PL2148873T3 - Pochodne 4-alkoksypirydazynowe jako szybko dysocjujący antagoniści receptora dopaminowego 2 - Google Patents
Pochodne 4-alkoksypirydazynowe jako szybko dysocjujący antagoniści receptora dopaminowego 2Info
- Publication number
- PL2148873T3 PL2148873T3 PL08749604T PL08749604T PL2148873T3 PL 2148873 T3 PL2148873 T3 PL 2148873T3 PL 08749604 T PL08749604 T PL 08749604T PL 08749604 T PL08749604 T PL 08749604T PL 2148873 T3 PL2148873 T3 PL 2148873T3
- Authority
- PL
- Poland
- Prior art keywords
- alkoxypyridazine
- derivatives
- receptor antagonists
- fast dissociating
- dissociating dopamine
- Prior art date
Links
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title 2
- 229960003638 dopamine Drugs 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07106704 | 2007-04-23 | ||
| EP08749604A EP2148873B1 (en) | 2007-04-23 | 2008-04-18 | 4-alkoxypyridazine derivatives as fast dissociating dopamine 2 receptor antagonists |
| PCT/EP2008/054731 WO2008128995A1 (en) | 2007-04-23 | 2008-04-18 | 4-alkoxypyridazine derivatives as fast dissociating dopamine 2 receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2148873T3 true PL2148873T3 (pl) | 2013-01-31 |
Family
ID=38476156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL08749604T PL2148873T3 (pl) | 2007-04-23 | 2008-04-18 | Pochodne 4-alkoksypirydazynowe jako szybko dysocjujący antagoniści receptora dopaminowego 2 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8906921B2 (pl) |
| EP (1) | EP2148873B1 (pl) |
| JP (1) | JP5431305B2 (pl) |
| KR (1) | KR20100016620A (pl) |
| CN (1) | CN101663292A (pl) |
| AU (1) | AU2008240728B2 (pl) |
| CA (1) | CA2683111A1 (pl) |
| CY (1) | CY1113820T1 (pl) |
| DK (1) | DK2148873T3 (pl) |
| ES (1) | ES2393818T3 (pl) |
| HR (1) | HRP20120913T1 (pl) |
| IL (1) | IL201663A (pl) |
| MX (1) | MX2009011415A (pl) |
| PL (1) | PL2148873T3 (pl) |
| PT (1) | PT2148873E (pl) |
| RS (1) | RS52518B (pl) |
| RU (1) | RU2464268C2 (pl) |
| SI (1) | SI2148873T1 (pl) |
| WO (1) | WO2008128995A1 (pl) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2769B1 (en) * | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
| JO2849B1 (en) * | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| JP2010525013A (ja) * | 2007-04-23 | 2010-07-22 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 高速解離性ドパミン２受容体アンタゴニストとしてのピリジン誘導体 |
| CA2683111A1 (en) | 2007-04-23 | 2008-10-30 | Janssen Pharmaceutica N.V. | 4-alkoxypyridazine derivatives as fast dissociating dopamine 2 receptor antagonists |
| MX2009011416A (es) * | 2007-04-23 | 2009-11-05 | Janssen Pharmaceutica Nv | Tia(di)azoles como antagonistas del receptor de dopamina 2 de disociacion rapida. |
| JP5417439B2 (ja) * | 2008-07-03 | 2014-02-12 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ５−ｈｔ６受容体アンタゴニストとしての置換された６−（１−ピペラジニル）−ピリダジン類 |
| CN102171189B (zh) | 2008-07-31 | 2013-11-20 | 詹森药业有限公司 | 作为快速解离多巴胺2受体拮抗剂的哌嗪-1-基-三氟甲基取代的吡啶 |
| US8324239B2 (en) | 2010-04-21 | 2012-12-04 | Novartis Ag | Furopyridine compounds and uses thereof |
| MX2015017821A (es) | 2013-07-02 | 2016-04-15 | Syngenta Participations Ag | Heterociclos bi-o triciclicos activos como plaguicidas con sustituyentes que contienen azufre. |
| EP4574152A1 (en) * | 2023-12-22 | 2025-06-25 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Potassium channel activators for use in the treatment of epileptic disorders |
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| US3933823A (en) * | 1971-03-29 | 1976-01-20 | E. R. Squibb & Sons, Inc. | Isoxazolopyridine ketone derivatives |
| DE2341965C3 (de) * | 1973-08-20 | 1979-01-25 | C.H. Boehringer Sohn, 6507 Ingelheim | 4- [N- (o-PyridyD- N-acyl] -aminolphenäthylpiperidine, Verfahren zu deren Herstellung sowie deren Verwendung bei der Bekämpfung von Schmerzzuständen |
| US4197304A (en) * | 1975-09-23 | 1980-04-08 | Janssen Pharmaceutica N.V. | N-Aryl-N-(1-L-4-piperidinyl)-arylacetamides |
| NO147672C (no) | 1975-09-23 | 1983-05-25 | Janssen Pharmaceutica Nv | Analogifremgangsmaate for fremstilling av n-aryl-n-(1-l1-4-piperidinyl)-arylacetamider |
| EG12406A (en) * | 1976-08-12 | 1979-03-31 | Janssen Pharmaceutica Nv | Process for preparing of novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides |
| DE3218482A1 (de) | 1982-05-15 | 1983-11-17 | Bayer Ag, 5090 Leverkusen | Substituierte 5-trifluormethyl-1,3,4-thiadiazol-2-yloxyessigsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als herbizide |
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| MX173362B (es) | 1987-03-02 | 1994-02-23 | Pfizer | Compuestos de piperazinil heterociclicos y procedimiento para su preparacion |
| PT93060B (pt) | 1989-02-07 | 1995-12-29 | Sanofi Sa | Processo para a obtencao de derivados de piridazina e de composicoes farmaceuticas que os contem |
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| ES2211344B1 (es) | 2002-12-26 | 2005-10-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| EP1608629A1 (en) | 2003-03-24 | 2005-12-28 | F. Hoffmann-La Roche Ag | Benzyl-pyridazinons as reverse transcriptase inhibitors |
| AU2003239845A1 (en) | 2003-05-07 | 2004-11-26 | Ifac Gmbh And Co.Kg | Compositions for the targetted release of fragrances and aromas |
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| WO2005005779A2 (en) | 2003-07-14 | 2005-01-20 | Genesis Mining Technologies (Pty) Ltd | Dual retention cutting arrangement |
| AU2004259263B2 (en) | 2003-07-29 | 2010-12-16 | High Point Pharmaceuticals, Llc | Pyridazinyl- piperazines and their use as histamine H3 receptor ligands |
| NZ545265A (en) | 2003-07-30 | 2009-11-27 | Xenon Pharmaceuticals Inc | Pyridazine derivatives and their use for treating diseases mediated by stearoyl-CoA desaturase (SCD) enzymes |
| EP1653969A4 (en) | 2003-08-07 | 2006-12-20 | Japan Tobacco Inc | PYRROLO 1,2-B PYRIDAZINE DERIVATIVES |
| WO2005046581A2 (en) | 2003-10-24 | 2005-05-26 | Cheng Tao M D | P18 in stem cell manipulations |
| WO2005077914A1 (en) | 2004-02-10 | 2005-08-25 | Janssen Pharmaceutica, N.V. | PYRIDAZINONE UREAS AS ANTAGONISTS OF α4 INTEGRINS |
| CA2559552A1 (en) | 2004-03-23 | 2005-09-29 | F. Hoffmann-La Roche Ag | Benzyl-pyridazinone derivatives as non-nucleoside reverse transcriptase inhibitors |
| CA2563963A1 (en) | 2004-04-28 | 2005-11-10 | Pfizer Inc. | 3-heterocyclyl-4-phenyl-triazole derivatives as inhibitors of the vasopressin v1a receptor |
| CN101005842A (zh) | 2004-05-28 | 2007-07-25 | 弗特克斯药品有限公司 | 蕈毒碱性受体调节剂 |
| ES2251866B1 (es) | 2004-06-18 | 2007-06-16 | Laboratorios Almirall S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| ES2251867B1 (es) | 2004-06-21 | 2007-06-16 | Laboratorios Almirall S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| CA2580855A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| WO2006034341A2 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
| HUE039584T2 (hu) | 2004-10-29 | 2019-01-28 | Kalypsys Inc | PPAR-modulátor szulfonil-szubsztituált biciklusos vegyületek |
| JP2008523029A (ja) * | 2004-12-08 | 2008-07-03 | ソルベイ・フアーマシユーチカルズ・ベー・ブイ | 部分的ドーパミン−ｄ２受容体作動性とセロトニン再摂取阻害の組み合わせを示すアリールオキシエチルアミン誘導体 |
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| EP1902046B1 (en) | 2005-06-20 | 2009-12-02 | Schering Corporation | Piperidine derivatives useful as histamine h3 antagonists |
| JO2769B1 (en) * | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
| WO2007130383A2 (en) | 2006-04-28 | 2007-11-15 | Northwestern University | Compositions and treatments using pyridazine compounds and secretases |
| CA2606658A1 (en) * | 2006-10-13 | 2008-04-13 | Mike Tyers | Compositions and methods for treating neurological disorders or damage |
| TW200829566A (en) | 2006-12-08 | 2008-07-16 | Astrazeneca Ab | Chemical compounds |
| JO2642B1 (en) * | 2006-12-08 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| JO2849B1 (en) | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| JP2010525013A (ja) * | 2007-04-23 | 2010-07-22 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 高速解離性ドパミン２受容体アンタゴニストとしてのピリジン誘導体 |
| MX2009011416A (es) * | 2007-04-23 | 2009-11-05 | Janssen Pharmaceutica Nv | Tia(di)azoles como antagonistas del receptor de dopamina 2 de disociacion rapida. |
| CA2683111A1 (en) | 2007-04-23 | 2008-10-30 | Janssen Pharmaceutica N.V. | 4-alkoxypyridazine derivatives as fast dissociating dopamine 2 receptor antagonists |
| US8299257B2 (en) * | 2007-09-20 | 2012-10-30 | Glaxo Group Limited | Compounds which have activity at M1receptor and their uses in medicine |
| JP5417439B2 (ja) * | 2008-07-03 | 2014-02-12 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ５−ｈｔ６受容体アンタゴニストとしての置換された６−（１−ピペラジニル）−ピリダジン類 |
| CN102171189B (zh) * | 2008-07-31 | 2013-11-20 | 詹森药业有限公司 | 作为快速解离多巴胺2受体拮抗剂的哌嗪-1-基-三氟甲基取代的吡啶 |
-
2008
- 2008-04-18 CA CA002683111A patent/CA2683111A1/en not_active Abandoned
- 2008-04-18 PT PT08749604T patent/PT2148873E/pt unknown
- 2008-04-18 DK DK08749604.8T patent/DK2148873T3/da active
- 2008-04-18 RU RU2009142997/04A patent/RU2464268C2/ru active
- 2008-04-18 MX MX2009011415A patent/MX2009011415A/es active IP Right Grant
- 2008-04-18 US US12/597,166 patent/US8906921B2/en active Active
- 2008-04-18 ES ES08749604T patent/ES2393818T3/es active Active
- 2008-04-18 WO PCT/EP2008/054731 patent/WO2008128995A1/en not_active Ceased
- 2008-04-18 RS RS20120481A patent/RS52518B/sr unknown
- 2008-04-18 KR KR1020097023941A patent/KR20100016620A/ko not_active Ceased
- 2008-04-18 SI SI200830823T patent/SI2148873T1/sl unknown
- 2008-04-18 PL PL08749604T patent/PL2148873T3/pl unknown
- 2008-04-18 CN CN200880012952A patent/CN101663292A/zh active Pending
- 2008-04-18 HR HRP20120913AT patent/HRP20120913T1/hr unknown
- 2008-04-18 AU AU2008240728A patent/AU2008240728B2/en not_active Ceased
- 2008-04-18 EP EP08749604A patent/EP2148873B1/en active Active
- 2008-04-18 JP JP2010504647A patent/JP5431305B2/ja active Active
-
2009
- 2009-10-21 IL IL201663A patent/IL201663A/en active IP Right Grant
-
2012
- 2012-11-28 CY CY20121101154T patent/CY1113820T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2148873A1 (en) | 2010-02-03 |
| US8906921B2 (en) | 2014-12-09 |
| ES2393818T3 (es) | 2012-12-28 |
| PT2148873E (pt) | 2012-11-20 |
| IL201663A0 (en) | 2010-05-31 |
| JP2010525014A (ja) | 2010-07-22 |
| RU2009142997A (ru) | 2011-05-27 |
| CA2683111A1 (en) | 2008-10-30 |
| SI2148873T1 (sl) | 2013-01-31 |
| US20100063058A1 (en) | 2010-03-11 |
| AU2008240728A1 (en) | 2008-10-30 |
| AU2008240728B2 (en) | 2013-01-10 |
| MX2009011415A (es) | 2009-11-05 |
| EP2148873B1 (en) | 2012-08-29 |
| RU2464268C2 (ru) | 2012-10-20 |
| WO2008128995A1 (en) | 2008-10-30 |
| KR20100016620A (ko) | 2010-02-12 |
| RS52518B (sr) | 2013-04-30 |
| CY1113820T1 (el) | 2016-10-05 |
| CN101663292A (zh) | 2010-03-03 |
| JP5431305B2 (ja) | 2014-03-05 |
| DK2148873T3 (da) | 2012-11-26 |
| HRP20120913T1 (hr) | 2012-12-31 |
| IL201663A (en) | 2013-05-30 |
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