ATE517869T1 - Herstellung substituierter morphinan-6-one und salzen und zwischenprodukten davon - Google Patents

Herstellung substituierter morphinan-6-one und salzen und zwischenprodukten davon

Info

Publication number
ATE517869T1
ATE517869T1 AT07837847T AT07837847T ATE517869T1 AT E517869 T1 ATE517869 T1 AT E517869T1 AT 07837847 T AT07837847 T AT 07837847T AT 07837847 T AT07837847 T AT 07837847T AT E517869 T1 ATE517869 T1 AT E517869T1
Authority
AT
Austria
Prior art keywords
salts
production
intermediate products
substituted morphinan
morphinan
Prior art date
Application number
AT07837847T
Other languages
English (en)
Inventor
Peter Xianqi Wang
Frank W Moser
Gary L Cantrell
Christopher W Grote
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of ATE517869T1 publication Critical patent/ATE517869T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
AT07837847T 2006-09-20 2007-09-06 Herstellung substituierter morphinan-6-one und salzen und zwischenprodukten davon ATE517869T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84595606P 2006-09-20 2006-09-20
US94046307P 2007-05-29 2007-05-29
PCT/US2007/019489 WO2008036172A1 (en) 2006-09-20 2007-09-06 Preparation of substituted morphinan-6-ones and salts and intermediates thereof

Publications (1)

Publication Number Publication Date
ATE517869T1 true ATE517869T1 (de) 2011-08-15

Family

ID=38926227

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07837847T ATE517869T1 (de) 2006-09-20 2007-09-06 Herstellung substituierter morphinan-6-one und salzen und zwischenprodukten davon

Country Status (10)

Country Link
US (1) US8115002B2 (de)
EP (1) EP2099764B1 (de)
JP (1) JP2010504325A (de)
AT (1) ATE517869T1 (de)
AU (1) AU2007297827B2 (de)
CA (1) CA2663909A1 (de)
MX (1) MX2009002844A (de)
NZ (1) NZ575620A (de)
RU (1) RU2009112685A (de)
WO (1) WO2008036172A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ586203A (en) 2007-12-17 2012-10-26 Mallinckrodt Llc Process and compounds for the production of (+) opiates
NZ586187A (en) * 2007-12-17 2013-07-26 Mallinckrodt Llc Processes for the synthesis of sinomenine derivatives and their intermediate
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
PT2506712T (pt) 2009-12-04 2019-05-31 Alkermes Pharma Ireland Ltd Derivados de morfinano para o tratamento da overdose por fármaco
JP5728084B2 (ja) * 2010-07-08 2015-06-03 アルカーメス ファーマ アイルランド リミテッド 置換モルフィナンの合成のための方法
HRP20240109T1 (hr) 2010-08-23 2024-03-29 Alkermes Pharma Ireland Limited Postupci za liječenje povećanja tjelesne težine induciranog antipsihoticima
BR112014005421A2 (pt) 2011-09-08 2017-04-04 Mallinckrodt Llc produção de alcaloides sem o isolamento de intermediários
US9211293B2 (en) 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
ES2770978T3 (es) 2013-05-24 2020-07-06 Alkermes Pharma Ireland Ltd Análogos de morfanos y morfinanos y métodos de uso
WO2014190271A2 (en) 2013-05-24 2014-11-27 Alkermes Pharma Ireland Limted Methods for treating depressive symptoms
JP7330898B2 (ja) * 2017-05-03 2023-08-22 メルク パテント ゲーエムベーハー 有機機能材料の調合物
EP4243768A1 (de) 2020-11-12 2023-09-20 Alkermes Pharma Ireland Limited Mehrschichttablette mit sofortiger freisetzung
CN114105875B (zh) * 2021-12-06 2023-11-03 四川大学 一种吗啡衍生物二氢埃托啡的合成方法

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3101339A (en) 1958-10-30 1963-08-20 Boehringer Sohn Ingelheim Quaternary salts of normorphine and its acylated derivatives
US4141897A (en) 1976-12-20 1979-02-27 Research Corporation N-dealkylation of N-alkyl-14-hydroxymorphinans and derivatives thereof
US4176186A (en) 1978-07-28 1979-11-27 Boehringer Ingelheim Gmbh Quaternary derivatives of noroxymorphone which relieve intestinal immobility
FR2469413B1 (fr) 1979-11-13 1986-04-25 Urpha Derives de la 6h-dibenzo(a,g) 5,8,13,13a-tetrahydroquinolizine, procede d'obtention et compositions pharmaceutiques les contenant
PL124001B1 (en) 1980-01-25 1982-12-31 Inst Przemyslu Zielarskiego Process for preparing quaternary halides of n-alkylor n-aralkyl- derivatives of tropanic and isoquinolylic alkaloids
US4322426A (en) 1980-04-28 1982-03-30 E. I. Du Pont De Nemours And Company 17-Substituted-6-desoxy-7,8-dihydro-6α-methylnoroxymorphone narcotic antagonists
US4727146A (en) 1980-07-03 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Synthesis of chiral 1-benzyl-1,2,3,4-tetra-hydroisoquinolines by asymmetric reduction
US4368326A (en) * 1980-07-03 1983-01-11 Rice Kenner C Short total synthesis of dihydrothebainone, dihydrocodeinone, and nordihydroccodeinone
US4410700A (en) 1980-07-03 1983-10-18 The United States Of America As Represented By The Department Of Health And Human Services Preparation of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines by optical resolution
US4556712A (en) * 1981-05-20 1985-12-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Preparation and racemization of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines
US4521601A (en) 1981-05-20 1985-06-04 The United States Of America As Represented By The Department Of Health & Human Services Practical total synthesis unnatural enantiomers of opium-derived morphinans
WO1983004290A1 (en) 1982-05-25 1983-12-08 Matsushita Electric Industrial Co., Ltd. Direction-of-flow controller
US4456712A (en) 1982-06-14 1984-06-26 International Business Machines Corporation Bismaleimide triazine composition
DE3229046A1 (de) * 1982-08-04 1984-02-16 Hoechst Ag, 6230 Frankfurt Verfahren zur umkehrung der konfiguration optisch aktiver verbindungen und optisch aktive zwischenprodukte dieses verfahrens
US4535157A (en) 1983-11-01 1985-08-13 Key Pharmaceuticals, Inc. Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone
JPS60132983A (ja) 1983-12-21 1985-07-16 Tanabe Seiyaku Co Ltd チアゾ−ル酢酸誘導体及びその製法
US4613668A (en) 1983-12-22 1986-09-23 The United States Of America As Represented By The Department Of Health And Human Services Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl
US5112975A (en) 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
US5668285A (en) 1986-10-31 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
US5352780A (en) * 1989-07-20 1994-10-04 Ecosorb International, Inc. Absorbent material and litter from ground cellulose
DE4132159A1 (de) 1991-09-27 1993-04-01 Boehringer Ingelheim Kg 14-hydroxy-n-(2-methoxyethyl)-7,8-dihydromorphin und -norisomorphin, verfahren zu deren herstellung und deren verwendung als arzneimittel
US5574159A (en) 1992-02-03 1996-11-12 Delta Pharmaceuticals, Inc. Opioid compounds and methods for making therefor
US5352680A (en) 1992-07-15 1994-10-04 Regents Of The University Of Minnesota Delta opioid receptor antagonists to block opioid agonist tolerance and dependence
WO1994008599A1 (en) 1992-10-14 1994-04-28 The Regents Of The University Of Colorado Ion-pairing of drugs for improved efficacy and delivery
DE4333892A1 (de) * 1993-10-05 1995-04-06 Brose Fahrzeugteile Manuell betätigbare mechanische Memory-Vorrichtung
SE9401728D0 (sv) 1994-05-18 1994-05-18 Astra Ab New compounds II
US5869669A (en) 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
US5756851A (en) 1996-10-21 1998-05-26 Albemarle Corporation Production of nabumetone or precursors thereof
NZ331001A (en) 1996-11-25 2000-05-26 Toray Industries Use of an opiate K receptor agonist as an antipruritic
ES2121554B1 (es) 1996-12-23 1999-06-16 Univ Santiago Compostela Procedimiento de obtencion de 14-hidroximofinonas mediante fotooxidac ion de alcaloides morfinicos con sistema alcoxidienico en el anillo c.
GB9713703D0 (en) 1997-06-30 1997-09-03 Johnson Matthey Plc Preparation of opiates
ES2172376B1 (es) 2000-01-28 2003-11-16 Servier Lab Nuevos derivados de isoquinoleinas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
US20020128496A1 (en) * 2001-01-12 2002-09-12 Sou-Jeng Chang Process for the preparation of matrix metalloproteinase inhibitors
DE10229842A1 (de) 2002-07-03 2004-02-05 Helmut Prof. Dr. Schmidhammer Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung
KR20050074462A (ko) 2002-09-25 2005-07-18 유로-셀티큐 에스.에이. Ｎ―치환 하이드로모르폰 및 그 용도
US7285665B2 (en) 2002-11-08 2007-10-23 Mallinckrodt Inc. Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
GEP20084454B (en) 2004-02-06 2008-08-10 Euro Celtique Sa Methods for making 3-o-protected morphinones and 3-o-protected morphinone dienol carboxylates
WO2006084389A1 (de) 2005-02-11 2006-08-17 Cilag Ltd. Verfahren zur reinigung von noroxymorphon-verbindungen
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
ES2357216T3 (es) 2005-06-16 2011-04-20 Mallinckrodt, Inc. Una ruta de síntesis de 14-hidroxil-opiáceos a través de 1-halo-tebaína o análogos.

