ES2154741T3 - Uso de agentes de union a cd23 en el tratamiento de enfermedades autoinmunes. - Google Patents

Uso de agentes de union a cd23 en el tratamiento de enfermedades autoinmunes.

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Publication number
ES2154741T3
ES2154741T3 ES95936525T ES95936525T ES2154741T3 ES 2154741 T3 ES2154741 T3 ES 2154741T3 ES 95936525 T ES95936525 T ES 95936525T ES 95936525 T ES95936525 T ES 95936525T ES 2154741 T3 ES2154741 T3 ES 2154741T3
Authority
ES
Spain
Prior art keywords
treatment
autoimmune diseases
agents
union
union agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95936525T
Other languages
English (en)
Inventor
Jean-Yves Marcel Paul Bonnefoy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27267444&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2154741(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB9421463A external-priority patent/GB9421463D0/en
Priority claimed from GBGB9512480.6A external-priority patent/GB9512480D0/en
Priority claimed from GBGB9513415.1A external-priority patent/GB9513415D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ES2154741T3 publication Critical patent/ES2154741T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/12—Antidiarrhoeals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P27/00—Drugs for disorders of the senses
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    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • C12N2710/16211—Lymphocryptovirus, e.g. human herpesvirus 4, Epstein-Barr Virus
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    • C12N2710/16011—Herpesviridae
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Abstract

AGENTES DE UNION A CD23, UTILES PARA EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS, AUTOINMUNES O ALERGICAS.
ES95936525T 1994-10-25 1995-10-20 Uso de agentes de union a cd23 en el tratamiento de enfermedades autoinmunes. Expired - Lifetime ES2154741T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9421463A GB9421463D0 (en) 1994-10-25 1994-10-25 Binding agents
GBGB9512480.6A GB9512480D0 (en) 1995-06-20 1995-06-20 Binding agents
GBGB9513415.1A GB9513415D0 (en) 1995-06-30 1995-06-30 Binding agents

Publications (1)

Publication Number Publication Date
ES2154741T3 true ES2154741T3 (es) 2001-04-16

Family

ID=27267444

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95936525T Expired - Lifetime ES2154741T3 (es) 1994-10-25 1995-10-20 Uso de agentes de union a cd23 en el tratamiento de enfermedades autoinmunes.

Country Status (21)

Country Link
US (2) US6627195B1 (es)
EP (3) EP1018517A3 (es)
JP (3) JPH10507460A (es)
KR (1) KR20040058016A (es)
CN (1) CN1171119A (es)
AT (1) ATE198895T1 (es)
AU (2) AU710369B2 (es)
BR (2) BR9509434A (es)
CA (2) CA2203364A1 (es)
DE (1) DE69519997T2 (es)
DK (1) DK0788513T3 (es)
ES (1) ES2154741T3 (es)
FI (1) FI971756A (es)
HK (1) HK1002765A1 (es)
HU (1) HU223006B1 (es)
IL (1) IL115733A (es)
MX (1) MX9702797A (es)
NO (1) NO971902L (es)
NZ (2) NZ295352A (es)
PT (1) PT788513E (es)
WO (2) WO1996012741A1 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7033589B1 (en) 1997-02-20 2006-04-25 Biogen Idec Ma Inc. γ-1 anti-human CD23 monoclonal antibodies and use thereof as therapeutics
US6893636B2 (en) * 1997-02-20 2005-05-17 Biogen Idec Ma Inc. Gamma-1 and gamma-3 anti-human CD23 monoclonal antibodies and use thereof as therapeutics
US6011138A (en) * 1997-02-20 2000-01-04 Idec Pharmaceuticals Corporation Gamma-1 anti-human CD23 monoclonal antibodies
WO1999045777A1 (en) * 1998-03-10 1999-09-16 The Children's Hospital Of Philadelphia Compositions and methods for treatment of asthma
GB9809839D0 (en) * 1998-05-09 1998-07-08 Glaxo Group Ltd Antibody
US6299875B1 (en) 1998-06-04 2001-10-09 Panacea Pharmaceuticals, Llc Methods to block IGE binding to cell surface receptors of mast cells
WO2000040713A1 (en) * 1999-01-06 2000-07-13 Mcmaster University Method of preventing immune and hypersensitivity reactions
ES2299436T3 (es) * 1999-10-06 2008-06-01 ABBOTT GMBH & CO. KG Composicion que comprende un inhibidor de tnf-alfa y un antagonista de receptor de integrina alfavbeta3.
US20020028178A1 (en) * 2000-07-12 2002-03-07 Nabil Hanna Treatment of B cell malignancies using combination of B cell depleting antibody and immune modulating antibody related applications
US20070065436A1 (en) * 2001-01-31 2007-03-22 Biogen Idec Inc. Anti-cd80 antibody having adcc activity for adcc mediated killing of b cell lymphoma cells alone or in combination with other therapies
US20030103971A1 (en) * 2001-11-09 2003-06-05 Kandasamy Hariharan Immunoregulatory antibodies and uses thereof
US20030211107A1 (en) * 2002-01-31 2003-11-13 Kandasamy Hariharan Use of CD23 antagonists for the treatment of neoplastic disorders
US20020159996A1 (en) * 2001-01-31 2002-10-31 Kandasamy Hariharan Use of CD23 antagonists for the treatment of neoplastic disorders
US6820011B2 (en) 2001-04-11 2004-11-16 The Regents Of The University Of Colorado Three-dimensional structure of complement receptor type 2 and uses thereof
CN100515496C (zh) * 2003-02-14 2009-07-22 上海张江生物技术有限公司 免疫调节剂及其应用
ES2322267T3 (es) * 2003-04-09 2009-06-18 Genentech, Inc. Terapia de una enfermedad autoinmunologica en un paciente que presenta una respuesta inadecuada a un inhibidor de tnf-alfa.
CA2526284C (en) 2003-06-25 2014-11-18 Crucell Holland B.V. Binding molecules for the treatment of myeloid cell malignancies
US8071552B2 (en) 2004-04-05 2011-12-06 Universite Bordeaux 2 Peptides and peptidomimetics binding to CD23
US20070286855A1 (en) * 2004-08-03 2007-12-13 Mayo Foundation For Medical Education And Research Improving treatments
US20090291048A1 (en) * 2005-10-25 2009-11-26 Baker Idi Heart And Diabetes Institute Holdings Limited Leukocyte-binding polypeptides and uses thereof
RU2489166C2 (ru) * 2006-04-09 2013-08-10 Джинентех, Инк. Применение антитела для лечения аутоиммунных заболеваний у пациента с неадекватным ответом на ингибитор tnf-альфа
PL2044111T3 (pl) 2006-06-21 2015-02-27 Musc Found For Res Dev Celowanie czynnika H dopełniacza do leczenia chorób
WO2009043051A2 (en) * 2007-09-27 2009-04-02 Biogen Idec Ma Inc. Cd23 binding molecules and methods of use thereof
EP2453906A4 (en) 2009-07-02 2014-01-15 Musc Found For Res Dev METHOD FOR STIMULATING THE LIVER REGENERATION
CN102958535A (zh) 2009-11-05 2013-03-06 亚力史剑桥公司 阵发性夜间血红蛋白尿、溶血性贫血和涉及血管内和血管外溶血的疾病状态的治疗
CN103038252A (zh) 2010-05-14 2013-04-10 科罗拉多大学董事会,法人团体 改良的补体受体2(cr2)靶向群
AU2011270959A1 (en) 2010-06-22 2013-01-10 Musc Foundation For Research Development Antibodies to the C3d fragment of complement component 3
CA2818712C (en) * 2010-11-24 2020-11-10 Government Of The U.S.A. Represented By The Secretary, Dept. Of Health & Human Services Compositions and methods for treating or preventing lupus
US10017762B2 (en) * 2010-11-24 2018-07-10 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Compositions and methods for treating or preventing lupus
US10413620B2 (en) 2012-08-17 2019-09-17 The Regents Of The University Of Colorado, A Body Corporate Light-emitting versions of the monoclonal antibody to C3D (MAB 3D29) for imaging
AU2013302441B2 (en) 2012-08-17 2018-05-10 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for detecting complement activation

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946788A (en) * 1985-06-11 1990-08-07 Ciba-Geigy Corporation Purified immunoglobulin-related factor, novel monoclonal antibodies, hybridoma cell lines, processes and applications
FR2599513B1 (fr) * 1986-05-27 1989-09-15 Unicet Laboratoires Anticorps monoclonaux inhibant la liaison de ige soluble aux lymphocytes humains, hybridomes monoclonaux produisant de tels anticorps, leur utilisation
GB8726230D0 (en) * 1987-11-10 1987-12-16 Rosen H Antibodies
EP0321842A1 (en) * 1987-12-22 1989-06-28 Kishimoto, Tadamitsu, Prof. Soluble recombinant Fc-Epsilon-receptor, the preparation and the use thereof
DE3830271A1 (de) * 1988-09-06 1990-03-15 Goetze Otto Mittel mit immunsuppressiver wirkung
EP0436626A1 (en) * 1988-10-03 1991-07-17 Scripps Clinic And Research Foundation THE RECEPTOR BINDING REGION OF EBVgp350
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
IE912528A1 (en) * 1990-07-19 1992-01-29 Scripps Clinic Res Inhabition of mac-1 receptor binding fibrinogen using d30¹homologs
DE69233011T2 (de) * 1991-07-25 2003-11-06 Idec Pharma Corp Rekombinante antikörper zur humanen therapie
AU3221793A (en) * 1991-11-22 1993-06-15 Scripps Research Institute, The Factor x-derived polypeptides and anti-peptide antibodies, systems and therapeutic methods for inhibiting inflammation
US5766943A (en) * 1992-08-17 1998-06-16 University Of Iowa Research Foundation DNA sequences for soluble form of CD23
CA2144738A1 (en) * 1992-10-09 1994-04-28 Michael Diamond A subpopulation of mac-1 (cd11b/cd18) molecules which mediate neutrophil adhesion to icam-1 and fibrinogen

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Publication number Publication date
BR9509434A (pt) 1998-01-06
DK0788513T3 (da) 2001-04-02
CA2203364A1 (en) 1996-05-02
JPH10507460A (ja) 1998-07-21
AU710369B2 (en) 1999-09-16
DE69519997D1 (de) 2001-03-01
IL115733A (en) 1999-12-22
HK1002765A1 (en) 1998-09-18
JP2001316291A (ja) 2001-11-13
NZ295158A (en) 1999-09-29
ATE198895T1 (de) 2001-02-15
BR9509498A (pt) 1997-12-23
DE69519997T2 (de) 2001-06-21
AU3867995A (en) 1996-05-15
US20040022783A1 (en) 2004-02-05
AU698158B2 (en) 1998-10-22
US6627195B1 (en) 2003-09-30
NO971902D0 (no) 1997-04-24
NZ295352A (en) 1999-09-29
EP0788514A1 (en) 1997-08-13
HU223006B1 (hu) 2004-03-01
CA2203363A1 (en) 1996-05-02
PT788513E (pt) 2001-06-29
CN1171119A (zh) 1998-01-21
IL115733A0 (en) 1996-01-19
JP3323508B2 (ja) 2002-09-09
FI971756A0 (fi) 1997-04-24
EP1018517A2 (en) 2000-07-12
WO1996012741A1 (en) 1996-05-02
JPH09511757A (ja) 1997-11-25
MX9702797A (es) 1997-06-28
EP0788513B1 (en) 2001-01-24
HUT77572A (hu) 1998-06-29
NO971902L (no) 1997-04-24
EP0788513A1 (en) 1997-08-13
AU3843595A (en) 1996-05-15
FI971756A (fi) 1997-04-24
EP1018517A3 (en) 2000-07-26
WO1996012742A1 (en) 1996-05-02
KR20040058016A (ko) 2004-07-02

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