CY1113820T1 - Παραγωγα 4-αλκοξυπυριδαζινης ως ταχεως διασπομενοι ανταγωνιστες υποδοχεα ντοπαμινης 2 - Google Patents
Παραγωγα 4-αλκοξυπυριδαζινης ως ταχεως διασπομενοι ανταγωνιστες υποδοχεα ντοπαμινης 2Info
- Publication number
- CY1113820T1 CY1113820T1 CY20121101154T CY121101154T CY1113820T1 CY 1113820 T1 CY1113820 T1 CY 1113820T1 CY 20121101154 T CY20121101154 T CY 20121101154T CY 121101154 T CY121101154 T CY 121101154T CY 1113820 T1 CY1113820 T1 CY 1113820T1
- Authority
- CY
- Cyprus
- Prior art keywords
- alkoxypyridazine
- producer
- compounds
- dopamine receptor
- highly distributed
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
Abstract
Η παρούσα εφεύρεση αναφέρεται σε (1-βενζυλ-πιπεριδιν-4-υλ) - (4-αλκοξυ-πυριδαζιν-3-υλ) - αμίνες του τύπου (I) που είναι ταχέως διασπόμενοι ανταγωνιστές υποδοχέων ντοπαμίνης 2, διεργασίες για την παρασκευή αυτών των ενώσεων, φαρμακευτικές συνθέσεις που περιλαμβάνουν αυτές τις ενώσεις ως ενεργό συστατικό. Οι ενώσεις βρίσκουν χρησιμότητα ως φάρμακα για τη θεραπεία ή την πρόληψη διαταραχών του κεντρικού νευρικού συστήματος, για παράδειγμα σχιζοφρένεια, προκαλώντας μία αντιψυχωτική επίδραση χωρίς κινητικές παρενέργειες.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07106704 | 2007-04-23 | ||
EP08749604A EP2148873B1 (en) | 2007-04-23 | 2008-04-18 | 4-alkoxypyridazine derivatives as fast dissociating dopamine 2 receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1113820T1 true CY1113820T1 (el) | 2016-10-05 |
Family
ID=38476156
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121101154T CY1113820T1 (el) | 2007-04-23 | 2012-11-28 | Παραγωγα 4-αλκοξυπυριδαζινης ως ταχεως διασπομενοι ανταγωνιστες υποδοχεα ντοπαμινης 2 |
Country Status (19)
Country | Link |
---|---|
US (1) | US8906921B2 (el) |
EP (1) | EP2148873B1 (el) |
JP (1) | JP5431305B2 (el) |
KR (1) | KR20100016620A (el) |
CN (1) | CN101663292A (el) |
AU (1) | AU2008240728B2 (el) |
CA (1) | CA2683111A1 (el) |
CY (1) | CY1113820T1 (el) |
DK (1) | DK2148873T3 (el) |
ES (1) | ES2393818T3 (el) |
HR (1) | HRP20120913T1 (el) |
IL (1) | IL201663A (el) |
MX (1) | MX2009011415A (el) |
PL (1) | PL2148873T3 (el) |
PT (1) | PT2148873E (el) |
RS (1) | RS52518B (el) |
RU (1) | RU2464268C2 (el) |
SI (1) | SI2148873T1 (el) |
WO (1) | WO2008128995A1 (el) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO2769B1 (en) * | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
JO2849B1 (en) * | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
JP2010525013A (ja) * | 2007-04-23 | 2010-07-22 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 高速解離性ドパミン2受容体アンタゴニストとしてのピリジン誘導体 |
JP5431305B2 (ja) | 2007-04-23 | 2014-03-05 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 高速解離性ドパミン2受容体アンタゴニストとしての4−アルコキシピリダジン誘導体 |
AU2008240729B2 (en) * | 2007-04-23 | 2012-08-23 | Janssen Pharmaceutica N.V. | Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists |
CA2729313C (en) * | 2008-07-03 | 2016-08-30 | Janssen Pharmaceutica Nv | Substituted 6-(1-piperazinyl)-pyridazines as 5-ht6 receptor antagonists |
DK2307374T3 (en) | 2008-07-31 | 2017-05-01 | Janssen Pharmaceutica Nv | PIPERAZIN-1-YLTRIFLUORMETHYL-SUBSTITUTED PYRIDINES AS QUICK DISSOCATING DOPAMIN-2 RECEPTOR ANTAGONISTS |
US8324239B2 (en) | 2010-04-21 | 2012-12-04 | Novartis Ag | Furopyridine compounds and uses thereof |
