PT3565905T - Sequenciação de ácidos nucleicos utilizando reagentes de afinidade - Google Patents

Sequenciação de ácidos nucleicos utilizando reagentes de afinidade

Info

Publication number
PT3565905T
PT3565905T PT187361712T PT18736171T PT3565905T PT 3565905 T PT3565905 T PT 3565905T PT 187361712 T PT187361712 T PT 187361712T PT 18736171 T PT18736171 T PT 18736171T PT 3565905 T PT3565905 T PT 3565905T
Authority
PT
Portugal
Prior art keywords
natural nucleotides
reversible terminators
labeled reversible
stepwise sequencing
stepwise
Prior art date
Application number
PT187361712T
Other languages
English (en)
Original Assignee
Mgi Tech Co Ltd
Bgi Shenzhen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62791177&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT3565905(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mgi Tech Co Ltd, Bgi Shenzhen filed Critical Mgi Tech Co Ltd
Publication of PT3565905T publication Critical patent/PT3565905T/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804Nucleic acid analysis using immunogens
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • C12Q1/6874Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
PT187361712T 2017-01-04 2018-01-04 Sequenciação de ácidos nucleicos utilizando reagentes de afinidade PT3565905T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762442263P 2017-01-04 2017-01-04
US201762490511P 2017-04-26 2017-04-26

Publications (1)

Publication Number Publication Date
PT3565905T true PT3565905T (pt) 2022-08-02

Family

ID=62791177

Family Applications (1)

Application Number Title Priority Date Filing Date
PT187361712T PT3565905T (pt) 2017-01-04 2018-01-04 Sequenciação de ácidos nucleicos utilizando reagentes de afinidade

Country Status (17)

Country Link
US (3) US10851410B2 (pt)
EP (2) EP3565905B1 (pt)
JP (2) JP2020508037A (pt)
KR (1) KR102349259B1 (pt)
CN (1) CN110418847A (pt)
AU (2) AU2018205472B2 (pt)
BR (1) BR112019013715B1 (pt)
CA (1) CA3048486A1 (pt)
DK (1) DK3565905T3 (pt)
ES (1) ES2924223T3 (pt)
HU (1) HUE059673T2 (pt)
IL (1) IL267836B2 (pt)
MX (1) MX2019008016A (pt)
PL (1) PL3565905T3 (pt)
PT (1) PT3565905T (pt)
RS (1) RS63419B1 (pt)
WO (1) WO2018129214A1 (pt)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3565905T (pt) 2017-01-04 2022-08-02 Mgi Tech Co Ltd Sequenciação de ácidos nucleicos utilizando reagentes de afinidade
CN112840035B (zh) * 2018-11-07 2024-01-30 青岛华大智造科技有限责任公司 对多核苷酸进行测序的方法
CN113272448A (zh) * 2018-11-09 2021-08-17 深圳华大智造科技股份有限公司 使用未标记的核苷酸进行大规模平行测序
CA3122127C (en) 2018-12-05 2023-05-16 Egi Tech (Shen Zhen) Co, Limited Rolling circle amplification method, method for preparing sequencing library, and dna nanosphere prepared therefrom
EP3702474A1 (en) * 2019-02-26 2020-09-02 QIAGEN GmbH Sequencing method and kit
KR20220009992A (ko) * 2019-05-15 2022-01-25 이지아이 테크 (센젠) 컴퍼니 리미티드 자가-발광을 기초로 하는 단일-채널 시퀀싱 방법
KR20220115857A (ko) * 2019-12-16 2022-08-19 일루미나, 인코포레이티드 키트 및 플로우 셀
US20210189483A1 (en) 2019-12-23 2021-06-24 Mgi Tech Co. Ltd. Controlled strand-displacement for paired end sequencing
CN113795595B (zh) 2020-04-20 2023-02-28 深圳华大智造科技股份有限公司 Dna成像缓冲液中的dna保护试剂
CN115997030A (zh) 2020-04-30 2023-04-21 德迈逊科技有限公司 用于大分子操作的装置和方法
US20220033900A1 (en) 2020-07-28 2022-02-03 Illumina Cambridge Limited Substituted coumarin dyes and uses as fluorescent labels
GB2599729A (en) * 2020-10-12 2022-04-13 Sumitomo Chemical Co Method comprising light emitting marker
WO2022078319A1 (en) * 2020-10-12 2022-04-21 Mgi Tech Co., Ltd. Protein detection and tracking using nucleoside tags
EP4234566A1 (en) 2020-10-21 2023-08-30 BGI Shenzhen Modified nucleoside or nucleotide
US20220195517A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Long stokes shift chromenoquinoline dyes and uses in sequencing applications
US20220195196A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Alkylpyridinium coumarin dyes and uses in sequencing applications
US20220195516A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Methods, systems and compositions for nucleic acid sequencing
US20220195518A1 (en) * 2020-12-22 2022-06-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing
WO2022197589A1 (en) 2021-03-15 2022-09-22 President And Fellows Of Harvard College Methods for in situ sequencing
CN115197291A (zh) 2021-04-01 2022-10-18 深圳华大生命科学研究院 用于测序的核苷酸类似物
EP4334327A1 (en) 2021-05-05 2024-03-13 Illumina Cambridge Limited Fluorescent dyes containing bis-boron fused heterocycles and uses in sequencing
CN113372402A (zh) * 2021-06-15 2021-09-10 中国人民解放军军事科学院军事医学研究院 3’-o-可逆封闭的核苷酸及其在无模板酶促核酸合成中的应用
WO2023114896A1 (en) 2021-12-16 2023-06-22 Illumina Cambridge Limited Methods for metal directed cleavage of surface-bound polynucleotides
CA3222842A1 (en) 2021-12-20 2023-06-29 Oliver MILLER Periodate compositions and methods for chemical cleavage of surface-bound polynucleotides
WO2023122491A1 (en) 2021-12-20 2023-06-29 Illumina Cambridge Limited Periodate compositions and methods for chemical cleavage of surface-bound polynucleotides
US20230313292A1 (en) 2022-03-29 2023-10-05 Illumina Cambridge Limited Chromenoquinoline dyes and uses in sequencing
AU2023246691A1 (en) 2022-03-30 2024-01-18 Illumina, Inc. Methods for chemical cleavage of surface-bound polynucleotides
WO2023192900A1 (en) * 2022-03-31 2023-10-05 Illumina Singapore Pte. Ltd. Nucleosides and nucleotides with 3' vinyl blocking group useful in sequencing by synthesis
CA3223128A1 (en) 2022-03-31 2023-10-05 Illumina, Inc. Compositions and methods for improving sequencing signals
WO2024003087A1 (en) 2022-06-28 2024-01-04 Illumina, Inc. Fluorescent dyes containing fused tetracyclic bis-boron heterocycle and uses in sequencing
WO2024068889A2 (en) 2022-09-30 2024-04-04 Illumina, Inc. Compositions and methods for reducing photo damage during sequencing
CN116536399A (zh) * 2023-07-07 2023-08-04 之江实验室 一种基于微珠测序的基因芯片编解码方法及基因芯片

