MX2011008662A - 2-mercapto-3-aminopiridinas sustituidas como moduladores de kcnq2/3. - Google Patents
2-mercapto-3-aminopiridinas sustituidas como moduladores de kcnq2/3.Info
- Publication number
- MX2011008662A MX2011008662A MX2011008662A MX2011008662A MX2011008662A MX 2011008662 A MX2011008662 A MX 2011008662A MX 2011008662 A MX2011008662 A MX 2011008662A MX 2011008662 A MX2011008662 A MX 2011008662A MX 2011008662 A MX2011008662 A MX 2011008662A
- Authority
- MX
- Mexico
- Prior art keywords
- aminopyridines
- mercapto
- substituted
- kcnq2
- modulators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se relaciona con 2-mercapto-3-aminopiridinas sustituidas, métodos para la producción de estos, medicamentos conteniendo los compuestos referidos y el uso de los compuestos referidos para la producción de medicamentos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09003604 | 2009-03-12 | ||
PCT/EP2010/001508 WO2010102810A1 (de) | 2009-03-12 | 2010-03-11 | Substituierte 2-mercapto-3-aminopyridine als kcnq2/3 modulatoren |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2011008662A true MX2011008662A (es) | 2011-09-06 |
Family
ID=40886174
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2011008662A MX2011008662A (es) | 2009-03-12 | 2010-03-11 | 2-mercapto-3-aminopiridinas sustituidas como moduladores de kcnq2/3. |
Country Status (20)
Country | Link |
---|---|
US (1) | US8247573B2 (es) |
EP (1) | EP2406224B1 (es) |
JP (1) | JP5583148B2 (es) |
KR (1) | KR20110126751A (es) |
CN (1) | CN102341373A (es) |
AR (1) | AR078027A1 (es) |
AU (1) | AU2010223512B2 (es) |
BR (1) | BRPI1008963A2 (es) |
CA (1) | CA2755002A1 (es) |
CO (1) | CO6410290A2 (es) |
EC (1) | ECSP11011345A (es) |
ES (1) | ES2484371T3 (es) |
IL (1) | IL214947A0 (es) |
MX (1) | MX2011008662A (es) |
NZ (1) | NZ595627A (es) |
PE (1) | PE20120667A1 (es) |
RU (1) | RU2011141189A (es) |
TW (1) | TW201038565A (es) |
WO (1) | WO2010102810A1 (es) |
ZA (1) | ZA201107443B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2754934A1 (en) * | 2009-03-10 | 2010-09-16 | Gruenenthal Gmbh | Substituted 3-aminoisoxazolopyridines as kcnq2/3 modulators |
TWI504395B (zh) * | 2009-03-10 | 2015-10-21 | Substituted 3-amino-2-mercaptoquinoline as a KCNQ2 / 3 modifier | |
TWI461197B (zh) * | 2009-03-12 | 2014-11-21 | 2-mercaptoquinoline-3-carboxamide as a KCNQ2 / 3 modifier | |
TWI475020B (zh) | 2009-03-12 | 2015-03-01 | The substituted nicotine amide as a KCNQ2 / 3 modifier | |
ES2537628T3 (es) | 2010-08-27 | 2015-06-10 | Grünenthal GmbH | 2-Oxiquinolin-3-carboxamidas sustituidas como moduladores de KCNQ2/3 |
EP2609084A1 (en) | 2010-08-27 | 2013-07-03 | Grünenthal GmbH | Substituted 2-amino-quinoline-3-carboxamides as kcnq2/3 modulators |
TWI552750B (zh) | 2010-08-27 | 2016-10-11 | 歌林達股份有限公司 | 作為kcnq2/3鉀離子通道調節劑之經取代之2-氧基-及2-硫基-二氫喹啉-3-羧醯胺 |
BR112013005056A2 (pt) | 2010-09-01 | 2016-05-31 | Gruenenthal Gmbh | 1-oxo-di-hidroisoquinolina-3-carboxamidas substituídas como moduladores kcnq2/3 |
BR112013010957A2 (pt) * | 2010-10-20 | 2016-08-30 | Gruenenthal Gmbh | 6-amino-nicotinamidas substituídas como moduladores kcnq2/3 |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2706977A1 (de) | 1977-02-18 | 1978-08-24 | Hoechst Ag | Benzoesaeuren und deren derivate sowie verfahren zu ihrer herstellung |
FR2532939A1 (fr) | 1982-09-13 | 1984-03-16 | Roussel Uclaf | Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, les compositions les renfermant et les nouveaux intermediaires obtenus |
DE4032147A1 (de) | 1990-10-10 | 1992-04-16 | Bayer Ag | Verwendung von substituierten 2-mercaptonicotinsaeurederivaten zur bekaempfung von endoparasiten, neue substituierte 2-mercaptonicotinsaeurederivate und verfahren zu ihrer herstellung |
EP0716077A1 (de) | 1994-12-08 | 1996-06-12 | Ciba-Geigy Ag | Aromatisch substituierte Omega-Aminoalkansäureamide und Alkansäurediamide und ihre Verwendung als Renininhibitoren |
WO1996026925A1 (fr) | 1995-03-01 | 1996-09-06 | Banyu Pharmaceutical Co., Ltd. | Derives de l'arylthioacetamide |
DE19738616A1 (de) | 1997-09-04 | 1999-03-11 | Clariant Gmbh | 4-Hydroxychinolin-3-carbonsäure-Derivate als Lichtschutzmittel |
EP1147094A1 (en) | 1999-01-15 | 2001-10-24 | Novo Nordisk A/S | Non-peptide glp-1 agonists |
JP2003506388A (ja) | 1999-08-04 | 2003-02-18 | アイカゲン インコーポレイテッド | 疼痛および不安症を処置または予防するための方法 |
DE60037321T4 (de) | 1999-08-04 | 2010-01-07 | Icagen, Inc. | Benzanilide als öffner des kaliumkanals |
PL372944A1 (en) | 2001-02-20 | 2005-08-08 | Bristol-Myers Squibb Company | 2,4-disubstituted pyrimidine-5-carboxamide derivatives as kcnq potassium channel modulators |
MXPA03007397A (es) | 2001-02-20 | 2003-12-04 | Bristol Myers Squibb Co | Moduladores de canales de potasio kcnq y uso de los mismos en tratamiento de migrana y enfermedades mecanicamente relacionadas. |
US6593349B2 (en) | 2001-03-19 | 2003-07-15 | Icagen, Inc. | Bisarylamines as potassium channel openers |
AU2002256085A1 (en) | 2001-04-06 | 2002-10-21 | Smithkline Beecham Corporation | Quinoline inhibitors of hyak1 and hyak3 kinases |
CA2499213A1 (en) | 2002-09-17 | 2004-04-01 | Pharmacia Corporation | Aromatic liver x-receptor modulators |
CA2505195C (en) | 2002-12-23 | 2012-07-10 | Icagen, Inc. | Quinazolinones as potassium channel modulators |
EP1449841A1 (en) | 2003-02-19 | 2004-08-25 | Bayer CropScience SA | New fungicidal compounds |
JP2007509044A (ja) | 2003-10-08 | 2007-04-12 | バーテックス ファーマシューティカルズ インコーポレイテッド | シクロアルキルピラニル基を含むatp結合カセットトランスポーターのモジュレータ |
JP4054369B2 (ja) | 2004-05-04 | 2008-02-27 | ファイザー株式会社 | オルト置換アリールまたはヘテロアリールアミド化合物 |
JP2008519814A (ja) | 2004-11-12 | 2008-06-12 | ガラパゴス・ナムローゼ・フェンノートシャップ | プロテインキナーゼ酵素の活性部位と結合する窒素複素環式芳香族化合物 |
EP2298766B1 (en) | 2005-03-03 | 2013-09-18 | H. Lundbeck A/S | Pharmaceutical formulations comrpising a substituted pyridine derivative |
DE102005038947A1 (de) | 2005-05-18 | 2006-11-30 | Grünenthal GmbH | Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln |
DE602006007012D1 (de) | 2005-07-20 | 2009-07-09 | Lilly Co Eli | Pyridinderivate als dipeptedyl-peptidase-hemmer |
US7915410B2 (en) | 2005-09-09 | 2011-03-29 | Bristol-Myers Squibb Company | Acyclic IKur inhibitors |
EP1951685A1 (en) | 2005-11-18 | 2008-08-06 | NeuroSearch A/S | Novel quinazoline derivatives and their medical use |
AU2007275653B2 (en) | 2006-07-20 | 2010-12-23 | Amgen Inc. | Benzo(d) isoxazole derivatives as c-kit tyrosine kinase inhibitors for the treatment of disorders associated with the over production of histamine |
WO2008011110A2 (en) | 2006-07-20 | 2008-01-24 | Amgen Inc. | Di-amino-substituted heterocyclic compounds and methods of use |
WO2008012532A2 (en) | 2006-07-27 | 2008-01-31 | Astrazeneca Ab | : pyridine-3-carboxamide compounds and their use for inhibiting 11-beta-hydroxysteroid dehydrogenase |
DE102006049452A1 (de) | 2006-10-17 | 2008-05-08 | Grünenthal GmbH | Substituierte Tetrahydropyrolopiperazin-Verbindungen und deren Verwendung in Arzneimitteln |
US8563566B2 (en) | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
CA2695331A1 (en) | 2007-08-03 | 2009-02-12 | F. Hoffmann-La Roche Ag | Pyridinecarboxamide and benzamide derivatives as taar1 ligands |
EP2215065B1 (en) | 2007-10-19 | 2012-07-11 | Boehringer Ingelheim International GmbH | Ccr10 antagonists |
TWI504395B (zh) | 2009-03-10 | 2015-10-21 | Substituted 3-amino-2-mercaptoquinoline as a KCNQ2 / 3 modifier | |
CA2754934A1 (en) | 2009-03-10 | 2010-09-16 | Gruenenthal Gmbh | Substituted 3-aminoisoxazolopyridines as kcnq2/3 modulators |
TWI461197B (zh) | 2009-03-12 | 2014-11-21 | 2-mercaptoquinoline-3-carboxamide as a KCNQ2 / 3 modifier | |
TWI475020B (zh) | 2009-03-12 | 2015-03-01 | The substituted nicotine amide as a KCNQ2 / 3 modifier |
-
2010
- 2010-02-12 TW TW099104569A patent/TW201038565A/zh unknown
- 2010-03-10 US US12/720,836 patent/US8247573B2/en not_active Expired - Fee Related
- 2010-03-11 MX MX2011008662A patent/MX2011008662A/es active IP Right Grant
- 2010-03-11 AU AU2010223512A patent/AU2010223512B2/en not_active Ceased
- 2010-03-11 EP EP10708140.8A patent/EP2406224B1/de not_active Not-in-force
- 2010-03-11 JP JP2011553351A patent/JP5583148B2/ja not_active Expired - Fee Related
- 2010-03-11 WO PCT/EP2010/001508 patent/WO2010102810A1/de active Application Filing
- 2010-03-11 ES ES10708140.8T patent/ES2484371T3/es active Active
- 2010-03-11 CA CA2755002A patent/CA2755002A1/en not_active Abandoned
- 2010-03-11 PE PE2011001596A patent/PE20120667A1/es not_active Application Discontinuation
- 2010-03-11 BR BRPI1008963A patent/BRPI1008963A2/pt not_active IP Right Cessation
- 2010-03-11 CN CN2010800106472A patent/CN102341373A/zh active Pending
- 2010-03-11 NZ NZ595627A patent/NZ595627A/xx not_active IP Right Cessation
- 2010-03-11 KR KR1020117023786A patent/KR20110126751A/ko not_active Application Discontinuation
- 2010-03-11 RU RU2011141189/04A patent/RU2011141189A/ru not_active Application Discontinuation
- 2010-03-12 AR ARP100100779A patent/AR078027A1/es not_active Application Discontinuation
-
2011
- 2011-09-02 CO CO11113005A patent/CO6410290A2/es not_active Application Discontinuation
- 2011-09-04 IL IL214947A patent/IL214947A0/en unknown
- 2011-09-23 EC EC2011011345A patent/ECSP11011345A/es unknown
- 2011-10-11 ZA ZA2011/07443A patent/ZA201107443B/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2010102810A1 (de) | 2010-09-16 |
CA2755002A1 (en) | 2010-09-16 |
ECSP11011345A (es) | 2011-10-31 |
KR20110126751A (ko) | 2011-11-23 |
TW201038565A (en) | 2010-11-01 |
ES2484371T3 (es) | 2014-08-11 |
US8247573B2 (en) | 2012-08-21 |
RU2011141189A (ru) | 2013-04-20 |
PE20120667A1 (es) | 2012-06-01 |
ZA201107443B (en) | 2012-07-25 |
JP2012520248A (ja) | 2012-09-06 |
AU2010223512B2 (en) | 2015-01-22 |
AR078027A1 (es) | 2011-10-12 |
EP2406224B1 (de) | 2014-04-23 |
BRPI1008963A2 (pt) | 2016-03-15 |
CN102341373A (zh) | 2012-02-01 |
EP2406224A1 (de) | 2012-01-18 |
CO6410290A2 (es) | 2012-03-30 |
AU2010223512A1 (en) | 2011-11-03 |
NZ595627A (en) | 2012-10-26 |
JP5583148B2 (ja) | 2014-09-03 |
IL214947A0 (en) | 2011-11-30 |
US20100234428A1 (en) | 2010-09-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2011009369A (es) | 2-mercaptoquinolin-3-carboxamidas sustituidas como moduladores de kcnq2/3. | |
MX2011008262A (es) | Espiroamidas sustituidas como moduladores de b1r:. | |
MX2011008825A (es) | 3-aminoisoxazolopiridinas sustituidas como moduladores de kcnq2/3. | |
MX2011008662A (es) | 2-mercapto-3-aminopiridinas sustituidas como moduladores de kcnq2/3. | |
MX2011009338A (es) | 3-amino-2-mercaptoquinolinas sustituidas como moduladores de kcnq2/3. | |
MX2009003382A (es) | Derivados de sulfonamidas sustituidos. | |
MX2011008864A (es) | Tetrahidroazolopirazinas sulfoniladas y su uso como productos medicinales. | |
PL1891004T3 (pl) | Pentafluorosulfanylo-podstawiony związek i jego zastosowanie do wytwarzania środków leczniczych | |
TW200800968A (en) | Sulfoximine-substituted pyrimidines, processes for production thereof and use thereof as drugs | |
MX2013003309A (es) | Compuestos de benzamida sustituidos. | |
ZA201107806B (en) | Organisms for the production of 1,3-butanediol | |
TW201129381A (en) | Antibodies against human CSF-1R and uses thereof | |
MX336682B (es) | Anticuerpos contra csf-1r humanos y usos de los mismos. | |
MX2020012825A (es) | Compuestos multiciclicos y metodos de uso de los mismos. | |
AU2010233994A8 (en) | Bispecific anti-ErbB-3/anti-c-Met antibodies | |
MX2010012298A (es) | Activadores de glucocinasa. | |
CY1110209T1 (el) | Υποκατεστημενες ενωσεις βενζο(d)ισοξαζολ-3-υλ-αμινης σαν αναλγητικα | |
WO2008046581A3 (de) | Substituierte tetrahydropyrrolopyrazin-verbindungen als inhibitoren der monoaminwiederaufnahme und deren verwendung in arzeimitteln | |
MX2009007436A (es) | Derivados espirociclicos de acido tetronico. | |
MY156769A (en) | Heat-aging-resistant polyamides | |
MX2012008141A (es) | Compuestos y metodos. | |
TN2012000610A1 (en) | Heterocyclic compounds, their preparation and their therapeutic application | |
MX2010010597A (es) | Procesos para la preparacion de derivados de dioxina benzofusionados. | |
MX2009004983A (es) | Pirazoles sustituidos, composiciones que los contienen, procedimiento de fabricacion y utilizacion. | |
MY158910A (en) | Surface modified silicic acid semi-gels |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |