AR017019A1 - Compuestos derivados del 2-(4-aril o heteroarilpiperazin-1-ilmetil)-1h-indol, composiciones y su uso en la manufactura de medicamentos - Google Patents
Compuestos derivados del 2-(4-aril o heteroarilpiperazin-1-ilmetil)-1h-indol, composiciones y su uso en la manufactura de medicamentosInfo
- Publication number
- AR017019A1 AR017019A1 ARP980104021A ARP980104021A AR017019A1 AR 017019 A1 AR017019 A1 AR 017019A1 AR P980104021 A ARP980104021 A AR P980104021A AR P980104021 A ARP980104021 A AR P980104021A AR 017019 A1 AR017019 A1 AR 017019A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- cyano
- nitrogen
- trifluoromethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Un compuesto derivado de 2-(4-aril o heteroarilpiperazin-1-ilmetil)-1H-indol de formula (I) o sal farmacéuticamente aceptable del mismo, donde lalínea discontinua representa un doble enlace opcional; a es 0 o 1, en el que cuando a es 0, X puedeforma r un doble enlace opcional con el carbono adyacente aV; V es CHR10, en el que R10 es hidrogeno o alquilo C1-6; T es nitrogeno o CH; X es nitrogeno o CR11, en el que R11 es hidrogeno, alquilo C1-6, alcoxi C1-6,hidroxi o ciano; Y y Z son cadauno de el los independientemente nitrogeno o CR12, en el que R12 es hidrogeno, cloro, bromo, trifluorometilo, trifluorometoxi,ciano, alcoxi C1-6 o alquilo C1-6; R1 es hidrogeno, fluoro, cloro, bromo, trifluorometilo, trifluorometoxi, ciano o alquiloC1-6; R2, R6, R7, R8 y R9 estáncada uno de ellos independientemente seleccionados entre hidrogeno, fluoro, cloro, bromo, trifluorometilo, trifluorometoxi, ciano, alcoxi C1-6 y alquiloC1-6; R3 y R4 son cada uno de ellos independientemente hidrogeno oalquilo C1 -6; y R5 es hidrogeno, alcoxi C1-6, trifluorometilo, ciano, alquilo C1-6 oR13CO, en el que R13 es amino, alquil C1-6-amino, (alquilo C1-6)2 amino, alquilo C1-6, arilo C6-10; o cuando a es 1, R1 y R10 se pueden unir con loscarbonos a losque están uni dos para formar un compuesto de formula (II) en la que las líneas discontinuas representan enlaces opcionales; T, X, Y, Z, R2, R3,R4, R5, R6, R7, R8 y R9 son lo definido anteriormente; b es 0 o 1; y A y B son cada uno de ellosindependientemente CH, CH2,oxígeno, azufre, NH o nitrogeno;con la condicion de que cuando X es nitrogeno, el doble enlace opcional entre X y V no existe; con la condicion de que cuando b es 0, el doble enlaceopcional entre A y B no existe; y con lacondicion de que cuando b es 1, A y B no pueden ser ninguno de ellos oxígeno o azufre. Los compuestos antesmencionados son utiles para el tratamiento de trastornos del sistema de la dopamina. Se describen también composiciones y el uso de loscompuestos enla manufactura de medicamentos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5576497P | 1997-08-15 | 1997-08-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR017019A1 true AR017019A1 (es) | 2001-08-22 |
Family
ID=22000003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980104021A AR017019A1 (es) | 1997-08-15 | 1998-08-13 | Compuestos derivados del 2-(4-aril o heteroarilpiperazin-1-ilmetil)-1h-indol, composiciones y su uso en la manufactura de medicamentos |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1003739A2 (es) |
| JP (1) | JP2002536291A (es) |
| KR (1) | KR20010022507A (es) |
| CN (1) | CN1265660A (es) |
| AP (1) | AP9801321A0 (es) |
| AR (1) | AR017019A1 (es) |
| AU (1) | AU8457298A (es) |
| BG (1) | BG104069A (es) |
| BR (1) | BR9811557A (es) |
| CA (1) | CA2297486C (es) |
| CO (1) | CO4960656A1 (es) |
| DZ (1) | DZ2583A1 (es) |
| EA (1) | EA200000023A1 (es) |
| HR (1) | HRP980441A2 (es) |
| HU (1) | HUP0003425A3 (es) |
| ID (1) | ID23803A (es) |
| IL (1) | IL133960A0 (es) |
| IS (1) | IS5336A (es) |
