ES8802151A1 - Un procedimiento para la preparacion de nuevos piridazinaminas. - Google Patents

Un procedimiento para la preparacion de nuevos piridazinaminas.

Info

Publication number
ES8802151A1
ES8802151A1 ES556738A ES556738A ES8802151A1 ES 8802151 A1 ES8802151 A1 ES 8802151A1 ES 556738 A ES556738 A ES 556738A ES 556738 A ES556738 A ES 556738A ES 8802151 A1 ES8802151 A1 ES 8802151A1
Authority
ES
Spain
Prior art keywords
aryl
substituted
6alkyl
compounds
pyridazines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES556738A
Other languages
English (en)
Other versions
ES556738A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of ES556738A0 publication Critical patent/ES556738A0/es
Publication of ES8802151A1 publication Critical patent/ES8802151A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22—Nitrogen and oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE PIRIDAZINAMINAS, DE FORMULA GENERAL (I), CON FORMA N-OXIDO, UNA SAL DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLE O UNA FORMA ESTEROQUIMICAMENTE ISOMERICA DEL MISMO. CONSISTE EN SOMETER A REACCION DE N-ALQUILACION UNA AMINA DE FORMULA GENERAL (II), CON UN REACTIVO DE FORMULA GENERAL (III), EN LAS QUE M ES 2 O 3; R1, R2, R3 Y R4 SON CADA UNO DE ELLOS INDEPENDIENTEMENTE HIDROGENO O ALQUILO C1-6; R5 ES (ARIL) ALQUENILO C2-6 O (ARIL) ALQUINILO C2-6; R ES HIDROGENO, HALO, HIDROXI O FENILO; Y W REPRESENTA UN GRUPO SALIENTE REACTIVO, TAL COMO HALOGENO O SULFONILOXI. DICHA REACCION SE EFECTUA EN PRESENCIA DE UN DISOLVENTE ORGANICO. DE APLICACION EN MEDICINA PARA PREVENIR Y COMBATIR EL DOLOR EN ANIMALES DE SANGRE CALIENTE.
ES556738A 1985-07-31 1986-06-25 Un procedimiento para la preparacion de nuevos piridazinaminas. Expired ES8802151A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76084585A 1985-07-31 1985-07-31

Publications (2)

Publication Number Publication Date
ES556738A0 ES556738A0 (es) 1988-04-01
ES8802151A1 true ES8802151A1 (es) 1988-04-01

Family

ID=25060338

Family Applications (1)

Application Number Title Priority Date Filing Date
ES556738A Expired ES8802151A1 (es) 1985-07-31 1986-06-25 Un procedimiento para la preparacion de nuevos piridazinaminas.

Country Status (18)

Country Link
EP (1) EP0211457A3 (es)
JP (1) JPS6229575A (es)
KR (1) KR870001192A (es)
CN (1) CN86105558A (es)
AU (1) AU6073986A (es)
DK (1) DK363186A (es)
ES (1) ES8802151A1 (es)
FI (1) FI863120A (es)
GR (1) GR862022B (es)
HU (1) HU195501B (es)
IL (1) IL79549A0 (es)
NO (1) NO863083L (es)
NZ (1) NZ216918A (es)
PH (1) PH22884A (es)
PT (1) PT83098B (es)
TN (1) TNSN86117A1 (es)
ZA (1) ZA865700B (es)
ZW (1) ZW14886A1 (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY104343A (en) * 1987-11-23 1994-03-31 Janssen Pharmaceutica Nv Novel pyridizinamine deravatives
US4992433A (en) * 1987-11-23 1991-02-12 Janssen Pharmaceutica N.V. Novel pyridazinamine derivatives
GB8911158D0 (en) * 1989-05-16 1989-07-05 Janssen Pharmaceutica Nv Antiviral pyridazinamines
US5070090A (en) * 1989-05-15 1991-12-03 Janssen Pharmaceutica N.V. Antipicorpaviral herterocyclic-substituted morpholinyl alkylphenol ethers
US5270312A (en) * 1990-11-05 1993-12-14 Warner-Lambert Company Substituted piperazines as central nervous system agents
DK1027336T3 (da) * 1997-10-27 2005-01-24 Neurosearch As Heteroaryldiazacycloalkaner, deres fremstilling og anvendelse
CN1348449A (zh) 1999-04-26 2002-05-08 神经研究公司 杂芳基二氮杂环烷烃及其制备方法和应用
EP1430033A4 (en) 2001-08-31 2004-12-15 Univ Northwestern PROTEIN KINASE ANTI-INFLAMMATORY AND INHIBITOR COMPOSITION AND METHOD OF USE
US7390813B1 (en) 2001-12-21 2008-06-24 Xenon Pharmaceuticals Inc. Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents
US7759348B2 (en) 2003-07-30 2010-07-20 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
BRPI0412343A (pt) * 2003-07-30 2006-09-05 Xenon Pharmaceuticals Inc derivados de piridazina e seu uso como agentes terapêuticos
US7754711B2 (en) * 2003-07-30 2010-07-13 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
EP2316827B1 (en) 2003-07-30 2016-01-27 Xenon Pharmaceuticals Inc. Piperazine derivatives and their use as therapeutic agents
EP2269610A3 (en) 2004-09-20 2011-03-09 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
MX2007003318A (es) 2004-09-20 2007-05-18 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como agentes terapeuticos.
MX2007003327A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa.
CN101084207A (zh) 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途
BRPI0515488A (pt) 2004-09-20 2008-07-29 Xenon Pharmaceuticals Inc derivados de heterocìclicos e seu uso como agentes terapêuticos
CA2580845A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase
AU2005286647A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
CN101087766B (zh) 2004-11-02 2011-09-07 西北大学 哒嗪化合物、组合物和方法
EP1812007B1 (en) 2004-11-02 2011-09-07 Northwestern University Pyridazine compounds and methods
AU2016203312B2 (en) * 2004-11-02 2018-05-24 Centre National De La Recherche Scientifique Pyridazine compounds, compositions and methods
JP2009513563A (ja) 2005-06-03 2009-04-02 ゼノン・ファーマシューティカルズ・インコーポレイテッド ヒトのステアロイル−ＣｏＡデサチュラーゼ阻害剤としてのアミノチアゾール誘導体
JO2769B1 (en) 2005-10-26 2014-03-15 جانسين فارماسوتيكا ان. في Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
CA2650711A1 (en) 2006-04-28 2007-11-08 Northwestern University Compositions and treatments using pyridazine compounds and cholinesterase inhibitors
JP2009535344A (ja) 2006-04-28 2009-10-01 ノースウェスタン ユニバーシティ 神経炎症性疾患の処置のためのピリダジン化合物を含む処方物
JO2849B1 (en) 2007-02-13 2015-03-15 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
KR101506156B1 (ko) 2007-04-23 2015-03-26 얀센 파마슈티카 엔.브이. 속해리성 도파민 2 수용체 길항제로서의 티아(디아)졸
ES2393818T3 (es) 2007-04-23 2012-12-28 Janssen Pharmaceutica, N.V. Derivados de tipo 4-alcoxipiridazina como antagonistas de los receptores 2 de la dopamina de disociación rápida
WO2008145681A2 (en) * 2007-05-31 2008-12-04 Boehringer Ingelheim International Gmbh Ccr2 receptor antagonists and uses thereof
CN102171189B (zh) 2008-07-31 2013-11-20 詹森药业有限公司 作为快速解离多巴胺2受体拮抗剂的哌嗪-1-基-三氟甲基取代的吡啶
WO2012159662A1 (en) * 2011-05-24 2012-11-29 Universita' Degli Studi Di Bari New 1-arylpiperazinic ligands of 5-ht7 receptor and use thereof
BR112017028492B1 (pt) 2015-07-02 2023-12-26 Centrexion Therapeutics Corporation Citrato de (4-((3r,4r)-3-metoxitetra-hidro-piran-4- ilamino)piperidin-1-il) (5- metil-6-(((2r, 6s)-6-(p-tolil) tetra-hidro-2h-piran-2-il)metilamino)pirimidin-4-il) metanona, seu uso e seu método de preparação, e composição farmacêutica

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2985657A (en) * 1959-10-12 1961-05-23 Paul A J Janssen 1-(aroylalkyl)-4-heterocyclylpiperazines
US5001125A (en) * 1984-03-26 1991-03-19 Janssen Pharmaceutica N.V. Anti-virally active pyridazinamines

Also Published As

Publication number Publication date
CN86105558A (zh) 1987-01-28
IL79549A0 (en) 1986-10-31
ZA865700B (en) 1988-03-30
DK363186A (da) 1987-02-01
KR870001192A (ko) 1987-03-12
HU195501B (en) 1988-05-30
PT83098B (en) 1988-07-13
FI863120A (fi) 1987-02-01
AU6073986A (en) 1987-02-05
JPS6229575A (ja) 1987-02-07
ES556738A0 (es) 1988-04-01
HUT41772A (en) 1987-05-28
FI863120A0 (fi) 1986-07-30
ZW14886A1 (en) 1988-02-24
NZ216918A (en) 1988-11-29
PH22884A (en) 1989-01-19
EP0211457A2 (en) 1987-02-25
NO863083D0 (no) 1986-07-30
NO863083L (no) 1987-02-02
EP0211457A3 (en) 1987-07-22
GR862022B (en) 1986-12-24
TNSN86117A1 (fr) 1990-01-01
PT83098A (en) 1986-08-01
DK363186D0 (da) 1986-07-30

Similar Documents

Publication Publication Date Title
ES8802151A1 (es) Un procedimiento para la preparacion de nuevos piridazinaminas.
NZ226920A (en) Substituted pyridazine amines and pharmaceutical compositions
ZW290A1 (en) 2-aminopyrimidinone derivatives
GR3004114T3 (es)
AU1906888A (en) Hydroxamic acid derivatives
ZA895978B (en) Antipsychotic 3-piperazinylbenzazole derivatives
BG51251A3 (en) Method for the preparetion of tetrahydroimidazo /1,4/-benzodiazepine (?)-2-ketons
AU583429B2 (en) Novel ``, ``-diaryl-4-aryl-4-hydroxy-1-piperidinebutanamide, N-oxides
GR3017435T3 (en) Antihypertensive 3-piperidinyl-indazole derivatives.