Also Published As

Publication number Publication date
RU2009112685A (ru) 2010-10-27
US8115002B2 (en) 2012-02-14
US20100048906A1 (en) 2010-02-25
CA2663909A1 (en) 2008-03-27
AU2007297827A1 (en) 2008-03-27
EP2099764B1 (de) 2011-07-27
AU2007297827B2 (en) 2012-09-20
MX2009002844A (es) 2009-03-30
NZ575620A (en) 2010-11-26
EP2099764A1 (de) 2009-09-16
JP2010504325A (ja) 2010-02-12
WO2008036172A1 (en) 2008-03-27

Similar Documents

Publication Publication Date Title
ATE517869T1 (de) Herstellung substituierter morphinan-6-one und salzen und zwischenprodukten davon
CO6311079A2 (es) Derivados de aminodihidrotiazina como inhibidores de la enzima bace para el tratamiento de la enfermedad de alzheimer
CY1112495T1 (el) Κυτταροτοξικοι παραγοντες που περιλαμβανουν νεα παραγωγα τομαϋμυκινης
EA200900945A1 (ru) Новый способ синтеза агомелатина
EA201170618A1 (ru) Способ получения защищенных производных l-аланина
NO20076371L (no) Fremgangsmate for fremstilling av fenoliske 4-bifenylylazetidin-2-oner
MX2009003382A (es) Derivados de sulfonamidas sustituidos.
EA201101675A1 (ru) Спироэпоксиды как промежуточные продукты синтеза
EA200900946A1 (ru) Новый способ синтеза агомелатина
BRPI0821102A2 (pt) Preparação de derivados de di-hidropirrol como intermediários
BRPI0812222A2 (pt) Compostos ciclobutenodiona substituídos anti-inflamatórios.
CR20130501A (es) Derivados novedosos de cefalosporinas y composiciones farmacéuticas de estos
MX2008012424A (es) Proceso convergente para la sintesis de derivados de taxanos.
EA201101015A1 (ru) Способ получения бивалирудина
EA200900090A1 (ru) Бензиламины, способ их получения и их применение в качестве противовоспалительных средств
EA201270256A1 (ru) Производные т1-замещенного 5-фтор-2-оксопиримидинон-1 (2h) -карбоксамида
EA200701588A1 (ru) Способы получения замещённых фенилпиразолмочевин
MX2011008825A (es) 3-aminoisoxazolopiridinas sustituidas como moduladores de kcnq2/3.
CY1109569T1 (el) Υποκατεστημενα παραγωγα κυκλοεξανο-1,4-διαμινης
MY146671A (en) Tetrahydronaphthaline derivatives, methods for the production and use thereof as anti-inflammatory agents
MX2011008662A (es) 2-mercapto-3-aminopiridinas sustituidas como moduladores de kcnq2/3.
MA32945B1 (fr) Tétrahydropyrane spiro pyrrolidinone et pipéridinone substituées, leur préparation et leur utilisation thérapeutique
CL2012003371A1 (es) Compuestos intermediarios de la síntesis de agomelatina; y el procedimiento de obtención de agomelatina a partir de dichos compuestos intermediarios
EA201200820A1 (ru) Способ синтеза промежуточных продуктов, применимых для получения замещенных индазолов и азаиндазолов
ATE517900T1 (de) Heptarylen-und octarylentetracarbonsäurediimide und deren herstellung

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties