PL338947A1 - Derivatives of 2-(4-aryl or heteroaryl piperazin-1-ylmethyl)-1h-indole - Google Patents

Derivatives of 2-(4-aryl or heteroaryl piperazin-1-ylmethyl)-1h-indole

Info

Publication number
PL338947A1
PL338947A1 PL98338947A PL33894798A PL338947A1 PL 338947 A1 PL338947 A1 PL 338947A1 PL 98338947 A PL98338947 A PL 98338947A PL 33894798 A PL33894798 A PL 33894798A PL 338947 A1 PL338947 A1 PL 338947A1
Authority
PL
Poland
Prior art keywords
piperazin
ylmethyl
indole
heteroaryl
aryl
Prior art date
Application number
PL98338947A
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PL338947A1 publication Critical patent/PL338947A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
PL98338947A 1997-08-15 1998-08-05 Derivatives of 2-(4-aryl or heteroaryl piperazin-1-ylmethyl)-1h-indole PL338947A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5576497P 1997-08-15 1997-08-15
PCT/IB1998/001198 WO1999009025A2 (en) 1997-08-15 1998-08-05 2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1h-indole derivatives interacting with the dopamine d4 receptor

Publications (1)

Publication Number Publication Date
PL338947A1 true PL338947A1 (en) 2000-12-04

Family

ID=22000003

Family Applications (1)

Application Number Title Priority Date Filing Date
PL98338947A PL338947A1 (en) 1997-08-15 1998-08-05 Derivatives of 2-(4-aryl or heteroaryl piperazin-1-ylmethyl)-1h-indole

Country Status (30)

