ATE517869T1 - Herstellung substituierter morphinan-6-one und salzen und zwischenprodukten davon - Google Patents

Herstellung substituierter morphinan-6-one und salzen und zwischenprodukten davon

Info

Publication number
ATE517869T1
ATE517869T1 AT07837847T AT07837847T ATE517869T1 AT E517869 T1 ATE517869 T1 AT E517869T1 AT 07837847 T AT07837847 T AT 07837847T AT 07837847 T AT07837847 T AT 07837847T AT E517869 T1 ATE517869 T1 AT E517869T1
Authority
AT
Austria
Prior art keywords
salts
production
intermediate products
substituted morphinan
morphinan
Prior art date
Application number
AT07837847T
Other languages
English (en)
Inventor
Peter Xianqi Wang
Frank W Moser
Gary L Cantrell
Christopher W Grote
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of ATE517869T1 publication Critical patent/ATE517869T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT07837847T 2006-09-20 2007-09-06 Herstellung substituierter morphinan-6-one und salzen und zwischenprodukten davon ATE517869T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84595606P 2006-09-20 2006-09-20
US94046307P 2007-05-29 2007-05-29
PCT/US2007/019489 WO2008036172A1 (en) 2006-09-20 2007-09-06 Preparation of substituted morphinan-6-ones and salts and intermediates thereof

Publications (1)

Publication Number Publication Date
ATE517869T1 true ATE517869T1 (de) 2011-08-15

Family

ID=38926227

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07837847T ATE517869T1 (de) 2006-09-20 2007-09-06 Herstellung substituierter morphinan-6-one und salzen und zwischenprodukten davon

Country Status (10)

Country Link
US (1) US8115002B2 (de)
EP (1) EP2099764B1 (de)
JP (1) JP2010504325A (de)
AT (1) ATE517869T1 (de)
AU (1) AU2007297827B2 (de)
CA (1) CA2663909A1 (de)
MX (1) MX2009002844A (de)
NZ (1) NZ575620A (de)
RU (1) RU2009112685A (de)
WO (1) WO2008036172A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008338970B2 (en) * 2007-12-17 2013-08-22 SpecGx LLC Sinomenine derivatives and processes for their synthesis
EP2222642B1 (de) * 2007-12-17 2014-02-12 Mallinckrodt LLC Verfahren und verbindungen zur herstellung von (+) opiaten
WO2011009020A2 (en) 2009-07-16 2011-01-20 Mallinckrodt Inc. Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
SI2506712T1 (sl) 2009-12-04 2019-06-28 Alkermes Pharma Ireland Limited, Derivati morfinana za zdravljenje prevelikega odmerka mamil
WO2012005795A1 (en) * 2010-07-08 2012-01-12 Alkermes, Inc. Process for the synthesis of substituted morphinans
AU2011293502B2 (en) 2010-08-23 2015-03-19 Alkermes Pharma Ireland Limited Methods for treating antipsychotic-induced weight gain
KR20140063763A (ko) 2011-09-08 2014-05-27 말린크로트 엘엘씨 중간체를 단리하지 않는 알칼로이드의 제조 방법
US9211293B2 (en) 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
EP3003311A2 (de) 2013-05-24 2016-04-13 Alkermes Pharma Ireland Limited Verfahren zur behandlung von symptomen für depression
CA2911231C (en) 2013-05-24 2021-12-07 Alkermes Pharma Ireland Limited Morphan and morphinan analogues, and methods of use
JP7330898B2 (ja) * 2017-05-03 2023-08-22 メルク パテント ゲーエムベーハー 有機機能材料の調合物
WO2022101444A1 (en) 2020-11-12 2022-05-19 Alkermes Pharma Ireland Limited Immediate release multilayer tablet
CN114105875B (zh) * 2021-12-06 2023-11-03 四川大学 一种吗啡衍生物二氢埃托啡的合成方法

