DE69216013D1 - Imidazoindolizinderivate mit Angiotensin-II Hemmwirkung - Google Patents

Imidazoindolizinderivate mit Angiotensin-II Hemmwirkung

Info

Publication number
DE69216013D1
DE69216013D1 DE69216013T DE69216013T DE69216013D1 DE 69216013 D1 DE69216013 D1 DE 69216013D1 DE 69216013 T DE69216013 T DE 69216013T DE 69216013 T DE69216013 T DE 69216013T DE 69216013 D1 DE69216013 D1 DE 69216013D1
Authority
DE
Germany
Prior art keywords
imidazoindolizine
angiotensin
substituted
inhibitory effect
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69216013T
Other languages
English (en)
Other versions
DE69216013T2 (de
Inventor
Yasushi Honma
Yasuo Sekine
Sumihiro Nomura
Kazuaki Naito
Hiroshi Narita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Application granted granted Critical
Publication of DE69216013D1 publication Critical patent/DE69216013D1/de
Publication of DE69216013T2 publication Critical patent/DE69216013T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
DE69216013T 1991-09-10 1992-09-02 Imidazoindolizinderivate mit Angiotensin-II Hemmwirkung Expired - Fee Related DE69216013T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP30856091 1991-09-10
JP5304492 1992-01-27

Publications (2)

Publication Number Publication Date
DE69216013D1 true DE69216013D1 (de) 1997-01-30
DE69216013T2 DE69216013T2 (de) 1997-05-07

Family

ID=26393753

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69216013T Expired - Fee Related DE69216013T2 (de) 1991-09-10 1992-09-02 Imidazoindolizinderivate mit Angiotensin-II Hemmwirkung

Country Status (16)

Country Link
US (1) US5268377A (de)
EP (1) EP0531876B1 (de)
JP (1) JP2590797B2 (de)
KR (1) KR0168457B1 (de)
AT (1) ATE146474T1 (de)
AU (1) AU644539B2 (de)
CA (1) CA2077420C (de)
DE (1) DE69216013T2 (de)
DK (1) DK0531876T3 (de)
ES (1) ES2098403T3 (de)
FI (1) FI98369C (de)
GR (1) GR3022106T3 (de)
ID (1) ID902B (de)
IL (1) IL103021A (de)
MY (1) MY129927A (de)
SG (1) SG42962A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06271576A (ja) * 1993-03-19 1994-09-27 Upjohn Co:The イミダゾール誘導体の製法
FR2712592B1 (fr) * 1993-11-17 1995-12-22 Adir Nouveaux dérivés tricycliques azotés, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
EP2527360B1 (de) 2007-06-04 2015-10-28 Synergy Pharmaceuticals Inc. Für die Behandlung von gastrointestinalen Erkrankungen, Entzündungen, Krebs und anderen Erkrankungen geeignete Agonisten von Guanylatcyclase
US20100120694A1 (en) 2008-06-04 2010-05-13 Synergy Pharmaceuticals, Inc. Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
US10011637B2 (en) 2013-06-05 2018-07-03 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase C, method of making and using same
AU2017289974B2 (en) 2016-06-29 2021-08-12 Bristol-Myers Squibb Company Biarylmethyl heterocycles

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1047148A1 (ru) * 1981-03-30 1986-12-23 Институт физико-органической химии и углехимии АН УССР Бензилиденпроизводные имидазо-[4,5-L]-индолизинов,обладающие бактериостатической и фунгистатической активностью
US4686226A (en) * 1985-09-03 1987-08-11 Merck & Co., Inc. Substituted benzo[b]furo- and benzo[b]thieno quinolizines
US4812462A (en) * 1986-04-01 1989-03-14 Warner-Lambert Company 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity
US4816463A (en) * 1986-04-01 1989-03-28 Warner-Lambert Company Substituted diimidazo [1,5-a: 4',5'-d]pyridines having antihypertensive activity
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
DE3928177A1 (de) * 1989-04-08 1991-02-28 Thomae Gmbh Dr K Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
IL96019A0 (en) * 1989-10-31 1991-07-18 Fujisawa Pharmaceutical Co Imidazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same

Also Published As

Publication number Publication date
MY129927A (en) 2007-05-31
CA2077420C (en) 1998-08-25
IL103021A0 (en) 1993-02-21
ATE146474T1 (de) 1997-01-15
EP0531876A3 (de) 1993-05-05
EP0531876A2 (de) 1993-03-17
AU644539B2 (en) 1993-12-09
IL103021A (en) 1996-10-16
CA2077420A1 (en) 1993-03-11
FI98369C (fi) 1997-06-10
KR930006024A (ko) 1993-04-20
FI924043A0 (fi) 1992-09-10
JP2590797B2 (ja) 1997-03-12
US5268377A (en) 1993-12-07
KR0168457B1 (ko) 1999-01-15
SG42962A1 (en) 1997-10-17
JPH05279365A (ja) 1993-10-26
FI924043A (fi) 1993-03-11
DE69216013T2 (de) 1997-05-07
DK0531876T3 (de) 1997-02-17
EP0531876B1 (de) 1996-12-18
AU2205692A (en) 1993-03-11
ID902B (id) 1996-09-09
ES2098403T3 (es) 1997-05-01
FI98369B (fi) 1997-02-28
GR3022106T3 (en) 1997-03-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee