ES2182847T3 - Nucleosidos y nucleotidos de anillo expandido. - Google Patents

Nucleosidos y nucleotidos de anillo expandido.

Info

Publication number
ES2182847T3
ES2182847T3 ES94929358T ES94929358T ES2182847T3 ES 2182847 T3 ES2182847 T3 ES 2182847T3 ES 94929358 T ES94929358 T ES 94929358T ES 94929358 T ES94929358 T ES 94929358T ES 2182847 T3 ES2182847 T3 ES 2182847T3
Authority
ES
Spain
Prior art keywords
compositions
nucleosids
nucleotides
ring
expanded ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94929358T
Other languages
English (en)
Inventor
Barry Burns
Ramachandra Hosmane
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nabi Inc
University of Maryland at Baltimore
University of Maryland at Baltimore County UMBC
Original Assignee
Nabi Inc
University of Maryland at Baltimore
University of Maryland at Baltimore County UMBC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nabi Inc, University of Maryland at Baltimore, University of Maryland at Baltimore County UMBC filed Critical Nabi Inc
Application granted granted Critical
Publication of ES2182847T3 publication Critical patent/ES2182847T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPOSICIONES QUE COMPRENDEN ANALOGOS DE NUCLEOSIDOS DE PURINA QUE CONTIENEN UN ANILLO HETEROCICLICO DE ANILLO EXPANDIDO ("GRASO"), EN LUGAR DE PURINA, Y UN RESIDUO DE AZUCAR NO MODIFICADO O MODIFICADO, DERIVADOS FARMACEUTICAMENTE ACEPTABLES DE TALES COMPOSICIONES, ASI COMO METODOS DE USO DE LAS MISMAS. EN PARTICULAR, ESTAS COMPOSICIONES PUEDEN UTILIZARSE EN EL TRATAMIENTO DE CIERTOS CANCERES, INFECCIONES POR BACTERIAS, HONGOS, PARASITOS Y VIRUS, INCLUYENDO, PERO NO LIMITANDOSE AL SINDROME DE INMUNODEFICIENCIA ADQUIRIDA (SIDA) Y HEPATITIS.
ES94929358T 1993-09-29 1994-09-29 Nucleosidos y nucleotidos de anillo expandido. Expired - Lifetime ES2182847T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12821293A 1993-09-29 1993-09-29

Publications (1)

Publication Number Publication Date
ES2182847T3 true ES2182847T3 (es) 2003-03-16

Family

ID=22434211

Family Applications (2)

Application Number Title Priority Date Filing Date
ES02001587T Expired - Lifetime ES2269528T3 (es) 1993-09-29 1994-09-29 Nucleosidos y nucleotidos con un anillo heterociclico.
ES94929358T Expired - Lifetime ES2182847T3 (es) 1993-09-29 1994-09-29 Nucleosidos y nucleotidos de anillo expandido.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES02001587T Expired - Lifetime ES2269528T3 (es) 1993-09-29 1994-09-29 Nucleosidos y nucleotidos con un anillo heterociclico.

Country Status (9)

Country Link
EP (2) EP1227103B1 (es)
AT (2) ATE223428T1 (es)
AU (1) AU7844594A (es)
CA (1) CA2173116C (es)
DE (2) DE69431304T2 (es)
DK (2) DK0724587T3 (es)
ES (2) ES2269528T3 (es)
PT (2) PT1227103E (es)
WO (1) WO1995009175A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7094766B1 (en) 1995-06-06 2006-08-22 Trustees Of Boston University Use of locally applied DNA fragments
US20030032610A1 (en) 1996-06-03 2003-02-13 Gilchrest Barbara A. Method to inhibit cell growth using oligonucleotides
US6147056A (en) * 1995-06-06 2000-11-14 Trustees Of Boston University Use of locally applied DNA fragments
US5955059A (en) * 1995-06-06 1999-09-21 Trustees Of Boston University Use of locally applied DNA fragments
EP1274410A2 (en) 2000-03-31 2003-01-15 Trustees Of Boston University Use of locally applied dna fragments
US6555581B1 (en) 2001-02-15 2003-04-29 Jones Pharma, Inc. Levothyroxine compositions and methods
FR2825705B1 (fr) 2001-06-08 2005-05-20 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens
FR2835186B1 (fr) 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
FR2844273B1 (fr) 2002-09-05 2008-04-04 Aventis Pharma Sa Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens.
CN107074904B (zh) 2014-10-23 2022-12-23 深圳华大智造科技股份有限公司 信号约束测序(scs)和用于信号约束测序的核苷酸类似物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60992B2 (ja) * 1977-03-15 1985-01-11 財団法人微生物化学研究会 コホルマイシンおよび関連物質の分離法
US4163839A (en) * 1977-12-09 1979-08-07 Zaidan Hojin Biselbutsu Kagaku Kenkyu Kai Isocoformycin and a process for the production thereof
US4935505A (en) * 1983-05-03 1990-06-19 Townsend Leroy B Novel azolo [1,3] diazepine-5-ol compounds and their uses
US4713372A (en) * 1984-03-16 1987-12-15 Warner-Lambert Company 2-chloropentostatin compound having adenosine diaminase inhibitory activity
IL108524A0 (en) * 1993-02-03 1994-05-30 Gensia Inc Imidazodiazepine analogs

Also Published As

Publication number Publication date
DK0724587T3 (da) 2003-01-06
DE69434805T2 (de) 2007-02-22
CA2173116C (en) 2006-02-28
DE69431304D1 (de) 2002-10-10
WO1995009175A1 (en) 1995-04-06
DE69434805D1 (de) 2006-09-07
PT724587E (pt) 2003-01-31
DK1227103T3 (da) 2006-11-27
PT1227103E (pt) 2006-12-29
AU7844594A (en) 1995-04-18
ATE334137T1 (de) 2006-08-15
ES2269528T3 (es) 2007-04-01
EP1227103A3 (en) 2002-10-16
EP0724587A1 (en) 1996-08-07
EP0724587B1 (en) 2002-09-04
DE69431304T2 (de) 2003-05-15
EP1227103B1 (en) 2006-07-26
EP0724587A4 (en) 1996-12-27
ATE223428T1 (de) 2002-09-15
EP0724587B8 (en) 2003-01-29
CA2173116A1 (en) 1995-04-06
EP1227103A2 (en) 2002-07-31

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