BR9810031A - Derivados de ácido pirrolidina carboxìlico como antagonistas á endotelina - Google Patents

Derivados de ácido pirrolidina carboxìlico como antagonistas á endotelina

Info

Publication number
BR9810031A
BR9810031A BR9810031-9A BR9810031A BR9810031A BR 9810031 A BR9810031 A BR 9810031A BR 9810031 A BR9810031 A BR 9810031A BR 9810031 A BR9810031 A BR 9810031A
Authority
BR
Brazil
Prior art keywords
acid derivatives
carboxylic acid
endothelin antagonists
pyrrolidine carboxylic
endothelin
Prior art date
Application number
BR9810031-9A
Other languages
English (en)
Inventor
Andrew S Tasker
Martin Winn
Steven A Boyd
Hwan-Soo Jae
Thomas W Von Geldern
Bryan K Sorensen
Kenneth J Henry
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/087,178 external-priority patent/US6124341A/en
Application filed by Abbott Lab filed Critical Abbott Lab
Priority claimed from PCT/US1998/011821 external-priority patent/WO1998057933A1/en
Publication of BR9810031A publication Critical patent/BR9810031A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"DERIVADOS DE áCIDO PIRROLIDINA CARBOXìLICO COMO ANTAGONISTAS à ENDOTELINA" é divulgado um composto de fórmula (I), ou um sal farmaceuticamente aceitável do mesmo, assim como os processos para a, e os intermediários na preparação do mesmo, e um método de antagonizar a endotelina.
BR9810031-9A 1997-06-17 1998-06-08 Derivados de ácido pirrolidina carboxìlico como antagonistas á endotelina BR9810031A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87718797A 1997-06-17 1997-06-17
US09/087,178 US6124341A (en) 1996-02-13 1998-05-29 Endothelin antagonists
PCT/US1998/011821 WO1998057933A1 (en) 1997-06-17 1998-06-08 Pyrrolidine carboxylic acid derivatives as endothelin antagonists

Publications (1)

Publication Number Publication Date
BR9810031A true BR9810031A (pt) 2000-09-12

Family

ID=26776689

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9810031-9A BR9810031A (pt) 1997-06-17 1998-06-08 Derivados de ácido pirrolidina carboxìlico como antagonistas á endotelina

Country Status (7)

Country Link
EP (1) EP0991620A1 (pt)
KR (1) KR20010013954A (pt)
CN (1) CN1265097A (pt)
BR (1) BR9810031A (pt)
CA (1) CA2292604A1 (pt)
IL (1) IL132615A0 (pt)
SK (1) SK170699A3 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108929258A (zh) * 2018-07-09 2018-12-04 张立国 一种Rho激酶抑制剂及其在癌症治疗中的应用
CN108569990A (zh) * 2018-07-09 2018-09-25 张立国 多取代吡咯烷衍生物及其作为Rho激酶抑制剂在癌症中的应用

Also Published As

Publication number Publication date
EP0991620A1 (en) 2000-04-12
CA2292604A1 (en) 1998-12-23
SK170699A3 (en) 2000-05-16
CN1265097A (zh) 2000-08-30
IL132615A0 (en) 2001-03-19
KR20010013954A (ko) 2001-02-26

Similar Documents

Publication Publication Date Title
PT894084E (pt) Derivados de acido cinamico e sua utilizacao como antagonistas de integrina
ATE219077T1 (de) Endothelin antagoniste
ES2182852T3 (es) Derivados de prolinamida.
DK0889875T3 (da) Cycloproylalkansyrederivater
EP0664289A3 (en) Isoquinolines
BR9815296A (pt) Derivados de ácido carboxìlico 3-pirrolidina e ouso dos mesmos como antagonistas endotelina
DK144685D0 (da) Substituerede benzopyraner, fremgangsmaader til fremstilling deraf samt deres anvendelse i laegemidler
NO922380L (no) Substituerte 4-fenyl-4-piperidinkarboksamider med baade lokal anestetisk og analgetisk effekt samt fremgangsmaater for deres fremstilling
BR9810031A (pt) Derivados de ácido pirrolidina carboxìlico como antagonistas á endotelina
EP1211251A4 (en) CHROMONE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF
BR0013750A (pt) Intermediários para a produção de derivados de ácido naftiridina-3-carboxìlico
BR9611572A (pt) Produção de um sal de ácido clavulânico
PT855398E (pt) Derivados sasquiterpeno tendo actividade antiviral
NO996244L (no) Pyrrolidinkarboksylsyrederivater som endotelinantagonister
ES2031816T3 (es) Derivados triciclicos de la piridona.
PL248638A1 (en) Method of obtaining new penicillin derivatives
EP0318085A3 (en) Heterazole dialkanoic acids
DE3666588D1 (en) Spiroûbenzofuran-2(3h), 1'cycloheptane¨s, a process and intermediates for their preparation and their use as medicaments
FR2646347B1 (fr) Nouveau derive d'hydroxyphenethylamine et ses sels, procede de preparation, application a titre de medicaments et utilisation comme outil pharmacologique specifique
BR0008545A (pt) Processo para a preparação de um composto, e, composto
MX9701220A (es) Antagonistas de endotelina.

Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]