HK1245800A1 - 被取代的核苷、核苷酸及其類似物 - Google Patents

被取代的核苷、核苷酸及其類似物

Info

Publication number
HK1245800A1
HK1245800A1 HK18105072.0A HK18105072A HK1245800A1 HK 1245800 A1 HK1245800 A1 HK 1245800A1 HK 18105072 A HK18105072 A HK 18105072A HK 1245800 A1 HK1245800 A1 HK 1245800A1
Authority
HK
Hong Kong
Prior art keywords
nucleotides
analogs
substituted nucleosides
nucleosides
substituted
Prior art date
Application number
HK18105072.0A
Other languages
English (en)
Inventor
Guangyi Wang
David Bernard Smith
Leonid Beigelman
Christian Andreas Jekle
Original Assignee
Alios Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alios Biopharma Inc filed Critical Alios Biopharma Inc
Publication of HK1245800A1 publication Critical patent/HK1245800A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
HK18105072.0A 2014-12-19 2018-04-19 被取代的核苷、核苷酸及其類似物 HK1245800A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462094418P 2014-12-19 2014-12-19
PCT/US2015/066193 WO2016100569A1 (en) 2014-12-19 2015-12-16 Substituted nucleosides, nucleotides and analogs thereof

Publications (1)

Publication Number Publication Date
HK1245800A1 true HK1245800A1 (zh) 2018-08-31

Family

ID=56127561

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18105072.0A HK1245800A1 (zh) 2014-12-19 2018-04-19 被取代的核苷、核苷酸及其類似物

Country Status (12)

Country Link
US (2) US9890188B2 (zh)
EP (1) EP3233879A4 (zh)
JP (1) JP2017538722A (zh)
CN (1) CN107250145A (zh)
AU (1) AU2015364630A1 (zh)
CA (1) CA2970936A1 (zh)
HK (1) HK1245800A1 (zh)
MA (1) MA41213A (zh)
MX (1) MX2017008184A (zh)
TW (1) TW201625658A (zh)
WO (1) WO2016100569A1 (zh)
ZA (1) ZA201704876B (zh)

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US9815864B2 (en) 2013-06-26 2017-11-14 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
AU2014331863C1 (en) 2013-10-11 2019-05-16 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
EP3797782A1 (en) 2014-06-24 2021-03-31 Janssen BioPharma, Inc. Substituted nucleosides, nucleotides and analogs thereof for use in the treatment of viral infections
CA2952959C (en) 2014-06-24 2023-03-07 Alios Biopharma, Inc. Use of nucleosides and nucleotides to treat filoviridae viral infection
CN107108681B (zh) 2014-10-28 2021-04-06 詹森生物制药有限公司 制备取代的核苷类似物的方法
MA41441A (fr) 2014-12-19 2017-12-12 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
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US11149049B2 (en) * 2017-09-18 2021-10-19 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
JP2021521118A (ja) 2018-04-10 2021-08-26 アテア ファーマシューティカルズ， インコーポレイテッド 肝硬変を伴うｈｃｖ感染患者の治療
TWI794742B (zh) 2020-02-18 2023-03-01 美商基利科學股份有限公司 抗病毒化合物
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WO2023073239A1 (en) 2021-11-01 2023-05-04 Immunic Ag Medical use of n4-hydroxy citicoline compounds
CN116554249A (zh) * 2022-01-28 2023-08-08 北京恩泰伟医药科技有限公司 抗病毒化合物及其用途
CN114288313B (zh) * 2022-02-18 2023-07-04 常晓宇 嘧啶核苷类药物在制备预防或治疗冠状病毒感染性疾病药物中的用途

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US8916538B2 (en) 2012-03-21 2014-12-23 Vertex Pharmaceuticals Incorporated Solid forms of a thiophosphoramidate nucleotide prodrug
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MA41441A (fr) 2014-12-19 2017-12-12 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci

Also Published As

Publication number Publication date
WO2016100569A1 (en) 2016-06-23
US9890188B2 (en) 2018-02-13
AU2015364630A1 (en) 2017-07-06
MX2017008184A (es) 2018-03-06
CA2970936A1 (en) 2016-06-23
EP3233879A1 (en) 2017-10-25
US20180155384A1 (en) 2018-06-07
JP2017538722A (ja) 2017-12-28
US20160176910A1 (en) 2016-06-23
EP3233879A4 (en) 2018-09-19
CN107250145A (zh) 2017-10-13
TW201625658A (zh) 2016-07-16
MA41213A (fr) 2017-10-24
ZA201704876B (en) 2020-01-29

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