MX2009011415A - Derivados de 4-alcoxipiridazina como antagonistas del receptor de dopamina 2 de rapida disociacion. - Google Patents
Derivados de 4-alcoxipiridazina como antagonistas del receptor de dopamina 2 de rapida disociacion.Info
- Publication number
- MX2009011415A MX2009011415A MX2009011415A MX2009011415A MX2009011415A MX 2009011415 A MX2009011415 A MX 2009011415A MX 2009011415 A MX2009011415 A MX 2009011415A MX 2009011415 A MX2009011415 A MX 2009011415A MX 2009011415 A MX2009011415 A MX 2009011415A
- Authority
- MX
- Mexico
- Prior art keywords
- receptor antagonists
- alkoxypyridazine
- derivatives
- compounds
- fast dissociating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se refiere a (1-bencil-piperidin-4-il)-(4-al coxi-piridazin-3-il)-aminas de fórmula (I) (ver fórmula (I)) que son antagonistas del receptor de dopamina 2 de rápida disociación, procedimientos para preparar estos compuestos, composiciones farmacéuticas que comprenden estos compuestos como un ingrediente activo; los compuestos encuentran utilidad como medicamentos para tratar o prevenir trastornos del sistema nervioso central, por ejemplo esquizofrenia, al ejercer un efecto antipsicótico sin efectos secundarios motrices.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07106704 | 2007-04-23 | ||
PCT/EP2008/054731 WO2008128995A1 (en) | 2007-04-23 | 2008-04-18 | 4-alkoxypyridazine derivatives as fast dissociating dopamine 2 receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009011415A true MX2009011415A (es) | 2009-11-05 |
Family
ID=38476156
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009011415A MX2009011415A (es) | 2007-04-23 | 2008-04-18 | Derivados de 4-alcoxipiridazina como antagonistas del receptor de dopamina 2 de rapida disociacion. |
Country Status (19)
Country | Link |
---|---|
US (1) | US8906921B2 (es) |
EP (1) | EP2148873B1 (es) |
JP (1) | JP5431305B2 (es) |
KR (1) | KR20100016620A (es) |
CN (1) | CN101663292A (es) |
AU (1) | AU2008240728B2 (es) |
CA (1) | CA2683111A1 (es) |
CY (1) | CY1113820T1 (es) |
DK (1) | DK2148873T3 (es) |
ES (1) | ES2393818T3 (es) |
HR (1) | HRP20120913T1 (es) |
IL (1) | IL201663A (es) |
MX (1) | MX2009011415A (es) |
PL (1) | PL2148873T3 (es) |
PT (1) | PT2148873E (es) |
RS (1) | RS52518B (es) |
RU (1) | RU2464268C2 (es) |
SI (1) | SI2148873T1 (es) |
WO (1) | WO2008128995A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO2769B1 (en) * | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
JO2849B1 (en) | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
JP5431306B2 (ja) * | 2007-04-23 | 2014-03-05 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 高速解離性ドパミン2受容体アンタゴニストとしてのチア(ジア)ゾール |
AU2008240727C1 (en) * | 2007-04-23 | 2013-10-03 | Janssen Pharmaceutica N.V. | Pyridine derivatives as fast dissociating dopamine 2 receptor antagonists |
RU2464268C2 (ru) | 2007-04-23 | 2012-10-20 | Янссен Фармацевтика Н.В. | 4-алкоксипиридазиновые производные в качестве быстро диссоциирующихся антагонистов рецептора 2 допамина |
BRPI0915834A2 (pt) * | 2008-07-03 | 2015-11-03 | Janssen Pharmaceutica Nv | 6-(1-piperazinil)-piridazinas substituídas como antagonistas do receptor de 5-ht6 |
KR101609218B1 (ko) | 2008-07-31 | 2016-04-05 | 얀센 파마슈티카 엔.브이. | 속해리성 도파민 2 수용체 길항제로서의 피페라진-1-일-트리플루오로메틸-치환된-피리딘 |
US8324239B2 (en) | 2010-04-21 | 2012-12-04 | Novartis Ag | Furopyridine compounds and uses thereof |
US10939682B2 (en) | 2013-07-02 | 2021-03-09 | Syngenta Participations Ag | Pesticidally active bi- or tricyclic heterocycles with sulfur containing substituents |
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DE2341965C3 (de) * | 1973-08-20 | 1979-01-25 | C.H. Boehringer Sohn, 6507 Ingelheim | 4- [N- (o-PyridyD- N-acyl] -aminolphenäthylpiperidine, Verfahren zu deren Herstellung sowie deren Verwendung bei der Bekämpfung von Schmerzzuständen |
US4197304A (en) * | 1975-09-23 | 1980-04-08 | Janssen Pharmaceutica N.V. | N-Aryl-N-(1-L-4-piperidinyl)-arylacetamides |
NO147672C (no) | 1975-09-23 | 1983-05-25 | Janssen Pharmaceutica Nv | Analogifremgangsmaate for fremstilling av n-aryl-n-(1-l1-4-piperidinyl)-arylacetamider |
EG12406A (en) * | 1976-08-12 | 1979-03-31 | Janssen Pharmaceutica Nv | Process for preparing of novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides |
DE3218482A1 (de) | 1982-05-15 | 1983-11-17 | Bayer Ag, 5090 Leverkusen | Substituierte 5-trifluormethyl-1,3,4-thiadiazol-2-yloxyessigsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als herbizide |
