BRPI0810665A2 - Processo para a preparação de intermediário de inibidor da protease de hcv - Google Patents
Processo para a preparação de intermediário de inibidor da protease de hcvInfo
- Publication number
- BRPI0810665A2 BRPI0810665A2 BRPI0810665-7A2A BRPI0810665A BRPI0810665A2 BR PI0810665 A2 BRPI0810665 A2 BR PI0810665A2 BR PI0810665 A BRPI0810665 A BR PI0810665A BR PI0810665 A2 BRPI0810665 A2 BR PI0810665A2
- Authority
- BR
- Brazil
- Prior art keywords
- hcv protease
- protease inhibitor
- inhibitor intermediate
- tripeptides
- macrocyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07106771 | 2007-04-24 | ||
PCT/EP2008/054518 WO2008128921A1 (en) | 2007-04-24 | 2008-04-15 | Process for hcv protease inhibitor intermediate |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0810665A2 true BRPI0810665A2 (pt) | 2014-11-04 |
Family
ID=39564613
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0810665-7A2A BRPI0810665A2 (pt) | 2007-04-24 | 2008-04-15 | Processo para a preparação de intermediário de inibidor da protease de hcv |
Country Status (14)
Country | Link |
---|---|
US (1) | US7847106B2 (pt) |
EP (1) | EP2150548B1 (pt) |
JP (1) | JP5390510B2 (pt) |
KR (1) | KR101467598B1 (pt) |
CN (1) | CN101663294A (pt) |
AT (1) | ATE490961T1 (pt) |
AU (1) | AU2008240834B2 (pt) |
BR (1) | BRPI0810665A2 (pt) |
CA (1) | CA2684086C (pt) |
DE (1) | DE602008003922D1 (pt) |
ES (1) | ES2355437T3 (pt) |
IL (1) | IL201299A (pt) |
MX (1) | MX2009011370A (pt) |
WO (1) | WO2008128921A1 (pt) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
RU2008152171A (ru) | 2006-07-05 | 2010-08-10 | Интермьюн, Инк. (Us) | Новые ингибиторы вирусной репликации гепатита с |
AP2009005057A0 (en) | 2007-05-10 | 2009-12-31 | Array Biopharma Inc | Novel peptide inhibitors of hepatitis c virus replication |
AR070413A1 (es) | 2008-02-04 | 2010-04-07 | Idenix Pharmaceuticals Inc | Inhibidores macrociclicos de proteasa de serina |
AP2010005416A0 (en) | 2008-04-15 | 2010-10-31 | Intermune Inc | Novel macrocyclic inhibitors of hepatitis c virus replication. |
WO2009147537A2 (en) | 2008-05-27 | 2009-12-10 | Dako Denmark A/S | Compositions and methods for detection of chromosomal aberrations with novel hybridization buffers |
US8207341B2 (en) | 2008-09-04 | 2012-06-26 | Bristol-Myers Squibb Company | Process or synthesizing substituted isoquinolines |
UY32099A (es) | 2008-09-11 | 2010-04-30 | Enanta Pharm Inc | Inhibidores macrocíclicos de serina proteasas de hepatitis c |
US9303287B2 (en) * | 2009-02-26 | 2016-04-05 | Dako Denmark A/S | Compositions and methods for RNA hybridization applications |
AR075584A1 (es) | 2009-02-27 | 2011-04-20 | Intermune Inc | COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO. |
TW201040181A (en) | 2009-04-08 | 2010-11-16 | Idenix Pharmaceuticals Inc | Macrocyclic serine protease inhibitors |
US8232246B2 (en) | 2009-06-30 | 2012-07-31 | Abbott Laboratories | Anti-viral compounds |
JP2012532146A (ja) * | 2009-07-02 | 2012-12-13 | ドクター・レディーズ・ラボラトリーズ・リミテッド | アミノビニルシクロプロパンカルボン酸誘導体の分割のための酵素および方法 |
AR077712A1 (es) | 2009-08-05 | 2011-09-14 | Idenix Pharmaceuticals Inc | Inhibidores de serina proteasa macrociclica |
PE20140039A1 (es) | 2010-12-30 | 2014-03-01 | Enanta Pharm Inc | Inhibidores de serina proteasa de hepatitis c a base de macrociclicos de fenantridina |
CA2822556A1 (en) | 2010-12-30 | 2012-07-05 | Enanta Pharmaceuticals, Inc | Macrocyclic hepatitis c serine protease inhibitors |
TW201309690A (zh) | 2011-02-10 | 2013-03-01 | Idenix Pharmaceuticals Inc | 巨環絲胺酸蛋白酶抑制劑,其醫藥組合物及其於治療hcv感染之用途 |
US8957203B2 (en) | 2011-05-05 | 2015-02-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
US8691757B2 (en) | 2011-06-15 | 2014-04-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
