MX2009009174A - Inhibidores de serina-proteasas para el tratamiento de infecciones por el virus de hepatitis c. - Google Patents

Inhibidores de serina-proteasas para el tratamiento de infecciones por el virus de hepatitis c.

Info

Publication number
MX2009009174A
MX2009009174A MX2009009174A MX2009009174A MX2009009174A MX 2009009174 A MX2009009174 A MX 2009009174A MX 2009009174 A MX2009009174 A MX 2009009174A MX 2009009174 A MX2009009174 A MX 2009009174A MX 2009009174 A MX2009009174 A MX 2009009174A
Authority
MX
Mexico
Prior art keywords
inhibitors
treatment
serine proteases
hcv infections
compounds
Prior art date
Application number
MX2009009174A
Other languages
English (en)
Inventor
Qing Tang
Anne-Laure Grillot
Emanuele Perola
Kevin M Cottrell
John Maxwell
Arnaud Le Tiran
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39469472&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2009009174(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of MX2009009174A publication Critical patent/MX2009009174A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere a compuestos de la fórmula (I): o una sal farmacéuticamente aceptable del mismo. Estos compuestos inhiben serina-proteasas, particularmente la proteasa NS3-NS4A del virus de hepatitis C.
MX2009009174A 2007-02-27 2008-02-27 Inhibidores de serina-proteasas para el tratamiento de infecciones por el virus de hepatitis c. MX2009009174A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/711,845 US7964624B1 (en) 2005-08-26 2007-02-27 Inhibitors of serine proteases
PCT/US2008/002541 WO2008106139A1 (en) 2007-02-27 2008-02-27 Inhibitors of serine proteases for the treatment of hcv infections

Publications (1)

Publication Number Publication Date
MX2009009174A true MX2009009174A (es) 2009-09-07

Family

ID=39469472

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009009174A MX2009009174A (es) 2007-02-27 2008-02-27 Inhibidores de serina-proteasas para el tratamiento de infecciones por el virus de hepatitis c.

Country Status (22)

Country Link
US (2) US7964624B1 (es)
EP (2) EP2631238A1 (es)
JP (1) JP2010523474A (es)
KR (1) KR20090127292A (es)
CN (1) CN102015727A (es)
AP (1) AP2009004971A0 (es)
AR (1) AR065499A1 (es)
AU (1) AU2008219689A1 (es)
BR (1) BRPI0807904A2 (es)
CA (1) CA2679429A1 (es)
CL (1) CL2008000579A1 (es)
CO (1) CO6220931A2 (es)
EA (1) EA200970805A1 (es)
EC (1) ECSP099601A (es)
GE (1) GEP20125683B (es)
IL (1) IL200611A0 (es)
MX (1) MX2009009174A (es)
NZ (1) NZ579296A (es)
PE (1) PE20081792A1 (es)
TW (1) TW200843738A (es)
UY (1) UY30941A1 (es)
WO (1) WO2008106139A1 (es)

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