AR052332A1 - Derivados de benzdioxanpiperazina con una afinidad combinada para receptores de dopamina-d2 y sitios de reabsorcion de serotonina, composiciones farmaceuticas que los contienen y su empleo como medicamentos para el tratamiento de enfermedades del snc - Google Patents
Derivados de benzdioxanpiperazina con una afinidad combinada para receptores de dopamina-d2 y sitios de reabsorcion de serotonina, composiciones farmaceuticas que los contienen y su empleo como medicamentos para el tratamiento de enfermedades del sncInfo
- Publication number
- AR052332A1 AR052332A1 ARP050105088A ARP050105088A AR052332A1 AR 052332 A1 AR052332 A1 AR 052332A1 AR P050105088 A ARP050105088 A AR P050105088A AR P050105088 A ARP050105088 A AR P050105088A AR 052332 A1 AR052332 A1 AR 052332A1
- Authority
- AR
- Argentina
- Prior art keywords
- benzdioxanpiperazine
- dopamine
- receptors
- derivatives
- treatment
- Prior art date
Links
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title abstract 3
- 102000004980 Dopamine D2 Receptors Human genes 0.000 title abstract 2
- 108090001111 Dopamine D2 Receptors Proteins 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- 150000001204 N-oxides Chemical class 0.000 abstract 2
- 229910052736 halogen Chemical group 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- SADQVAVFGNTEOD-UHFFFAOYSA-N indalpine Chemical class C=1NC2=CC=CC=C2C=1CCC1CCNCC1 SADQVAVFGNTEOD-UHFFFAOYSA-N 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000009103 reabsorption Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Derivados de 3-(2-piperidin-4-il-etil)-1H-indol con un doble modo de accion: inhibicion de la reabsorcion de la serotonina y afinidad para receptores de dopamina-D2 y al uso de un compuesto revelado en ésta para la fabricacion de un medicamento para el tratamiento de enfermedades del SNC. Reivindicacion 1: Compuestos derivados de benzdioxanpiperazina, caracterizados porque tienen la formula general (1), donde Y es CH2, O o S; X es CH2, O, NH o S; m es 1, 3, 5 o 6; n es 0, 1, 2 o 3; R4 es hidrogeno o halogeno; R2 y R3 son independientemente H o alquilo C1-3, o R2+R3 representa un grupo -(CH2)p- donde p tiene el valor 3, 4 o 5; y R1 es alquilo C1-3, alcoxi C1-3, halogeno o ciano, o, cuando R1 se encuentra en la posicion 7 del grupo indol, R1+R3 puede representar un grupo -(CH2)q- donde q tiene el valor 2, 3 o 4, y tautomeros, estereoisomeros y N-oxidos de los mismos, como así también las sales, hidratos y solvatos farmacologicamente aceptables de dichos compuestos de formula (1) y sus tautomeros, estereoisomeros y N-oxidos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04106361 | 2004-12-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR052332A1 true AR052332A1 (es) | 2007-03-14 |
Family
ID=34930008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050105088A AR052332A1 (es) | 2004-12-07 | 2005-12-06 | Derivados de benzdioxanpiperazina con una afinidad combinada para receptores de dopamina-d2 y sitios de reabsorcion de serotonina, composiciones farmaceuticas que los contienen y su empleo como medicamentos para el tratamiento de enfermedades del snc |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1824486B1 (es) |
| JP (1) | JP2008523028A (es) |
| KR (1) | KR20070087644A (es) |
| CN (1) | CN101072563A (es) |
| AR (1) | AR052332A1 (es) |
| AT (1) | ATE425754T1 (es) |
| AU (1) | AU2005313388A1 (es) |
| BR (1) | BRPI0518372A2 (es) |
| CA (1) | CA2587940A1 (es) |
| MX (1) | MX2007006758A (es) |
| RU (1) | RU2007125691A (es) |
| SA (1) | SA05260390B1 (es) |
| TW (1) | TW200631952A (es) |
| WO (1) | WO2006061374A1 (es) |
| ZA (1) | ZA200704156B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8063062B2 (en) | 2006-12-20 | 2011-11-22 | Solvay Pharmaceuticals B.V. | Compounds with a combination of cannabinoid-CB1 antagonism and acetylcholinesterase inhibition |
| WO2008084057A1 (en) * | 2007-01-10 | 2008-07-17 | Solvay Pharmaceuticals B.V. | Compounds with a combination of cannabinoid-cb1 antagonism and serotonin reuptake inhibition |
| US8138174B2 (en) | 2007-01-10 | 2012-03-20 | Solvay Pharmaceuticals B.V. | Compounds with a combination of cannabinoid CB1 antagonism and serotonin reuptake inhibition |
| KR101387970B1 (ko) | 2011-04-20 | 2014-04-25 | 인제대학교 산학협력단 | 암 예방 및 치료용 조성물 및 건강기능식품 |
| US9598401B2 (en) | 2013-07-29 | 2017-03-21 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use thereof |
| CN110041318B (zh) * | 2018-01-17 | 2022-07-29 | 中国科学院上海药物研究所 | 一类多巴胺d5受体激动剂及其制备和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8830312D0 (en) * | 1988-12-28 | 1989-02-22 | Lundbeck & Co As H | Heterocyclic compounds |
| KR100545329B1 (ko) * | 1997-07-25 | 2006-01-24 | 하. 룬트벡 아크티에 셀스카브 | 인돌 및 2,3-디히드로인돌 유도체, 그들의 제조방법 및 사용 |
| DK1212320T3 (da) * | 1999-08-23 | 2005-08-08 | Solvay Pharm Bv | Phenylpiperazinderivater som inhibitorer for genoptag af serotonin |
| DE10259244A1 (de) * | 2002-12-17 | 2004-07-01 | Merck Patent Gmbh | N-(Indolethyl-)cycloamin-Verbindungen |
-
2005
- 2005-12-06 EP EP05817508A patent/EP1824486B1/en active Active
- 2005-12-06 AT AT05817508T patent/ATE425754T1/de not_active IP Right Cessation
- 2005-12-06 BR BRPI0518372-3A patent/BRPI0518372A2/pt not_active IP Right Cessation
- 2005-12-06 RU RU2007125691/04A patent/RU2007125691A/ru not_active Application Discontinuation
- 2005-12-06 CA CA002587940A patent/CA2587940A1/en not_active Abandoned
- 2005-12-06 SA SA05260390A patent/SA05260390B1/ar unknown
- 2005-12-06 JP JP2007544894A patent/JP2008523028A/ja not_active Withdrawn
- 2005-12-06 AR ARP050105088A patent/AR052332A1/es not_active Application Discontinuation
- 2005-12-06 AU AU2005313388A patent/AU2005313388A1/en not_active Abandoned
- 2005-12-06 MX MX2007006758A patent/MX2007006758A/es active IP Right Grant
- 2005-12-06 TW TW094142943A patent/TW200631952A/zh unknown
- 2005-12-06 KR KR1020077015622A patent/KR20070087644A/ko not_active Application Discontinuation
- 2005-12-06 WO PCT/EP2005/056503 patent/WO2006061374A1/en active Application Filing
- 2005-12-06 CN CNA200580042069XA patent/CN101072563A/zh active Pending
-
2007
- 2007-05-22 ZA ZA200704156A patent/ZA200704156B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0518372A2 (pt) | 2008-11-18 |
| JP2008523028A (ja) | 2008-07-03 |
| KR20070087644A (ko) | 2007-08-28 |
| ZA200704156B (en) | 2008-05-28 |
| ATE425754T1 (de) | 2009-04-15 |
| EP1824486B1 (en) | 2009-03-18 |
| CN101072563A (zh) | 2007-11-14 |
| AU2005313388A1 (en) | 2006-06-15 |
| CA2587940A1 (en) | 2006-06-15 |
| RU2007125691A (ru) | 2009-01-20 |
| SA05260390B1 (ar) | 2009-04-01 |
| EP1824486A1 (en) | 2007-08-29 |
| TW200631952A (en) | 2006-09-16 |
| MX2007006758A (es) | 2007-11-09 |
| WO2006061374A1 (en) | 2006-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |