MX2017008184A - Nucleosidos sustituidos, nucleotidos y analogos de estos. - Google Patents
Nucleosidos sustituidos, nucleotidos y analogos de estos.Info
- Publication number
- MX2017008184A MX2017008184A MX2017008184A MX2017008184A MX2017008184A MX 2017008184 A MX2017008184 A MX 2017008184A MX 2017008184 A MX2017008184 A MX 2017008184A MX 2017008184 A MX2017008184 A MX 2017008184A MX 2017008184 A MX2017008184 A MX 2017008184A
- Authority
- MX
- Mexico
- Prior art keywords
- nucleotides
- analogs
- substituted nucleosides
- nucleosides
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
En la presente descripción se describen nucleósidos, nucleótidos y análogos de nucleótidos, métodos para sintetizarlos y métodos para tratar enfermedades y/o afecciones, tales como una infección por Picornavirus, con uno o más nucleósidos, Nucleótidos y análogos de nucleótidos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462094418P | 2014-12-19 | 2014-12-19 | |
PCT/US2015/066193 WO2016100569A1 (en) | 2014-12-19 | 2015-12-16 | Substituted nucleosides, nucleotides and analogs thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017008184A true MX2017008184A (es) | 2018-03-06 |
Family
ID=56127561
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017008184A MX2017008184A (es) | 2014-12-19 | 2015-12-16 | Nucleosidos sustituidos, nucleotidos y analogos de estos. |
Country Status (12)
Country | Link |
---|---|
US (2) | US9890188B2 (es) |
EP (1) | EP3233879A4 (es) |
JP (1) | JP2017538722A (es) |
CN (1) | CN107250145A (es) |
AU (1) | AU2015364630A1 (es) |
CA (1) | CA2970936A1 (es) |
HK (1) | HK1245800A1 (es) |
MA (1) | MA41213A (es) |
MX (1) | MX2017008184A (es) |
TW (1) | TW201625658A (es) |
WO (1) | WO2016100569A1 (es) |
ZA (1) | ZA201704876B (es) |
Families Citing this family (31)
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UY34536A (es) | 2011-12-22 | 2013-07-31 | Alios Biopharma Inc | Nucleósidos sustituidos, nucleótidos y análogos de los mismos |
US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
CN104321333A (zh) | 2012-03-21 | 2015-01-28 | 沃泰克斯药物股份有限公司 | 硫代氨基磷酸酯核苷酸前药的固体形式 |
USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
EP2935305A4 (en) | 2012-12-21 | 2016-08-03 | Alios Biopharma Inc | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGUE THEREOF |
KR102168621B1 (ko) | 2012-12-21 | 2020-10-22 | 얀센 바이오파마, 인코퍼레이트. | 치환된 뉴클레오사이드, 뉴클레오타이드 및 그것의 유사체 |
US9504705B2 (en) | 2013-04-05 | 2016-11-29 | Alios Biopharma, Inc. | Hepatitis C viral infection treatment using a combination of compounds |
JP6453322B2 (ja) | 2013-06-26 | 2019-01-16 | アリオス バイオファーマ インク. | 置換ヌクレオシド、置換ヌクレオチドおよびそれらの類似体 |
US9815864B2 (en) | 2013-06-26 | 2017-11-14 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
SG11201602595TA (en) | 2013-10-11 | 2016-04-28 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
MX2016017381A (es) | 2014-06-24 | 2017-08-14 | Alios Biopharma Inc | Nucleosidos sustituidos, nucleotidos y analogos de los mismos. |
EA201692535A1 (ru) | 2014-06-24 | 2017-05-31 | Элиос Биофарма, Инк. | Замещенные нуклеозиды, нуклеотиды и их аналоги |
CN107108681B (zh) | 2014-10-28 | 2021-04-06 | 詹森生物制药有限公司 | 制备取代的核苷类似物的方法 |
MA41441A (fr) | 2014-12-19 | 2017-12-12 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
RU2764767C2 (ru) | 2015-03-06 | 2022-01-21 | Атеа Фармасьютикалс, Инк. | β-D-2'-ДЕЗОКСИ-2'-α-ФТОР-2'-β-С-ЗАМЕЩЕННЫЕ-2-МОДИФИЦИРОВАННЫЕ-N6-ЗАМЕЩЕННЫЕ ПУРИНОВЫЕ НУКЛЕОТИДЫ ДЛЯ ЛЕЧЕНИЯ ВЫЗВАННЫХ HCV ЗАБОЛЕВАНИЙ |
EP3268368A4 (en) | 2015-03-11 | 2018-11-14 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
TW201718618A (zh) | 2015-09-18 | 2017-06-01 | 田邊三菱製藥股份有限公司 | 架橋型核酸GuNA,其製造方法,及中間體化合物 |
US10202412B2 (en) | 2016-07-08 | 2019-02-12 | Atea Pharmaceuticals, Inc. | β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections |
PL3512863T3 (pl) | 2016-09-07 | 2022-04-04 | Atea Pharmaceuticals, Inc. | 2'-Podstawione-N6-podstawione nukleotydy purynowe do leczenia zakażeń wirusem RNA |
WO2018110591A1 (ja) * | 2016-12-13 | 2018-06-21 | ヤマサ醤油株式会社 | 抗ウイルス活性を有する2'-デオキシ-7-デアザプリンヌクレオシド誘導体 |
