CN1265660A - 2－(4－芳基或杂芳基－哌嗪－1－基甲基)－1h－吲哚衍生物 - Google Patents
2－(4－芳基或杂芳基－哌嗪－1－基甲基)－1h－吲哚衍生物 Download PDFInfo
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- CN1265660A CN1265660A CN98807831A CN98807831A CN1265660A CN 1265660 A CN1265660 A CN 1265660A CN 98807831 A CN98807831 A CN 98807831A CN 98807831 A CN98807831 A CN 98807831A CN 1265660 A CN1265660 A CN 1265660A
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- Prior art keywords
- piperazine
- fluoro
- disorder
- compound
- hydrogen
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Ophthalmology & Optometry (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5576497P | 1997-08-15 | 1997-08-15 | |
| US60/055,764 | 1997-08-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1265660A true CN1265660A (zh) | 2000-09-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN98807831A Pending CN1265660A (zh) | 1997-08-15 | 1998-08-05 | 2－(4－芳基或杂芳基－哌嗪－1－基甲基)－1h－吲哚衍生物 |
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| EP (1) | EP1003739A2 (es) |
| JP (1) | JP2002536291A (es) |
| KR (1) | KR20010022507A (es) |
| CN (1) | CN1265660A (es) |
| AP (1) | AP9801321A0 (es) |
| AR (1) | AR017019A1 (es) |
| AU (1) | AU8457298A (es) |
| BG (1) | BG104069A (es) |
| BR (1) | BR9811557A (es) |
| CA (1) | CA2297486C (es) |
| CO (1) | CO4960656A1 (es) |
| DZ (1) | DZ2583A1 (es) |
| EA (1) | EA200000023A1 (es) |
| HR (1) | HRP980441A2 (es) |
| HU (1) | HUP0003425A3 (es) |
| ID (1) | ID23803A (es) |
| IL (1) | IL133960A0 (es) |
| IS (1) | IS5336A (es) |
| MA (1) | MA24632A1 (es) |
| NO (1) | NO20000722L (es) |
| OA (1) | OA11286A (es) |
| PA (1) | PA8457001A1 (es) |
| PE (1) | PE106299A1 (es) |
| PL (1) | PL338947A1 (es) |
| SK (1) | SK1352000A3 (es) |
| TN (1) | TNSN98151A1 (es) |
| TR (1) | TR200000414T2 (es) |
| UY (1) | UY25144A1 (es) |
| WO (1) | WO1999009025A2 (es) |
| ZA (1) | ZA987304B (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101291925B (zh) * | 2005-10-26 | 2013-04-10 | 詹森药业有限公司 | 作为快速解离的多巴胺2受体拮抗剂的哌啶-4-基哒嗪-3-胺衍生物 |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL203140B1 (pl) * | 1997-10-27 | 2009-08-31 | Neurosearch As | Pochodna homopiperazyny, kompozycja farmaceutyczna zawierająca te pochodne i zastosowanie tej pochodnej |
| EP0953567A3 (en) * | 1998-04-29 | 2003-04-02 | Pfizer Products Inc. | Bicyclic substituted piperazine-, piperidine- and tetrahydropyridine derivatives, their preparation and their use as agents with central dopaminergic (dopamine D4 receptor) activity |
| AU783786B2 (en) * | 1999-12-30 | 2005-12-08 | H. Lundbeck A/S | 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives |
| GB0017952D0 (en) * | 2000-07-22 | 2000-09-13 | Univ Manchester | Treatment of dyskinesia |
| EP1177792A3 (en) | 2000-07-27 | 2002-10-23 | Pfizer Products Inc. | Dopamine D4 Ligands for the treatment of novelty-seeking disorders |
| JP4544820B2 (ja) * | 2001-03-09 | 2010-09-15 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | 複素環化合物 |
| AU2003265886A1 (en) | 2002-09-06 | 2004-03-29 | Janssen Pharmaceutica N.V. | (1H-Benzoimidazol-2-yl)-(piperazinyl)-methanone derivatives and related compounds as histamine H4-receptor antagonists for the treatment of inflammatory and allergic disorders |
| WO2004108671A1 (en) * | 2003-06-06 | 2004-12-16 | Suven Life Sciences Limited | Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them |
| WO2005095338A1 (ja) | 2004-03-30 | 2005-10-13 | Takeda Pharmaceutical Company Limited | アルコキシフェニルプロパン酸誘導体 |
| US7618980B2 (en) | 2004-07-14 | 2009-11-17 | Bristol-Myers Squibb Company | Pyrrolo(oxo)quinolines as 5HT ligands |
| US7572805B2 (en) | 2004-07-14 | 2009-08-11 | Bristol-Myers Squibb Company | Pyrrolo(oxo)isoquinolines as 5HT ligands |
| JO2642B1 (en) * | 2006-12-08 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| JO2849B1 (en) * | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| MX2009011415A (es) | 2007-04-23 | 2009-11-05 | Janssen Pharmaceutica Nv | Derivados de 4-alcoxipiridazina como antagonistas del receptor de dopamina 2 de rapida disociacion. |
| CA2682671C (en) | 2007-04-23 | 2015-11-17 | Janssen Pharmaceutica N.V. | Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists |
| JP5417439B2 (ja) | 2008-07-03 | 2014-02-12 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ５−ｈｔ６受容体アンタゴニストとしての置換された６−（１−ピペラジニル）−ピリダジン類 |
| CN102171189B (zh) | 2008-07-31 | 2013-11-20 | 詹森药业有限公司 | 作为快速解离多巴胺2受体拮抗剂的哌嗪-1-基-三氟甲基取代的吡啶 |
| CN109843872B (zh) * | 2017-09-20 | 2022-08-30 | 杭州英创医药科技有限公司 | 作为ido抑制剂和/或ido-hdac双重抑制剂的多环化合物 |
| WO2021216665A1 (en) * | 2020-04-22 | 2021-10-28 | Anima Biotech Inc. | Collagen 1 translation inhibitors and methods of use thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB944443A (es) * | 1959-09-25 | 1900-01-01 | ||
| EP0594702B1 (en) * | 1991-07-03 | 1997-01-29 | PHARMACIA & UPJOHN COMPANY | Substituted indoles as anti-aids pharmaceuticals |
| JPH05255089A (ja) * | 1991-12-18 | 1993-10-05 | Sanwa Kagaku Kenkyusho Co Ltd | 抗ウイルス剤 |
| JPH08502958A (ja) * | 1992-10-23 | 1996-04-02 | メルク シヤープ エンド ドーム リミテツド | ドーパミンレセプターサブタイプリガンド |
| GB9305644D0 (en) * | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
| US5576336A (en) * | 1993-03-18 | 1996-11-19 | Merck Sharp & Dohme Limited | Indole derivatives as dopamine D4 antagonists |
| US5814644A (en) * | 1993-04-15 | 1998-09-29 | Merck Sharp & Dohme, Ltd. | Indole derivatives as dopamine D4 antagonists |
| DE4414113A1 (de) * | 1994-04-22 | 1995-10-26 | Merck Patent Gmbh | 3-Indolylpiperidine |
| TW406075B (en) * | 1994-12-13 | 2000-09-21 | Upjohn Co | Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds |
| ZA968661B (en) * | 1995-11-17 | 1998-04-14 | Upjohn Co | Oxazolidinone antibacterial agent with tricyclic substituents. |
| TW504510B (en) * | 1996-05-10 | 2002-10-01 | Janssen Pharmaceutica Nv | 2,4-diaminopyrimidine derivatives |
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1998
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- 1998-08-05 EA EA200000023A patent/EA200000023A1/ru unknown
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- 1998-08-05 CN CN98807831A patent/CN1265660A/zh active Pending
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- 1998-08-05 HU HU0003425A patent/HUP0003425A3/hu unknown
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- 1998-08-05 SK SK135-2000A patent/SK1352000A3/sk unknown
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- 1998-08-05 PL PL98338947A patent/PL338947A1/xx unknown
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- 1998-08-12 TN TNTNSN98151A patent/TNSN98151A1/fr unknown
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101291925B (zh) * | 2005-10-26 | 2013-04-10 | 詹森药业有限公司 | 作为快速解离的多巴胺2受体拮抗剂的哌啶-4-基哒嗪-3-胺衍生物 |
Also Published As
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| NO20000722D0 (no) | 2000-02-14 |
| HRP980441A2 (en) | 1999-04-30 |
| SK1352000A3 (en) | 2000-08-14 |
| UY25144A1 (es) | 2000-12-29 |
| IL133960A0 (en) | 2001-04-30 |
| EA200000023A1 (ru) | 2000-08-28 |
| ZA987304B (en) | 2000-02-14 |
| ID23803A (id) | 2000-05-11 |
| PA8457001A1 (es) | 2000-09-29 |
| CO4960656A1 (es) | 2000-09-25 |
| JP2002536291A (ja) | 2002-10-29 |
| HUP0003425A3 (en) | 2002-02-28 |
| WO1999009025A3 (en) | 1999-04-15 |
| AP9801321A0 (en) | 2000-02-14 |
| KR20010022507A (ko) | 2001-03-15 |
| BR9811557A (pt) | 2000-08-22 |
| MA24632A1 (fr) | 1999-04-01 |
| CA2297486C (en) | 2005-05-03 |
| WO1999009025A2 (en) | 1999-02-25 |
| BG104069A (en) | 2001-05-31 |
| DZ2583A1 (fr) | 2003-02-22 |
| HUP0003425A2 (hu) | 2001-10-28 |
| PE106299A1 (es) | 1999-11-02 |
| EP1003739A2 (en) | 2000-05-31 |
| OA11286A (en) | 2003-10-22 |
| AR017019A1 (es) | 2001-08-22 |
| NO20000722L (no) | 2000-02-14 |
| IS5336A (is) | 2000-01-11 |
| TNSN98151A1 (fr) | 2005-03-15 |
| TR200000414T2 (tr) | 2000-08-21 |
| CA2297486A1 (en) | 1999-02-25 |
| AU8457298A (en) | 1999-03-08 |
| PL338947A1 (en) | 2000-12-04 |
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