DE60027435D1 - Substituierte 2-arylbenzazole und ihre verwendung als antitumorale mittel - Google Patents

Substituierte 2-arylbenzazole und ihre verwendung als antitumorale mittel

Info

Publication number
DE60027435D1
DE60027435D1 DE60027435T DE60027435T DE60027435D1 DE 60027435 D1 DE60027435 D1 DE 60027435D1 DE 60027435 T DE60027435 T DE 60027435T DE 60027435 T DE60027435 T DE 60027435T DE 60027435 D1 DE60027435 D1 DE 60027435D1
Authority
DE
Germany
Prior art keywords
substituted
arylbenzazole
antitumorous
amino acid
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60027435T
Other languages
English (en)
Other versions
DE60027435T2 (de
Inventor
Francis Stevens
Dawn Poole
David Westwell
Paul Hutchinson
Mei-Sze Chua
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cancer Research Technology Ltd
Original Assignee
Cancer Research Ventures Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Research Ventures Ltd filed Critical Cancer Research Ventures Ltd
Application granted granted Critical
Publication of DE60027435D1 publication Critical patent/DE60027435D1/de
Publication of DE60027435T2 publication Critical patent/DE60027435T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE60027435T 1999-08-20 2000-08-21 Substituierte 2-arylbenzazole und ihre verwendung als antitumorale mittel Expired - Lifetime DE60027435T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9919673 1999-08-20
GBGB9919673.5A GB9919673D0 (en) 1999-08-20 1999-08-20 2-Arlybenzazole compounds
PCT/GB2000/003210 WO2001014354A1 (en) 1999-08-20 2000-08-21 Substituted 2-arylbenzazole compounds and their use as antitumour agents

Publications (2)

Publication Number Publication Date
DE60027435D1 true DE60027435D1 (de) 2006-05-24
DE60027435T2 DE60027435T2 (de) 2007-04-19

Family

ID=10859458

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60027435T Expired - Lifetime DE60027435T2 (de) 1999-08-20 2000-08-21 Substituierte 2-arylbenzazole und ihre verwendung als antitumorale mittel

Country Status (13)

Country Link
US (1) US6858633B1 (de)
EP (1) EP1204650B1 (de)
JP (1) JP2003507462A (de)
AT (1) ATE323686T1 (de)
AU (1) AU783360B2 (de)
CA (1) CA2382406C (de)
CY (1) CY1105091T1 (de)
DE (1) DE60027435T2 (de)
DK (1) DK1204650T3 (de)
ES (1) ES2263483T3 (de)
GB (1) GB9919673D0 (de)
PT (1) PT1204650E (de)
WO (1) WO2001014354A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7270800B2 (en) 2000-08-24 2007-09-18 University Of Pittsburgh Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
ES2536449T3 (es) * 2000-08-24 2015-05-25 University Of Pittsburgh Of The Commonwealth System Of Higher Education Derivados de tioflavina para uso en diagnosis de la enfermedad de Alzheimer
US20050123477A1 (en) * 2002-02-13 2005-06-09 Ian Wilson Benzothiazole derivatives for in vivo imaging of amloid plaques
KR20050033052A (ko) * 2002-07-01 2005-04-08 메르크 파텐트 게엠베하 중합가능한 발광성 화합물 및 혼합물, 발광성 중합체 물질및 이들의 용도
DK1587821T3 (da) 2002-12-19 2008-11-10 Scripps Research Inst Sammensætninger og fremgangsmåder til stabilisering af transthyretin og inhibering af transthyretin-fejlfolding
GB0229686D0 (en) 2002-12-20 2003-01-29 Amersham Plc Solid-phase fluorination of benzothiazoles
CN102532055B (zh) * 2003-03-14 2016-05-11 匹兹堡大学联邦制高等教育 苯并噻唑衍生物化合物、组合物及用途
CA2438032C (en) * 2003-03-14 2013-05-07 University Of Pittsburgh Benzothiazole derivative compounds, compositions and uses
US8236282B2 (en) 2003-08-22 2012-08-07 University of Pittsburgh—of the Commonwealth System of Higher Education Benzothiazole derivative compounds, compositions and uses
US7868033B2 (en) 2004-05-20 2011-01-11 Foldrx Pharmaceuticals, Inc. Compounds, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding
ATE533485T1 (de) 2005-10-31 2011-12-15 Merck Sharp & Dohme Cetp-inhibitoren
EP2021340B1 (de) * 2006-04-21 2014-07-23 The Government Of The United States, As Represented by The Secretary Of Health And Human Services Beta-amyloid-pet-bildgebungsmittel
JP2010530417A (ja) 2007-06-20 2010-09-09 メルク・シャープ・エンド・ドーム・コーポレイション ベンゾオキサゾールアリールアミドから誘導されたｃｅｔｐ阻害剤
WO2008156715A1 (en) 2007-06-20 2008-12-24 Merck & Co., Inc. Cetp inhibitors derived from benzoxazole arylamides
CA2689525A1 (en) 2007-06-20 2008-12-24 Merck Sharp & Dohme Corp. Cetp inhibitors derived from benzoxazole arylamides
DK2182988T3 (da) * 2007-08-30 2014-05-26 Ge Healthcare Ltd Radiofarmaceutisk præparat
EP2627361B1 (de) 2010-10-12 2017-09-20 Mayo Foundation For Medical Education And Research Abbildung von meningiomen mit phenylbenzothiazol-, stilben- oder biphenylalkynderivaten
US8592603B2 (en) * 2011-02-22 2013-11-26 Kaohsiung Medical University Synthesis of 2-(4-aminophenyl) benzothiazole derivatives and use thereof
US9249112B2 (en) 2011-09-16 2016-02-02 Pfizer Inc. Solid forms of a transthyretin dissociation inhibitor
US20150157744A1 (en) 2012-06-27 2015-06-11 Geoffrey B. Johnson Treatment of meningiomas using phenylbenzothiazole, stilbene, biphenylalkyne, or pyridine derivatives
CN104884424B (zh) * 2012-12-25 2016-08-24 日本曹达株式会社 卤代苯胺及其制造方法
CA2977839C (en) * 2014-02-28 2022-07-26 The Royal Institution For The Advancement Of Learning / Mcgill University Tc-ptp inhibitors as apc activators for immunotherapy
JP6618550B2 (ja) * 2015-05-09 2019-12-11 江▲蘇▼新元素医▲薬▼科技有限公司 乳癌の予防又は治療用の化合物
CN111170962B (zh) * 2018-11-12 2023-05-23 江苏新元素医药科技有限公司 4-(苯并硒唑-2-基)芳胺类化合物治疗肠癌的用途
CN111170963B (zh) * 2018-11-12 2023-05-23 江苏新元素医药科技有限公司 4-(苯并硒唑-2-基)芳胺类化合物治疗胃癌的用途
CN111166744B (zh) * 2018-11-12 2024-06-25 诺丁汉大学 4-(苯并噻唑-2-基)芳胺类化合物治疗胃癌的用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE581862A (de) * 1958-08-22
US3401048A (en) * 1964-06-22 1968-09-10 Mitsui Kagaku Kogyo Kabushiki 2-styrylazole optical brightener
DE2333378A1 (de) * 1973-06-30 1975-01-23 Basf Ag Neue verbindungen der benzoxazol- und der benzthiazolreihe und farbbildner fuer kopierverfahren
GB9317949D0 (en) 1993-08-28 1993-10-13 Stevens Malcolm F G Benzothiazole compounds
GB9503946D0 (en) * 1995-02-28 1995-04-19 Cancer Res Campaign Tech Benzazole compounds
JPH1160573A (ja) 1997-08-22 1999-03-02 Nippon Kayaku Co Ltd トリアジン誘導体及びテロメラーゼ阻害剤

Also Published As

Publication number Publication date
DE60027435T2 (de) 2007-04-19
WO2001014354A1 (en) 2001-03-01
GB9919673D0 (en) 1999-10-20
JP2003507462A (ja) 2003-02-25
CA2382406C (en) 2009-05-19
CY1105091T1 (el) 2009-11-04
AU783360B2 (en) 2005-10-20
ATE323686T1 (de) 2006-05-15
AU6708500A (en) 2001-03-19
ES2263483T3 (es) 2006-12-16
DK1204650T3 (da) 2006-08-21
EP1204650A1 (de) 2002-05-15
CA2382406A1 (en) 2001-03-01
EP1204650B1 (de) 2006-04-19
US6858633B1 (en) 2005-02-22
PT1204650E (pt) 2006-08-31

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Legal Events

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8327 Change in the person/name/address of the patent owner

Owner name: CANCER RESEARCH TECHNOLOGY LTD., LONDON, GB

8364 No opposition during term of opposition