DK1204650T3 - Substituerede 2-arylbenzazol-forbindelser og anvendelse deraf som antitumormidler - Google Patents

Substituerede 2-arylbenzazol-forbindelser og anvendelse deraf som antitumormidler

Info

Publication number
DK1204650T3
DK1204650T3 DK00954726T DK00954726T DK1204650T3 DK 1204650 T3 DK1204650 T3 DK 1204650T3 DK 00954726 T DK00954726 T DK 00954726T DK 00954726 T DK00954726 T DK 00954726T DK 1204650 T3 DK1204650 T3 DK 1204650T3
Authority
DK
Denmark
Prior art keywords
substituted
compounds
antitumor agents
amino acid
substituent
Prior art date
Application number
DK00954726T
Other languages
Danish (da)
English (en)
Inventor
Malcolm Francis Graham Stevens
Tracey Dawn Poole
Andrew David Westwell
Ian Paul Hutchinson
Mei-Sze Chua
Original Assignee
Cancer Rec Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Rec Tech Ltd filed Critical Cancer Rec Tech Ltd
Application granted granted Critical
Publication of DK1204650T3 publication Critical patent/DK1204650T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK00954726T 1999-08-20 2000-08-21 Substituerede 2-arylbenzazol-forbindelser og anvendelse deraf som antitumormidler DK1204650T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9919673.5A GB9919673D0 (en) 1999-08-20 1999-08-20 2-Arlybenzazole compounds

Publications (1)

Publication Number Publication Date
DK1204650T3 true DK1204650T3 (da) 2006-08-21

Family

ID=10859458

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00954726T DK1204650T3 (da) 1999-08-20 2000-08-21 Substituerede 2-arylbenzazol-forbindelser og anvendelse deraf som antitumormidler

Country Status (13)