WO2013046033A1 (en) | 2011-09-30 | 2013-04-04 | Dako Denmark A/S | Hybridization compositions and methods using formamide |
US11118226B2 (en) | 2011-10-21 | 2021-09-14 | Agilent Technologies, Inc. | Hybridization compositions and methods |
US20140100364A1 (en) | 2012-10-08 | 2014-04-10 | Abbvie Inc. | Compounds Useful For Making HCV Protease Inhibitors |
MA37992B1 (fr) | 2012-10-19 | 2018-09-28 | Bristol Myers Squibb Co | Composes inhibiteurs de protéase ns3 pour une utilisation dans le traitement de l’infection par le virus de l'hépatite c. |
EP2914613B1 (en) | 2012-11-02 | 2017-11-22 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
US9334279B2 (en) | 2012-11-02 | 2016-05-10 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US9643999B2 (en) | 2012-11-02 | 2017-05-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
EP2914614B1 (en) | 2012-11-05 | 2017-08-16 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
US9580463B2 (en) | 2013-03-07 | 2017-02-28 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
WO2015103490A1 (en) | 2014-01-03 | 2015-07-09 | Abbvie, Inc. | Solid antiviral dosage forms |
CN109678787A (zh) * | 2018-12-31 | 2019-04-26 | 南京晓庄学院 | 一种新的hcv病毒ns3/4a抑制剂合成中间体及合成方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5283293A (en) * | 1990-12-14 | 1994-02-01 | Corvas, Inc. | Reagents for automated synthesis of peptide analogs |
AR045047A1 (es) * | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
CA2540858C (en) * | 2003-10-14 | 2009-12-08 | Intermune, Inc. | Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of hcv replication |
TWI387603B (zh) * | 2005-07-20 | 2013-03-01 | Merck Sharp & Dohme | Hcv ns3蛋白酶抑制劑 |
GB0517279D0 (en) * | 2005-08-23 | 2005-10-05 | Amura Therapeutics Ltd | Biologically active compounds |
RU2008152171A (ru) * | 2006-07-05 | 2010-08-10 | Интермьюн, Инк. (Us) | Новые ингибиторы вирусной репликации гепатита с |
US7582605B2 (en) * | 2006-08-11 | 2009-09-01 | Enanta Pharmaceuticals, Inc. | Phosphorus-containing hepatitis C serine protease inhibitors |
-
2008
- 2008-04-15 MX MX2009011370A patent/MX2009011370A/es active IP Right Grant
- 2008-04-15 JP JP2010504621A patent/JP5390510B2/ja not_active Expired - Fee Related
- 2008-04-15 DE DE602008003922T patent/DE602008003922D1/de active Active
- 2008-04-15 AU AU2008240834A patent/AU2008240834B2/en not_active Ceased
- 2008-04-15 CN CN200880012457A patent/CN101663294A/zh active Pending
- 2008-04-15 BR BRPI0810665-7A2A patent/BRPI0810665A2/pt not_active IP Right Cessation
- 2008-04-15 CA CA2684086A patent/CA2684086C/en not_active Expired - Fee Related
- 2008-04-15 KR KR1020097021836A patent/KR101467598B1/ko not_active IP Right Cessation
- 2008-04-15 ES ES08736214T patent/ES2355437T3/es active Active
- 2008-04-15 EP EP08736214A patent/EP2150548B1/en not_active Expired - Fee Related
- 2008-04-15 WO PCT/EP2008/054518 patent/WO2008128921A1/en active Application Filing
- 2008-04-15 AT AT08736214T patent/ATE490961T1/de active
- 2008-04-24 US US12/150,029 patent/US7847106B2/en not_active Expired - Fee Related
-
2009
- 2009-10-01 IL IL201299A patent/IL201299A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE602008003922D1 (de) | 2011-01-20 |
WO2008128921A1 (en) | 2008-10-30 |
IL201299A (en) | 2013-11-28 |
JP5390510B2 (ja) | 2014-01-15 |
EP2150548B1 (en) | 2010-12-08 |
ES2355437T3 (es) | 2011-03-25 |
CA2684086C (en) | 2014-05-27 |
IL201299A0 (en) | 2010-05-31 |
KR20100015710A (ko) | 2010-02-12 |
AU2008240834A1 (en) | 2008-10-30 |
CN101663294A (zh) | 2010-03-03 |
EP2150548A1 (en) | 2010-02-10 |
AU2008240834B2 (en) | 2012-08-23 |
US7847106B2 (en) | 2010-12-07 |
MX2009011370A (es) | 2009-11-05 |
JP2010525007A (ja) | 2010-07-22 |
ATE490961T1 (de) | 2010-12-15 |
KR101467598B1 (ko) | 2014-12-01 |
CA2684086A1 (en) | 2008-10-30 |
US20080269502A1 (en) | 2008-10-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] |