TR200000414T2 - 2-(4-Aril ya da heteroaril-piperazin-1-ilmetil)-1H-indol türevleri. - Google Patents
2-(4-Aril ya da heteroaril-piperazin-1-ilmetil)-1H-indol türevleri.Info
- Publication number
- TR200000414T2 TR200000414T2 TR2000/00414T TR200000414T TR200000414T2 TR 200000414 T2 TR200000414 T2 TR 200000414T2 TR 2000/00414 T TR2000/00414 T TR 2000/00414T TR 200000414 T TR200000414 T TR 200000414T TR 200000414 T2 TR200000414 T2 TR 200000414T2
- Authority
- TR
- Turkey
- Prior art keywords
- piperazin
- ylmethyl
- heteroaryl
- aryl
- indole derivatives
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Ophthalmology & Optometry (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Formül (I)'in bir bilesimi, burada a, T,V,X,Y,Z,R1,R2,R3,R4,R5,R6,R7,R8 ve R9 yukarida tanimlandigi gibidir, onlarin farmasötik olarak uygun tuzlari ve bu tür bilesimleri ve onlarin tuzlarini içeren farmasötik kompozisyonlar.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5576497P | 1997-08-15 | 1997-08-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200000414T2 true TR200000414T2 (tr) | 2000-08-21 |
Family
ID=22000003
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2000/00414T TR200000414T2 (tr) | 1997-08-15 | 1998-08-05 | 2-(4-Aril ya da heteroaril-piperazin-1-ilmetil)-1H-indol türevleri. |
Country Status (30)
Country | Link |
---|---|
EP (1) | EP1003739A2 (tr) |
JP (1) | JP2002536291A (tr) |
KR (1) | KR20010022507A (tr) |
CN (1) | CN1265660A (tr) |
AP (1) | AP9801321A0 (tr) |
AR (1) | AR017019A1 (tr) |
AU (1) | AU8457298A (tr) |
BG (1) | BG104069A (tr) |
BR (1) | BR9811557A (tr) |
CA (1) | CA2297486C (tr) |
CO (1) | CO4960656A1 (tr) |
DZ (1) | DZ2583A1 (tr) |
EA (1) | EA200000023A1 (tr) |
HR (1) | HRP980441A2 (tr) |
HU (1) | HUP0003425A3 (tr) |
ID (1) | ID23803A (tr) |
IL (1) | IL133960A0 (tr) |
IS (1) | IS5336A (tr) |
MA (1) | MA24632A1 (tr) |
NO (1) | NO20000722D0 (tr) |
OA (1) | OA11286A (tr) |
PA (1) | PA8457001A1 (tr) |
PE (1) | PE106299A1 (tr) |
PL (1) | PL338947A1 (tr) |
SK (1) | SK1352000A3 (tr) |
TN (1) | TNSN98151A1 (tr) |
TR (1) | TR200000414T2 (tr) |
UY (1) | UY25144A1 (tr) |
WO (1) | WO1999009025A2 (tr) |
ZA (1) | ZA987304B (tr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999021834A1 (en) * | 1997-10-27 | 1999-05-06 | Neurosearch A/S | Heteroaryl diazacycloalkanes as cholinergic ligands at nicotinic acetylcholine receptors |
EP0953567A3 (en) | 1998-04-29 | 2003-04-02 | Pfizer Products Inc. | Bicyclic substituted piperazine-, piperidine- and tetrahydropyridine derivatives, their preparation and their use as agents with central dopaminergic (dopamine D4 receptor) activity |
SK11072002A3 (sk) * | 1999-12-30 | 2003-03-04 | H. Lundbeck A/S | Halogénom substituované 4-fenyl-1-piperazinylové, -piperidinylové a -tetrahydropyridylové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie |
GB0017952D0 (en) * | 2000-07-22 | 2000-09-13 | Univ Manchester | Treatment of dyskinesia |
EP1177792A3 (en) | 2000-07-27 | 2002-10-23 | Pfizer Products Inc. | Dopamine D4 Ligands for the treatment of novelty-seeking disorders |
