DK0531876T3 - - Google Patents
Info
- Publication number
- DK0531876T3 DK0531876T3 DK92114987.8T DK92114987T DK0531876T3 DK 0531876 T3 DK0531876 T3 DK 0531876T3 DK 92114987 T DK92114987 T DK 92114987T DK 0531876 T3 DK0531876 T3 DK 0531876T3
- Authority
- DK
- Denmark
- Prior art keywords
- substituted
- pharmaceutically acceptable
- imidazoindolizine
- unsubstituted phenyl
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Abstract
An imidazoindolizine derivative of the formula [I]: <CHEM> wherein R<1> is lower alkyl, R<2> is hydrogen, cyano, lower alkyl, lower alkanoyl, lower alkoxycarbonyl, phenyl-lower alkoxycarbonyl, lower alkylsulfonyl, substituted or unsubstituted phenyl, arylcarbonyl, or 5- or 6-membered nitrogen-containing heteromonocyclic group-substituted carbonyl, Ring A is substituted or unsubstituted phenyl, and m is 0 or 1, or a pharmaceutically acceptable salt thereof, and process for preparation thereof, said imidazoindolizine derivatives and pharmaceutically acceptable salts thereof show excellent angiotensin II inhibitory activities and are useful in the prophylaxis or treatment of hypertension.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP30856091 | 1991-09-10 | ||
JP5304492 | 1992-01-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0531876T3 true DK0531876T3 (en) | 1997-02-17 |
Family
ID=26393753
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK92114987.8T DK0531876T3 (en) | 1991-09-10 | 1992-09-02 |
Country Status (16)
Country | Link |
---|---|
US (1) | US5268377A (en) |
EP (1) | EP0531876B1 (en) |
JP (1) | JP2590797B2 (en) |
KR (1) | KR0168457B1 (en) |
AT (1) | ATE146474T1 (en) |
AU (1) | AU644539B2 (en) |
CA (1) | CA2077420C (en) |
DE (1) | DE69216013T2 (en) |
DK (1) | DK0531876T3 (en) |
ES (1) | ES2098403T3 (en) |
FI (1) | FI98369C (en) |
GR (1) | GR3022106T3 (en) |
ID (1) | ID902B (en) |
IL (1) | IL103021A (en) |
MY (1) | MY129927A (en) |
SG (1) | SG42962A1 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06271576A (en) * | 1993-03-19 | 1994-09-27 | Upjohn Co:The | Manufacturing of imidazole derivative |
FR2712592B1 (en) * | 1993-11-17 | 1995-12-22 | Adir | New nitrogenous tricyclic derivatives, process for their preparation and pharmaceutical compositions containing them. |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
CA3089569C (en) | 2007-06-04 | 2023-12-05 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
JP2011522828A (en) | 2008-06-04 | 2011-08-04 | シナジー ファーマシューティカルズ インコーポレイテッド | Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer, and other disorders |
EP2321341B1 (en) | 2008-07-16 | 2017-02-22 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
US9486494B2 (en) | 2013-03-15 | 2016-11-08 | Synergy Pharmaceuticals, Inc. | Compositions useful for the treatment of gastrointestinal disorders |
JP6606491B2 (en) | 2013-06-05 | 2019-11-13 | シナジー ファーマシューティカルズ インコーポレイテッド | Ultra high purity agonist of guanylate cyclase C, method for producing and using the same |
KR102538999B1 (en) | 2016-06-29 | 2023-05-31 | 유니버시떼 드 몬트리얼 | biarylmethyl heterocycle |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU1047148A1 (en) * | 1981-03-30 | 1986-12-23 | Институт физико-органической химии и углехимии АН УССР | Benzylidene-derivatives of imidazo-/4,5-g/-indolysines possessing bacteriostatic and fungistatic activity |
US4686226A (en) * | 1985-09-03 | 1987-08-11 | Merck & Co., Inc. | Substituted benzo[b]furo- and benzo[b]thieno quinolizines |
US4812462A (en) * | 1986-04-01 | 1989-03-14 | Warner-Lambert Company | 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity |
US4816463A (en) * | 1986-04-01 | 1989-03-28 | Warner-Lambert Company | Substituted diimidazo [1,5-a: 4',5'-d]pyridines having antihypertensive activity |
CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
DE3928177A1 (en) * | 1989-04-08 | 1991-02-28 | Thomae Gmbh Dr K | BENZIMIDAZOLE, MEDICAMENTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
IL96019A0 (en) * | 1989-10-31 | 1991-07-18 | Fujisawa Pharmaceutical Co | Imidazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
-
1992
- 1992-09-02 AU AU22056/92A patent/AU644539B2/en not_active Ceased
- 1992-09-02 DK DK92114987.8T patent/DK0531876T3/da active
- 1992-09-02 ES ES92114987T patent/ES2098403T3/en not_active Expired - Lifetime
- 1992-09-02 IL IL10302192A patent/IL103021A/en not_active IP Right Cessation
- 1992-09-02 CA CA002077420A patent/CA2077420C/en not_active Expired - Fee Related
- 1992-09-02 DE DE69216013T patent/DE69216013T2/en not_active Expired - Fee Related
- 1992-09-02 EP EP92114987A patent/EP0531876B1/en not_active Expired - Lifetime
- 1992-09-02 SG SG1996001486A patent/SG42962A1/en unknown
- 1992-09-02 AT AT92114987T patent/ATE146474T1/en not_active IP Right Cessation
- 1992-09-03 US US07/939,652 patent/US5268377A/en not_active Expired - Fee Related
- 1992-09-07 MY MYPI92001597A patent/MY129927A/en unknown
- 1992-09-08 KR KR1019920016409A patent/KR0168457B1/en not_active IP Right Cessation
- 1992-09-08 JP JP4239080A patent/JP2590797B2/en not_active Expired - Lifetime
- 1992-09-10 ID IDP469892A patent/ID902B/en unknown
- 1992-09-10 FI FI924043A patent/FI98369C/en active
-
1996
- 1996-12-19 GR GR960403177T patent/GR3022106T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
FI98369B (en) | 1997-02-28 |
GR3022106T3 (en) | 1997-03-31 |
AU644539B2 (en) | 1993-12-09 |
DE69216013D1 (en) | 1997-01-30 |
ES2098403T3 (en) | 1997-05-01 |
EP0531876B1 (en) | 1996-12-18 |
KR930006024A (en) | 1993-04-20 |
FI98369C (en) | 1997-06-10 |
US5268377A (en) | 1993-12-07 |
JP2590797B2 (en) | 1997-03-12 |
ID902B (en) | 1996-09-09 |
AU2205692A (en) | 1993-03-11 |
CA2077420C (en) | 1998-08-25 |
JPH05279365A (en) | 1993-10-26 |
DE69216013T2 (en) | 1997-05-07 |
MY129927A (en) | 2007-05-31 |
KR0168457B1 (en) | 1999-01-15 |
IL103021A (en) | 1996-10-16 |
IL103021A0 (en) | 1993-02-21 |
FI924043A (en) | 1993-03-11 |
SG42962A1 (en) | 1997-10-17 |
CA2077420A1 (en) | 1993-03-11 |
FI924043A0 (en) | 1992-09-10 |
EP0531876A3 (en) | 1993-05-05 |
ATE146474T1 (en) | 1997-01-15 |
EP0531876A2 (en) | 1993-03-17 |
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