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3101339A (en) 1958-10-30 1963-08-20 Boehringer Sohn Ingelheim Quaternary salts of normorphine and its acylated derivatives
US4141897A (en) 1976-12-20 1979-02-27 Research Corporation N-dealkylation of N-alkyl-14-hydroxymorphinans and derivatives thereof
US4176186A (en) 1978-07-28 1979-11-27 Boehringer Ingelheim Gmbh Quaternary derivatives of noroxymorphone which relieve intestinal immobility
FR2469413B1 (fr) 1979-11-13 1986-04-25 Urpha Derives de la 6h-dibenzo(a,g) 5,8,13,13a-tetrahydroquinolizine, procede d'obtention et compositions pharmaceutiques les contenant
PL124001B1 (en) 1980-01-25 1982-12-31 Inst Przemyslu Zielarskiego Process for preparing quaternary halides of n-alkylor n-aralkyl- derivatives of tropanic and isoquinolylic alkaloids
US4322426A (en) 1980-04-28 1982-03-30 E. I. Du Pont De Nemours And Company 17-Substituted-6-desoxy-7,8-dihydro-6α-methylnoroxymorphone narcotic antagonists
US4368326A (en) 1980-07-03 1983-01-11 Rice Kenner C Short total synthesis of dihydrothebainone, dihydrocodeinone, and nordihydroccodeinone
US4556712A (en) * 1981-05-20 1985-12-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Preparation and racemization of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines
US4727146A (en) 1980-07-03 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Synthesis of chiral 1-benzyl-1,2,3,4-tetra-hydroisoquinolines by asymmetric reduction
US4410700A (en) 1980-07-03 1983-10-18 The United States Of America As Represented By The Department Of Health And Human Services Preparation of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines by optical resolution
US4521601A (en) * 1981-05-20 1985-06-04 The United States Of America As Represented By The Department Of Health & Human Services Practical total synthesis unnatural enantiomers of opium-derived morphinans
EP0109444B1 (de) 1982-05-25 1986-11-26 Matsushita Electric Industrial Co., Ltd. Regelung der flussrichtung
US4456712A (en) 1982-06-14 1984-06-26 International Business Machines Corporation Bismaleimide triazine composition
DE3229046A1 (de) * 1982-08-04 1984-02-16 Hoechst Ag, 6230 Frankfurt Verfahren zur umkehrung der konfiguration optisch aktiver verbindungen und optisch aktive zwischenprodukte dieses verfahrens
US4535157A (en) 1983-11-01 1985-08-13 Key Pharmaceuticals, Inc. Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone
JPS60132983A (ja) 1983-12-21 1985-07-16 Tanabe Seiyaku Co Ltd チアゾ−ル酢酸誘導体及びその製法
US4613668A (en) 1983-12-22 1986-09-23 The United States Of America As Represented By The Department Of Health And Human Services Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl
US5112975A (en) 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
US5668285A (en) 1986-10-31 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
US5352780A (en) * 1989-07-20 1994-10-04 Ecosorb International, Inc. Absorbent material and litter from ground cellulose
DE4132159A1 (de) 1991-09-27 1993-04-01 Boehringer Ingelheim Kg 14-hydroxy-n-(2-methoxyethyl)-7,8-dihydromorphin und -norisomorphin, verfahren zu deren herstellung und deren verwendung als arzneimittel
US5574159A (en) 1992-02-03 1996-11-12 Delta Pharmaceuticals, Inc. Opioid compounds and methods for making therefor
US5352680A (en) 1992-07-15 1994-10-04 Regents Of The University Of Minnesota Delta opioid receptor antagonists to block opioid agonist tolerance and dependence
AU5171293A (en) 1992-10-14 1994-05-09 Regents Of The University Of Colorado, The Ion-pairing of drugs for improved efficacy and delivery
DE4333892A1 (de) * 1993-10-05 1995-04-06 Brose Fahrzeugteile Manuell betätigbare mechanische Memory-Vorrichtung
SE9401728D0 (sv) 1994-05-18 1994-05-18 Astra Ab New compounds II
US5869669A (en) 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
US5756851A (en) 1996-10-21 1998-05-26 Albemarle Corporation Production of nabumetone or precursors thereof
EP1327444B1 (de) 1996-11-25 2005-03-23 Toray Industries, Inc. Mittel gegen Juckreiz
ES2121554B1 (es) 1996-12-23 1999-06-16 Univ Santiago Compostela Procedimiento de obtencion de 14-hidroximofinonas mediante fotooxidac ion de alcaloides morfinicos con sistema alcoxidienico en el anillo c.
GB9713703D0 (en) 1997-06-30 1997-09-03 Johnson Matthey Plc Preparation of opiates
ES2172376B1 (es) 2000-01-28 2003-11-16 Servier Lab Nuevos derivados de isoquinoleinas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
US20020128496A1 (en) * 2001-01-12 2002-09-12 Sou-Jeng Chang Process for the preparation of matrix metalloproteinase inhibitors
DE10229842A1 (de) 2002-07-03 2004-02-05 Helmut Prof. Dr. Schmidhammer Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung
JP4806190B2 (ja) 2002-09-25 2011-11-02 ユーロ−セルティーク エス．エイ． Ｎ−置換ヒドロモルホン及びそれらの使用
MXPA05004759A (es) 2002-11-08 2005-08-02 Mallinckrodt Inc Proceso para la preparacion de sales alcaloides n-alquil morfinan cuaternarias.
SI1711502T1 (sl) 2004-02-06 2009-02-28 Euro Celtique Sa Postopki za izdelavo 3-O-zaščitenih morfinonov in 3-O-zaščitenih morfinondienol karboksilatov
WO2006084389A1 (de) 2005-02-11 2006-08-17 Cilag Ltd. Verfahren zur reinigung von noroxymorphon-verbindungen
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
US8067597B2 (en) 2005-06-16 2011-11-29 Mallinckrodt Llc Synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs

Also Published As

Publication number Publication date
AU2007297827A1 (en) 2008-03-27
MX2009002844A (es) 2009-03-30
WO2008036172A1 (en) 2008-03-27
NZ575620A (en) 2010-11-26
US8115002B2 (en) 2012-02-14
US20100048906A1 (en) 2010-02-25
CA2663909A1 (en) 2008-03-27
EP2099764B1 (de) 2011-07-27
EP2099764A1 (de) 2009-09-16
AU2007297827B2 (en) 2012-09-20
JP2010504325A (ja) 2010-02-12
RU2009112685A (ru) 2010-10-27

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