ATE121087T1 - 4-alkylimidazolderivate. - Google Patents
4-alkylimidazolderivate.Info
- Publication number
- ATE121087T1 ATE121087T1 AT91914167T AT91914167T ATE121087T1 AT E121087 T1 ATE121087 T1 AT E121087T1 AT 91914167 T AT91914167 T AT 91914167T AT 91914167 T AT91914167 T AT 91914167T AT E121087 T1 ATE121087 T1 AT E121087T1
- Authority
- AT
- Austria
- Prior art keywords
- alkylimidazole derivatives
- alkylimidazole
- derivatives
- angiotensin
- potency
- Prior art date
Links
- 229940123413 Angiotensin II antagonist Drugs 0.000 abstract 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Lubricants (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55263790A | 1990-07-13 | 1990-07-13 | |
US07/650,258 US5137902A (en) | 1990-07-13 | 1991-02-04 | 4-alkylimidazole derivatives and anti-hypertensive use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE121087T1 true ATE121087T1 (de) | 1995-04-15 |
Family
ID=27070086
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT91914167T ATE121087T1 (de) | 1990-07-13 | 1991-07-15 | 4-alkylimidazolderivate. |
Country Status (23)
Country | Link |
---|---|
US (1) | US5137902A (de) |
EP (1) | EP0539509B1 (de) |
JP (1) | JP2550455B2 (de) |
KR (1) | KR0162669B1 (de) |
AT (1) | ATE121087T1 (de) |
AU (1) | AU639400B2 (de) |
BG (1) | BG61341B1 (de) |
CA (1) | CA2087274C (de) |
CZ (1) | CZ280018B6 (de) |
DE (1) | DE69108913T2 (de) |
DK (1) | DK0539509T3 (de) |
ES (1) | ES2071325T3 (de) |
FI (1) | FI102752B1 (de) |
HU (2) | HU223530B1 (de) |
IE (1) | IE69849B1 (de) |
IL (1) | IL98794A (de) |
MY (1) | MY140243A (de) |
NO (1) | NO303015B1 (de) |
NZ (1) | NZ238920A (de) |
PL (1) | PL168311B1 (de) |
RO (1) | RO111270B1 (de) |
SK (1) | SK279326B6 (de) |
WO (1) | WO1992000977A2 (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5616599A (en) * | 1991-02-21 | 1997-04-01 | Sankyo Company, Limited | Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use |
DE4132633A1 (de) * | 1991-10-01 | 1993-04-08 | Bayer Ag | Cyclisch substituierte imidazolyl-propensaeurederivate |
US5250558A (en) * | 1992-01-28 | 1993-10-05 | Merck & Co., Inc. | Substituted triazolinones, triazolinethiones, and triazolinimines as neurotensin antagonists used to treat psychosis |
US5326776A (en) * | 1992-03-02 | 1994-07-05 | Abbott Laboratories | Angiotensin II receptor antagonists |
GB9218449D0 (en) | 1992-08-29 | 1992-10-14 | Boots Co Plc | Therapeutic agents |
US5310929A (en) * | 1992-08-06 | 1994-05-10 | E. I. Du Pont De Nemours And Company | Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists |
CZ283315B6 (cs) * | 1992-12-17 | 1998-02-18 | Sankyo Company Limited | Bifenylové deriváty, způsob výroby a farmaceutické prostředky k léčení hypertense a srdečních onemocnění, které tyto deriváty obsahují |
US5338740A (en) * | 1993-07-13 | 1994-08-16 | Pfizer Inc. | Angiotensin II receptor antagonists |
SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
AU2001267404A1 (en) * | 2000-05-04 | 2001-11-12 | Ipf Pharmaceuticals Gmbh | Novel compounds for the treatment of inflammatory and cardiovascular diseases |
DE602005025755D1 (de) | 2004-06-04 | 2011-02-17 | Teva Pharma | Irbesartan enthaltende pharmazeutische zusammensetzung |
US20070054948A1 (en) * | 2004-09-02 | 2007-03-08 | Lilach Hedvati | Purification of olmesartan medoxomil |
CA2575177A1 (en) * | 2004-09-02 | 2006-03-16 | Teva Pharmaceutical Industries Ltd. | Purification of olmesartan medoxomil |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
EA020466B1 (ru) | 2007-06-04 | 2014-11-28 | Синерджи Фармасьютикалз Инк. | Агонисты гуанилатциклазы, пригодные для лечения желудочно-кишечных нарушений, воспаления, рака и других заболеваний |
EP2810951B1 (de) | 2008-06-04 | 2017-03-15 | Synergy Pharmaceuticals Inc. | Für die Behandlung von gastrointestinalen Erkrankungen, Entzündungen, Krebs und anderen Erkrankungen geeignete Agonisten von Guanylatcyclase |
ES2624828T3 (es) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
CA2905438A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
PT3004138T (pt) | 2013-06-05 | 2024-06-18 | Bausch Health Ireland Ltd | Agonistas ultrapuros de guanilato ciclase c, método de produção e utilização dos mesmos |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4820843A (en) * | 1987-05-22 | 1989-04-11 | E. I. Du Pont De Nemours And Company | Tetrazole intermediates to antihypertensive compounds |
