MX2009011415A - Derivados de 4-alcoxipiridazina como antagonistas del receptor de dopamina 2 de rapida disociacion. - Google Patents

Derivados de 4-alcoxipiridazina como antagonistas del receptor de dopamina 2 de rapida disociacion.

Info

Publication number
MX2009011415A
MX2009011415A MX2009011415A MX2009011415A MX2009011415A MX 2009011415 A MX2009011415 A MX 2009011415A MX 2009011415 A MX2009011415 A MX 2009011415A MX 2009011415 A MX2009011415 A MX 2009011415A MX 2009011415 A MX2009011415 A MX 2009011415A
Authority
MX
Mexico
Prior art keywords
receptor antagonists
alkoxypyridazine
derivatives
compounds
fast dissociating
Prior art date
Application number
MX2009011415A
Other languages
English (en)
Inventor
Gregor James Macdonald
Jose Manuel Bartolome-Nebreda
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2009011415A publication Critical patent/MX2009011415A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a (1-bencil-piperidin-4-il)-(4-al coxi-piridazin-3-il)-aminas de fórmula (I) (ver fórmula (I)) que son antagonistas del receptor de dopamina 2 de rápida disociación, procedimientos para preparar estos compuestos, composiciones farmacéuticas que comprenden estos compuestos como un ingrediente activo; los compuestos encuentran utilidad como medicamentos para tratar o prevenir trastornos del sistema nervioso central, por ejemplo esquizofrenia, al ejercer un efecto antipsicótico sin efectos secundarios motrices.
MX2009011415A 2007-04-23 2008-04-18 Derivados de 4-alcoxipiridazina como antagonistas del receptor de dopamina 2 de rapida disociacion. MX2009011415A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07106704 2007-04-23
PCT/EP2008/054731 WO2008128995A1 (en) 2007-04-23 2008-04-18 4-alkoxypyridazine derivatives as fast dissociating dopamine 2 receptor antagonists

Publications (1)

Publication Number Publication Date
MX2009011415A true MX2009011415A (es) 2009-11-05

Family

ID=38476156

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009011415A MX2009011415A (es) 2007-04-23 2008-04-18 Derivados de 4-alcoxipiridazina como antagonistas del receptor de dopamina 2 de rapida disociacion.

Country Status (19)

Country Link
US (1) US8906921B2 (es)
EP (1) EP2148873B1 (es)
JP (1) JP5431305B2 (es)
KR (1) KR20100016620A (es)
CN (1) CN101663292A (es)
AU (1) AU2008240728B2 (es)
CA (1) CA2683111A1 (es)
CY (1) CY1113820T1 (es)
DK (1) DK2148873T3 (es)
ES (1) ES2393818T3 (es)
HR (1) HRP20120913T1 (es)
IL (1) IL201663A (es)
MX (1) MX2009011415A (es)
PL (1) PL2148873T3 (es)
PT (1) PT2148873E (es)
RS (1) RS52518B (es)
RU (1) RU2464268C2 (es)
SI (1) SI2148873T1 (es)
WO (1) WO2008128995A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2769B1 (en) 2005-10-26 2014-03-15 جانسين فارماسوتيكا ان. في Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
JO2849B1 (en) 2007-02-13 2015-03-15 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
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SI2148873T1 (sl) 2007-04-23 2013-01-31 Janssen Pharmaceutica, N.V. Derivati 4-alkoksipiridazina kot antagonisti receptorja dopamina 2 s hitro disociacijo
WO2008128996A1 (en) * 2007-04-23 2008-10-30 Janssen Pharmaceutica N.V. Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists
JP5417439B2 (ja) * 2008-07-03 2014-02-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ５−ｈｔ６受容体アンタゴニストとしての置換された６−（１−ピペラジニル）−ピリダジン類
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CA2730774C (en) 2008-07-31 2016-09-13 Janssen Pharmaceutica Nv Piperazin-1-yl-trifluoromethyl-substituted-pyridines as fast dissociating dopamine 2 receptor antagonists

Also Published As

Publication number Publication date
US20100063058A1 (en) 2010-03-11
JP2010525014A (ja) 2010-07-22
PL2148873T3 (pl) 2013-01-31
WO2008128995A1 (en) 2008-10-30
RU2464268C2 (ru) 2012-10-20
HRP20120913T1 (hr) 2012-12-31
CA2683111A1 (en) 2008-10-30
RS52518B (en) 2013-04-30
EP2148873A1 (en) 2010-02-03
EP2148873B1 (en) 2012-08-29
DK2148873T3 (da) 2012-11-26
AU2008240728B2 (en) 2013-01-10
US8906921B2 (en) 2014-12-09
IL201663A0 (en) 2010-05-31
RU2009142997A (ru) 2011-05-27
ES2393818T3 (es) 2012-12-28
KR20100016620A (ko) 2010-02-12
CY1113820T1 (el) 2016-10-05
IL201663A (en) 2013-05-30
PT2148873E (pt) 2012-11-20
AU2008240728A1 (en) 2008-10-30
JP5431305B2 (ja) 2014-03-05
SI2148873T1 (sl) 2013-01-31
CN101663292A (zh) 2010-03-03

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