DE69527072D1 - Endothelin antagoniste - Google Patents
Endothelin antagonisteInfo
- Publication number
- DE69527072D1 DE69527072D1 DE69527072T DE69527072T DE69527072D1 DE 69527072 D1 DE69527072 D1 DE 69527072D1 DE 69527072 T DE69527072 T DE 69527072T DE 69527072 T DE69527072 T DE 69527072T DE 69527072 D1 DE69527072 D1 DE 69527072D1
- Authority
- DE
- Germany
- Prior art keywords
- endothelin
- antagoniste
- processes
- preparing
- chem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29334994A | 1994-08-19 | 1994-08-19 | |
US33471794A | 1994-11-04 | 1994-11-04 | |
US08/442,575 US5767144A (en) | 1994-08-19 | 1995-05-30 | Endothelin antagonists |
US49799895A | 1995-08-02 | 1995-08-02 | |
PCT/US1995/009924 WO1996006095A1 (en) | 1994-08-19 | 1995-08-04 | Endothelin antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69527072D1 true DE69527072D1 (de) | 2002-07-18 |
DE69527072T2 DE69527072T2 (de) | 2003-02-13 |
Family
ID=27501591
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69527072T Expired - Lifetime DE69527072T2 (de) | 1994-08-19 | 1995-08-04 | Endothelin antagoniste |
Country Status (13)
Country | Link |
---|---|
EP (2) | EP0776324B1 (de) |
JP (1) | JP3741441B2 (de) |
KR (2) | KR100447000B1 (de) |
AT (1) | ATE219077T1 (de) |
AU (1) | AU711832B2 (de) |
CA (2) | CA2517691A1 (de) |
DE (1) | DE69527072T2 (de) |
DK (1) | DK0776324T3 (de) |
ES (1) | ES2179881T3 (de) |
HK (1) | HK1008328A1 (de) |
IL (2) | IL134905A (de) |
PT (1) | PT776324E (de) |
WO (1) | WO1996006095A1 (de) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5852046A (en) * | 1993-08-03 | 1998-12-22 | Hoechst Aktiengesellschaft | Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them |
US6162927A (en) * | 1994-08-19 | 2000-12-19 | Abbott Laboratories | Endothelin antagonists |
US5767144A (en) * | 1994-08-19 | 1998-06-16 | Abbott Laboratories | Endothelin antagonists |
US7208517B1 (en) | 1994-08-19 | 2007-04-24 | Abbott Labortories | Endothelin antagonists |
AU2763602A (en) * | 1996-02-13 | 2002-05-16 | Abbott Laboratories | Endothelin antagonists |
WO1997030045A1 (en) * | 1996-02-13 | 1997-08-21 | Abbott Laboratories | Novel benzo-1,3-dioxolyl- and benzofuranyl substituted pyrrolidine derivatives as endothelin antagonists |
IL125453A0 (en) * | 1996-02-13 | 1999-03-12 | Abbott Lab | 4-(Benzo-1,3-dioxylyl)-pyrrolidine-3-carboxylic acid derivatives as endothelin antagonists |
AU781355B2 (en) * | 1996-02-13 | 2005-05-19 | Abbott Laboratories | Novel benzo-1,3-dioxolyl-and benzofuranyl substituted pyrrolidine derivatives as endothelin antagonists |
US5801250A (en) * | 1996-12-13 | 1998-09-01 | Abbott Laboratories | Process for the stereoselective production of nitro-enamine compounds |
US6030975A (en) * | 1997-03-14 | 2000-02-29 | Basf Aktiengesellschaft | Carboxylic acid derivatives, their preparation and use in treating cancer |
PL348667A1 (en) * | 1997-06-17 | 2002-06-03 | Abbott Lab | Pyrrolidine carboxylic acid derivatives as endothelin antagonists |
HUP0003484A3 (en) * | 1997-08-04 | 2002-02-28 | Abbott Lab | Pyrrolidine-3-crboxylic acid derivatives and their use as endothelin antagonists |
US6339087B1 (en) | 1997-08-18 | 2002-01-15 | Syntex (U.S.A.) Llc | Cyclic amine derivatives-CCR-3 receptor antagonists |
IL125658A0 (en) | 1997-08-18 | 1999-04-11 | Hoffmann La Roche | Ccr-3 receptor antagonists |
DE19743681A1 (de) * | 1997-10-02 | 1999-04-08 | Knoll Ag | Methode zur Verhinderung der Transplantatabstoßung |
US6410554B1 (en) | 1998-03-23 | 2002-06-25 | Merck & Co., Inc. | Combination therapy for the treatment of benign prostatic hyperplasia |
US6245801B1 (en) * | 1998-09-14 | 2001-06-12 | Warner-Lambert Company | Branched alkyl pyrrolidine-3-carboxylic acids |
TR200101397T2 (tr) | 1998-11-20 | 2001-11-21 | F.Hoffmann-La Roche Ag | Piperidin CCR-3 reseptörü antagonistleri |
WO2002017912A1 (en) * | 2000-08-31 | 2002-03-07 | Abbott Laboratories | Endothelin antagonists |
US8168616B1 (en) | 2000-11-17 | 2012-05-01 | Novartis Ag | Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension |
GB0327839D0 (en) | 2003-12-01 | 2003-12-31 | Novartis Ag | Organic compounds |
SG153831A1 (en) | 2004-03-17 | 2009-07-29 | Novartis Ag | Use of renin inhibitors in therapy |
CA2904447C (en) | 2007-08-22 | 2017-01-03 | Abbvie Deutschland Gmbh & Co Kg | Therapy for complications of diabetes |
WO2011114103A1 (en) | 2010-03-18 | 2011-09-22 | Biolipox Ab | Pyrimidinones for use as medicaments |
JO2998B1 (ar) | 2010-06-04 | 2016-09-05 | Amgen Inc | مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان |
EP2760845B1 (de) | 2011-09-27 | 2016-11-16 | Amgen Inc. | Heterocyclische verbindungen als mdm2-hemmer zur behandlung von krebs |
US11407721B2 (en) | 2013-02-19 | 2022-08-09 | Amgen Inc. | CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer |
CN105121407B (zh) | 2013-02-28 | 2017-07-18 | 美国安进公司 | 用于治疗癌症的苯甲酸衍生物mdm2抑制剂 |
JP6377123B2 (ja) | 2013-03-14 | 2018-08-22 | アムジエン・インコーポレーテツド | 癌の治療のためのmdm2阻害剤としてのヘテロアリール酸モルホリノン化合物 |
JOP20200296A1 (ar) | 2013-06-10 | 2017-06-16 | Amgen Inc | عمليات صنع وأشكال بلورية من mdm2 مثبط |
US8962675B1 (en) * | 2013-09-12 | 2015-02-24 | Abbvie Inc. | Atrasentan mandelate salts |
KR102091932B1 (ko) | 2018-08-16 | 2020-03-20 | 장남순 | 안전하고 간편한 접첩구조를 갖는 접이식 트램펄린 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3342833A (en) * | 1964-08-07 | 1967-09-19 | Shell Oil Co | Pyrrolidine production from aziridines and olefins |
RO117847B1 (ro) * | 1991-11-05 | 2002-08-30 | Smithkline Beecham Corp | Derivati de indan, procedeu de preparare, compozitie farmaceutica care ii contine si metoda de tratament |
EP0650484B1 (de) * | 1992-07-17 | 2000-01-26 | Smithkline Beecham Corporation | Endothelin rezeptor antagonisten |
-
1995
- 1995-08-04 DE DE69527072T patent/DE69527072T2/de not_active Expired - Lifetime
- 1995-08-04 CA CA002517691A patent/CA2517691A1/en not_active Abandoned
- 1995-08-04 PT PT95928323T patent/PT776324E/pt unknown
- 1995-08-04 KR KR1019970701079A patent/KR100447000B1/ko not_active IP Right Cessation
- 1995-08-04 EP EP95928323A patent/EP0776324B1/de not_active Expired - Lifetime
- 1995-08-04 CA CA002195677A patent/CA2195677C/en not_active Expired - Lifetime
- 1995-08-04 DK DK95928323T patent/DK0776324T3/da active
- 1995-08-04 JP JP50810196A patent/JP3741441B2/ja not_active Expired - Lifetime
- 1995-08-04 ES ES95928323T patent/ES2179881T3/es not_active Expired - Lifetime
- 1995-08-04 KR KR10-2004-7004682A patent/KR100483222B1/ko not_active IP Right Cessation
- 1995-08-04 EP EP01125462A patent/EP1186603A3/de not_active Withdrawn
- 1995-08-04 WO PCT/US1995/009924 patent/WO1996006095A1/en active Search and Examination
- 1995-08-04 AT AT95928323T patent/ATE219077T1/de active
- 1995-08-04 AU AU32137/95A patent/AU711832B2/en not_active Expired
- 1995-08-10 IL IL134905A patent/IL134905A/en not_active IP Right Cessation
- 1995-08-10 IL IL11489495A patent/IL114894A/xx not_active IP Right Cessation
-
1998
- 1998-07-15 HK HK98109192A patent/HK1008328A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2517691A1 (en) | 1996-02-29 |
EP1186603A3 (de) | 2003-07-09 |
DK0776324T3 (da) | 2002-10-07 |
DE69527072T2 (de) | 2003-02-13 |
KR100447000B1 (ko) | 2004-12-10 |
JP3741441B2 (ja) | 2006-02-01 |
CA2195677A1 (en) | 1996-02-29 |
IL134905A0 (en) | 2001-05-20 |
EP1186603A2 (de) | 2002-03-13 |
KR20040045036A (ko) | 2004-05-31 |
EP0776324B1 (de) | 2002-06-12 |
HK1008328A1 (en) | 1999-05-07 |
EP0776324A1 (de) | 1997-06-04 |
IL134905A (en) | 2009-06-15 |
ATE219077T1 (de) | 2002-06-15 |
KR100483222B1 (ko) | 2005-04-15 |
JPH10504565A (ja) | 1998-05-06 |
ES2179881T3 (es) | 2003-02-01 |
KR970705561A (ko) | 1997-10-09 |
AU3213795A (en) | 1996-03-14 |
CA2195677C (en) | 2005-11-08 |
IL114894A0 (en) | 1995-12-08 |
WO1996006095A1 (en) | 1996-02-29 |
AU711832B2 (en) | 1999-10-21 |
IL114894A (en) | 2003-04-10 |
PT776324E (pt) | 2002-11-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |