EA200601785A1 - Соединения и способы лечения дислипидемии - Google Patents

Соединения и способы лечения дислипидемии

Info

Publication number
EA200601785A1
EA200601785A1 EA200601785A EA200601785A EA200601785A1 EA 200601785 A1 EA200601785 A1 EA 200601785A1 EA 200601785 A EA200601785 A EA 200601785A EA 200601785 A EA200601785 A EA 200601785A EA 200601785 A1 EA200601785 A1 EA 200601785A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
dyslipidemia
connections
treatment
sequelae
Prior art date
Application number
EA200601785A
Other languages
English (en)
Inventor
Майкл Грегори Белл
Гуоцин Цао
Ана Мария Эскрибано
Мария Кармен Фернандес
Питер Амброз Ландер
Натан Брайан Мэнтло
Эва Мария Мартин Де Ла Нава
Ана Исабель Матео Эрранс
Дэниел Рэй Мэйхью
Сяодун Ванг
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA200601785A1 publication Critical patent/EA200601785A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)

Abstract

Настоящее изобретение описывает соединения формулы Iгде A, n, q, K, W, X, Y, Z, R, R, R, R, Rи Rявляются такими, как определено в описании, и их фармацевтические композиции и способы применения описаны в качестве полезных для лечения дислипидемии и ее осложнений.
EA200601785A 2004-03-26 2005-03-17 Соединения и способы лечения дислипидемии EA200601785A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55713404P 2004-03-26 2004-03-26
US62116204P 2004-10-22 2004-10-22
PCT/US2005/009301 WO2005097806A1 (en) 2004-03-26 2005-03-17 Compounds and methods for treating dyslipidemia

Publications (1)

Publication Number Publication Date
EA200601785A1 true EA200601785A1 (ru) 2007-02-27

Family

ID=34963426

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200601785A EA200601785A1 (ru) 2004-03-26 2005-03-17 Соединения и способы лечения дислипидемии

Country Status (21)

Country Link
US (2) US20070208003A1 (ru)
EP (2) EP1735320B1 (ru)
JP (1) JP2007530550A (ru)
KR (1) KR20070007112A (ru)
AT (2) ATE433984T1 (ru)
AU (1) AU2005230915A1 (ru)
BR (1) BRPI0508966A (ru)
CA (1) CA2557010A1 (ru)
CY (1) CY1110398T1 (ru)
DE (2) DE602005014955D1 (ru)
DK (1) DK1732933T3 (ru)
EA (1) EA200601785A1 (ru)
EC (1) ECSP066886A (ru)
ES (2) ES2326326T3 (ru)
IL (1) IL177962A0 (ru)
MA (1) MA28550B1 (ru)
NO (1) NO20064763L (ru)
PL (1) PL1732933T3 (ru)
PT (1) PT1732933E (ru)
SI (1) SI1732933T1 (ru)
WO (2) WO2005097806A1 (ru)

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EP2993169B1 (en) 2009-11-17 2017-12-20 Novartis AG Aryl-pyridine derivatives as aldosterone synthase inhibitors
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
EP2507234B1 (en) 2009-11-30 2014-03-12 Novartis AG Imidazole derivatives as aldosterone synthase inhibitors
AU2011220745B2 (en) * 2010-02-24 2016-12-01 Relypsa, Inc. Polyimidazoles for use as bile acid sequestrants
PL2566505T3 (pl) 2010-05-06 2020-06-29 Alphacore Pharma Llc Dostarczanie estru cholesterylowego do tkanek steroidogennych
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
MX2014000342A (es) 2011-07-08 2014-05-01 Novartis Ag Metodo para tratar la aterosclerosis en sujetos con alto nivel de trigliceridos.
JP5964965B2 (ja) 2011-08-18 2016-08-03 ドクター レディズ ラボラトリーズ リミテッド コレステリルエステル転送タンパク質（ｃｅｔｐ）インヒビターとしての置換複素環式アミン化合物
KR101803866B1 (ko) 2011-09-27 2017-12-04 닥터 레디스 레보러터리즈 리미티드 동맥경화증 치료에 유용한 콜레스테릴 에스테르-전달 단백질(cetp) 억제제로서 5-벤질아미노메틸-6-아미노피라졸로[3,4-b]피리딘 유도체
JO3210B1 (ar) 2011-10-28 2018-03-08 Merck Sharp & Dohme مثبط منصهر لبروتين نقل الكوليسترليستير اوكسازوليدينون ثمائي الحلقة
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KR20160031552A (ko) 2013-07-25 2016-03-22 노파르티스 아게 합성 아펠린 폴리펩티드의 생체접합체
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Also Published As

Publication number Publication date
KR20070007112A (ko) 2007-01-12
US7470705B2 (en) 2008-12-30
DE602005014955D1 (de) 2009-07-30
MA28550B1 (fr) 2007-04-03
DE602005008416D1 (de) 2008-09-04
DK1732933T3 (da) 2008-10-27
CA2557010A1 (en) 2005-10-20
EP1735320A1 (en) 2006-12-27
WO2005097806A1 (en) 2005-10-20
EP1732933A1 (en) 2006-12-20
ES2308477T3 (es) 2008-12-01
SI1732933T1 (sl) 2008-10-31
PT1732933E (pt) 2008-10-20
PL1732933T3 (pl) 2008-12-31
ECSP066886A (es) 2006-11-24
JP2007530550A (ja) 2007-11-01
WO2005097805A1 (en) 2005-10-20
ATE433984T1 (de) 2009-07-15
US20070208003A1 (en) 2007-09-06
AU2005230915A1 (en) 2005-10-20
US20070173526A1 (en) 2007-07-26
ATE402180T1 (de) 2008-08-15
CY1110398T1 (el) 2015-04-29
EP1732933B1 (en) 2008-07-23
EP1735320B1 (en) 2009-06-17
BRPI0508966A (pt) 2007-08-21
ES2326326T3 (es) 2009-10-07
IL177962A0 (en) 2006-12-31
NO20064763L (no) 2006-11-22

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