SK170699A3 - Pyrrolidine carboxylic acid derivatives as endothelin antagonists - Google Patents
Pyrrolidine carboxylic acid derivatives as endothelin antagonists Download PDFInfo
- Publication number
- SK170699A3 SK170699A3 SK1706-99A SK170699A SK170699A3 SK 170699 A3 SK170699 A3 SK 170699A3 SK 170699 A SK170699 A SK 170699A SK 170699 A3 SK170699 A3 SK 170699A3
- Authority
- SK
- Slovakia
- Prior art keywords
- group
- phenyl
- fluoro
- propoxyphenyl
- methoxyphenyl
- Prior art date
Links
- 0 CCCC*c1ccc(C(C[C@](CC2O[C@]2C[C@@](C)c2c(CC)cccc2CC)C2)C(*(C)C)[C@]2c(cc2*)cc3c2OCO3)cc1 Chemical compound CCCC*c1ccc(C(C[C@](CC2O[C@]2C[C@@](C)c2c(CC)cccc2CC)C2)C(*(C)C)[C@]2c(cc2*)cc3c2OCO3)cc1 0.000 description 22
- FTSILXKCVPFNIY-RFGGMRNLSA-N CCc(cc(C)cc1C=C)c1[N](C)(C)C(CN(C[C@]1(C2)C3=CC=C4OCOC4=CC13)[C@@]2(C1C=C2)C1=CC=C2OCCCOC)=O Chemical compound CCc(cc(C)cc1C=C)c1[N](C)(C)C(CN(C[C@]1(C2)C3=CC=C4OCOC4=CC13)[C@@]2(C1C=C2)C1=CC=C2OCCCOC)=O FTSILXKCVPFNIY-RFGGMRNLSA-N 0.000 description 1
- QXNIVHCQTAPMQB-QKQXUSNTSA-N CCc(cc(C)cc1CC)c1NC(CC(C[C@@H](C1)c(cc2F)cc3c2OCO3)[C@H]1c(ccc(OCC)c1)c1F)=O Chemical compound CCc(cc(C)cc1CC)c1NC(CC(C[C@@H](C1)c(cc2F)cc3c2OCO3)[C@H]1c(ccc(OCC)c1)c1F)=O QXNIVHCQTAPMQB-QKQXUSNTSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87718797A | 1997-06-17 | 1997-06-17 | |
| US09/087,178 US6124341A (en) | 1996-02-13 | 1998-05-29 | Endothelin antagonists |
| PCT/US1998/011821 WO1998057933A1 (en) | 1997-06-17 | 1998-06-08 | Pyrrolidine carboxylic acid derivatives as endothelin antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK170699A3 true SK170699A3 (en) | 2000-05-16 |
Family
ID=26776689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1706-99A SK170699A3 (en) | 1997-06-17 | 1998-06-08 | Pyrrolidine carboxylic acid derivatives as endothelin antagonists |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0991620A1 (pt) |
| KR (1) | KR20010013954A (pt) |
| CN (1) | CN1265097A (pt) |
| BR (1) | BR9810031A (pt) |
| CA (1) | CA2292604A1 (pt) |
| IL (1) | IL132615A0 (pt) |
| SK (1) | SK170699A3 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108569990A (zh) * | 2018-07-09 | 2018-09-25 | 张立国 | 多取代吡咯烷衍生物及其作为Rho激酶抑制剂在癌症中的应用 |
| CN108929258A (zh) * | 2018-07-09 | 2018-12-04 | 张立国 | 一种Rho激酶抑制剂及其在癌症治疗中的应用 |
-
1998
- 1998-06-08 KR KR1019997011980A patent/KR20010013954A/ko not_active Application Discontinuation
- 1998-06-08 SK SK1706-99A patent/SK170699A3/sk unknown
- 1998-06-08 EP EP98926419A patent/EP0991620A1/en not_active Withdrawn
- 1998-06-08 BR BR9810031-9A patent/BR9810031A/pt not_active Application Discontinuation
- 1998-06-08 CN CN98806184A patent/CN1265097A/zh active Pending
- 1998-06-08 CA CA002292604A patent/CA2292604A1/en not_active Abandoned
- 1998-06-08 IL IL13261598A patent/IL132615A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL132615A0 (en) | 2001-03-19 |
| EP0991620A1 (en) | 2000-04-12 |
| CN1265097A (zh) | 2000-08-30 |
| CA2292604A1 (en) | 1998-12-23 |
| BR9810031A (pt) | 2000-09-12 |
| KR20010013954A (ko) | 2001-02-26 |
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