ATE433984T1 - Verbindungen und verfahren zur behandlung von dyslipidämie - Google Patents

Verbindungen und verfahren zur behandlung von dyslipidämie

Info

Publication number
ATE433984T1
ATE433984T1 AT05725968T AT05725968T ATE433984T1 AT E433984 T1 ATE433984 T1 AT E433984T1 AT 05725968 T AT05725968 T AT 05725968T AT 05725968 T AT05725968 T AT 05725968T AT E433984 T1 ATE433984 T1 AT E433984T1
Authority
AT
Austria
Prior art keywords
methods
compounds
treating dyslipidemia
dyslipidemia
treating
Prior art date
Application number
AT05725968T
Other languages
English (en)
Inventor
Michael Bell
Guoqing Cao
Ana Maria Escribano
Maria Carmen Fernandez
Peter Lander
Nathan Mantlo
De La Nava Eva Maria Martin
Herranz Ana Isabel Mateo
Daniel Mayhugh
Xiaodong Wang
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE433984T1 publication Critical patent/ATE433984T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT05725968T 2004-03-26 2005-03-17 Verbindungen und verfahren zur behandlung von dyslipidämie ATE433984T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55713404P 2004-03-26 2004-03-26
US62116204P 2004-10-22 2004-10-22
PCT/US2005/009301 WO2005097806A1 (en) 2004-03-26 2005-03-17 Compounds and methods for treating dyslipidemia

Publications (1)

Publication Number Publication Date
ATE433984T1 true ATE433984T1 (de) 2009-07-15

Family

ID=34963426

Family Applications (2)

Application Number Title Priority Date Filing Date
AT05732643T ATE402180T1 (de) 2004-03-26 2005-03-17 Verbindungen zur behandlung von dyslipidemie
AT05725968T ATE433984T1 (de) 2004-03-26 2005-03-17 Verbindungen und verfahren zur behandlung von dyslipidämie

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT05732643T ATE402180T1 (de) 2004-03-26 2005-03-17 Verbindungen zur behandlung von dyslipidemie

Country Status (21)

Country Link
US (2) US7470705B2 (de)
EP (2) EP1735320B1 (de)
JP (1) JP2007530550A (de)
KR (1) KR20070007112A (de)
AT (2) ATE402180T1 (de)
AU (1) AU2005230915A1 (de)
BR (1) BRPI0508966A (de)
CA (1) CA2557010A1 (de)
CY (1) CY1110398T1 (de)
DE (2) DE602005008416D1 (de)
DK (1) DK1732933T3 (de)
EA (1) EA200601785A1 (de)
EC (1) ECSP066886A (de)
ES (2) ES2308477T3 (de)
IL (1) IL177962A0 (de)
MA (1) MA28550B1 (de)
NO (1) NO20064763L (de)
PL (1) PL1732933T3 (de)
PT (1) PT1732933E (de)
SI (1) SI1732933T1 (de)
WO (2) WO2005097806A1 (de)

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WO2005097806A1 (en) * 2004-03-26 2005-10-20 Eli Lilly And Company Compounds and methods for treating dyslipidemia
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CA2707651A1 (en) 2007-12-03 2009-06-11 Novartis Ag 1,2-disubstituted-4-benzylamino-pyrrolidine derivatives as cetp inhibitors useful for the treatment of diseases such as hyperli pidemia or arteriosclerosis
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EP2412710A4 (de) * 2009-03-27 2012-08-08 Kowa Co Kondensierte piperidinverbindung und pharmazeutischer wirkstoff damit
BRPI1012852A2 (pt) 2009-05-15 2018-06-19 Novartis Ag derivados de benzoxazolona como inibidores da sintase de aldoesterona
SI2429995T1 (sl) 2009-05-15 2014-05-30 Novartis Ag Arilpiridini kot inhibitorji aldosteron sintaze
NZ596304A (en) 2009-05-28 2014-01-31 Novartis Ag Substituted aminopropionic derivatives as neprilysin inhibitors
EP2435402B1 (de) 2009-05-28 2016-04-13 Novartis AG Substituierte aminobuttersäurederivate als neprilysininhibitoren
TWI450896B (zh) 2009-06-30 2014-09-01 Lilly Co Eli 反式-4-〔〔(5s)-5-〔〔〔3,5-雙(三氟甲基)苯基〕甲基〕(2-甲基-2h-四唑-5-基)胺基〕-2,3,4,5-四氫-7,9-二甲基-1h-1-苯并氮呯-1-基〕甲基〕-環己基羧酸
EP2993169B1 (de) 2009-11-17 2017-12-20 Novartis AG Aryl-pyridin derivate als aldosteron synthase hemmer
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
US8575160B2 (en) 2009-11-30 2013-11-05 Novartis Ag Imidazole derivatives as aldosterone synthase inhibitors
WO2011106545A1 (en) * 2010-02-24 2011-09-01 Relypsa, Inc. Polyimidazoles for use as bile acid sequestrants
LT2566505T (lt) 2010-05-06 2020-02-10 Alphacore Pharma Llc Cholesterilo esterio tiekimas į steroidogeninius audinius
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
TWI627167B (zh) 2011-07-08 2018-06-21 諾華公司 用於高三酸甘油酯個體治療動脈粥狀硬化之方法
CN103827105B (zh) 2011-08-18 2016-08-17 雷迪博士实验室有限公司 作为胆固醇酯转移蛋白(cetp)抑制剂的取代的杂环胺化合物
CN103958511A (zh) 2011-09-27 2014-07-30 雷迪博士实验室有限公司 作为胆固醇酯转移蛋白(CETP)抑制剂用于治疗动脉粥样硬化的5-苄基氨基甲基-6-氨基吡唑并[3,4-b]吡啶衍生物
JO3210B1 (ar) 2011-10-28 2018-03-08 Merck Sharp & Dohme مثبط منصهر لبروتين نقل الكوليسترليستير اوكسازوليدينون ثمائي الحلقة
US20140303198A1 (en) 2011-11-29 2014-10-09 Kowa Company, Ltd. Agent for inhibiting expression of npc1l1 and/or lipg mrna and agent for preventing and/or treating obesity
UY35144A (es) 2012-11-20 2014-06-30 Novartis Ag Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
LT2956464T (lt) 2013-02-14 2018-07-10 Novartis Ag Pakeisti bisfenilbutanoinės fosfonrūgšties dariniai, kaip nep (neutralios endopeptidazės) inhibitoriai
KR20160031551A (ko) 2013-07-25 2016-03-22 노파르티스 아게 심부전의 치료를 위한 시클릭 폴리펩티드
MX2016001021A (es) 2013-07-25 2016-08-03 Novartis Ag Bioconjugados de polipeptidos de apelina sinteticos.
SG11201704758XA (en) 2015-01-23 2017-08-30 Novartis Ag Synthetic apelin fatty acid conjugates with improved half-life
JOP20190086A1 (ar) 2016-10-21 2019-04-18 Novartis Ag مشتقات نافثيريدينون جديدة واستخدامها في معالجة عدم انتظام ضربات القلب
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AR127698A1 (es) 2021-11-23 2024-02-21 Novartis Ag Derivados de naftiridinona para el tratamiento de una enfermedad o un trastorno

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WO2005097806A1 (en) 2004-03-26 2005-10-20 Eli Lilly And Company Compounds and methods for treating dyslipidemia
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Also Published As

Publication number Publication date
MA28550B1 (fr) 2007-04-03
US20070173526A1 (en) 2007-07-26
KR20070007112A (ko) 2007-01-12
EP1732933B1 (de) 2008-07-23
US7470705B2 (en) 2008-12-30
WO2005097806A1 (en) 2005-10-20
BRPI0508966A (pt) 2007-08-21
ES2326326T3 (es) 2009-10-07
EP1735320B1 (de) 2009-06-17
JP2007530550A (ja) 2007-11-01
PL1732933T3 (pl) 2008-12-31
DK1732933T3 (da) 2008-10-27
IL177962A0 (en) 2006-12-31
US20070208003A1 (en) 2007-09-06
EA200601785A1 (ru) 2007-02-27
SI1732933T1 (sl) 2008-10-31
EP1732933A1 (de) 2006-12-20
ES2308477T3 (es) 2008-12-01
DE602005008416D1 (de) 2008-09-04
PT1732933E (pt) 2008-10-20
WO2005097805A1 (en) 2005-10-20
CA2557010A1 (en) 2005-10-20
NO20064763L (no) 2006-11-22
DE602005014955D1 (de) 2009-07-30
ECSP066886A (es) 2006-11-24
EP1735320A1 (de) 2006-12-27
AU2005230915A1 (en) 2005-10-20
ATE402180T1 (de) 2008-08-15
CY1110398T1 (el) 2015-04-29

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