HUP0303436A2 - Diaril-peptidek mint a hepatitis C vírus NS3-szerin proteáz inhibitorai, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents

Diaril-peptidek mint a hepatitis C vírus NS3-szerin proteáz inhibitorai, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk

Info

Publication number
HUP0303436A2
HUP0303436A2 HU0303436A HUP0303436A HUP0303436A2 HU P0303436 A2 HUP0303436 A2 HU P0303436A2 HU 0303436 A HU0303436 A HU 0303436A HU P0303436 A HUP0303436 A HU P0303436A HU P0303436 A2 HUP0303436 A2 HU P0303436A2
Authority
HU
Hungary
Prior art keywords
group
chr
oxygen
atom
crr
Prior art date
Application number
HU0303436A
Other languages
English (en)
Inventor
Ashok Arasappan
Kevin X. Chen
Viyyoor M. Girijavallabhan
Raymond G. Lovey
Bruce A. Malcolm
F. George Njoroge
Zhong-Yue Sun
Srikanth Venkatraman
Zhaoning Zhu
Original Assignee
Schering Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp. filed Critical Schering Corp.
Publication of HUP0303436A2 publication Critical patent/HUP0303436A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

A találmány tárgyát új általános képletű vegyületek - ahol X és Yadott esetben szubsztituált alkil-, aril-, heteroalkil-, heteroaril-vagy cikloalkilcsoport; W karbonil-, tiokarbonil- vagyszulfonilcsoport; Q metilidéncsoport, nitrogén-, foszfor- oxigén-,kénatom, szulfonil-, (CH2)p, (CHR)p, (CRR')p vagy RNR általánosképletű csoport; A oxigén- kénatom, metilén-, (CHR)p, (CHR-CHR')p,(CRR')p, NR általános képletű csoport vagy egy kötés; U oxigén-,nitrogénatom vagy metiléncsoport; E metiléncsoport, nitrogénatom, =CR-általános képletű csoport vagy kettős kötés; G (CH2)p, (CHR)p vagy(CRR')p általános képletű csoport; J szulfonil-, imino-, (CH2)p,(CHR)p, NR vagy (CRR')p általános képletű csoport vagy oxigénatom; Lmetiledén-, CR vagy NR általános képletű csoport, oxigén vagy kénatom;M oxigén-, kénatom, szulfonil-, NR, (CH2)p, (CHR)p, (CHR-CHR')p vagy(CRR')p általános képletű csoport; P1a, P1b, P1' és P3 hidrogénatom,adott esetben szubsztituált alkil-, alkenil-, cikloalkil-,heterocikloalkil-, aril-, heteroarilcsoport, vagy P1a és P1b együttegy adott esetben szubsztituált spiro- vagy spiroheterogyűrűt képez; Zoxigénatom, imino- vagy NR'< általános képletű csoport; Ar1 és Ar2adott esetben szubsztituált heterogyűrű; p4 hidrogénatom, alkil-,aralkil- vagy arilcsoport; és R2' hidrogénatom, ciano-, adott esetbenszubsztituált alkil-, alkenil-, alkinil-, cikloalkil-, aril-,heteroaril- vagy karboxilcsoport - és az előállításukra szolgálóeljárások, a vegyületeket tartalurazó gyógyszerkészítmények képezik ésalkalmazásuk például hepatitis C kezelésére. Ó
HU0303436A 2000-12-12 2001-12-10 Diaril-peptidek mint a hepatitis C vírus NS3-szerin proteáz inhibitorai, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk HUP0303436A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25486900P 2000-12-12 2000-12-12
PCT/US2001/047383 WO2002048172A2 (en) 2000-12-12 2001-12-10 Diaryl peptides as ns3-serine protease inhibitors of hepatits c virus

Publications (1)

Publication Number Publication Date
HUP0303436A2 true HUP0303436A2 (hu) 2004-01-28

Family

ID=22965900

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303436A HUP0303436A2 (hu) 2000-12-12 2001-12-10 Diaril-peptidek mint a hepatitis C vírus NS3-szerin proteáz inhibitorai, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk

Country Status (18)

Country Link
US (1) US6911428B2 (hu)
EP (1) EP1343807B1 (hu)
JP (1) JP4368581B2 (hu)
KR (1) KR20030091946A (hu)
CN (1) CN1301994C (hu)
AR (1) AR031905A1 (hu)
AT (1) ATE430166T1 (hu)
AU (2) AU2002236591B2 (hu)
CA (1) CA2430458A1 (hu)
DE (1) DE60138567D1 (hu)
ES (1) ES2324594T3 (hu)
HK (1) HK1054394B (hu)
HU (1) HUP0303436A2 (hu)
IL (1) IL155842A0 (hu)
MX (1) MXPA03005219A (hu)
PE (1) PE20020691A1 (hu)
WO (1) WO2002048172A2 (hu)
ZA (1) ZA200304382B (hu)

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