B2 (en) | 2006-10-27 | 2011-03-22 | Complete Genomics, Inc. | Efficient arrays of amplified polynucleotides |
EP4134667A1 (en) | 2006-12-14 | 2023-02-15 | Life Technologies Corporation | Apparatus for measuring analytes using fet arrays |
US8262900B2 (en) | 2006-12-14 | 2012-09-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
US8349167B2 (en) | 2006-12-14 | 2013-01-08 | Life Technologies Corporation | Methods and apparatus for detecting molecular interactions using FET arrays |
US8518640B2 (en) | 2007-10-29 | 2013-08-27 | Complete Genomics, Inc. | Nucleic acid sequencing and process |
US8298768B2 (en) | 2007-11-29 | 2012-10-30 | Complete Genomics, Inc. | Efficient shotgun sequencing methods |
US8415099B2 (en) | 2007-11-05 | 2013-04-09 | Complete Genomics, Inc. | Efficient base determination in sequencing reactions |
US7897344B2 (en) | 2007-11-06 | 2011-03-01 | Complete Genomics, Inc. | Methods and oligonucleotide designs for insertion of multiple adaptors into library constructs |
WO2009061840A1 (en) | 2007-11-05 | 2009-05-14 | Complete Genomics, Inc. | Methods and oligonucleotide designs for insertion of multiple adaptors employing selective methylation |
WO2009097368A2 (en) | 2008-01-28 | 2009-08-06 | Complete Genomics, Inc. | Methods and compositions for efficient base calling in sequencing reactions |
US8236499B2 (en) | 2008-03-28 | 2012-08-07 | Pacific Biosciences Of California, Inc. | Methods and compositions for nucleic acid sample preparation |
GB0807065D0 (en) | 2008-04-18 | 2008-05-21 | Univ Leeds | Novel scaffolds |
US20110118142A1 (en) * | 2008-05-16 | 2011-05-19 | Life Technologies Corporation | Dual labeling methods for measuring cellular proliferation |
US20100137143A1 (en) | 2008-10-22 | 2010-06-03 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
EP2379748A4 (en) | 2008-12-23 | 2012-08-29 | Illumina Inc | MULTIBASE RELEASE FOR LONG READINGS IN SEQUENCING BY SYNTHESIS PROTOCOLS |
US20140228223A1 (en) | 2010-05-10 | 2014-08-14 | Andreas Gnirke | High throughput paired-end sequencing of large-insert clone libraries |
US9005565B2 (en) | 2010-06-24 | 2015-04-14 | Hamid-Reza Jahangiri-Famenini | Method and apparatus for forming graphene |
US8669374B2 (en) | 2010-08-25 | 2014-03-11 | Gene Shen | Functionalized cyanine dyes (PEG) |
SI3623481T1 (sl) * | 2011-09-23 | 2022-01-31 | Illumina, Inc. | Sestavki za sekvenciranje nukleinske kisline |
US8671811B2 (en) | 2011-09-30 | 2014-03-18 | Robert Bosch Gmbh | Pivoting saw system |
GB201301178D0 (en) | 2013-01-23 | 2013-03-06 | Dynamic Biosensors Gmbh | Method for sequencing a template nucleic acid immobilized on a substrate |
US9650406B2 (en) * | 2013-02-28 | 2017-05-16 | Centrillion Technology Holdings Corporation | Reversible terminator molecules and methods of their use |
US9944924B2 (en) | 2014-01-16 | 2018-04-17 | Illumina, Inc. | Polynucleotide modification on solid support |
WO2016065248A1 (en) * | 2014-10-23 | 2016-04-28 | Complete Genomics, Inc. | Signal confinement sequencing (scs) and nucleotide analogues for signal confinement sequencing |
CN104448001A (zh) | 2014-11-14 | 2015-03-25 | 杭州博谱医药科技有限公司 | 抗5-甲基-胞嘧啶单克隆抗体及其应用 |
WO2016133764A1 (en) | 2015-02-17 | 2016-08-25 | Complete Genomics, Inc. | Dna sequencing using controlled strand displacement |
US20170240961A1 (en) | 2016-02-23 | 2017-08-24 | Complete Genomics, Inc. | Affinity tag labeled nucleosides and uses |
WO2017185026A1 (en) * | 2016-04-22 | 2017-10-26 | Complete Genomics, Inc. | Reversibly blocked nucleoside analogues and their use |
JP6828140B2 (ja) | 2016-08-15 | 2021-02-10 | オムニオム インコーポレイテッドOmniome, Inc. | 核酸をシーケンシングするための方法及びシステム |
PT3565905T (pt) | 2017-01-04 | 2022-08-02 | Mgi Tech Co Ltd | Sequenciação de ácidos nucleicos utilizando reagentes de afinidade |
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2018
- 2018-01-04 PT PT187361712T patent/PT3565905T/pt unknown
- 2018-01-04 WO PCT/US2018/012425 patent/WO2018129214A1/en unknown
- 2018-01-04 MX MX2019008016A patent/MX2019008016A/es unknown
- 2018-01-04 PL PL18736171.2T patent/PL3565905T3/pl unknown
- 2018-01-04 ES ES18736171T patent/ES2924223T3/es active Active
- 2018-01-04 EP EP18736171.2A patent/EP3565905B1/en active Active
- 2018-01-04 EP EP22174722.3A patent/EP4112741A1/en active Pending
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AU2018205472B2 (en) | 2022-12-15 |
HUE059673T2 (hu) | 2022-12-28 |
RS63419B1 (sr) | 2022-08-31 |
JP2022046677A (ja) | 2022-03-23 |
BR112019013715B1 (pt) | 2021-08-24 |
AU2023201547A1 (en) | 2023-04-13 |
KR20190141120A (ko) | 2019-12-23 |
AU2018205472A1 (en) | 2019-07-25 |
BR112019013715A2 (pt) | 2020-03-03 |
US11788138B2 (en) | 2023-10-17 |
IL267836B2 (en) | 2023-09-01 |
WO2018129214A1 (en) | 2018-07-12 |
US20240117425A1 (en) | 2024-04-11 |
DK3565905T3 (da) | 2022-07-25 |
JP7025595B1 (ja) | 2022-02-24 |
IL267836A (en) | 2019-09-26 |
KR102349259B9 (ko) | 2022-07-20 |
US20180223358A1 (en) | 2018-08-09 |
CN110418847A (zh) | 2019-11-05 |
EP3565905B1 (en) | 2022-05-25 |
EP4112741A1 (en) | 2023-01-04 |
MX2019008016A (es) | 2019-10-15 |
US20210254150A1 (en) | 2021-08-19 |
EP3565905A1 (en) | 2019-11-13 |
KR102349259B1 (ko) | 2022-01-07 |
EP3565905A4 (en) | 2020-11-04 |
PL3565905T3 (pl) | 2022-09-26 |
CA3048486A1 (en) | 2018-07-12 |
ES2924223T3 (es) | 2022-10-05 |
IL267836B1 (en) | 2023-05-01 |
JP2020508037A (ja) | 2020-03-19 |
US10851410B2 (en) | 2020-12-01 |
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