EA200870060A1 - Эмульсия бутилфталида для внутривенного введения и ее применение - Google Patents

Эмульсия бутилфталида для внутривенного введения и ее применение

Info

Publication number
EA200870060A1
EA200870060A1 EA200870060A EA200870060A EA200870060A1 EA 200870060 A1 EA200870060 A1 EA 200870060A1 EA 200870060 A EA200870060 A EA 200870060A EA 200870060 A EA200870060 A EA 200870060A EA 200870060 A1 EA200870060 A1 EA 200870060A1
Authority
EA
Eurasian Patent Office
Prior art keywords
emulsion
phthalide
butyl
application
intravenous introduction
Prior art date
Application number
EA200870060A
Other languages
English (en)
Other versions
EA014518B1 (ru
Inventor
Чуньшунь Чжао
Чжаньци Ню
Чжэнь Чэнь
Хайбо Го
Original Assignee
СиЭсПиСи ЭнБиПи ФАРМАСЬЮТИКЛ КО., ЛТД.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by СиЭсПиСи ЭнБиПи ФАРМАСЬЮТИКЛ КО., ЛТД. filed Critical СиЭсПиСи ЭнБиПи ФАРМАСЬЮТИКЛ КО., ЛТД.
Publication of EA200870060A1 publication Critical patent/EA200870060A1/ru
Publication of EA014518B1 publication Critical patent/EA014518B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Настоящее изобретение относится к эмульсии бутилфталида для внутривенного введения для внутривенной инъекции или инфузии, содержащей бутилфталид или его производные как активный ингредиент в количестве от 0,01 до приблизительно 50 мас.% и наполнитель в количестве от 50 до приблизительно 99,99 мас.% от общей массы эмульсии.
EA200870060A 2005-12-16 2006-12-15 Эмульсия бутилфталида для внутривенного введения и ее применение EA014518B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNB2005101023552A CN100367951C (zh) 2005-12-16 2005-12-16 丁苯酞静脉乳剂及其应用
PCT/CN2006/003434 WO2007068212A1 (fr) 2005-12-16 2006-12-15 Emulsion intraveineuse de butylbenzene phtaleine et son application

Publications (2)

Publication Number Publication Date
EA200870060A1 true EA200870060A1 (ru) 2009-02-27
EA014518B1 EA014518B1 (ru) 2010-12-30

Family

ID=36934680

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200870060A EA014518B1 (ru) 2005-12-16 2006-12-15 Эмульсия бутилфталида для внутривенного введения и ее применение

Country Status (13)

Country Link
US (2) US20090281177A1 (ru)
EP (1) EP1970050B1 (ru)
JP (2) JP5571311B2 (ru)
KR (1) KR101061268B1 (ru)
CN (1) CN100367951C (ru)
AU (1) AU2006324219B2 (ru)
BR (1) BRPI0619915B1 (ru)
CA (1) CA2633170C (ru)
CU (1) CU23814A3 (ru)
EA (1) EA014518B1 (ru)
IL (1) IL192169A (ru)
UA (1) UA89315C2 (ru)
WO (1) WO2007068212A1 (ru)

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JP5860399B2 (ja) * 2009-08-14 2016-02-16 オプコ ヘルス， インコーポレイテッド ニューロキニン−１アンタゴニストの静脈内用製剤
CN102178643B (zh) * 2011-04-29 2014-05-14 石药集团恩必普药业有限公司 一种丁苯酞或其衍生物的微乳透皮凝胶剂及其制备方法
CN102716121B (zh) * 2012-06-06 2017-10-24 石药集团中奇制药技术（石家庄）有限公司 一种丁苯酞药物活性组合物及其制备方法
CN103505409B (zh) * 2012-06-27 2017-12-26 石药集团中奇制药技术（石家庄）有限公司 一种丁苯酞注射液及其制备方法
CN103505414B (zh) * 2012-06-28 2017-08-08 石药集团恩必普药业有限公司 丁苯酞滴鼻剂及其制备方法
EP2953613B1 (en) * 2013-02-06 2020-01-08 Jingjun Huang Stable pharmaceutical composition of clopidogrel free base for oral and parenteral delivery
CN105030760B (zh) 2014-04-24 2018-10-02 长弘生物科技股份有限公司 稳定医药组合物
TWI547280B (zh) * 2014-04-24 2016-09-01 長弘生物科技股份有限公司 穩定醫藥組合物
WO2017037593A2 (zh) * 2015-08-28 2017-03-09 康霈生技股份有限公司 用于减少局部脂肪的医药组成物及其用途
CN105796486A (zh) * 2016-03-17 2016-07-27 南京天翔医药科技有限公司 丁苯酞脂肪乳注射剂及其制备工艺
CN110101658B (zh) * 2018-02-01 2021-09-07 北京睿悦生物医药科技有限公司 丁苯酞脂微球注射液及其制备方法
CN110548004B (zh) * 2018-05-30 2023-05-16 成都施贝康生物医药科技有限公司 一种稳定的丁苯酞大容量注射液及其制备方法
CN111407725A (zh) * 2020-04-13 2020-07-14 中山大学 一种拉莫三嗪乳剂及其制备方法
CN114073694B (zh) * 2020-08-14 2024-03-12 北京科莱博医药开发有限责任公司 丁苯酞制剂及其制备方法
CN115177614A (zh) * 2021-04-01 2022-10-14 长春藤生物科技股份有限公司 正丁基苯酞的应用
CN114010595A (zh) * 2021-10-14 2022-02-08 山东诚创蓝海医药科技有限公司 一种丁苯酞乳剂及其制备方法
CN114886848B (zh) * 2022-05-20 2024-03-08 山东泰合医药科技有限公司 一种纳米胶束组合物制备方法及制备的纳米胶束组合物

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CN100361656C (zh) * 2004-08-27 2008-01-16 石药集团中奇制药技术（石家庄）有限公司 丁苯酞自乳化释药体系及其制备方法和应用
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Also Published As

Publication number Publication date
AU2006324219B2 (en) 2010-03-04
CU23814A3 (es) 2012-06-21
JP2009519253A (ja) 2009-05-14
UA89315C2 (en) 2010-01-11
IL192169A0 (en) 2008-12-29
JP2012193206A (ja) 2012-10-11
CU20080114A7 (es) 2010-08-30
BRPI0619915A2 (pt) 2011-10-25
KR101061268B1 (ko) 2011-08-31
US20090281177A1 (en) 2009-11-12
CN100367951C (zh) 2008-02-13
IL192169A (en) 2016-02-29
CN1823729A (zh) 2006-08-30
BRPI0619915B1 (pt) 2021-06-01
EP1970050A4 (en) 2009-12-09
US10463614B2 (en) 2019-11-05
CA2633170C (en) 2011-05-24
EP1970050A1 (en) 2008-09-17
JP5571311B2 (ja) 2014-08-13
WO2007068212A1 (fr) 2007-06-21
EP1970050B1 (en) 2016-05-11
US20110288167A1 (en) 2011-11-24
KR20080091141A (ko) 2008-10-09
EA014518B1 (ru) 2010-12-30
AU2006324219A1 (en) 2007-06-21
CA2633170A1 (en) 2007-06-21

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM