MY129927A - Imidazoidolizine derivatives and process for preparation thereof. - Google Patents
Imidazoidolizine derivatives and process for preparation thereof.Info
- Publication number
- MY129927A MY129927A MYPI92001597A MYPI9201597A MY129927A MY 129927 A MY129927 A MY 129927A MY PI92001597 A MYPI92001597 A MY PI92001597A MY PI9201597 A MYPI9201597 A MY PI9201597A MY 129927 A MY129927 A MY 129927A
- Authority
- MY
- Malaysia
- Prior art keywords
- substituted
- preparation
- derivatives
- pharmaceutically acceptable
- imidazoindolizine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Abstract
AN IMIDAZOINDOLIZINE DERIVATIVE OF THE FORMULA [I]: WHEREIN RL IS LOWER ALKYL, R2 IS HYDROGEN, CYANO, LOWER ALKYL, LOWER ALKANOYL, LOWER ALKOXYCARBONYL, PHENYL-LOWER ALKOXYCARBONYL, LOWER ALKYLSULFONYL, SUBSTITUTED OR UNSUBSTITUTED PHENYL, ARYLCARBONYL, OR 5- OR 6-MEMBERED NITROGEN-CONTAINING HETEROMONOCYCLIC GROUP-SUBSTITUTED CARBONYL, RING A IS SUBSTITUTED OR UNSUBSTITUTED PHENYL, AND M IS 0 OR 1, OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PROCESS FOR PREPARATION THEREOF, SAID IMIDAZOINDOLIZINE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF SHOW EXCELLENT ANGIOTENSIN II INHIBITORY ACTIVITIES AND ARE USEFUL IN THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP30856091 | 1991-09-10 | ||
JP5304492 | 1992-01-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
MY129927A true MY129927A (en) | 2007-05-31 |
Family
ID=26393753
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MYPI92001597A MY129927A (en) | 1991-09-10 | 1992-09-07 | Imidazoidolizine derivatives and process for preparation thereof. |
Country Status (16)
Country | Link |
---|---|
US (1) | US5268377A (en) |
EP (1) | EP0531876B1 (en) |
JP (1) | JP2590797B2 (en) |
KR (1) | KR0168457B1 (en) |
AT (1) | ATE146474T1 (en) |
AU (1) | AU644539B2 (en) |
CA (1) | CA2077420C (en) |
DE (1) | DE69216013T2 (en) |
DK (1) | DK0531876T3 (en) |
ES (1) | ES2098403T3 (en) |
FI (1) | FI98369C (en) |
GR (1) | GR3022106T3 (en) |
ID (1) | ID902B (en) |
IL (1) | IL103021A (en) |
MY (1) | MY129927A (en) |
SG (1) | SG42962A1 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06271576A (en) * | 1993-03-19 | 1994-09-27 | Upjohn Co:The | Manufacturing of imidazole derivative |
FR2712592B1 (en) * | 1993-11-17 | 1995-12-22 | Adir | New nitrogenous tricyclic derivatives, process for their preparation and pharmaceutical compositions containing them. |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
EA020466B1 (en) | 2007-06-04 | 2014-11-28 | Синерджи Фармасьютикалз Инк. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
EP2810951B1 (en) | 2008-06-04 | 2017-03-15 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
ES2624828T3 (en) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer and others |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
CA2905438A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
PT3004138T (en) | 2013-06-05 | 2024-06-18 | Bausch Health Ireland Ltd | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
EP3478672B1 (en) | 2016-06-29 | 2024-04-10 | Université de Montréal | Biarylmethyl heterocycles |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU1047148A1 (en) * | 1981-03-30 | 1986-12-23 | Институт физико-органической химии и углехимии АН УССР | Benzylidene-derivatives of imidazo-/4,5-g/-indolysines possessing bacteriostatic and fungistatic activity |
US4686226A (en) * | 1985-09-03 | 1987-08-11 | Merck & Co., Inc. | Substituted benzo[b]furo- and benzo[b]thieno quinolizines |
US4812462A (en) * | 1986-04-01 | 1989-03-14 | Warner-Lambert Company | 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity |
US4816463A (en) * | 1986-04-01 | 1989-03-28 | Warner-Lambert Company | Substituted diimidazo [1,5-a: 4',5'-d]pyridines having antihypertensive activity |
CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
DE3928177A1 (en) * | 1989-04-08 | 1991-02-28 | Thomae Gmbh Dr K | BENZIMIDAZOLE, MEDICAMENTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
IL96019A0 (en) * | 1989-10-31 | 1991-07-18 | Fujisawa Pharmaceutical Co | Imidazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
-
1992
- 1992-09-02 AU AU22056/92A patent/AU644539B2/en not_active Ceased
- 1992-09-02 AT AT92114987T patent/ATE146474T1/en not_active IP Right Cessation
- 1992-09-02 EP EP92114987A patent/EP0531876B1/en not_active Expired - Lifetime
- 1992-09-02 DK DK92114987.8T patent/DK0531876T3/da active
- 1992-09-02 SG SG1996001486A patent/SG42962A1/en unknown
- 1992-09-02 ES ES92114987T patent/ES2098403T3/en not_active Expired - Lifetime
- 1992-09-02 CA CA002077420A patent/CA2077420C/en not_active Expired - Fee Related
- 1992-09-02 DE DE69216013T patent/DE69216013T2/en not_active Expired - Fee Related
- 1992-09-02 IL IL10302192A patent/IL103021A/en not_active IP Right Cessation
- 1992-09-03 US US07/939,652 patent/US5268377A/en not_active Expired - Fee Related
- 1992-09-07 MY MYPI92001597A patent/MY129927A/en unknown
- 1992-09-08 JP JP4239080A patent/JP2590797B2/en not_active Expired - Lifetime
- 1992-09-08 KR KR1019920016409A patent/KR0168457B1/en not_active IP Right Cessation
- 1992-09-10 FI FI924043A patent/FI98369C/en active
- 1992-09-10 ID IDP469892A patent/ID902B/en unknown
-
1996
- 1996-12-19 GR GR960403177T patent/GR3022106T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR0168457B1 (en) | 1999-01-15 |
IL103021A (en) | 1996-10-16 |
DE69216013T2 (en) | 1997-05-07 |
JP2590797B2 (en) | 1997-03-12 |
FI98369C (en) | 1997-06-10 |
ATE146474T1 (en) | 1997-01-15 |
JPH05279365A (en) | 1993-10-26 |
EP0531876A2 (en) | 1993-03-17 |
AU2205692A (en) | 1993-03-11 |
FI924043A (en) | 1993-03-11 |
ID902B (en) | 1996-09-09 |
KR930006024A (en) | 1993-04-20 |
US5268377A (en) | 1993-12-07 |
DE69216013D1 (en) | 1997-01-30 |
SG42962A1 (en) | 1997-10-17 |
EP0531876A3 (en) | 1993-05-05 |
FI924043A0 (en) | 1992-09-10 |
DK0531876T3 (en) | 1997-02-17 |
IL103021A0 (en) | 1993-02-21 |
CA2077420A1 (en) | 1993-03-11 |
ES2098403T3 (en) | 1997-05-01 |
FI98369B (en) | 1997-02-28 |
GR3022106T3 (en) | 1997-03-31 |
AU644539B2 (en) | 1993-12-09 |
EP0531876B1 (en) | 1996-12-18 |
CA2077420C (en) | 1998-08-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NZ514873A (en) | 4,5,6,7-tetrahydroindazole derivatives as antitumor agents | |
AU2001293233A1 (en) | Aza heterocyclic derivatives and their therapeutic use | |
MY129927A (en) | Imidazoidolizine derivatives and process for preparation thereof. | |
GEP20022653B (en) | Processes and Intermediates for Preparing Anti-Cancer Compounds | |
MX9800946A (en) | 4-mercaptopyrrolidine derivatives as farnesyl transferase inhibitors. | |
YU69902A (en) | New piperazine derivatives | |
MY123528A (en) | Aromatic nitrogen-containing 6-membered cyclic compounds. | |
BG103195A (en) | Substituted indazole derivatives and their application as inhibitors of phosphodiesterase (pde) type iv and of the production of a tumournecrotic factor (tnf) | |
EP0638560A4 (en) | Remedy for osteoporosis and diazepine compound. | |
NZ330816A (en) | Quinazoline derivatives as antitumor agents | |
NO932005L (en) | Angiotensin II antagonists | |
TW341565B (en) | Indole derivatives processes and intermediates for their preparation and pharmaceutical compositions containing them | |
EA004302B9 (en) | β-CARBOLINE DRUG PRODUCTS | |
GEP20053626B (en) | Substituted 8-Arylquinoline Phosphodiesterase-4 Inhibitors, Pharmaceutical Composition Containing Them and Use Thereof | |
AU4205197A (en) | New thiazole derivatives with phosphodiesterase-inhibiting effect | |
CA2244777A1 (en) | 2,3-benzodiazepine derivatives and their use as ampa-receptor inhibitors | |
MY117092A (en) | Chemotherapeutic pyrrolocarbazole derivatives | |
MX9709466A (en) | Methods of inhibiting melanoma. | |
AU2001261707A1 (en) | Pirazino '1$m(1)2$m(1) :1, 6! pyrido '3,4-b! indole derivatives | |
AP9400638A0 (en) | Water soluble derivatives of camptothecin. | |
BG106922A (en) | Heterocyclic amide derivatives | |
AU3402701A (en) | TRH-like peptide derivatives as inhibitors of the TRH-degrading ectoenzyme | |
DE69726437D1 (en) | BENZOTHIOPHENE DERIVATIVES, THEIR PRODUCTION AND USE AS UROKINASE INHIBITORS | |
PL324086A1 (en) | Antagonists of calcium passages | |
ES2076865A1 (en) | New derivatives of N-aryl- and N-heteroaryl-urea as acyl coenzyme A: cholesterol acyl transferase (ACAT) inhibitors |