CA2292604A1 - Pyrrolidine carboxylic acid derivatives as endothelin antagonists - Google Patents

Pyrrolidine carboxylic acid derivatives as endothelin antagonists Download PDF

Info

Publication number
CA2292604A1
CA2292604A1 CA002292604A CA2292604A CA2292604A1 CA 2292604 A1 CA2292604 A1 CA 2292604A1 CA 002292604 A CA002292604 A CA 002292604A CA 2292604 A CA2292604 A CA 2292604A CA 2292604 A1 CA2292604 A1 CA 2292604A1
Authority
CA
Canada
Prior art keywords
fluoro
phenyl
propoxyphenyl
methoxyphenyl
fluorophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002292604A
Other languages
English (en)
French (fr)
Inventor
Andrew S. Tasker
Martin Winn
Steven A. Boyd
Hwan-Soo Jae
Thomas W. Von Geldern
Bryan K. Sorensen
Kenneth J. Henry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/087,178 external-priority patent/US6124341A/en
Application filed by Individual filed Critical Individual
Priority claimed from PCT/US1998/011821 external-priority patent/WO1998057933A1/en
Publication of CA2292604A1 publication Critical patent/CA2292604A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA002292604A 1997-06-17 1998-06-08 Pyrrolidine carboxylic acid derivatives as endothelin antagonists Abandoned CA2292604A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US87718797A 1997-06-17 1997-06-17
US08/877,187 1997-06-17
US09/087,178 US6124341A (en) 1996-02-13 1998-05-29 Endothelin antagonists
US09/087,178 1998-05-29
PCT/US1998/011821 WO1998057933A1 (en) 1997-06-17 1998-06-08 Pyrrolidine carboxylic acid derivatives as endothelin antagonists

Publications (1)

Publication Number Publication Date
CA2292604A1 true CA2292604A1 (en) 1998-12-23

Family

ID=26776689

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002292604A Abandoned CA2292604A1 (en) 1997-06-17 1998-06-08 Pyrrolidine carboxylic acid derivatives as endothelin antagonists

Country Status (7)

Country Link
EP (1) EP0991620A1 (pt)
KR (1) KR20010013954A (pt)
CN (1) CN1265097A (pt)
BR (1) BR9810031A (pt)
CA (1) CA2292604A1 (pt)
IL (1) IL132615A0 (pt)
SK (1) SK170699A3 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108929258A (zh) * 2018-07-09 2018-12-04 张立国 一种Rho激酶抑制剂及其在癌症治疗中的应用
CN108569990A (zh) * 2018-07-09 2018-09-25 张立国 多取代吡咯烷衍生物及其作为Rho激酶抑制剂在癌症中的应用

Also Published As

Publication number Publication date
CN1265097A (zh) 2000-08-30
IL132615A0 (en) 2001-03-19
BR9810031A (pt) 2000-09-12
SK170699A3 (en) 2000-05-16
EP0991620A1 (en) 2000-04-12
KR20010013954A (ko) 2001-02-26

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Legal Events

Date Code Title Description
FZDE Discontinued