CA2917262A1 (en) | 2013-07-02 | 2015-01-08 | Syngenta Participations Ag | Pesticidally active bi- or tricyclic heterocycles with sulfur containing substituents |
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JO2642B1 (en) * | 2006-12-08 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
JO2849B1 (en) * | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
JP2010525013A (ja) * | 2007-04-23 | 2010-07-22 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 高速解離性ドパミン2受容体アンタゴニストとしてのピリジン誘導体 |
AU2008240729B2 (en) * | 2007-04-23 | 2012-08-23 | Janssen Pharmaceutica N.V. | Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists |
JP5431305B2 (ja) | 2007-04-23 | 2014-03-05 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 高速解離性ドパミン2受容体アンタゴニストとしての4−アルコキシピリダジン誘導体 |
UY31346A1 (es) * | 2007-09-20 | 2009-04-30 | Compuestos que tienen actividad en el receptor m1 y sus usos en medicina | |
CA2729313C (en) * | 2008-07-03 | 2016-08-30 | Janssen Pharmaceutica Nv | Substituted 6-(1-piperazinyl)-pyridazines as 5-ht6 receptor antagonists |
DK2307374T3 (en) | 2008-07-31 | 2017-05-01 | Janssen Pharmaceutica Nv | PIPERAZIN-1-YLTRIFLUORMETHYL-SUBSTITUTED PYRIDINES AS QUICK DISSOCATING DOPAMIN-2 RECEPTOR ANTAGONISTS |
-
2008
- 2008-04-18 JP JP2010504647A patent/JP5431305B2/ja active Active
- 2008-04-18 SI SI200830823T patent/SI2148873T1/sl unknown
- 2008-04-18 MX MX2009011415A patent/MX2009011415A/es active IP Right Grant
- 2008-04-18 DK DK08749604.8T patent/DK2148873T3/da active
- 2008-04-18 ES ES08749604T patent/ES2393818T3/es active Active
- 2008-04-18 US US12/597,166 patent/US8906921B2/en active Active
- 2008-04-18 RS RS20120481A patent/RS52518B/en unknown
- 2008-04-18 RU RU2009142997/04A patent/RU2464268C2/ru active
- 2008-04-18 EP EP08749604A patent/EP2148873B1/en active Active
- 2008-04-18 AU AU2008240728A patent/AU2008240728B2/en not_active Ceased
- 2008-04-18 CN CN200880012952A patent/CN101663292A/zh active Pending
- 2008-04-18 PT PT08749604T patent/PT2148873E/pt unknown
- 2008-04-18 CA CA002683111A patent/CA2683111A1/en not_active Abandoned
- 2008-04-18 WO PCT/EP2008/054731 patent/WO2008128995A1/en active Application Filing
- 2008-04-18 PL PL08749604T patent/PL2148873T3/pl unknown
- 2008-04-18 KR KR1020097023941A patent/KR20100016620A/ko not_active Application Discontinuation
-
2009
- 2009-10-21 IL IL201663A patent/IL201663A/en active IP Right Grant
-
2012
- 2012-11-13 HR HRP20120913AT patent/HRP20120913T1/hr unknown
- 2012-11-28 CY CY20121101154T patent/CY1113820T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
KR20100016620A (ko) | 2010-02-12 |
ES2393818T3 (es) | 2012-12-28 |
US8906921B2 (en) | 2014-12-09 |
US20100063058A1 (en) | 2010-03-11 |
PT2148873E (pt) | 2012-11-20 |
RU2464268C2 (ru) | 2012-10-20 |
AU2008240728A1 (en) | 2008-10-30 |
CA2683111A1 (en) | 2008-10-30 |
CN101663292A (zh) | 2010-03-03 |
SI2148873T1 (sl) | 2013-01-31 |
IL201663A (en) | 2013-05-30 |
IL201663A0 (en) | 2010-05-31 |
PL2148873T3 (pl) | 2013-01-31 |
AU2008240728B2 (en) | 2013-01-10 |
RU2009142997A (ru) | 2011-05-27 |
DK2148873T3 (da) | 2012-11-26 |
HRP20120913T1 (hr) | 2012-12-31 |
JP2010525014A (ja) | 2010-07-22 |
JP5431305B2 (ja) | 2014-03-05 |
RS52518B (en) | 2013-04-30 |
EP2148873B1 (en) | 2012-08-29 |
MX2009011415A (es) | 2009-11-05 |
WO2008128995A1 (en) | 2008-10-30 |
EP2148873A1 (en) | 2010-02-03 |
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