Family Cites Families (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2713102A (en) 1952-06-25 1955-07-12 Railroad Accessories Corp Test terminal
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4351760A (en) 1979-09-07 1982-09-28 Syva Company Novel alkyl substituted fluorescent compounds and polyamino acid conjugates
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
CA2020958C (en) 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
US5053336A (en) * 1989-07-17 1991-10-01 Regents Of The University Of California Monoclonal antibodies for the separate detection of halodeoxyuridines and method for their use
US5188934A (en) 1989-11-14 1993-02-23 Applied Biosystems, Inc. 4,7-dichlorofluorescein dyes as molecular probes
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US6401267B1 (en) 1993-09-27 2002-06-11 Radoje Drmanac Methods and compositions for efficient nucleic acid sequencing
US6232465B1 (en) 1994-09-02 2001-05-15 Andrew C. Hiatt Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
ATE428801T1 (de) 1996-06-04 2009-05-15 Univ Utah Res Found Überwachung der hybridisierung während pcr
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
GB9626815D0 (en) 1996-12-23 1997-02-12 Cemu Bioteknik Ab Method of sequencing DNA
US6969488B2 (en) 1998-05-22 2005-11-29 Solexa, Inc. System and apparatus for sequential processing of analytes
AU737174B2 (en) 1997-10-10 2001-08-09 President & Fellows Of Harvard College Replica amplification of nucleic acid arrays
US6743605B1 (en) 1998-06-24 2004-06-01 Enzo Life Sciences, Inc. Linear amplification of specific nucleic acid sequences
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
US20030022207A1 (en) 1998-10-16 2003-01-30 Solexa, Ltd. Arrayed polynucleotides and their use in genome analysis
US6287824B1 (en) 1998-09-15 2001-09-11 Yale University Molecular cloning using rolling circle amplification
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
GB9901475D0 (en) 1999-01-22 1999-03-17 Pyrosequencing Ab A method of DNA sequencing
US20050191698A1 (en) 1999-04-20 2005-09-01 Illumina, Inc. Nucleic acid sequencing using microsphere arrays
CA2374596A1 (en) 1999-05-20 2000-11-30 Illumina, Inc. Method and apparatus for retaining and presenting at least one microsphere array to solutions and/or to optical imaging systems
US6544732B1 (en) 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US6274320B1 (en) 1999-09-16 2001-08-14 Curagen Corporation Method of sequencing a nucleic acid
EP1218543A2 (en) 1999-09-29 2002-07-03 Solexa Ltd. Polynucleotide sequencing
JP2001245698A (ja) * 1999-11-22 2001-09-11 Xiao Bing Wang 核酸検出法
GB0002389D0 (en) 2000-02-02 2000-03-22 Solexa Ltd Molecular arrays
JP3852555B2 (ja) 2000-09-01 2006-11-29 三菱電機株式会社 熱制御装置、宇宙機および熱制御方法
WO2002027029A2 (en) 2000-09-27 2002-04-04 Lynx Therapeutics, Inc. Method for determining relative abundance of nucleic acid sequences
EP3034627B1 (en) 2000-10-06 2019-01-30 The Trustees of Columbia University in the City of New York Massive parallel method for decoding dna and rna
GB0105831D0 (en) * 2001-03-09 2001-04-25 Toumaz Technology Ltd Method for dna sequencing utilising enzyme linked field effect transistors
US20030124560A1 (en) 2001-06-14 2003-07-03 Yoshihiko Makino Method for analyzing a target nucleic acid fragment and a kit for analyzing a target nucleic acid fragment
WO2002103039A1 (en) * 2001-06-14 2002-12-27 Cavidi Tech Ab A method for measuring dna polymerization and applications of the method
JP4500540B2 (ja) * 2001-06-29 2010-07-14 ヴェリ‐キュー,インコーポレイテッド 化学的に合成された核酸の純度を決定し、かつ化学的に合成された核酸を精製するための方法および組成物
FR2836995B1 (fr) * 2002-03-05 2006-09-22 Centre Nat Rech Scient Utilisation de derives de nucleosides comportant un groupement citrate pour la production d'anticorps ayant une affinite pour des nucleosides triphosphorylees et leurs applications
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
ES2338654T5 (es) * 2003-01-29 2017-12-11 454 Life Sciences Corporation Amplificación de ácidos nucleicos en emulsión de perlas
US8399196B2 (en) 2003-02-21 2013-03-19 Geneform Technologies Limited Nucleic acid sequencing methods, kits and reagents
CN103397082B (zh) 2003-02-26 2017-05-31 考利达基因组股份有限公司 通过杂交进行的随机阵列dna分析
GB0321306D0 (en) 2003-09-11 2003-10-15 Solexa Ltd Modified polymerases for improved incorporation of nucleotide analogues