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MX173362B (es) | 1987-03-02 | 1994-02-23 | Pfizer | Compuestos de piperazinil heterociclicos y procedimiento para su preparacion |
US5461053A (en) * | 1989-02-07 | 1995-10-24 | Sanofi | Pyridazine derivatives |
PT93060B (pt) | 1989-02-07 | 1995-12-29 | Sanofi Sa | Processo para a obtencao de derivados de piridazina e de composicoes farmaceuticas que os contem |
GB9216298D0 (en) | 1991-08-15 | 1992-09-16 | Ici Plc | Piperidine derivatives |
WO1995018118A1 (en) | 1993-12-28 | 1995-07-06 | The Upjohn Company | Heterocyclic compounds for the treatment of cns and cardiovascular disorders |
DE4425145A1 (de) * | 1994-07-15 | 1996-01-18 | Basf Ag | Verwendung von Thiazol- und Thiadiazolverbindungen |
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US5753679A (en) | 1995-05-10 | 1998-05-19 | Hoffmann-La Roche Inc. | Benzyl-piperidine derivatives |
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JO2769B1 (en) * | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
WO2007130383A2 (en) | 2006-04-28 | 2007-11-15 | Northwestern University | Compositions and treatments using pyridazine compounds and secretases |
US8058243B2 (en) * | 2006-10-13 | 2011-11-15 | Hsc Research And Development Limited Partnership | Method for treating a brain cancer with ifenprodil |
TW200829566A (en) | 2006-12-08 | 2008-07-16 | Astrazeneca Ab | Chemical compounds |
JO2642B1 (en) * | 2006-12-08 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
JO2849B1 (en) * | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
AU2008240727C1 (en) * | 2007-04-23 | 2013-10-03 | Janssen Pharmaceutica N.V. | Pyridine derivatives as fast dissociating dopamine 2 receptor antagonists |
RU2464268C2 (ru) | 2007-04-23 | 2012-10-20 | Янссен Фармацевтика Н.В. | 4-алкоксипиридазиновые производные в качестве быстро диссоциирующихся антагонистов рецептора 2 допамина |
JP5431306B2 (ja) * | 2007-04-23 | 2014-03-05 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 高速解離性ドパミン2受容体アンタゴニストとしてのチア(ジア)ゾール |
WO2009037296A1 (en) * | 2007-09-20 | 2009-03-26 | Glaxo Group Limited | Compounds which have activity at m1 receptor and their uses in medicine |
BRPI0915834A2 (pt) * | 2008-07-03 | 2015-11-03 | Janssen Pharmaceutica Nv | 6-(1-piperazinil)-piridazinas substituídas como antagonistas do receptor de 5-ht6 |
KR101609218B1 (ko) * | 2008-07-31 | 2016-04-05 | 얀센 파마슈티카 엔.브이. | 속해리성 도파민 2 수용체 길항제로서의 피페라진-1-일-트리플루오로메틸-치환된-피리딘 |
-
2008
- 2008-04-18 RU RU2009142997/04A patent/RU2464268C2/ru active
- 2008-04-18 SI SI200830823T patent/SI2148873T1/sl unknown
- 2008-04-18 RS RS20120481A patent/RS52518B/en unknown
- 2008-04-18 EP EP08749604A patent/EP2148873B1/en active Active
- 2008-04-18 KR KR1020097023941A patent/KR20100016620A/ko not_active Application Discontinuation
- 2008-04-18 PL PL08749604T patent/PL2148873T3/pl unknown
- 2008-04-18 ES ES08749604T patent/ES2393818T3/es active Active
- 2008-04-18 US US12/597,166 patent/US8906921B2/en active Active
- 2008-04-18 DK DK08749604.8T patent/DK2148873T3/da active
- 2008-04-18 CN CN200880012952A patent/CN101663292A/zh active Pending
- 2008-04-18 AU AU2008240728A patent/AU2008240728B2/en not_active Ceased
- 2008-04-18 WO PCT/EP2008/054731 patent/WO2008128995A1/en active Application Filing
- 2008-04-18 PT PT08749604T patent/PT2148873E/pt unknown
- 2008-04-18 CA CA002683111A patent/CA2683111A1/en not_active Abandoned
- 2008-04-18 MX MX2009011415A patent/MX2009011415A/es active IP Right Grant
- 2008-04-18 JP JP2010504647A patent/JP5431305B2/ja active Active
-
2009
- 2009-10-21 IL IL201663A patent/IL201663A/en active IP Right Grant
-
2012
- 2012-11-13 HR HRP20120913AT patent/HRP20120913T1/hr unknown
- 2012-11-28 CY CY20121101154T patent/CY1113820T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
SI2148873T1 (sl) | 2013-01-31 |
CA2683111A1 (en) | 2008-10-30 |
JP2010525014A (ja) | 2010-07-22 |
ES2393818T3 (es) | 2012-12-28 |
IL201663A0 (en) | 2010-05-31 |
EP2148873A1 (en) | 2010-02-03 |
US20100063058A1 (en) | 2010-03-11 |
AU2008240728A1 (en) | 2008-10-30 |
RU2009142997A (ru) | 2011-05-27 |
CY1113820T1 (el) | 2016-10-05 |
IL201663A (en) | 2013-05-30 |
JP5431305B2 (ja) | 2014-03-05 |
AU2008240728B2 (en) | 2013-01-10 |
CN101663292A (zh) | 2010-03-03 |
EP2148873B1 (en) | 2012-08-29 |
RU2464268C2 (ru) | 2012-10-20 |
WO2008128995A1 (en) | 2008-10-30 |
PT2148873E (pt) | 2012-11-20 |
RS52518B (en) | 2013-04-30 |
KR20100016620A (ko) | 2010-02-12 |
DK2148873T3 (da) | 2012-11-26 |
PL2148873T3 (pl) | 2013-01-31 |
HRP20120913T1 (hr) | 2012-12-31 |
US8906921B2 (en) | 2014-12-09 |
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