SG10202012214WA (en) | 2017-02-01 | 2021-01-28 | Atea Pharmaceuticals Inc | Nucleotide hemi-sulfate salt for the treatment of hepatitis c virus |
KR20200098483A (ko) | 2017-09-18 | 2020-08-20 | 얀센 바이오파마, 인크. | 치환된 뉴클레오시드, 뉴클레오티드 및 이들의 유사체 |
WO2019200005A1 (en) | 2018-04-10 | 2019-10-17 | Atea Pharmaceuticals, Inc. | Treatment of hcv infected patients with cirrhosis |
TW202322824A (zh) | 2020-02-18 | 2023-06-16 | 美商基利科學股份有限公司 | 抗病毒化合物 |
JP7429799B2 (ja) * | 2020-02-18 | 2024-02-08 | ギリアード サイエンシーズ, インコーポレイテッド | 抗ウイルス化合物 |
US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
EP4121437A1 (en) | 2020-03-20 | 2023-01-25 | Gilead Sciences, Inc. | Prodrugs of 4'-c-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same |
CN117120444A (zh) | 2021-04-16 | 2023-11-24 | 吉利德科学公司 | 使用酰胺制备卡巴核苷的方法 |
TW202333706A (zh) | 2021-11-01 | 2023-09-01 | 德商埃慕尼克股份公司 | N—羥基胞磷膽鹼(citicoline)化合物的醫藥用途 |
CN116554249A (zh) * | 2022-01-28 | 2023-08-08 | 北京恩泰伟医药科技有限公司 | 抗病毒化合物及其用途 |
CN114288313B (zh) * | 2022-02-18 | 2023-07-04 | 常晓宇 | 嘧啶核苷类药物在制备预防或治疗冠状病毒感染性疾病药物中的用途 |
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UY34536A (es) * | 2011-12-22 | 2013-07-31 | Alios Biopharma Inc | Nucleósidos sustituidos, nucleótidos y análogos de los mismos |
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US9815864B2 (en) | 2013-06-26 | 2017-11-14 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
JP6453322B2 (ja) | 2013-06-26 | 2019-01-16 | アリオス バイオファーマ インク. | 置換ヌクレオシド、置換ヌクレオチドおよびそれらの類似体 |
SG11201602595TA (en) * | 2013-10-11 | 2016-04-28 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
PE20170203A1 (es) * | 2014-02-06 | 2017-03-16 | Riboscience Llc | Derivados de nucleosido sustituidos con 4'-difluorometilo como inhibidores de la replicacion de arn de la influeza |
WO2015143712A1 (en) * | 2014-03-28 | 2015-10-01 | Merck Sharp & Dohme Corp. | 4'-substituted nucleoside reverse transcriptase inhibitors |
BR112016029994A2 (pt) | 2014-06-24 | 2017-08-22 | Alios Biopharma Inc | métodos de preparação de análogos de nucleotídeo substituídos |
EA201692535A1 (ru) | 2014-06-24 | 2017-05-31 | Элиос Биофарма, Инк. | Замещенные нуклеозиды, нуклеотиды и их аналоги |
MX2016017381A (es) | 2014-06-24 | 2017-08-14 | Alios Biopharma Inc | Nucleosidos sustituidos, nucleotidos y analogos de los mismos. |
MX2017000983A (es) | 2014-07-22 | 2017-09-01 | Alios Biopharma Inc | Metodos para tratar el paramixovirus. |
CA2957017A1 (en) | 2014-08-05 | 2016-02-11 | Alios Biopharma, Inc. | Combination therapy for treating a paramyxovirus |
CN107108681B (zh) | 2014-10-28 | 2021-04-06 | 詹森生物制药有限公司 | 制备取代的核苷类似物的方法 |
MA41441A (fr) | 2014-12-19 | 2017-12-12 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
-
2015
- 2015-12-15 MA MA041213A patent/MA41213A/fr unknown
- 2015-12-16 US US14/971,926 patent/US9890188B2/en not_active Expired - Fee Related
- 2015-12-16 MX MX2017008184A patent/MX2017008184A/es unknown
- 2015-12-16 CA CA2970936A patent/CA2970936A1/en not_active Abandoned
- 2015-12-16 EP EP15871022.8A patent/EP3233879A4/en not_active Withdrawn
- 2015-12-16 JP JP2017532656A patent/JP2017538722A/ja not_active Withdrawn
- 2015-12-16 CN CN201580076647.5A patent/CN107250145A/zh active Pending
- 2015-12-16 AU AU2015364630A patent/AU2015364630A1/en not_active Abandoned
- 2015-12-16 WO PCT/US2015/066193 patent/WO2016100569A1/en active Application Filing
- 2015-12-18 TW TW104142822A patent/TW201625658A/zh unknown
-
2017
- 2017-07-18 ZA ZA2017/04876A patent/ZA201704876B/en unknown
-
2018
- 2018-01-30 US US15/884,052 patent/US20180155384A1/en not_active Abandoned
- 2018-04-19 HK HK18105072.0A patent/HK1245800A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
MA41213A (fr) | 2017-10-24 |
US9890188B2 (en) | 2018-02-13 |
WO2016100569A1 (en) | 2016-06-23 |
CA2970936A1 (en) | 2016-06-23 |
HK1245800A1 (zh) | 2018-08-31 |
US20180155384A1 (en) | 2018-06-07 |
CN107250145A (zh) | 2017-10-13 |
TW201625658A (zh) | 2016-07-16 |
EP3233879A4 (en) | 2018-09-19 |
EP3233879A1 (en) | 2017-10-25 |
JP2017538722A (ja) | 2017-12-28 |
ZA201704876B (en) | 2020-01-29 |
AU2015364630A1 (en) | 2017-07-06 |
US20160176910A1 (en) | 2016-06-23 |
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