WO2005082098A2 (en) 2004-02-27 2005-09-09 President And Fellows Of Harvard College Polony fluorescent in situ sequencing beads
US20060024711A1 (en) 2004-07-02 2006-02-02 Helicos Biosciences Corporation Methods for nucleic acid amplification and sequence determination
WO2006073504A2 (en) 2004-08-04 2006-07-13 President And Fellows Of Harvard College Wobble sequencing
JP4990886B2 (ja) 2005-05-10 2012-08-01 ソレックサ リミテッド 改良ポリメラーゼ
WO2006131749A2 (en) 2005-06-10 2006-12-14 Medical Research Council Scaffold
JP5331476B2 (ja) 2005-06-15 2013-10-30 カリダ・ジェノミックス・インコーポレイテッド 遺伝子解析および化学解析用の単分子アレイ
US7960104B2 (en) 2005-10-07 2011-06-14 Callida Genomics, Inc. Self-assembled single molecule arrays and uses thereof
WO2007120208A2 (en) 2005-11-14 2007-10-25 President And Fellows Of Harvard College Nanogrid rolling circle dna sequencing
EP1994180A4 (en) 2006-02-24 2009-11-25 Callida Genomics Inc GENOME SEQUENCING ON DNA ARRAYS WITH HIGH THROUGHPUT
SG10201405158QA (en) 2006-02-24 2014-10-30 Callida Genomics Inc High throughput genome sequencing on dna arrays
WO2008045575A2 (en) 2006-10-13 2008-04-17 J. Craig Venter Institute, Inc. Sequencing method
US7910302B2 (en) 2006-10-27 2011-03-22 Complete Genomics, Inc. Efficient arrays of amplified polynucleotides
EP4134667A1 (en) 2006-12-14 2023-02-15 Life Technologies Corporation Apparatus for measuring analytes using fet arrays
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
US8518640B2 (en) 2007-10-29 2013-08-27 Complete Genomics, Inc. Nucleic acid sequencing and process
US8298768B2 (en) 2007-11-29 2012-10-30 Complete Genomics, Inc. Efficient shotgun sequencing methods
US8415099B2 (en) 2007-11-05 2013-04-09 Complete Genomics, Inc. Efficient base determination in sequencing reactions
US7897344B2 (en) 2007-11-06 2011-03-01 Complete Genomics, Inc. Methods and oligonucleotide designs for insertion of multiple adaptors into library constructs
WO2009061840A1 (en) 2007-11-05 2009-05-14 Complete Genomics, Inc. Methods and oligonucleotide designs for insertion of multiple adaptors employing selective methylation
WO2009097368A2 (en) 2008-01-28 2009-08-06 Complete Genomics, Inc. Methods and compositions for efficient base calling in sequencing reactions
US8236499B2 (en) 2008-03-28 2012-08-07 Pacific Biosciences Of California, Inc. Methods and compositions for nucleic acid sample preparation
GB0807065D0 (en) 2008-04-18 2008-05-21 Univ Leeds Novel scaffolds
US20110118142A1 (en) * 2008-05-16 2011-05-19 Life Technologies Corporation Dual labeling methods for measuring cellular proliferation
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
EP2379748A4 (en) 2008-12-23 2012-08-29 Illumina Inc MULTIBASE RELEASE FOR LONG READINGS IN SEQUENCING BY SYNTHESIS PROTOCOLS
US20140228223A1 (en) 2010-05-10 2014-08-14 Andreas Gnirke High throughput paired-end sequencing of large-insert clone libraries
US9005565B2 (en) 2010-06-24 2015-04-14 Hamid-Reza Jahangiri-Famenini Method and apparatus for forming graphene
US8669374B2 (en) 2010-08-25 2014-03-11 Gene Shen Functionalized cyanine dyes (PEG)
SI3623481T1 (sl) * 2011-09-23 2022-01-31 Illumina, Inc. Sestavki za sekvenciranje nukleinske kisline
US8671811B2 (en) 2011-09-30 2014-03-18 Robert Bosch Gmbh Pivoting saw system
GB201301178D0 (en) 2013-01-23 2013-03-06 Dynamic Biosensors Gmbh Method for sequencing a template nucleic acid immobilized on a substrate
US9650406B2 (en) * 2013-02-28 2017-05-16 Centrillion Technology Holdings Corporation Reversible terminator molecules and methods of their use
US9944924B2 (en) 2014-01-16 2018-04-17 Illumina, Inc. Polynucleotide modification on solid support
WO2016065248A1 (en) * 2014-10-23 2016-04-28 Complete Genomics, Inc. Signal confinement sequencing (scs) and nucleotide analogues for signal confinement sequencing
CN104448001A (zh) 2014-11-14 2015-03-25 杭州博谱医药科技有限公司 抗5-甲基-胞嘧啶单克隆抗体及其应用
WO2016133764A1 (en) 2015-02-17 2016-08-25 Complete Genomics, Inc. Dna sequencing using controlled strand displacement
US20170240961A1 (en) 2016-02-23 2017-08-24 Complete Genomics, Inc. Affinity tag labeled nucleosides and uses
WO2017185026A1 (en) * 2016-04-22 2017-10-26 Complete Genomics, Inc. Reversibly blocked nucleoside analogues and their use
JP6828140B2 (ja) 2016-08-15 2021-02-10 オムニオム インコーポレイテッドOmniome, Inc. 核酸をシーケンシングするための方法及びシステム
PT3565905T (pt) 2017-01-04 2022-08-02 Mgi Tech Co Ltd Sequenciação de ácidos nucleicos utilizando reagentes de afinidade

Also Published As

Publication number Publication date
AU2018205472B2 (en) 2022-12-15
HUE059673T2 (hu) 2022-12-28
RS63419B1 (sr) 2022-08-31
JP2022046677A (ja) 2022-03-23
BR112019013715B1 (pt) 2021-08-24
AU2023201547A1 (en) 2023-04-13
KR20190141120A (ko) 2019-12-23
AU2018205472A1 (en) 2019-07-25
BR112019013715A2 (pt) 2020-03-03
US11788138B2 (en) 2023-10-17
IL267836B2 (en) 2023-09-01
WO2018129214A1 (en) 2018-07-12
US20240117425A1 (en) 2024-04-11
DK3565905T3 (da) 2022-07-25
JP7025595B1 (ja) 2022-02-24
IL267836A (en) 2019-09-26
KR102349259B9 (ko) 2022-07-20
US20180223358A1 (en) 2018-08-09
CN110418847A (zh) 2019-11-05
EP3565905B1 (en) 2022-05-25
EP4112741A1 (en) 2023-01-04
MX2019008016A (es) 2019-10-15
US20210254150A1 (en) 2021-08-19
EP3565905A1 (en) 2019-11-13
KR102349259B1 (ko) 2022-01-07
EP3565905A4 (en) 2020-11-04
PL3565905T3 (pl) 2022-09-26
CA3048486A1 (en) 2018-07-12
ES2924223T3 (es) 2022-10-05
IL267836B1 (en) 2023-05-01
JP2020508037A (ja) 2020-03-19
US10851410B2 (en) 2020-12-01

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