| MA (1) | MA24632A1 (es) |
| NO (1) | NO20000722D0 (es) |
| OA (1) | OA11286A (es) |
| PA (1) | PA8457001A1 (es) |
| PE (1) | PE106299A1 (es) |
| PL (1) | PL338947A1 (es) |
| SK (1) | SK1352000A3 (es) |
| TN (1) | TNSN98151A1 (es) |
| TR (1) | TR200000414T2 (es) |
| UY (1) | UY25144A1 (es) |
| WO (1) | WO1999009025A2 (es) |
| ZA (1) | ZA987304B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK285198B6 (sk) * | 1997-10-27 | 2006-08-03 | Neurosearch A/S | Homopiperazínový derivát, farmaceutická kompozícia obsahujúca tento derivát a jeho použitie |
| EP0953567A3 (en) * | 1998-04-29 | 2003-04-02 | Pfizer Products Inc. | Bicyclic substituted piperazine-, piperidine- and tetrahydropyridine derivatives, their preparation and their use as agents with central dopaminergic (dopamine D4 receptor) activity |
| MXPA02006590A (es) * | 1999-12-30 | 2002-12-13 | Lundbeck & Co As H | Derivados de 4-fenil-1-piperazinilo, -piperidinilo y -tetrahidropiridilo. |
| GB0017952D0 (en) * | 2000-07-22 | 2000-09-13 | Univ Manchester | Treatment of dyskinesia |
| EP1177792A3 (en) | 2000-07-27 | 2002-10-23 | Pfizer Products Inc. | Dopamine D4 Ligands for the treatment of novelty-seeking disorders |
| MXPA03008143A (es) * | 2001-03-09 | 2005-08-16 | Johnson & Johnson | Compuestos heterociclicos. |
| BR0314059A (pt) | 2002-09-06 | 2005-07-05 | Janssen Pharmaceutica Nv | Compostos heterocìclicos |
| WO2004108671A1 (en) * | 2003-06-06 | 2004-12-16 | Suven Life Sciences Limited | Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them |
| WO2005095338A1 (ja) | 2004-03-30 | 2005-10-13 | Takeda Pharmaceutical Company Limited | アルコキシフェニルプロパン酸誘導体 |
| US7618980B2 (en) | 2004-07-14 | 2009-11-17 | Bristol-Myers Squibb Company | Pyrrolo(oxo)quinolines as 5HT ligands |
| US7572805B2 (en) | 2004-07-14 | 2009-08-11 | Bristol-Myers Squibb Company | Pyrrolo(oxo)isoquinolines as 5HT ligands |
| JO2769B1 (en) * | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
| JO2642B1 (en) * | 2006-12-08 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| JO2849B1 (en) * | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| SI2148873T1 (sl) | 2007-04-23 | 2013-01-31 | Janssen Pharmaceutica, N.V. | Derivati 4-alkoksipiridazina kot antagonisti receptorja dopamina 2 s hitro disociacijo |
| US8933101B2 (en) | 2007-04-23 | 2015-01-13 | Janssen Pharmaceutica Nv | Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists |
| US8530474B2 (en) | 2008-07-03 | 2013-09-10 | Janssen Pharmaceutica Nv | Substituted 6-(1-piperazinyl)-pyridazines as 5-HT6 receptor antagonists |
| CA2730774C (en) | 2008-07-31 | 2016-09-13 | Janssen Pharmaceutica Nv | Piperazin-1-yl-trifluoromethyl-substituted-pyridines as fast dissociating dopamine 2 receptor antagonists |
| US11266640B2 (en) * | 2017-09-20 | 2022-03-08 | Hangzhou Innogate Pharma Co., Ltd. | Polycyclic compound acting as IDO inhibitor and/or IDO-HDAC dual inhibitor |
| WO2021216665A1 (en) * | 2020-04-22 | 2021-10-28 | Anima Biotech Inc. | Collagen 1 translation inhibitors and methods of use thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB944443A (es) * | 1959-09-25 | 1900-01-01 | ||
| CA2109934C (en) * | 1991-07-03 | 2002-12-10 | Donna Lee Romero | Substituted indoles as anti-aids pharmaceuticals |
| JPH05255089A (ja) * | 1991-12-18 | 1993-10-05 | Sanwa Kagaku Kenkyusho Co Ltd | 抗ウイルス剤 |
| EP0665840A1 (en) * | 1992-10-23 | 1995-08-09 | MERCK SHARP & DOHME LTD. | Dopamine receptor subtype ligands |
| GB9305644D0 (en) * | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
| US5576336A (en) * | 1993-03-18 | 1996-11-19 | Merck Sharp & Dohme Limited | Indole derivatives as dopamine D4 antagonists |
| US5814644A (en) * | 1993-04-15 | 1998-09-29 | Merck Sharp & Dohme, Ltd. | Indole derivatives as dopamine D4 antagonists |
| DE4414113A1 (de) * | 1994-04-22 | 1995-10-26 | Merck Patent Gmbh | 3-Indolylpiperidine |
| TW406075B (en) * | 1994-12-13 | 2000-09-21 | Upjohn Co | Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds |
| ZA968661B (en) * | 1995-11-17 | 1998-04-14 | Upjohn Co | Oxazolidinone antibacterial agent with tricyclic substituents. |
| TW504510B (en) * | 1996-05-10 | 2002-10-01 | Janssen Pharmaceutica Nv | 2,4-diaminopyrimidine derivatives |
-
1998
- 1998-08-05 TR TR2000/00414T patent/TR200000414T2/xx unknown
- 1998-08-05 ID IDW20000197A patent/ID23803A/id unknown
- 1998-08-05 JP JP2000509706A patent/JP2002536291A/ja active Pending
- 1998-08-05 WO PCT/IB1998/001198 patent/WO1999009025A2/en not_active Application Discontinuation
- 1998-08-05 AP APAP/P/1998/001321A patent/AP9801321A0/en unknown
- 1998-08-05 IL IL13396098A patent/IL133960A0/xx unknown
- 1998-08-05 EA EA200000023A patent/EA200000023A1/ru unknown
- 1998-08-05 PL PL98338947A patent/PL338947A1/xx unknown
- 1998-08-05 CN CN98807831A patent/CN1265660A/zh active Pending
- 1998-08-05 KR KR1020007001093A patent/KR20010022507A/ko not_active Application Discontinuation
- 1998-08-05 BR BR9811557-0A patent/BR9811557A/pt not_active IP Right Cessation
- 1998-08-05 HU HU0003425A patent/HUP0003425A3/hu unknown
- 1998-08-05 CA CA002297486A patent/CA2297486C/en not_active Expired - Fee Related
- 1998-08-05 SK SK135-2000A patent/SK1352000A3/sk unknown
- 1998-08-05 EP EP98935229A patent/EP1003739A2/en not_active Withdrawn
- 1998-08-05 AU AU84572/98A patent/AU8457298A/en not_active Abandoned
- 1998-08-10 PA PA19988457001A patent/PA8457001A1/es unknown
- 1998-08-10 PE PE1998000717A patent/PE106299A1/es not_active Application Discontinuation
- 1998-08-12 DZ DZ980193A patent/DZ2583A1/xx active
- 1998-08-12 MA MA25210A patent/MA24632A1/fr unknown
- 1998-08-12 TN TNTNSN98151A patent/TNSN98151A1/fr unknown
- 1998-08-13 AR ARP980104021A patent/AR017019A1/es unknown
- 1998-08-14 HR HR60/055,764A patent/HRP980441A2/hr not_active Application Discontinuation
- 1998-08-14 CO CO98046788A patent/CO4960656A1/es unknown
- 1998-08-14 ZA ZA9807304A patent/ZA987304B/xx unknown
- 1998-08-17 UY UY25144A patent/UY25144A1/es not_active Application Discontinuation
-
2000
- 2000-01-10 BG BG104069A patent/BG104069A/xx unknown
- 2000-01-11 IS IS5336A patent/IS5336A/is unknown
- 2000-02-08 OA OA1200000030A patent/OA11286A/en unknown
- 2000-02-14 NO NO20000722A patent/NO20000722D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IS5336A (is) | 2000-01-11 |
| OA11286A (en) | 2003-10-22 |
| TR200000414T2 (tr) | 2000-08-21 |
| PL338947A1 (en) | 2000-12-04 |
| NO20000722L (no) | 2000-02-14 |
| EP1003739A2 (en) | 2000-05-31 |
| HUP0003425A2 (hu) | 2001-10-28 |
| JP2002536291A (ja) | 2002-10-29 |
| CO4960656A1 (es) | 2000-09-25 |
| CN1265660A (zh) | 2000-09-06 |
| DZ2583A1 (fr) | 2003-02-22 |
| IL133960A0 (en) | 2001-04-30 |
| NO20000722D0 (no) | 2000-02-14 |
| TNSN98151A1 (fr) | 2005-03-15 |
| AU8457298A (en) | 1999-03-08 |
| KR20010022507A (ko) | 2001-03-15 |
| SK1352000A3 (en) | 2000-08-14 |
| ID23803A (id) | 2000-05-11 |
| MA24632A1 (fr) | 1999-04-01 |
| CA2297486C (en) | 2005-05-03 |
| AP9801321A0 (en) | 2000-02-14 |
| BG104069A (en) | 2001-05-31 |
| HUP0003425A3 (en) | 2002-02-28 |
| PA8457001A1 (es) | 2000-09-29 |
| WO1999009025A2 (en) | 1999-02-25 |
| CA2297486A1 (en) | 1999-02-25 |
| UY25144A1 (es) | 2000-12-29 |
| ZA987304B (en) | 2000-02-14 |
| HRP980441A2 (en) | 1999-04-30 |
| WO1999009025A3 (en) | 1999-04-15 |
| BR9811557A (pt) | 2000-08-22 |
| EA200000023A1 (ru) | 2000-08-28 |
| PE106299A1 (es) | 1999-11-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |