DK0791007T3 - Antifungale sordaridinderivater - Google Patents

Antifungale sordaridinderivater

Info

Publication number
DK0791007T3
DK0791007T3 DK95938407T DK95938407T DK0791007T3 DK 0791007 T3 DK0791007 T3 DK 0791007T3 DK 95938407 T DK95938407 T DK 95938407T DK 95938407 T DK95938407 T DK 95938407T DK 0791007 T3 DK0791007 T3 DK 0791007T3
Authority
DK
Denmark
Prior art keywords
derivatives
antifungal
sordaridine
chem
formula
Prior art date
Application number
DK95938407T
Other languages
English (en)
Inventor
Gonzalo Jesus Chicharro
Jose Ramon Ruiz Gomez
Dorado Silvestre Garcia-Ochoa
De Las Heras Federico Gomez
Michael Victor Hayes
Michael John Dawson
Howard Geoffrey Wildman
Richard Malcolm Hall
Original Assignee
Glaxo Wellcome Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Wellcome Sa filed Critical Glaxo Wellcome Sa
Application granted granted Critical
Publication of DK0791007T3 publication Critical patent/DK0791007T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pyridine Compounds (AREA)
DK95938407T 1994-11-08 1995-11-06 Antifungale sordaridinderivater DK0791007T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94500174A EP0711783A1 (en) 1994-11-08 1994-11-08 Antifungal Sordarin derivatives
PCT/EP1995/004332 WO1996014327A1 (en) 1994-11-08 1995-11-06 Antifungal sordaridin derivatives

Publications (1)

Publication Number Publication Date
DK0791007T3 true DK0791007T3 (da) 2000-03-20

Family

ID=8218171

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95938407T DK0791007T3 (da) 1994-11-08 1995-11-06 Antifungale sordaridinderivater

Country Status (11)

Country Link
US (1) US6054478A (da)
EP (2) EP0711783A1 (da)
JP (1) JPH11502188A (da)
AT (1) ATE183189T1 (da)
AU (1) AU3981095A (da)
DE (1) DE69511424T2 (da)
DK (1) DK0791007T3 (da)
ES (1) ES2136887T3 (da)
GR (1) GR3031781T3 (da)
SI (1) SI0791007T1 (da)
WO (1) WO1996014327A1 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001503032A (ja) * 1996-09-18 2001-03-06 メルク エンド カンパニー インコーポレーテッド 作物抗真菌剤として使用されるソルダリンおよびその誘導体
US6436395B1 (en) 1996-09-18 2002-08-20 Merck & Co., Inc. Rosellinia subiculata ATCC 74386 and fungus ATCC 74387 for producing sordarin compounds for fungi control
US6040463A (en) * 1996-10-07 2000-03-21 Merck & Co., Inc. Sordarin derivatives
US6096511A (en) * 1997-06-10 2000-08-01 Merck & Co., Inc. Protein elongation factor 2 as a target for antifungal and antiparasitic agents
US5972996A (en) * 1997-08-22 1999-10-26 Merck & Co., Inc. 4-cyano-4-deformylsordarin derivatives
US5965612A (en) * 1997-08-22 1999-10-12 Merck & Co., Inc. 4-cyano-4-deformylsordaricin derivatives
CA2300319C (en) * 1997-08-22 2008-10-28 Merck & Co., Inc. 4-cyano-4-deformylsordaricin derivatives
AU740477B2 (en) * 1997-08-22 2001-11-08 Merck Sharp & Dohme Corp. 4-cyano-4-deformylsordarin derivatives
US6136853A (en) * 1997-10-03 2000-10-24 Merck & Co., Inc. Sordarin derivatives
US6410528B1 (en) 1998-05-11 2002-06-25 Glaxo Wellcome S.A. Morpholino ethers
MA26628A1 (fr) * 1998-05-11 2004-12-20 Glaxo Wellcome Sa Morpholino ethers
WO2000024728A1 (en) 1998-10-26 2000-05-04 Merck & Co., Inc. Microbial transformation product
AUPQ120899A0 (en) * 1999-06-25 1999-07-22 Fujisawa Pharmaceutical Co., Ltd. Novel compound
WO2001034583A1 (en) * 1999-11-11 2001-05-17 Glaxo Wellcome Sa Antifungal sordaricin derivatives
EP1228048A1 (en) * 1999-11-11 2002-08-07 Glaxo Wellcome S.A. Sordaricin derivatives having antifungal activity
WO2002022567A1 (en) * 2000-09-15 2002-03-21 Bristol-Myers Squibb Company Novel thio derivatives of sordarin as antifungal agents
WO2003007878A2 (en) 2001-07-18 2003-01-30 Merck & Co., Inc. Antifungal agents of sordarin derivatives
CA2469879A1 (en) * 2001-12-14 2003-06-26 Merck & Co. Inc. A novel sordarin derivative isolated from culture fermentations and functions as an antifungal agent
RU2005119172A (ru) * 2002-12-18 2006-01-20 Пфайзер Продактс Инк. (Us) Производные 4-анилинхиназолина для лечения патологического роста клеток
CN108085273B (zh) * 2017-12-11 2022-01-21 暨南大学 一株抗真菌链霉菌及其代谢物、代谢物制备方法与应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0615555B2 (ja) * 1985-08-14 1994-03-02 三共株式会社 抗生物質ゾフイマリン
JP3189443B2 (ja) * 1992-11-20 2001-07-16 萬有製薬株式会社 抗真菌性物質ｂｅ−３１４０５

Also Published As

Publication number Publication date
SI0791007T1 (en) 1999-12-31
JPH11502188A (ja) 1999-02-23
AU3981095A (en) 1996-05-31
EP0791007A1 (en) 1997-08-27
DE69511424T2 (de) 1999-12-16
WO1996014327A1 (en) 1996-05-17
ES2136887T3 (es) 1999-12-01
US6054478A (en) 2000-04-25
ATE183189T1 (de) 1999-08-15
GR3031781T3 (en) 2000-02-29
EP0791007B1 (en) 1999-08-11
DE69511424D1 (de) 1999-09-16
EP0711783A1 (en) 1996-05-15

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