Country Link
EP (1) EP1003739A2 (xx)
JP (1) JP2002536291A (xx)
KR (1) KR20010022507A (xx)
CN (1) CN1265660A (xx)
AP (1) AP9801321A0 (xx)
AR (1) AR017019A1 (xx)
AU (1) AU8457298A (xx)
BG (1) BG104069A (xx)
BR (1) BR9811557A (xx)
CA (1) CA2297486C (xx)
CO (1) CO4960656A1 (xx)
DZ (1) DZ2583A1 (xx)
EA (1) EA200000023A1 (xx)
HR (1) HRP980441A2 (xx)
HU (1) HUP0003425A3 (xx)
ID (1) ID23803A (xx)
IL (1) IL133960A0 (xx)
IS (1) IS5336A (xx)
MA (1) MA24632A1 (xx)
NO (1) NO20000722L (xx)
OA (1) OA11286A (xx)
PA (1) PA8457001A1 (xx)
PE (1) PE106299A1 (xx)
PL (1) PL338947A1 (xx)
SK (1) SK1352000A3 (xx)
TN (1) TNSN98151A1 (xx)
TR (1) TR200000414T2 (xx)
UY (1) UY25144A1 (xx)
WO (1) WO1999009025A2 (xx)
ZA (1) ZA987304B (xx)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2230723T3 (es) * 1997-10-27 2005-05-01 Neurosearch A/S Diazacicloalcanos de heteroarilo como ligandos colinergicos en recptores nicotinicos de acetilcolina.
EP0953567A3 (en) 1998-04-29 2003-04-02 Pfizer Products Inc. Bicyclic substituted piperazine-, piperidine- and tetrahydropyridine derivatives, their preparation and their use as agents with central dopaminergic (dopamine D4 receptor) activity
HUP0203839A3 (en) 1999-12-30 2004-07-28 Lundbeck & Co As H 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives, pharmaceutical compositions containing them and their use
GB0017952D0 (en) * 2000-07-22 2000-09-13 Univ Manchester Treatment of dyskinesia
EP1177792A3 (en) 2000-07-27 2002-10-23 Pfizer Products Inc. Dopamine D4 Ligands for the treatment of novelty-seeking disorders
JP4544820B2 (ja) * 2001-03-09 2010-09-15 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 複素環化合物
CN1694704A (zh) 2002-09-06 2005-11-09 詹森药业有限公司 （1h－苯并咪唑－2－基）－（哌嗪基）－甲酮衍生物及其相关化合物作为组胺h4受体拮抗剂用于治疗炎性和过敏性疾病
WO2004108671A1 (en) * 2003-06-06 2004-12-16 Suven Life Sciences Limited Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them
EP1731505B1 (en) 2004-03-30 2015-01-14 Takeda Pharmaceutical Company Limited Alkoxyphenylpropanoic acid derivatives
US7572805B2 (en) 2004-07-14 2009-08-11 Bristol-Myers Squibb Company Pyrrolo(oxo)isoquinolines as 5HT ligands
US7618980B2 (en) 2004-07-14 2009-11-17 Bristol-Myers Squibb Company Pyrrolo(oxo)quinolines as 5HT ligands
JO2769B1 (en) * 2005-10-26 2014-03-15 جانسين فارماسوتيكا ان. في Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
JO2642B1 (en) * 2006-12-08 2012-06-17 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
JO2849B1 (en) * 2007-02-13 2015-03-15 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
US8906921B2 (en) 2007-04-23 2014-12-09 Janssen Pharmaceutica Nv 4-alkoxypyridazine derivatives as fast dissociating dopamine 2 receptor antagonists
ES2400710T3 (es) 2007-04-23 2013-04-11 Janssen Pharmaceutica, N.V. Tia(dia)zoles como antagonistas del receptor de dopamina 2 de disociación rápida
BRPI0915834A2 (pt) 2008-07-03 2015-11-03 Janssen Pharmaceutica Nv 6-(1-piperazinil)-piridazinas substituídas como antagonistas do receptor de 5-ht6
EA019048B1 (ru) 2008-07-31 2013-12-30 Янссен Фармацевтика Нв Пиперазин-1-илтрифторметилзамещенные пиридины в качестве быстро диссоциирующихся антагонистов d-рецепторов дофамина
JP2020534336A (ja) * 2017-09-20 2020-11-26 ハンジョウ イノゲート ファーマ カンパニー リミテッドHangzhou Innogate Pharma Co., Ltd. Ｉｄｏ阻害剤および／またはｉｄｏ−ｈｄａｃ二重阻害剤としての多環式化合物
AU2021259580A1 (en) * 2020-04-22 2022-11-24 Anima Biotech Inc. Collagen 1 translation inhibitors and methods of use thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB944443A (xx) * 1959-09-25 1900-01-01
CA2109934C (en) * 1991-07-03 2002-12-10 Donna Lee Romero Substituted indoles as anti-aids pharmaceuticals
JPH05255089A (ja) * 1991-12-18 1993-10-05 Sanwa Kagaku Kenkyusho Co Ltd 抗ウイルス剤
EP0665840A1 (en) * 1992-10-23 1995-08-09 MERCK SHARP & DOHME LTD. Dopamine receptor subtype ligands
GB9305644D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
US5576336A (en) * 1993-03-18 1996-11-19 Merck Sharp & Dohme Limited Indole derivatives as dopamine D4 antagonists
US5814644A (en) * 1993-04-15 1998-09-29 Merck Sharp & Dohme, Ltd. Indole derivatives as dopamine D4 antagonists
DE4414113A1 (de) * 1994-04-22 1995-10-26 Merck Patent Gmbh 3-Indolylpiperidine
TW406075B (en) * 1994-12-13 2000-09-21 Upjohn Co Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds
ZA968661B (en) * 1995-11-17 1998-04-14 Upjohn Co Oxazolidinone antibacterial agent with tricyclic substituents.
TW504510B (en) * 1996-05-10 2002-10-01 Janssen Pharmaceutica Nv 2,4-diaminopyrimidine derivatives

Also Published As

Publication number Publication date
SK1352000A3 (en) 2000-08-14
CA2297486A1 (en) 1999-02-25
CA2297486C (en) 2005-05-03
KR20010022507A (ko) 2001-03-15
NO20000722D0 (no) 2000-02-14
DZ2583A1 (fr) 2003-02-22
HUP0003425A2 (hu) 2001-10-28
HUP0003425A3 (en) 2002-02-28
PE106299A1 (es) 1999-11-02
ZA987304B (en) 2000-02-14
IL133960A0 (en) 2001-04-30
AP9801321A0 (en) 2000-02-14
AU8457298A (en) 1999-03-08
JP2002536291A (ja) 2002-10-29
PA8457001A1 (es) 2000-09-29
CO4960656A1 (es) 2000-09-25
EP1003739A2 (en) 2000-05-31
MA24632A1 (fr) 1999-04-01
OA11286A (en) 2003-10-22
AR017019A1 (es) 2001-08-22
IS5336A (is) 2000-01-11
WO1999009025A3 (en) 1999-04-15
UY25144A1 (es) 2000-12-29
HRP980441A2 (en) 1999-04-30
CN1265660A (zh) 2000-09-06
BR9811557A (pt) 2000-08-22
TNSN98151A1 (fr) 2005-03-15
NO20000722L (no) 2000-02-14
ID23803A (id) 2000-05-11
BG104069A (en) 2001-05-31
TR200000414T2 (tr) 2000-08-21
WO1999009025A2 (en) 1999-02-25
EA200000023A1 (ru) 2000-08-28

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