Country Link
US (1) US6858633B1 (de)
EP (1) EP1204650B1 (de)
JP (1) JP2003507462A (de)
AT (1) ATE323686T1 (de)
AU (1) AU783360B2 (de)
CA (1) CA2382406C (de)
CY (1) CY1105091T1 (de)
DE (1) DE60027435T2 (de)
DK (1) DK1204650T3 (de)
ES (1) ES2263483T3 (de)
GB (1) GB9919673D0 (de)
PT (1) PT1204650E (de)
WO (1) WO2001014354A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5022554B2 (ja) * 2000-08-24 2012-09-12 ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション アルツハイマー病の生前診断ならびにアミロイド沈着物のインビボ画像化および予防に用いるためのチオフラビン誘導体
US7270800B2 (en) 2000-08-24 2007-09-18 University Of Pittsburgh Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
US20050123477A1 (en) * 2002-02-13 2005-06-09 Ian Wilson Benzothiazole derivatives for in vivo imaging of amloid plaques
US20050244718A1 (en) * 2002-07-01 2005-11-03 Eike Poetsch Polymerizable, luminescent compounds and mixtures, luminescent polymer materials and their use
CA2510455C (en) 2002-12-19 2013-03-12 The Scripps Research Institute Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding
GB0229686D0 (en) 2002-12-20 2003-01-29 Amersham Plc Solid-phase fluorination of benzothiazoles
DK1611115T3 (da) * 2003-03-14 2012-11-26 Univ Pittsburgh Benzothiazolderivatforbindelser, sammensætninger og anvendelser deraf
CA2438032C (en) * 2003-03-14 2013-05-07 University Of Pittsburgh Benzothiazole derivative compounds, compositions and uses
US8236282B2 (en) 2003-08-22 2012-08-07 University of Pittsburgh—of the Commonwealth System of Higher Education Benzothiazole derivative compounds, compositions and uses
EP2314584A1 (de) 2004-05-20 2011-04-27 Foldrx Pharmaceuticals, Inc. 2-(heteroaryl)-Benzoxazol-Verbindungen und Derivate, Zusammensetzungen und Verfahren zur Stabilisierung von Transthyretin und zur Hemmung von Transthyretin-Fehlfaltung
CA2627722A1 (en) 2005-10-31 2007-06-21 Merck & Co., Inc. Cetp inhibitors
EP2021340B1 (de) * 2006-04-21 2014-07-23 The Government Of The United States, As Represented by The Secretary Of Health And Human Services Beta-amyloid-pet-bildgebungsmittel
US8293721B2 (en) 2007-06-20 2012-10-23 Merck Sharpe & Dohme Corp. CETP inhibitors derived from benzoxazole arylamides
WO2008156715A1 (en) 2007-06-20 2008-12-24 Merck & Co., Inc. Cetp inhibitors derived from benzoxazole arylamides
US8436028B2 (en) 2007-06-20 2013-05-07 Merck Sharp & Dohme Corp CETP inhibitors derived from benzoxazole arylamides
EP2182988B1 (de) * 2007-08-30 2014-04-16 GE Healthcare Limited Radiopharmazeutische zusammensetzung
US9259495B2 (en) * 2010-10-12 2016-02-16 Mayo Foundation For Medical Education And Research Imaging of meningiomas using phenylbenzothiazole, stilbene, or biphenylalkyne derivatives
US8592603B2 (en) * 2011-02-22 2013-11-26 Kaohsiung Medical University Synthesis of 2-(4-aminophenyl) benzothiazole derivatives and use thereof
WO2013038351A1 (en) 2011-09-16 2013-03-21 Pfizer Inc. Solid forms of a transthyretin dissociation inhibitor
WO2014004664A2 (en) 2012-06-27 2014-01-03 Mayo Foundation For Medical Education And Research Treatment of meningiomas using phenylbenzothiazole, stilbene, biphenylalkyne, or pyridine derivatives
WO2014103947A1 (ja) * 2012-12-25 2014-07-03 日本曹達株式会社 ハロゲン化アニリンおよびその製造方法
WO2015127548A1 (en) * 2014-02-28 2015-09-03 The Royal Institution For The Advancement Of Learning / Mcgill University Tc-ptp inhibitors as apc activators for immunotherapy
EP3296294B1 (de) * 2015-05-09 2020-02-12 Jiangsu Atom Bioscience And Pharmaceutical Co., Ltd Verfahren zur behandlung oder prävention von brustkrebs
CN111170962B (zh) * 2018-11-12 2023-05-23 江苏新元素医药科技有限公司 4-(苯并硒唑-2-基)芳胺类化合物治疗肠癌的用途
CN111170963B (zh) * 2018-11-12 2023-05-23 江苏新元素医药科技有限公司 4-(苯并硒唑-2-基)芳胺类化合物治疗胃癌的用途
CN111166744B (zh) * 2018-11-12 2024-06-25 诺丁汉大学 4-(苯并噻唑-2-基)芳胺类化合物治疗胃癌的用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL242547A (de) * 1958-08-22
US3401048A (en) * 1964-06-22 1968-09-10 Mitsui Kagaku Kogyo Kabushiki 2-styrylazole optical brightener
DE2333378A1 (de) * 1973-06-30 1975-01-23 Basf Ag Neue verbindungen der benzoxazol- und der benzthiazolreihe und farbbildner fuer kopierverfahren
GB9317949D0 (en) * 1993-08-28 1993-10-13 Stevens Malcolm F G Benzothiazole compounds
GB9503946D0 (en) * 1995-02-28 1995-04-19 Cancer Res Campaign Tech Benzazole compounds
JPH1160573A (ja) * 1997-08-22 1999-03-02 Nippon Kayaku Co Ltd トリアジン誘導体及びテロメラーゼ阻害剤

Also Published As

Publication number Publication date
EP1204650A1 (de) 2002-05-15
DE60027435T2 (de) 2007-04-19
AU783360B2 (en) 2005-10-20
PT1204650E (pt) 2006-08-31
CY1105091T1 (el) 2009-11-04
JP2003507462A (ja) 2003-02-25
CA2382406A1 (en) 2001-03-01
AU6708500A (en) 2001-03-19
ATE323686T1 (de) 2006-05-15
EP1204650B1 (de) 2006-04-19
GB9919673D0 (en) 1999-10-20
ES2263483T3 (es) 2006-12-16
DE60027435D1 (de) 2006-05-24
CA2382406C (en) 2009-05-19
WO2001014354A1 (en) 2001-03-01
US6858633B1 (en) 2005-02-22

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