NO333700B1 - Modifiserte fluorerte nukleosid-analoger - Google Patents
Modifiserte fluorerte nukleosid-analoger Download PDFInfo
- Publication number
- NO333700B1 NO333700B1 NO20056221A NO20056221A NO333700B1 NO 333700 B1 NO333700 B1 NO 333700B1 NO 20056221 A NO20056221 A NO 20056221A NO 20056221 A NO20056221 A NO 20056221A NO 333700 B1 NO333700 B1 NO 333700B1
- Authority
- NO
- Norway
- Prior art keywords
- pharmaceutically acceptable
- fluoro
- deoxy
- virus
- methylnucleoside
- Prior art date
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- XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 description 1
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Classifications
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
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- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US47436803P | 2003-05-30 | 2003-05-30 | |
PCT/US2004/012472 WO2005003147A2 (en) | 2003-05-30 | 2004-04-21 | Modified fluorinated nucleoside analogues |
Publications (2)
Publication Number | Publication Date |
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NO20056221L NO20056221L (no) | 2005-12-28 |
NO333700B1 true NO333700B1 (no) | 2013-08-26 |
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Application Number | Title | Priority Date | Filing Date |
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NO20056221A NO333700B1 (no) | 2003-05-30 | 2005-12-28 | Modifiserte fluorerte nukleosid-analoger |
NO20110548A NO20110548L (no) | 2003-05-30 | 2011-04-11 | (2'R)-2'-deoksy-2'-fluor-2'-C-metyl-nukleosid ( β-D eller β-L) eller dets farmasoytisk akseptable salt |
NO20110549A NO20110549L (no) | 2003-05-30 | 2011-04-11 | (2'R)-2'-deoksy-2'-fluor-2'-C-metyl-nukleosid eller 4E) fremstilling av samme og farmasoytiske preparater omfattende nukleosidet |
NO20110550A NO20110550L (no) | 2003-05-30 | 2011-04-11 | Fremgangsmate for inhibering av proliferasjonenen av et Flaviviridae-virus |
NO20110547A NO20110547L (no) | 2003-05-30 | 2011-04-11 | Anvendelse av (2,R)-2'-deoksy-2'-fluor-2'-C-metyl-nukIeosider |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
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NO20110548A NO20110548L (no) | 2003-05-30 | 2011-04-11 | (2'R)-2'-deoksy-2'-fluor-2'-C-metyl-nukleosid ( β-D eller β-L) eller dets farmasoytisk akseptable salt |
NO20110549A NO20110549L (no) | 2003-05-30 | 2011-04-11 | (2'R)-2'-deoksy-2'-fluor-2'-C-metyl-nukleosid eller 4E) fremstilling av samme og farmasoytiske preparater omfattende nukleosidet |
NO20110550A NO20110550L (no) | 2003-05-30 | 2011-04-11 | Fremgangsmate for inhibering av proliferasjonenen av et Flaviviridae-virus |
NO20110547A NO20110547L (no) | 2003-05-30 | 2011-04-11 | Anvendelse av (2,R)-2'-deoksy-2'-fluor-2'-C-metyl-nukIeosider |
Country Status (29)
Country | Link |
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US (8) | US7429572B2 (es) |
EP (8) | EP1633766B1 (es) |
JP (5) | JP4958158B2 (es) |
KR (1) | KR100883703B1 (es) |
CN (1) | CN100503628C (es) |
AR (6) | AR044566A1 (es) |
AU (1) | AU2004253860B2 (es) |
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