NO973744L - Klavulinsyresalter - Google Patents

Klavulinsyresalter

Info

Publication number
NO973744L
NO973744L NO973744A NO973744A NO973744L NO 973744 L NO973744 L NO 973744L NO 973744 A NO973744 A NO 973744A NO 973744 A NO973744 A NO 973744A NO 973744 L NO973744 L NO 973744L
Authority
NO
Norway
Prior art keywords
salt
formula
salts
acid
klavulinsyresalter
Prior art date
Application number
NO973744A
Other languages
English (en)
Other versions
NO973744D0 (no
Inventor
George Leo Callewaert
Original Assignee
Spurcourt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26306586&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO973744(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9503839.4A external-priority patent/GB9503839D0/en
Application filed by Spurcourt Ltd filed Critical Spurcourt Ltd
Publication of NO973744L publication Critical patent/NO973744L/no
Publication of NO973744D0 publication Critical patent/NO973744D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D503/10—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Salter blir fremstilt ved reagering av et benzhydrylamin med fonnel (I) (eller et salt der- av) med klavoilinsyre (eller et salt derav) i et organisk oppløsningsmiddel, og isolering av det resulterende saltet. I formel (I) er hver av r1 og R2 hydrogen (foretrukket) eller en akseptabel substituent. KJavulinsyresaltene kan bli benyttet i farmasøytiske formuler- ingen sammen med en farmasøytisk akseptabel bærer og eventuelt et beta-laktam- antibiotika.
NO973744A 1995-02-25 1997-08-14 Klavulinsyresalter NO973744D0 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9503839.4A GB9503839D0 (en) 1995-02-25 1995-02-25 Claulanic acid salt
GBGB9520915.1A GB9520915D0 (en) 1995-02-25 1995-10-12 Clavulanic acid salt
PCT/GB1996/000382 WO1996026944A1 (en) 1995-02-25 1996-02-21 Clavulanic acid salts

Publications (2)

Publication Number Publication Date
NO973744L true NO973744L (no) 1997-08-14
NO973744D0 NO973744D0 (no) 1997-08-14

Family

ID=26306586

Family Applications (1)

Application Number Title Priority Date Filing Date
NO973744A NO973744D0 (no) 1995-02-25 1997-08-14 Klavulinsyresalter

Country Status (27)

Country Link
US (1) US5726170A (no)
EP (1) EP0729961B1 (no)
JP (1) JPH11501023A (no)
CN (1) CN1175952A (no)
AP (2) AP9701116A0 (no)
AT (1) ATE211143T1 (no)
AU (1) AU691727B2 (no)
BG (1) BG62490B1 (no)
BR (1) BR9607258A (no)
CA (1) CA2213563A1 (no)
CZ (1) CZ266697A3 (no)
DE (1) DE69618045D1 (no)
EE (1) EE9700186A (no)
FI (1) FI973287A (no)
HK (1) HK1006571A1 (no)
IL (1) IL117217A0 (no)
IS (1) IS4541A (no)
MD (1) MD1744F2 (no)
NO (1) NO973744D0 (no)
NZ (1) NZ301765A (no)
OA (1) OA10444A (no)
PL (1) PL321871A1 (no)
SE (1) SE9703056D0 (no)
SK (1) SK111197A3 (no)
TR (1) TR199700828T1 (no)
WO (1) WO1996026944A1 (no)
ZA (1) ZA961457B (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (de) * 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9400107A (en) 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
SI9500134B (sl) 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
ZA975198B (en) * 1996-06-13 1997-12-15 Smithkline Beecham Corp Improved process for preparing potassium clavulanate.
DZ2456A1 (fr) * 1997-04-04 2003-01-18 Smithkline Beecham Plc Procédé de préparation de sels de l'acide clavulanique.
US8034120B2 (en) * 2002-12-20 2011-10-11 Ossur Hf Suspension liner system with seal
CN103304583B (zh) * 2013-07-09 2016-01-20 山东新时代药业有限公司 一种从克拉维酸胺盐结晶母液中回收克拉维酸的方法
CN105384758B (zh) * 2015-12-01 2018-05-01 国药集团威奇达药业有限公司 克拉维酸胺盐的制备方法
CN113979856B (zh) * 2021-11-09 2024-04-19 国药集团威奇达药业有限公司 从克拉维酸钾釜残液中回收叔丁胺和异辛酸盐的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB157873A (en) * 1920-01-16 1921-08-17 Schneider & Cie Improvements in gas turbines
GB704438A (en) * 1951-04-06 1954-02-24 Chimiotherapie Lab Franc Penicillin preparations for injection
GB1508977A (en) * 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
GB1543563A (en) * 1975-02-07 1979-04-04 Glaxo Lab Ltd Beta-lactam antibiotic in purified form
GB1578739A (en) * 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
BE862211A (fr) * 1977-12-22 1978-06-22 Beecham Group Ltd Agents antibacteriens
DE3063683D1 (en) * 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
AR245221A1 (es) * 1984-10-27 1993-12-30 Beecham Group Plc Un metodo para la produccion de acido clavulanico por fermentacion de s. clavuligerus
ES2010143A6 (es) * 1989-03-01 1989-10-16 Pharma Mar S A Pharmar Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.
AT400033B (de) * 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
EP0719778A1 (en) * 1993-03-26 1996-07-03 Gist-Brocades N.V. Diamine salts of clavulanic acid

Also Published As

Publication number Publication date
IL117217A0 (en) 1996-06-18
BR9607258A (pt) 1997-12-30
IS4541A (is) 1997-08-08
AU691727B2 (en) 1998-05-21
FI973287A0 (fi) 1997-08-08
TR199700828T1 (xx) 1998-04-21
EE9700186A (et) 1998-02-16
MX9706461A (es) 1998-06-28
FI973287A (fi) 1997-08-22
CN1175952A (zh) 1998-03-11
BG101884A (en) 1998-10-30
HK1006571A1 (en) 1999-03-05
AP9701116A0 (en) 1997-10-31
AP9701067A0 (en) 1997-10-31
ZA961457B (en) 1996-09-26
ATE211143T1 (de) 2002-01-15
AU4726196A (en) 1996-09-18
BG62490B1 (bg) 1999-12-30
EP0729961B1 (en) 2001-12-19
US5726170A (en) 1998-03-10
JPH11501023A (ja) 1999-01-26
EP0729961A1 (en) 1996-09-04
AP749A (en) 1999-07-05
MD970269A (en) 1999-05-31
SE9703056L (sv) 1997-08-25
NZ301765A (en) 1999-10-28
CA2213563A1 (en) 1996-09-06
OA10444A (en) 2002-03-26
SK111197A3 (en) 1998-01-14
SE9703056D0 (sv) 1997-08-25
DE69618045D1 (de) 2002-01-31
NO973744D0 (no) 1997-08-14
MD1744F2 (ro) 2001-09-30
PL321871A1 (en) 1997-12-22
WO1996026944A1 (en) 1996-09-06
CZ266697A3 (en) 1997-11-12

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