CY1105091T1 - Αντικατεστημενες ενωσεις 2-αρυλοβενζαζολιου και η χρηση τους σαν παραγοντες κατα των ογκων - Google Patents

Αντικατεστημενες ενωσεις 2-αρυλοβενζαζολιου και η χρηση τους σαν παραγοντες κατα των ογκων

Info

Publication number
CY1105091T1
CY1105091T1 CY20061100982T CY061100982T CY1105091T1 CY 1105091 T1 CY1105091 T1 CY 1105091T1 CY 20061100982 T CY20061100982 T CY 20061100982T CY 061100982 T CY061100982 T CY 061100982T CY 1105091 T1 CY1105091 T1 CY 1105091T1
Authority
CY
Cyprus
Prior art keywords
substituted
compounds
arylobenzole
tumor agents
amino acid
Prior art date
Application number
CY20061100982T
Other languages
English (en)
Inventor
Malcolm Francis Graham Stevens
Tracey Dawn Poole
Andrew David Westwell
Ian Paul Hutchinson
Mei-Sze Chua
Original Assignee
Cancer Research Technology Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Research Technology Limited filed Critical Cancer Research Technology Limited
Publication of CY1105091T1 publication Critical patent/CY1105091T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Αντικατεστημένες ενώσεις 2-αρυλοβενζαζολίου του τύπου (I) όπου το Χ αντιπροσωπεύει S ή Ο και το Q αντιπροσωπεύει ένα άμεσο δεσμό, -CH2- ή -CH=CH-, επιδεικνύουν επιλεκτική αντι-πολλαπλασιαστική δράση σε σχέση με κύτταρα όγκου θηλαστικών. Τουλάχιστον σε προτιμητέες ενσωματώσεις, ο δακτύλιος του βενζενίου του πυρήνα του βενζαζολίου έχει ένα αλογονο-αντικαταστάτη, κατά προτίμηση φθόριο, και μια 2-φαινυλο-ομάδα έχει ένα 4'-αμινο-αντικαταστάτη ο οποίος μπορεί να συζευχθεί με ένα αμινοξύ για να παρασχεθεί ένα υδατοδιαλυτό αμιδικό προφάρμακο του αμινοξέος ή άλας του.
CY20061100982T 1999-08-20 2006-07-17 Αντικατεστημενες ενωσεις 2-αρυλοβενζαζολιου και η χρηση τους σαν παραγοντες κατα των ογκων CY1105091T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9919673.5A GB9919673D0 (en) 1999-08-20 1999-08-20 2-Arlybenzazole compounds
PCT/GB2000/003210 WO2001014354A1 (en) 1999-08-20 2000-08-21 Substituted 2-arylbenzazole compounds and their use as antitumour agents

Publications (1)

Publication Number Publication Date
CY1105091T1 true CY1105091T1 (el) 2009-11-04

Family

ID=10859458

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061100982T CY1105091T1 (el) 1999-08-20 2006-07-17 Αντικατεστημενες ενωσεις 2-αρυλοβενζαζολιου και η χρηση τους σαν παραγοντες κατα των ογκων

Country Status (13)

Country Link
US (1) US6858633B1 (el)
EP (1) EP1204650B1 (el)
JP (1) JP2003507462A (el)
AT (1) ATE323686T1 (el)
AU (1) AU783360B2 (el)
CA (1) CA2382406C (el)
CY (1) CY1105091T1 (el)
DE (1) DE60027435T2 (el)
DK (1) DK1204650T3 (el)
ES (1) ES2263483T3 (el)
GB (1) GB9919673D0 (el)
PT (1) PT1204650E (el)
WO (1) WO2001014354A1 (el)

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* Cited by examiner, † Cited by third party
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US7270800B2 (en) 2000-08-24 2007-09-18 University Of Pittsburgh Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
PL215711B1 (pl) * 2000-08-24 2014-01-31 Univ Pittsburgh Nowe zwiazki pochodne tioflawiny, sposób syntezy zwiazków i ich zastosowanie, kompozycja farmaceutyczna zawierajaca zwiazki i zastosowanie kompozycji
JP2005523903A (ja) * 2002-02-13 2005-08-11 アメルシャム・パブリック・リミテッド・カンパニー アミロイド斑の生体内撮像用のベンゾチアゾール誘導体
KR20050033052A (ko) * 2002-07-01 2005-04-08 메르크 파텐트 게엠베하 중합가능한 발광성 화합물 및 혼합물, 발광성 중합체 물질및 이들의 용도
PT1988397E (pt) 2002-12-19 2011-12-02 Scripps Research Inst Composições e utilizações para estabilização da transtirretina e inibição do enrolamento
GB0229686D0 (en) 2002-12-20 2003-01-29 Amersham Plc Solid-phase fluorination of benzothiazoles
PL1611115T3 (pl) * 2003-03-14 2013-01-31 Univ Pittsburgh Commonwealth Sys Higher Education Związki pochodne benzotiazolu, kompozycje i zastosowania
CA2438032C (en) * 2003-03-14 2013-05-07 University Of Pittsburgh Benzothiazole derivative compounds, compositions and uses
US8236282B2 (en) * 2003-08-22 2012-08-07 University of Pittsburgh—of the Commonwealth System of Higher Education Benzothiazole derivative compounds, compositions and uses
WO2005113523A1 (en) 2004-05-20 2005-12-01 Foldrx Pharmaceuticals, Inc. 2-((hetero) aryl)-benzoxazole compounds and derivatives, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding
WO2007070173A2 (en) 2005-10-31 2007-06-21 Merck & Co., Inc. Cetp inhibitors
EP2808020A1 (en) * 2006-04-21 2014-12-03 The Government Of The United States, As Represented by The Secretary Of Health And Human Services Beta-Amyloid Pet Imaging Agents
AU2008266957A1 (en) 2007-06-20 2008-12-24 Merck Sharp & Dohme Corp. CETP inhibitors derived from benzoxazole arylamides
CA2689575A1 (en) 2007-06-20 2008-12-24 Merck Sharp & Dohme Corp. Cetp inhibitors derived from benzoxazole arylamides
US8436028B2 (en) 2007-06-20 2013-05-07 Merck Sharp & Dohme Corp CETP inhibitors derived from benzoxazole arylamides
WO2009027452A2 (en) * 2007-08-30 2009-03-05 Ge Healthcare Limited Radiopharmaceutical composition
EP3263136A1 (en) 2010-10-12 2018-01-03 Mayo Foundation for Medical Education and Research Imaging of meningiomas using stilbene, or biphenylalkyne derivatives
US8592603B2 (en) * 2011-02-22 2013-11-26 Kaohsiung Medical University Synthesis of 2-(4-aminophenyl) benzothiazole derivatives and use thereof
JP5869677B2 (ja) 2011-09-16 2016-02-24 ファイザー・インク トランスサイレチン解離阻害剤の固体形態
WO2014004664A2 (en) 2012-06-27 2014-01-03 Mayo Foundation For Medical Education And Research Treatment of meningiomas using phenylbenzothiazole, stilbene, biphenylalkyne, or pyridine derivatives
JP5965499B2 (ja) * 2012-12-25 2016-08-03 日本曹達株式会社 ハロゲン化アニリンおよびその製造方法
WO2015127548A1 (en) * 2014-02-28 2015-09-03 The Royal Institution For The Advancement Of Learning / Mcgill University Tc-ptp inhibitors as apc activators for immunotherapy
JP6618550B2 (ja) * 2015-05-09 2019-12-11 江▲蘇▼新元素医▲薬▼科技有限公司 乳癌の予防又は治療用の化合物
CN111170963B (zh) * 2018-11-12 2023-05-23 江苏新元素医药科技有限公司 4-(苯并硒唑-2-基)芳胺类化合物治疗胃癌的用途
CN111170962B (zh) * 2018-11-12 2023-05-23 江苏新元素医药科技有限公司 4-(苯并硒唑-2-基)芳胺类化合物治疗肠癌的用途
CN111166744A (zh) * 2018-11-12 2020-05-19 诺丁汉大学 4-(苯并噻唑-2-基)芳胺类化合物治疗胃癌的用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU37546A1 (el) * 1958-08-22
US3401048A (en) 1964-06-22 1968-09-10 Mitsui Kagaku Kogyo Kabushiki 2-styrylazole optical brightener
DE2333378A1 (de) 1973-06-30 1975-01-23 Basf Ag Neue verbindungen der benzoxazol- und der benzthiazolreihe und farbbildner fuer kopierverfahren
GB9317949D0 (en) 1993-08-28 1993-10-13 Stevens Malcolm F G Benzothiazole compounds
GB9503946D0 (en) 1995-02-28 1995-04-19 Cancer Res Campaign Tech Benzazole compounds
JPH1160573A (ja) 1997-08-22 1999-03-02 Nippon Kayaku Co Ltd トリアジン誘導体及びテロメラーゼ阻害剤

Also Published As

Publication number Publication date
AU6708500A (en) 2001-03-19
DE60027435D1 (de) 2006-05-24
DK1204650T3 (da) 2006-08-21
WO2001014354A1 (en) 2001-03-01
DE60027435T2 (de) 2007-04-19
US6858633B1 (en) 2005-02-22
ATE323686T1 (de) 2006-05-15
AU783360B2 (en) 2005-10-20
GB9919673D0 (en) 1999-10-20
CA2382406C (en) 2009-05-19
PT1204650E (pt) 2006-08-31
EP1204650B1 (en) 2006-04-19
JP2003507462A (ja) 2003-02-25
ES2263483T3 (es) 2006-12-16
EP1204650A1 (en) 2002-05-15
CA2382406A1 (en) 2001-03-01

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