US4880804A (en) * | 1988-01-07 | 1989-11-14 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking benzimidazoles |
US5015651A (en) * | 1988-01-07 | 1991-05-14 | E. I. Du Pont De Nemours And Company | Treatment of hypertension with 1,2,4-angiotensin II antagonists |
CA1338238C (en) * | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
US5064825A (en) * | 1989-06-01 | 1991-11-12 | Merck & Co., Inc. | Angiotensin ii antagonists |
RU2099330C1 (ru) * | 1989-06-30 | 1997-12-20 | Е.И.Дюпон Де Немур Энд Компани | Замещенные имидазолы или их фармацевтически приемлемые соли и фармацевтическая композиция |
CA2059000C (en) * | 1989-06-30 | 1998-01-20 | Robert John Ardecky | Fused-ring aryl substituted imidazoles |
DE4132633A1 (de) * | 1991-10-01 | 1993-04-08 | Bayer Ag | Cyclisch substituierte imidazolyl-propensaeurederivate |
-
1991
- 1991-02-04 US US07/650,258 patent/US5137902A/en not_active Expired - Lifetime
- 1991-07-11 IL IL9879491A patent/IL98794A/en not_active IP Right Cessation
- 1991-07-11 NZ NZ238920A patent/NZ238920A/en not_active IP Right Cessation
- 1991-07-12 IE IE243891A patent/IE69849B1/en not_active IP Right Cessation
- 1991-07-12 MY MYPI91001263A patent/MY140243A/en unknown
- 1991-07-15 PL PL91297616A patent/PL168311B1/pl unknown
- 1991-07-15 CZ CS923912A patent/CZ280018B6/cs not_active IP Right Cessation
- 1991-07-15 AT AT91914167T patent/ATE121087T1/de not_active IP Right Cessation
- 1991-07-15 SK SK3912-92A patent/SK279326B6/sk not_active IP Right Cessation
- 1991-07-15 DK DK91914167.1T patent/DK0539509T3/da active
- 1991-07-15 CA CA002087274A patent/CA2087274C/en not_active Expired - Lifetime
- 1991-07-15 EP EP91914167A patent/EP0539509B1/de not_active Expired - Lifetime
- 1991-07-15 RO RO93-00803A patent/RO111270B1/ro unknown
- 1991-07-15 ES ES91914167T patent/ES2071325T3/es not_active Expired - Lifetime
- 1991-07-15 WO PCT/US1991/004826 patent/WO1992000977A2/en active IP Right Grant
- 1991-07-15 AU AU83116/91A patent/AU639400B2/en not_active Expired
- 1991-07-15 DE DE69108913T patent/DE69108913T2/de not_active Expired - Lifetime
- 1991-07-15 KR KR1019930700076A patent/KR0162669B1/ko not_active IP Right Cessation
- 1991-07-15 JP JP3513329A patent/JP2550455B2/ja not_active Expired - Lifetime
- 1991-07-15 HU HU9204058A patent/HU223530B1/hu active IP Right Grant
- 1991-07-15 HU HU924058A patent/HUT63411A/hu unknown
-
1993
- 1993-01-11 NO NO930088A patent/NO303015B1/no not_active IP Right Cessation
- 1993-01-12 FI FI930109A patent/FI102752B1/fi not_active IP Right Cessation
- 1993-02-11 BG BG97438A patent/BG61341B1/bg unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0539509T3 (da) | 4-Alkylimidazolderivater | |
DE69620443D1 (de) | Naphthyl substituierte benzimidazolderivate als antikoagulantien | |
LU91122I2 (fr) | Efalizumab et ses dérivés pharmaceutiquement acceptables (raptiva). | |
DE69717827D1 (de) | Benzofuran-4-carboxamide | |
LU88790I2 (fr) | Moxidectin et ses dérivés pharmaceutiquement acceptables | |
NO306116B1 (no) | Ny benzotiadiazinforbindelse og farmasöytiske sammensetninger | |
DK199587D0 (da) | Heterocykliske derivater af n'-substituerede-n,n'-diacylhydraziner | |
NO20033184D0 (no) | Anvendelse av forbindelsen (+)-<alfa>-(2,3-dimetoksyfenyl)-1- [2-(4-fluorfenyl)etyl]-4-piperidinmetanol | |
FI890185A0 (fi) | Foerfarande foer framstaellning av 1-alkyl-5-nitroimidazoler. | |
DE69100517D1 (de) | Polyethyleneiminphosphonatderivate als Dispergiermittel enthaltende Zementzusammensetzungen. | |
EE02942B1 (et) | Metüülpiperasinoasepiini derivaadid, nende valmistamine ja kasutamine | |
FI912963A0 (fi) | Hjaernverksamheten oekande pyrimidinylderivat. | |
ITMI911944A1 (it) | Quadro dei licci | |
ES2087567T3 (es) | Derivados antibioticos de 7'-amino-naftazarina. | |
LU88789I2 (fr) | Mésylate de tirilazad et ses dérivés pharmaceutiquement acceptables (Freedox (R)) | |
FI914087A0 (fi) | Foerfarande och anordning foer detektering av verktygshaverier i skaerande bearbetning. | |
ES2059097T3 (es) | Derivados de la ergolina. | |
FI970397A0 (fi) | Substituoituja 1,4-dihydroksylopent(b)indol-3(2H)-onijohdannaisia | |
DK336088A (da) | Antitumormiddel opnaaet ved mikrobiel stereoselektiv reduktion af 4'-deoxy-4'-ioddoxorubicin | |
IT1255093B (it) | Derivati imidazolidinonici come agenti nootropici | |
GR1001386B (el) | Ετεροκυκλικές ενώσεις. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
EELA | Cancelled due to lapse of time |