IT1289979B1 - 5-idrossimetil-6-idrossi-2-amminotetraline attive come agenti cardiovascolari - Google Patents

5-idrossimetil-6-idrossi-2-amminotetraline attive come agenti cardiovascolari

Info

Publication number
IT1289979B1
IT1289979B1 IT97MI000414A ITMI970414A IT1289979B1 IT 1289979 B1 IT1289979 B1 IT 1289979B1 IT 97MI000414 A IT97MI000414 A IT 97MI000414A IT MI970414 A ITMI970414 A IT MI970414A IT 1289979 B1 IT1289979 B1 IT 1289979B1
Authority
IT
Italy
Prior art keywords
pct
aminotethrals
hydroximethyl
hydroxy
active
Prior art date
Application number
IT97MI000414A
Other languages
English (en)
Inventor
Stefania Montanari
Paolo Cavalleri
Francesco Santangelo
Francesco Marchini
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT97MI000414A priority Critical patent/IT1289979B1/it
Application filed by Zambon Spa filed Critical Zambon Spa
Priority to ES98908052T priority patent/ES2169909T3/es
Priority to NZ336680A priority patent/NZ336680A/en
Priority to CA002282388A priority patent/CA2282388A1/en
Priority to JP53721898A priority patent/JP2001513763A/ja
Priority to EP98908052A priority patent/EP0970042B1/en
Priority to AT98908052T priority patent/ATE211727T1/de
Priority to US09/341,673 priority patent/US6063964A/en
Priority to PCT/EP1998/000589 priority patent/WO1998038155A1/en
Priority to DE69803445T priority patent/DE69803445T2/de
Priority to KR1019997007805A priority patent/KR20000075736A/ko
Priority to HU0001058A priority patent/HUP0001058A3/hu
Priority to DK98908052T priority patent/DK0970042T3/da
Priority to AU66198/98A priority patent/AU733001B2/en
Priority to PT98908052T priority patent/PT970042E/pt
Publication of ITMI970414A1 publication Critical patent/ITMI970414A1/it
Application granted granted Critical
Publication of IT1289979B1 publication Critical patent/IT1289979B1/it
Priority to NO994104A priority patent/NO994104L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IT97MI000414A 1997-02-26 1997-02-26 5-idrossimetil-6-idrossi-2-amminotetraline attive come agenti cardiovascolari IT1289979B1 (it)

Priority Applications (16)

Application Number Priority Date Filing Date Title
IT97MI000414A IT1289979B1 (it) 1997-02-26 1997-02-26 5-idrossimetil-6-idrossi-2-amminotetraline attive come agenti cardiovascolari
KR1019997007805A KR20000075736A (ko) 1997-02-26 1998-02-04 심혈관 작용제로서의 5-히드록시메틸-2-아미노테트랄린
CA002282388A CA2282388A1 (en) 1997-02-26 1998-02-04 5-hydroxymethyl-2-aminotetralins as cardiovascular agents
JP53721898A JP2001513763A (ja) 1997-02-26 1998-02-04 心血管剤としての５−ヒドロキシメチル−２−アミノテトラリン類
EP98908052A EP0970042B1 (en) 1997-02-26 1998-02-04 5-hydroxymethyl-2-aminotetralins as cardiovascular agents
AT98908052T ATE211727T1 (de) 1997-02-26 1998-02-04 5-hydroxymethyl-2-aminotetraline als cardiovasculäre mittel
US09/341,673 US6063964A (en) 1997-02-26 1998-02-04 5-hydroxymethyl-2-aminotetralins as cardiovascular agents
PCT/EP1998/000589 WO1998038155A1 (en) 1997-02-26 1998-02-04 5-hydroxymethyl-2-aminotetralins as cardiovascular agents
ES98908052T ES2169909T3 (es) 1997-02-26 1998-02-04 5-hidroximetil-2-aminotetralinas como agentes cardiovasculares.
NZ336680A NZ336680A (en) 1997-02-26 1998-02-04 5-hydroxymethyl-2-aminotetralins as cardiovascular agents
HU0001058A HUP0001058A3 (en) 1997-02-26 1998-02-04 5-hydroxymethyl-2-aminotetralins as cardiovascular agents, process for producing the same and pharmaceutical compositions containing them
DK98908052T DK0970042T3 (da) 1997-02-26 1998-02-04 5-hydroxymethyl-2-aminotetraliner som kardiovaskulære midler
AU66198/98A AU733001B2 (en) 1997-02-26 1998-02-04 5-hydroxymethyl-2-aminotetralins as cardiovascular agents
PT98908052T PT970042E (pt) 1997-02-26 1998-02-04 5-hidroximetil-2-aminotetralinas utilizadas como agentes cardiovasculares
DE69803445T DE69803445T2 (de) 1997-02-26 1998-02-04 5-hydroxymethyl-2-aminotetraline als cardiovasculäre mittel
NO994104A NO994104L (no) 1997-02-26 1999-08-25 5-hydroksymetyl-2-aminotetraliner i form av kardiovaskulaere midler

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI000414A IT1289979B1 (it) 1997-02-26 1997-02-26 5-idrossimetil-6-idrossi-2-amminotetraline attive come agenti cardiovascolari

Publications (2)

Publication Number Publication Date
ITMI970414A1 ITMI970414A1 (it) 1998-08-26
IT1289979B1 true IT1289979B1 (it) 1998-10-19

Family

ID=11376182

Family Applications (1)

Application Number Title Priority Date Filing Date
IT97MI000414A IT1289979B1 (it) 1997-02-26 1997-02-26 5-idrossimetil-6-idrossi-2-amminotetraline attive come agenti cardiovascolari

Country Status (16)

Country Link
US (1) US6063964A (it)
EP (1) EP0970042B1 (it)
JP (1) JP2001513763A (it)
KR (1) KR20000075736A (it)
AT (1) ATE211727T1 (it)
AU (1) AU733001B2 (it)
CA (1) CA2282388A1 (it)
DE (1) DE69803445T2 (it)
DK (1) DK0970042T3 (it)
ES (1) ES2169909T3 (it)
HU (1) HUP0001058A3 (it)
IT (1) IT1289979B1 (it)
NO (1) NO994104L (it)
NZ (1) NZ336680A (it)
PT (1) PT970042E (it)
WO (1) WO1998038155A1 (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202004461YA (en) 2017-11-24 2020-06-29 H Lundbeck As New catecholamine prodrugs for use in the treatment of parkinson's disease
US11111263B2 (en) 2019-05-20 2021-09-07 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11130775B2 (en) 2019-05-20 2021-09-28 H. Lundbeck A/S Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11104697B2 (en) 2019-05-20 2021-08-31 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11168056B2 (en) 2019-05-20 2021-11-09 H. Lundbeck A/S Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2803582A1 (de) * 1978-01-27 1979-08-02 Sandoz Ag Neue tetralinderivate, ihre herstellung und verwendung
IT1271411B (it) * 1993-09-14 1997-05-28 Zambon Spa Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare

Also Published As

Publication number Publication date
EP0970042B1 (en) 2002-01-09
ES2169909T3 (es) 2002-07-16
WO1998038155A1 (en) 1998-09-03
AU6619898A (en) 1998-09-18
HUP0001058A2 (hu) 2001-06-28
DE69803445T2 (de) 2002-08-29
EP0970042A1 (en) 2000-01-12
DE69803445D1 (en) 2002-02-28
ATE211727T1 (de) 2002-01-15
KR20000075736A (ko) 2000-12-26
DK0970042T3 (da) 2002-04-29
PT970042E (pt) 2002-06-28
NZ336680A (en) 2000-02-28
NO994104L (no) 1999-10-26
US6063964A (en) 2000-05-16
HUP0001058A3 (en) 2001-07-30
AU733001B2 (en) 2001-05-03
CA2282388A1 (en) 1998-09-03
NO994104D0 (no) 1999-08-25
ITMI970414A1 (it) 1998-08-26
JP2001513763A (ja) 2001-09-04

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Legal Events

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