WO2002072548A2 (en) * | 2001-03-09 | 2002-09-19 | Ortho-Mcneil Pharmaceutical, Inc. | Heterocyclic compounds and their use as histamine h4 ligands. |
US7504426B2 (en) | 2002-09-06 | 2009-03-17 | Janssen Pharmaceutica N.V. | Heterocyclic compounds |
WO2004108671A1 (en) * | 2003-06-06 | 2004-12-16 | Suven Life Sciences Limited | Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them |
WO2005095338A1 (ja) | 2004-03-30 | 2005-10-13 | Takeda Pharmaceutical Company Limited | アルコキシフェニルプロパン酸誘導体 |
US7618980B2 (en) | 2004-07-14 | 2009-11-17 | Bristol-Myers Squibb Company | Pyrrolo(oxo)quinolines as 5HT ligands |
US7572805B2 (en) | 2004-07-14 | 2009-08-11 | Bristol-Myers Squibb Company | Pyrrolo(oxo)isoquinolines as 5HT ligands |
JO2769B1 (en) | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
JO2642B1 (en) | 2006-12-08 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
JO2849B1 (en) * | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
RS52518B (en) | 2007-04-23 | 2013-04-30 | Janssen Pharmaceutica N.V. | 4-ALCOXYPYRIDASINE DERIVATIVES AS A FAST DISSOCATING DOPAMINE 2 RECEPTOR ANTAGONISTS |
EP2148879B1 (en) | 2007-04-23 | 2012-11-28 | Janssen Pharmaceutica, N.V. | Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists |
CN102159554B (zh) | 2008-07-03 | 2014-09-24 | 詹森药业有限公司 | 作为5-ht6受体拮抗剂的取代的6-(1-哌嗪基)-哒嗪 |
HUE033768T2 (en) | 2008-07-31 | 2017-12-28 | Janssen Pharmaceutica Nv | Piperazin-1-yl-trifluoromethyl-substituted pyridines as rapidly dissociating dopamine-2 receptor antagonists |
EP3686196B1 (en) * | 2017-09-20 | 2024-06-12 | Hangzhou Innogate Pharma Co., Ltd. | Polycyclic compound acting as ido inhibitor and/or ido-hdac dual inhibitor |
CN115427404A (zh) * | 2020-04-22 | 2022-12-02 | 艾尼莫生物科技公司 | 胶原蛋白1翻译抑制剂和其使用方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB944443A (tr) * | 1959-09-25 | 1900-01-01 | ||
DE69217224T2 (de) * | 1991-07-03 | 1997-06-05 | Pharmacia & Upjohn Co., Kalamazoo, Mich. | Substituierte indole als anti-aids pharmaceutische zubereitungen |
JPH05255089A (ja) * | 1991-12-18 | 1993-10-05 | Sanwa Kagaku Kenkyusho Co Ltd | 抗ウイルス剤 |
WO1994010162A1 (en) * | 1992-10-23 | 1994-05-11 | Merck Sharp & Dohme Limited | Dopamine receptor subtype ligands |
AU6215594A (en) * | 1993-03-18 | 1994-10-11 | Merck Sharp & Dohme Limited | Indole derivatives as dopamine d4 antagonists |
GB9305644D0 (en) * | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
US5814644A (en) * | 1993-04-15 | 1998-09-29 | Merck Sharp & Dohme, Ltd. | Indole derivatives as dopamine D4 antagonists |
DE4414113A1 (de) * | 1994-04-22 | 1995-10-26 | Merck Patent Gmbh | 3-Indolylpiperidine |
TW406075B (en) * | 1994-12-13 | 2000-09-21 | Upjohn Co | Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds |
ZA968661B (en) * | 1995-11-17 | 1998-04-14 | Upjohn Co | Oxazolidinone antibacterial agent with tricyclic substituents. |
TW504510B (en) * | 1996-05-10 | 2002-10-01 | Janssen Pharmaceutica Nv | 2,4-diaminopyrimidine derivatives |
-
1998
- 1998-08-05 JP JP2000509706A patent/JP2002536291A/ja active Pending
- 1998-08-05 PL PL98338947A patent/PL338947A1/xx unknown
- 1998-08-05 AP APAP/P/1998/001321A patent/AP9801321A0/en unknown
- 1998-08-05 WO PCT/IB1998/001198 patent/WO1999009025A2/en not_active Application Discontinuation
- 1998-08-05 CN CN98807831A patent/CN1265660A/zh active Pending
- 1998-08-05 BR BR9811557-0A patent/BR9811557A/pt not_active IP Right Cessation
- 1998-08-05 SK SK135-2000A patent/SK1352000A3/sk unknown
- 1998-08-05 HU HU0003425A patent/HUP0003425A3/hu unknown
- 1998-08-05 ID IDW20000197A patent/ID23803A/id unknown
- 1998-08-05 TR TR2000/00414T patent/TR200000414T2/tr unknown
- 1998-08-05 EA EA200000023A patent/EA200000023A1/ru unknown
- 1998-08-05 AU AU84572/98A patent/AU8457298A/en not_active Abandoned
- 1998-08-05 EP EP98935229A patent/EP1003739A2/en not_active Withdrawn
- 1998-08-05 IL IL13396098A patent/IL133960A0/xx unknown
- 1998-08-05 KR KR1020007001093A patent/KR20010022507A/ko not_active Application Discontinuation
- 1998-08-05 CA CA002297486A patent/CA2297486C/en not_active Expired - Fee Related
- 1998-08-10 PA PA19988457001A patent/PA8457001A1/es unknown
- 1998-08-10 PE PE1998000717A patent/PE106299A1/es not_active Application Discontinuation
- 1998-08-12 TN TNTNSN98151A patent/TNSN98151A1/fr unknown
- 1998-08-12 DZ DZ980193A patent/DZ2583A1/xx active
- 1998-08-12 MA MA25210A patent/MA24632A1/fr unknown
- 1998-08-13 AR ARP980104021A patent/AR017019A1/es unknown
- 1998-08-14 CO CO98046788A patent/CO4960656A1/es unknown
- 1998-08-14 HR HR60/055,764A patent/HRP980441A2/hr not_active Application Discontinuation
- 1998-08-14 ZA ZA9807304A patent/ZA987304B/xx unknown
- 1998-08-17 UY UY25144A patent/UY25144A1/es not_active Application Discontinuation
-
2000
- 2000-01-10 BG BG104069A patent/BG104069A/xx unknown
- 2000-01-11 IS IS5336A patent/IS5336A/is unknown
- 2000-02-08 OA OA1200000030A patent/OA11286A/en unknown
- 2000-02-14 NO NO20000722A patent/NO20000722D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1003739A2 (en) | 2000-05-31 |
IL133960A0 (en) | 2001-04-30 |
IS5336A (is) | 2000-01-11 |
ZA987304B (en) | 2000-02-14 |
ID23803A (id) | 2000-05-11 |
PL338947A1 (en) | 2000-12-04 |
DZ2583A1 (fr) | 2003-02-22 |
PE106299A1 (es) | 1999-11-02 |
WO1999009025A2 (en) | 1999-02-25 |
PA8457001A1 (es) | 2000-09-29 |
TNSN98151A1 (fr) | 2005-03-15 |
AP9801321A0 (en) | 2000-02-14 |
WO1999009025A3 (en) | 1999-04-15 |
BG104069A (en) | 2001-05-31 |
HUP0003425A3 (en) | 2002-02-28 |
CA2297486A1 (en) | 1999-02-25 |
UY25144A1 (es) | 2000-12-29 |
HRP980441A2 (en) | 1999-04-30 |
HUP0003425A2 (hu) | 2001-10-28 |
CN1265660A (zh) | 2000-09-06 |
KR20010022507A (ko) | 2001-03-15 |
OA11286A (en) | 2003-10-22 |
CA2297486C (en) | 2005-05-03 |
SK1352000A3 (en) | 2000-08-14 |
CO4960656A1 (es) | 2000-09-25 |
AU8457298A (en) | 1999-03-08 |
MA24632A1 (fr) | 1999-04-01 |
NO20000722L (no) | 2000-02-14 |
NO20000722D0 (no) | 2000-02-14 |
AR017019A1 (es) | 2001-08-22 |
EA200000023A1 (ru) | 2000-08-28 |
JP2002536291A (ja) | 2002-10-29 |
BR9811557A (pt) | 2000-08-22 |
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