MX2009011370A - Proceso para el intermediario del inhibidor proteasa de hcv. - Google Patents

Proceso para el intermediario del inhibidor proteasa de hcv.

Info

Publication number
MX2009011370A
MX2009011370A MX2009011370A MX2009011370A MX2009011370A MX 2009011370 A MX2009011370 A MX 2009011370A MX 2009011370 A MX2009011370 A MX 2009011370A MX 2009011370 A MX2009011370 A MX 2009011370A MX 2009011370 A MX2009011370 A MX 2009011370A
Authority
MX
Mexico
Prior art keywords
hcv protease
protease inhibitor
inhibitor intermediate
intermediates
serve
Prior art date
Application number
MX2009011370A
Other languages
English (en)
Inventor
Helmut Stahr
Francois Gantz
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2009011370A publication Critical patent/MX2009011370A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

La presente invención se relaciona con un proceso nuevo para la preparación de compuestos de dieno de la fórmula (I) en donde R1 es un grupo de protección amino y X es un átomo de halógeno que pueden servir como intermediarios para la fabricación de inhibidores macrocíclicos de proteasa HCV.
MX2009011370A 2007-04-24 2008-04-15 Proceso para el intermediario del inhibidor proteasa de hcv. MX2009011370A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07106771 2007-04-24
PCT/EP2008/054518 WO2008128921A1 (en) 2007-04-24 2008-04-15 Process for hcv protease inhibitor intermediate

Publications (1)

Publication Number Publication Date
MX2009011370A true MX2009011370A (es) 2009-11-05

Family

ID=39564613

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009011370A MX2009011370A (es) 2007-04-24 2008-04-15 Proceso para el intermediario del inhibidor proteasa de hcv.

Country Status (14)

Country Link
US (1) US7847106B2 (es)
EP (1) EP2150548B1 (es)
JP (1) JP5390510B2 (es)
KR (1) KR101467598B1 (es)
CN (1) CN101663294A (es)
AT (1) ATE490961T1 (es)
AU (1) AU2008240834B2 (es)
BR (1) BRPI0810665A2 (es)
CA (1) CA2684086C (es)
DE (1) DE602008003922D1 (es)
ES (1) ES2355437T3 (es)
IL (1) IL201299A (es)
MX (1) MX2009011370A (es)
WO (1) WO2008128921A1 (es)

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MY140680A (en) 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
KR20090024834A (ko) 2006-07-05 2009-03-09 인터뮨, 인크. Ｃ형 간염 바이러스 복제의 신규 억제제
BRPI0811447A2 (pt) 2007-05-10 2014-10-29 Intermune Inc Compostos, composição farmacêutica e métodos de inibição da atividade da protease ns3/ns4, de tratamento da fibrose hepática e de intensificação da função hepática num indivíduo tendo infecção de vírus da hepatite c.
KR20100118991A (ko) 2008-02-04 2010-11-08 아이데닉스 파마슈티칼스, 인코포레이티드 매크로시클릭 세린 프로테아제 억제제
US8048862B2 (en) 2008-04-15 2011-11-01 Intermune, Inc. Macrocyclic inhibitors of hepatitis C virus replication
CA2724552C (en) 2008-05-27 2018-10-09 Dako Denmark A/S Compositions and methods for detection of chromosomal aberrations with hybridization buffers comprising a polar aprotic solvent
US8207341B2 (en) 2008-09-04 2012-06-26 Bristol-Myers Squibb Company Process or synthesizing substituted isoquinolines
UY32099A (es) 2008-09-11 2010-04-30 Enanta Pharm Inc Inhibidores macrocíclicos de serina proteasas de hepatitis c
EP2401395A1 (en) 2009-02-26 2012-01-04 Dako Denmark A/S Compositions and methods for rna hybridization applications
AR075584A1 (es) 2009-02-27 2011-04-20 Intermune Inc COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO.
US8377962B2 (en) 2009-04-08 2013-02-19 Idenix Pharmaceuticals, Inc. Macrocyclic serine protease inhibitors
US8232246B2 (en) 2009-06-30 2012-07-31 Abbott Laboratories Anti-viral compounds
WO2011003063A2 (en) * 2009-07-02 2011-01-06 Dr. Reddy's Laboratories Ltd. Enzymes and methods for resolving amino vinyl cyclopropane carboxylic acid derivatives
TW201117812A (en) 2009-08-05 2011-06-01 Idenix Pharmaceuticals Inc Macrocyclic serine protease inhibitors
BR112013016480A2 (pt) 2010-12-30 2016-09-20 Abbvie Inc macrocíclo da fenantridina inibadores da protease da serina da hepatite c
JP2014502620A (ja) 2010-12-30 2014-02-03 エナンタ ファーマシューティカルズ インコーポレイテッド 大環状ｃ型肝炎セリンプロテアーゼ阻害剤
US9353100B2 (en) 2011-02-10 2016-05-31 Idenix Pharmaceuticals Llc Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections
US8957203B2 (en) 2011-05-05 2015-02-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
US8691757B2 (en) 2011-06-15 2014-04-08 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US10662465B2 (en) 2011-09-30 2020-05-26 Agilent Technologies, Inc. Hybridization compositions and methods using formamide
US11118226B2 (en) 2011-10-21 2021-09-14 Agilent Technologies, Inc. Hybridization compositions and methods
JP2015533124A (ja) 2012-10-08 2015-11-19 アッヴィ・インコーポレイテッド Ｈｃｖプロテアーゼ阻害剤を作製するのに有用な化合物
JP6154474B2 (ja) 2012-10-19 2017-06-28 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｃ型肝炎ウイルス阻害剤
US9643999B2 (en) 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2014070964A1 (en) 2012-11-02 2014-05-08 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
WO2014071007A1 (en) 2012-11-02 2014-05-08 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
US9409943B2 (en) 2012-11-05 2016-08-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9580463B2 (en) 2013-03-07 2017-02-28 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP3089757A1 (en) 2014-01-03 2016-11-09 AbbVie Inc. Solid antiviral dosage forms
CN109678787A (zh) * 2018-12-31 2019-04-26 南京晓庄学院 一种新的hcv病毒ns3/4a抑制剂合成中间体及合成方法

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Publication number Priority date Publication date Assignee Title
US5283293A (en) * 1990-12-14 1994-02-01 Corvas, Inc. Reagents for automated synthesis of peptide analogs
AR045047A1 (es) * 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
JP4584260B2 (ja) * 2003-10-14 2010-11-17 インターミューン・インコーポレーテッド Ｈｃｖ複製阻害剤としての大環状カルボン酸およびアシルスルホンアミド
US7470664B2 (en) * 2005-07-20 2008-12-30 Merck & Co., Inc. HCV NS3 protease inhibitors
GB0517279D0 (en) * 2005-08-23 2005-10-05 Amura Therapeutics Ltd Biologically active compounds
KR20090024834A (ko) * 2006-07-05 2009-03-09 인터뮨, 인크. Ｃ형 간염 바이러스 복제의 신규 억제제
US7582605B2 (en) * 2006-08-11 2009-09-01 Enanta Pharmaceuticals, Inc. Phosphorus-containing hepatitis C serine protease inhibitors

Also Published As

Publication number Publication date
ATE490961T1 (de) 2010-12-15
CN101663294A (zh) 2010-03-03
US20080269502A1 (en) 2008-10-30
WO2008128921A1 (en) 2008-10-30
AU2008240834A1 (en) 2008-10-30
IL201299A0 (en) 2010-05-31
KR101467598B1 (ko) 2014-12-01
JP5390510B2 (ja) 2014-01-15
DE602008003922D1 (de) 2011-01-20
KR20100015710A (ko) 2010-02-12
IL201299A (en) 2013-11-28
EP2150548B1 (en) 2010-12-08
JP2010525007A (ja) 2010-07-22
EP2150548A1 (en) 2010-02-10
US7847106B2 (en) 2010-12-07
ES2355437T3 (es) 2011-03-25
CA2684086A1 (en) 2008-10-30
CA2684086C (en) 2014-05-27
AU2008240834B2 (en) 2012-08-23
BRPI0810665A2 (pt) 2014-11-04

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