MA31258B1 - Composes organiques et leurs utilisations - Google Patents
Composes organiques et leurs utilisationsInfo
- Publication number
- MA31258B1 MA31258B1 MA32227A MA32227A MA31258B1 MA 31258 B1 MA31258 B1 MA 31258B1 MA 32227 A MA32227 A MA 32227A MA 32227 A MA32227 A MA 32227A MA 31258 B1 MA31258 B1 MA 31258B1
- Authority
- MA
- Morocco
- Prior art keywords
- organic compounds
- relating
- neoplasia
- diagnosis
- cancer
- Prior art date
Links
- 150000002894 organic compounds Chemical class 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 241000289669 Erinaceus europaeus Species 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 230000009826 neoplastic cell growth Effects 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 230000005740 tumor formation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
Abstract
La présente invention porte sur des composés se rapportant au diagnostic et au traitement de pathologies concernant la voie de hedgehog, comprenant mais sans y être limitées, la formation de tumeur, le cancer, la néoplasie, et les troubles hyperprolifératifs non malins. De façon précise, l'invention porte sur les composés représentés par la formule (i).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89499107P | 2007-03-15 | 2007-03-15 | |
PCT/EP2008/053040 WO2008110611A1 (fr) | 2007-03-15 | 2008-03-13 | Composés organiques et leurs utilisations |
Publications (1)
Publication Number | Publication Date |
---|---|
MA31258B1 true MA31258B1 (fr) | 2010-03-01 |
Family
ID=39472520
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA32227A MA31258B1 (fr) | 2007-03-15 | 2009-09-24 | Composes organiques et leurs utilisations |
Country Status (33)
Country | Link |
---|---|
US (1) | US8536168B2 (fr) |
EP (1) | EP2137162B1 (fr) |
JP (1) | JP5550352B2 (fr) |
KR (1) | KR101473504B1 (fr) |
CN (1) | CN101657430B (fr) |
AR (1) | AR065718A1 (fr) |
AU (1) | AU2008225766B2 (fr) |
BR (1) | BRPI0809193A2 (fr) |
CA (1) | CA2681162C (fr) |
CL (1) | CL2008000754A1 (fr) |
CO (1) | CO6220967A2 (fr) |
CR (1) | CR11016A (fr) |
CU (1) | CU23769B7 (fr) |
DK (1) | DK2137162T3 (fr) |
DO (1) | DOP2009000217A (fr) |
EA (1) | EA016564B1 (fr) |
EC (1) | ECSP099636A (fr) |
GE (1) | GEP20125487B (fr) |
GT (1) | GT200900244A (fr) |
IL (1) | IL200654A (fr) |
MA (1) | MA31258B1 (fr) |
MX (1) | MX2009009873A (fr) |
MY (1) | MY156814A (fr) |
NI (1) | NI200900168A (fr) |
NZ (1) | NZ579402A (fr) |
PE (1) | PE20090188A1 (fr) |
SG (1) | SG182205A1 (fr) |
SM (1) | SMP200900082B (fr) |
TN (1) | TN2009000373A1 (fr) |
TW (1) | TWI406857B (fr) |
UA (1) | UA100684C2 (fr) |
WO (1) | WO2008110611A1 (fr) |
ZA (1) | ZA200905949B (fr) |
Families Citing this family (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明(cyclopamine)類似物類 |
UA100684C2 (uk) | 2007-03-15 | 2013-01-25 | Новартіс Аг | Похідні бензилу та піридинілу як модулятори сигнального шляху hedgehog |
ES2499018T3 (es) | 2007-09-20 | 2014-09-26 | Irm Llc | Compuestos y composiciones como moduladores de la actividad de GPR119 |
AU2008345097A1 (en) | 2007-12-27 | 2009-07-09 | Infinity Pharmaceuticals, Inc. | Methods for stereoselective reduction |
US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
GEP20125664B (en) * | 2008-02-26 | 2012-10-10 | Takeda Pharmaceuticals Co | Condensed heterocyclic derivatives and application thereof |
BRPI0911618A2 (pt) * | 2008-04-29 | 2019-09-24 | Lilly Co Eli | antagonistas da via hedgehog de ftalazina dissubstituída. |
US20100041663A1 (en) * | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
CN102170873B (zh) * | 2008-10-01 | 2014-07-30 | 诺华股份有限公司 | 用于治疗与hedgehog通路有关的病症的smoothened拮抗 |
ES2418479T3 (es) * | 2008-11-03 | 2013-08-14 | Eli Lilly And Company | Antagonistas de la ruta erizo de ftalazinas disustituidas |
ES2392759T3 (es) | 2008-11-17 | 2012-12-13 | Eli Lilly And Company | Piridazina tetrasustituida como antagonistas de la vía Hedgehog. |
AU2009314288B2 (en) * | 2008-11-17 | 2013-05-02 | Eli Lilly And Company | Tetrasubstituted pyridazines hedgehog pathway antagonists |
AR077014A1 (es) * | 2009-06-19 | 2011-07-27 | Lilly Co Eli | Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer |
ES2567134T3 (es) | 2009-08-05 | 2016-04-20 | Infinity Pharmaceuticals, Inc. | Transaminación enzimática de análogos de ciclopamina |
US20110039850A1 (en) * | 2009-08-12 | 2011-02-17 | Mhairi Copland | Leukemia Treatment |
NZ598588A (en) * | 2009-08-25 | 2014-05-30 | Abraxis Bioscience Llc | Combination therapy with nanoparticle compositions of taxane and hedgehog inhibitors |
US20120232087A1 (en) * | 2009-11-18 | 2012-09-13 | Silvia Buonamici | Methods and compositions for treating solid tumors and other malignancies |
EP2571357B1 (fr) | 2010-05-21 | 2016-07-06 | Infinity Pharmaceuticals, Inc. | Composés chimiques, compositions et procédés pour modulation de kinases |
US9045445B2 (en) | 2010-06-04 | 2015-06-02 | Albany Molecular Research, Inc. | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
US9006450B2 (en) * | 2010-07-01 | 2015-04-14 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical compositions and uses thereof |
US9376447B2 (en) | 2010-09-14 | 2016-06-28 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
EP2637669A4 (fr) | 2010-11-10 | 2014-04-02 | Infinity Pharmaceuticals Inc | Composés hétérocycliques et utilisations de ceux-ci |
DK2663309T3 (en) | 2011-01-10 | 2017-06-19 | Infinity Pharmaceuticals Inc | METHODS FOR PRODUCING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES |
CN103946226A (zh) | 2011-07-19 | 2014-07-23 | 无限药品股份有限公司 | 杂环化合物及其应用 |
EP2734520B1 (fr) | 2011-07-19 | 2016-09-14 | Infinity Pharmaceuticals, Inc. | Composés hétérocycliques et leurs utilisations |
SG11201400310WA (en) | 2011-08-29 | 2014-06-27 | Infinity Pharmaceuticals Inc | Heterocyclic compounds and uses thereof |
US9630979B2 (en) | 2011-09-29 | 2017-04-25 | Infinity Pharmaceuticals, Inc. | Inhibitors of monoacylglycerol lipase and methods of their use |
WO2013079668A1 (fr) * | 2011-12-02 | 2013-06-06 | Boehringer Ingelheim International Gmbh | Dérivés de pipéridine, leurs compositions pharmaceutiques et leurs utilisations |
EA037918B1 (ru) | 2011-12-21 | 2021-06-07 | Новира Терапьютикс, Инк. | Противовирусные агенты против гепатита в |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
CR20200276A (es) | 2012-08-28 | 2021-01-27 | Janssen Sciences Ireland Uc | Sulfamoilarilamidas y su uso como medicamentos para el tratamientos de la hepatitis b (divisional exp. 2015-0059) |
PT2914296T (pt) | 2012-11-01 | 2018-10-30 | Infinity Pharmaceuticals Inc | Tratamento de cancros utilizando moduladores de isoformas de pi3-quinase |
WO2014085523A1 (fr) | 2012-11-29 | 2014-06-05 | Strasspharma Llc | Procédés de modulation de l'activité de l'hormone folliculo-stimulante |
HUE034820T2 (en) | 2013-02-28 | 2018-02-28 | Janssen Sciences Ireland Uc | Sulphamoyl arylamides and their use as medicaments for the treatment of hepatitis B |
EP2970194A1 (fr) | 2013-03-15 | 2016-01-20 | Infinity Pharmaceuticals, Inc. | Sels et formes solides d'isoquinolinones et compositions les comprenant et procédés pour les utiliser |
HUE033542T2 (en) | 2013-04-03 | 2017-12-28 | Janssen Sciences Ireland Uc | Their use as medicaments for the treatment of N-phenylcarboxamide derivatives and hepatitis B |
US9192609B2 (en) | 2013-04-17 | 2015-11-24 | Hedgepath Pharmaceuticals, Inc. | Treatment and prognostic monitoring of proliferation disorders using hedgehog pathway inhibitors |
CN105960400B (zh) | 2013-05-17 | 2019-05-31 | 爱尔兰詹森科学公司 | 氨磺酰基噻吩酰胺衍生物及其作为药物用于治疗乙型肝炎的用途 |
JO3603B1 (ar) | 2013-05-17 | 2020-07-05 | Janssen Sciences Ireland Uc | مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي |
MX2015016277A (es) | 2013-05-30 | 2016-08-11 | Infinity Pharmaceuticals Inc | Tratamiento de canceres utilizando moduladores de la isoforma pi3 cinasa. |
WO2015011281A1 (fr) | 2013-07-25 | 2015-01-29 | Janssen R&D Ireland | Dérivés de pyrrolamide à substitution glyoxamide et leur utilisation en tant que médicaments pour le traitement de l'hépatite b |
BR112016007467B1 (pt) | 2013-10-04 | 2022-09-20 | Infinity Pharmaceuticals, Inc | Compostos heterocíclicos e usos dos mesmos |
WO2015051241A1 (fr) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Composés hétérocycliques et leurs utilisations |
US20160244452A1 (en) | 2013-10-21 | 2016-08-25 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
UA117261C2 (uk) | 2013-10-23 | 2018-07-10 | ЯНССЕН САЙЄНСЕЗ АЙРЛЕНД ЮСі | Похідні карбоксаміду та їх застосування як медикаментів для лікування гепатиту b |
US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
US10392349B2 (en) | 2014-01-16 | 2019-08-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
WO2015107494A1 (fr) * | 2014-01-17 | 2015-07-23 | Novartis Ag | Dérivés de 1-(triazin-3-yl/pyridazin-3-yl)-piper(-azine)idine et compositions les contenant pour l'inhibition de l'activité de shp2 |
US10093646B2 (en) | 2014-01-17 | 2018-10-09 | Novartis Ag | 1-pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and compositions thereof for inhibiting the activity of SHP2 |
JO3517B1 (ar) | 2014-01-17 | 2020-07-05 | Novartis Ag | ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2 |
AU2015214096B2 (en) | 2014-02-05 | 2021-02-11 | Novira Therapeutics, Inc. | Combination therapy for treatment of HBV infections |
AU2015214961B2 (en) | 2014-02-06 | 2018-08-30 | Janssen Sciences Ireland Uc | Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
JP6701088B2 (ja) | 2014-03-19 | 2020-05-27 | インフィニティー ファーマシューティカルズ, インコーポレイテッド | Pi3k−ガンマ媒介障害の治療で使用するための複素環式化合物 |
US20150320754A1 (en) | 2014-04-16 | 2015-11-12 | Infinity Pharmaceuticals, Inc. | Combination therapies |
WO2015168079A1 (fr) | 2014-04-29 | 2015-11-05 | Infinity Pharmaceuticals, Inc. | Dérivés de pyrimidine ou de pyridine utiles en tant qu'inhibiteurs de pi3k |
WO2016054491A1 (fr) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Composés hétérocycliques et leurs utilisations |
CN105985319B (zh) * | 2015-02-11 | 2019-02-26 | 复旦大学 | 芳基酞嗪化合物及其制备方法和用途 |
CN105985320B (zh) * | 2015-02-11 | 2018-10-26 | 复旦大学 | 苄基酞嗪化合物及其制备方法和用途 |
CN105985321B (zh) * | 2015-02-11 | 2018-10-26 | 复旦大学 | 吡唑酞嗪化合物及其制备方法和用途 |
EP3271019A1 (fr) | 2015-03-19 | 2018-01-24 | Novira Therapeutics Inc. | Dérivés d'azocane et d'azonane, et méthodes de traitement d'infections provoquées par le virus de l'hépatite b |
JP6796638B2 (ja) | 2015-06-04 | 2020-12-09 | ペレファーム, インク.Pellepharm, Inc. | ヘッジホッグ阻害性化合物の送達のための局所的製剤及びその使用 |
EP3310779B1 (fr) | 2015-06-19 | 2019-05-08 | Novartis AG | Composés et compositions pour l'inhibition de l'activité de shp2 |
CN112625028A (zh) | 2015-06-19 | 2021-04-09 | 诺华股份有限公司 | 用于抑制shp2活性的化合物和组合物 |
US10308660B2 (en) | 2015-06-19 | 2019-06-04 | Novartis Ag | Compounds and compositions for inhibiting the activity of SHP2 |
US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
JP6845231B2 (ja) | 2015-09-29 | 2021-03-17 | ノヴィラ・セラピューティクス・インコーポレイテッド | B型肝炎抗ウイルス薬の結晶形態 |
WO2017139497A1 (fr) | 2016-02-11 | 2017-08-17 | PellePharm, Inc. | Inhibiteur de la voie hedgehog destiné à être utilisé pour soulager et traiter le prurit ou les démangeaisons |
US10195283B2 (en) * | 2016-03-18 | 2019-02-05 | R.P. Scherer Technologies, Llc | Hydrazinyl-substituted heteroaryl compounds and methods for producing a conjugate |
SG11201808949SA (en) | 2016-04-15 | 2018-11-29 | Novira Therapeutics Inc | Combinations and methods comprising a capsid assembly inhibitor |
US10919914B2 (en) | 2016-06-08 | 2021-02-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
ES2810852T3 (es) | 2016-06-14 | 2021-03-09 | Novartis Ag | Compuestos y composiciones para inhibir la actividad de shp2 |
WO2017223422A1 (fr) | 2016-06-24 | 2017-12-28 | Infinity Pharmaceuticals, Inc. | Polythérapies |
SI3700902T1 (sl) | 2017-10-27 | 2023-10-30 | Boehringer Ingelheim International Gmbh | Inhibitorji trpc6 |
DE102018105524A1 (de) * | 2018-03-09 | 2019-09-12 | Universität Duisburg-Essen | Verwendung von Modulatoren der Sphingosin-1-phosphat-Signaltransduktion |
AU2019235522A1 (en) | 2018-03-14 | 2020-09-03 | Janssen Sciences Ireland Unlimited Company | Capsid assembly modulator dosing regimen |
JP2021529830A (ja) * | 2018-07-02 | 2021-11-04 | エコール・ポリテクニーク・フェデラル・ドゥ・ローザンヌ(ウペエフエル)Ecole Polytechnique Federale de Lausanne (EPFL) | ラクテート増強化合物及びその使用 |
CN108997224B (zh) * | 2018-08-28 | 2023-04-28 | 韶远科技(上海)有限公司 | 一种2-氯-5-氰基含氮六元杂环化合物的制备方法 |
US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
US11096931B2 (en) | 2019-02-22 | 2021-08-24 | Janssen Sciences Ireland Unlimited Company | Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases |
US11491148B2 (en) | 2019-05-06 | 2022-11-08 | Janssen Sciences Ireland Unlimited Company | Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases |
CN110845426A (zh) * | 2019-11-29 | 2020-02-28 | 都创(上海)医药科技有限公司 | 一种2-氯-5-氰基嘧啶化合物制备方法 |
KR102394110B1 (ko) * | 2020-01-22 | 2022-05-04 | 가톨릭대학교 산학협력단 | 신규 화합물 및 이의 용도 |
EP4074317A1 (fr) | 2021-04-14 | 2022-10-19 | Bayer AG | Dérivés de phosphore en tant que nouveaux inhibiteurs de sos1 |
CN116199625A (zh) * | 2023-01-19 | 2023-06-02 | 上海昱菘医药科技有限公司 | 一种烟酸酯类化合物的制备方法 |
Family Cites Families (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1293565A (en) * | 1969-05-03 | 1972-10-18 | Aspro Nicholas Ltd | Aminophthalazines and pharmaceutical compositions thereof |
US3668207A (en) * | 1970-01-22 | 1972-06-06 | Ciba Geigy Corp | 2-amino-4-aryl-quinolines |
DE2643753A1 (de) | 1976-09-29 | 1978-04-06 | Thomae Gmbh Dr K | Neue 1h-pyrazolo eckige klammer auf 3,4-b eckige klammer zu pyridine |
FR2421900A1 (fr) * | 1977-03-17 | 1979-11-02 | Sauba Lab | Piperazino-3-indoles, leur procede de preparation et leurs applications therapeutiques |
FI70411C (fi) | 1980-12-29 | 1986-09-19 | Pfizer | Foerfarande foer framstaellning av nya antihypertensiva 4-amino-6,7-dimetoxi-2-piperazinokinazolin derivat |
MA20387A1 (fr) * | 1984-03-26 | 1985-10-01 | Janssen Pharmaceutica Nv | Pyridazinamines utiles comme agents anti-viraux et procede pour leur preparation |
EP0157037A3 (fr) | 1984-03-29 | 1986-11-05 | Bowmar Instrument Corporation | Commutateur à bouton poussoir à longue course |
US4569934A (en) * | 1984-10-09 | 1986-02-11 | American Cyanamid Company | Imidazo[1,2-b]pyridazines |
US4734418A (en) * | 1984-12-14 | 1988-03-29 | Mitsui Petrochemical Industries, Ltd. | Quinazoline compounds and antihypertensives |
US4760064A (en) * | 1984-12-18 | 1988-07-26 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril compounds, compositions containing same and processes for preparing same |
JP2544939B2 (ja) * | 1987-09-01 | 1996-10-16 | 大塚製薬株式会社 | ベンゾヘテロ環誘導体 |
JPH02193992A (ja) * | 1989-01-23 | 1990-07-31 | Kyowa Hakko Kogyo Co Ltd | キナゾリン誘導体 |
JPH03106875A (ja) * | 1989-09-20 | 1991-05-07 | Morishita Pharmaceut Co Ltd | 1―(3―ピリジルメチル)フタラジン誘導体 |
DE69533057T2 (de) | 1994-08-09 | 2005-06-16 | Eisai Co., Ltd. | Kondensierte pyridazinverbindungen |
JP3919835B2 (ja) * | 1994-08-09 | 2007-05-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 縮合ピリダジン系化合物 |
US5889006A (en) | 1995-02-23 | 1999-03-30 | Schering Corporation | Muscarinic antagonists |
US5859012A (en) | 1996-04-03 | 1999-01-12 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5935958A (en) * | 1996-07-01 | 1999-08-10 | Schering Corporation | Muscarinic antagonists |
WO1999054305A1 (fr) | 1998-04-20 | 1999-10-28 | Basf Aktiengesellschaft | Amides substitues par voie heterocyclique et utilises comme inhibiteurs de calpaine |
US6066636A (en) * | 1998-06-30 | 2000-05-23 | Schering Corporation | Muscarinic antagonists |
TW474933B (en) | 1998-06-30 | 2002-02-01 | Schering Corp | Muscarinic antagonists |
JP2002535365A (ja) * | 1999-01-28 | 2002-10-22 | ブリストル−マイヤーズ スクイブ カンパニー | 抗うつ性複素環化合物 |
JP2000281660A (ja) | 1999-03-29 | 2000-10-10 | Sumitomo Pharmaceut Co Ltd | キナゾリン誘導体 |
WO2000059509A1 (fr) * | 1999-03-30 | 2000-10-12 | Novartis Ag | Derives de phtalazine pour le traitement des maladies inflammatoires |
ATE299865T1 (de) | 1999-05-04 | 2005-08-15 | Schering Corp | Piperazinderivate verwendbar als ccr5 antagonisten |
ES2165274B1 (es) * | 1999-06-04 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
ATE283700T1 (de) * | 1999-06-08 | 2004-12-15 | Lorantis Ltd | Therapeutische verwendung eines inhibitors des hedgehog signalübertragungsweges |
FR2803593B1 (fr) * | 2000-01-06 | 2002-02-15 | Sanofi Synthelabo | Nouvelles tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant |
WO2001083481A1 (fr) | 2000-04-27 | 2001-11-08 | Yamanouchi Pharmaceutical Co., Ltd. | Derives d'imidazopyridine |
DE10043659A1 (de) | 2000-09-05 | 2002-03-14 | Merck Patent Gmbh | Arylpiperazinderivate |
ES2172436B1 (es) * | 2000-10-31 | 2004-01-16 | Almirall Prodesfarma Sa | Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
WO2002053160A1 (fr) | 2000-12-29 | 2002-07-11 | Alteon, Inc. | Methode de traitement du glaucome ivb |
SE0103754L (sv) | 2001-04-05 | 2002-10-06 | Forskarpatent I Syd Ab | Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid |
JP2004534743A (ja) * | 2001-04-09 | 2004-11-18 | ロランティス リミテッド | ヘッジホッグ |
JP4929547B2 (ja) | 2001-09-03 | 2012-05-09 | コニカミノルタホールディングス株式会社 | アゾメチン化合物、アゾメチン化合物と金属イオン含有化合物との混合物、感熱転写記録材料、カラートナー |
DE60221866T2 (de) | 2001-10-19 | 2008-05-29 | Ortho-Mcneil Pharmaceutical, Inc. | 2-PHENYL BENZIMIDAZOLE UND IMIDAZO-i4,5ö-PYRIDINE ALS CDS1/CHK2-INHIBITOREN UND ADJUVANTIEN IN DER CHEMOTHERAPIE ODER STRAHLUNGSTHERAPIE ZUR BEHANDLUNG VON KREBS |
WO2003080580A2 (fr) * | 2002-03-27 | 2003-10-02 | Glaxo Group Limited | Composes |
KR100721524B1 (ko) | 2002-10-16 | 2007-05-23 | 한국전자통신연구원 | 사용자의 저시력 시각 이상 증후 특성 및 컨텐츠 재생취향에 따른 비주얼 컨텐츠 적응 변환 방법 및 시스템 |
CN1751038A (zh) | 2003-02-24 | 2006-03-22 | 艾尼纳制药公司 | 作为葡萄糖代谢调节剂的经取代芳基和杂芳基衍生物及葡萄糖代谢失调的预防和治疗 |
SG145699A1 (en) * | 2003-07-30 | 2008-09-29 | Xenon Pharmaceuticals Inc | Pyridazine derivatives and their use as therapeutic agents |
DE10337184A1 (de) * | 2003-08-13 | 2005-03-10 | Gruenenthal Gmbh | Substituierte 3-Pyrrolidin-Indol-Derivate |
CA2535265C (fr) * | 2003-08-22 | 2014-01-28 | Dendreon Corporation | Compositions et methodes permettant de traiter une maladie associee a l'expression de trp-p8 |
WO2005033288A2 (fr) * | 2003-09-29 | 2005-04-14 | The Johns Hopkins University | Antagonistes de la voie hedgehog |
EP1750727A2 (fr) | 2004-04-23 | 2007-02-14 | Exelixis, Inc. | Modulateurs des proteines kinases et leurs methodes d'utilisation |
EP1789390B1 (fr) * | 2004-09-02 | 2011-11-09 | Genentech, Inc. | Inhibiteurs pyridyles de la signalisation hedgehog |
GB0422263D0 (en) * | 2004-10-07 | 2004-11-10 | Glaxo Group Ltd | Novel compounds |
US7759337B2 (en) | 2005-03-03 | 2010-07-20 | Amgen Inc. | Phthalazine compounds and methods of use |
DE102005023943A1 (de) | 2005-05-20 | 2006-11-23 | Grünenthal GmbH | Pentafluorsulfanyl-substituierte Verbindung und deren Verwendung zur Herstellung von Arzneimitteln |
WO2006138304A2 (fr) * | 2005-06-14 | 2006-12-28 | Taigen Biotechnology | Composes pyrimidine |
US8364148B2 (en) * | 2005-07-07 | 2013-01-29 | Qualcomm Incorporated | Methods and devices for interworking of wireless wide area networks and wireless local area networks or wireless personal area networks |
AU2006315467B2 (en) * | 2005-11-14 | 2013-02-07 | Curis, Inc. | Bisamide inhibitors of hedgehog signaling |
EP1963329B1 (fr) * | 2005-11-30 | 2013-01-23 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de c-met et leurs utilisations |
GB0602335D0 (en) * | 2006-02-07 | 2006-03-15 | Remynd Nv | Thiadiazole Derivatives For The Treatment Of Neurodegenerative Diseases |
AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
RU2008141368A (ru) | 2006-03-21 | 2010-04-27 | Шеринг Корпорейшн (US) | Новые гетероциклические соединения замещенного пиридина с антагонистической активностью схсr3 |
JP2009535344A (ja) * | 2006-04-28 | 2009-10-01 | ノースウェスタン ユニバーシティ | 神経炎症性疾患の処置のためのピリダジン化合物を含む処方物 |
WO2007127475A2 (fr) | 2006-04-28 | 2007-11-08 | Northwestern University | Compositions et traitements contre des maladies démyélinisantes et des troubles de type douleur |
EP1849781A1 (fr) | 2006-04-28 | 2007-10-31 | Laboratorios del Dr. Esteve S.A. | Dérivés de 3-Amino-4-hydroxy pyrrolidine, procédé de fabrication et utilisation come medicaments |
EP2015751A2 (fr) | 2006-04-28 | 2009-01-21 | Northwestern University | Sels de composés de pyridazine |
AU2007272884A1 (en) * | 2006-07-14 | 2008-01-17 | Pharmacopeia, Inc. | Heterocyclic substituted piperazine compounds with CXCR3 antagonist activity |
GB0623258D0 (en) | 2006-11-22 | 2007-01-03 | Remynd Nv | Thiadiazole derivatives for the treatment of neuro-degenerative diseases |
NZ577571A (en) | 2006-12-14 | 2012-03-30 | Syngenta Participations Ag | 4-phenyl-pyrane-3,5-diones, 4-phenyl-thiopyrane-3,5-diones and cyclohexanetriones as novel herbicides |
US20120157466A1 (en) * | 2006-12-22 | 2012-06-21 | Qingbei Zeng | Heterocyclic compounds with cxcr3 antagonist activity |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
TW200900391A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-phenyl-piperidin-1-yl)-pyridin-2-one derivatives |
AU2008225922B2 (en) | 2007-03-15 | 2012-04-26 | F. Hoffmann-La Roche Ag | Malonamides as orexin antagonists |
CN101730692A (zh) | 2007-03-15 | 2010-06-09 | 先灵公司 | 用作葡聚糖合成酶抑制剂的哒嗪酮衍生物 |
UA100684C2 (uk) | 2007-03-15 | 2013-01-25 | Новартіс Аг | Похідні бензилу та піридинілу як модулятори сигнального шляху hedgehog |
ES2392157T3 (es) | 2007-09-07 | 2012-12-05 | Amgen Inc. | Piridazinas anilladas para el tratamiento de tumores dirigidos por señalización Hedgehog inapropiada |
GB0808888D0 (en) * | 2008-05-15 | 2008-06-25 | Syngenta Participations Ag | Insecticidal compounds |
RU2502734C2 (ru) * | 2008-07-03 | 2013-12-27 | Янссен Фармацевтика Нв | Замещенные 6-(1-пиперазинил)-пиридазины в качестве антагонистов 5-нт6 рецептора |
WO2010006096A1 (fr) * | 2008-07-11 | 2010-01-14 | Smithkline Beecham Corporation | Procédés de préparation de composés antiviraux et compositions les contenant |
US20110301162A1 (en) * | 2008-08-04 | 2011-12-08 | Amgen Inc. | Aurora kinase modulators and methods of use |
ES2418479T3 (es) * | 2008-11-03 | 2013-08-14 | Eli Lilly And Company | Antagonistas de la ruta erizo de ftalazinas disustituidas |
FR2939134A1 (fr) * | 2008-12-01 | 2010-06-04 | Sanofi Aventis | Derives de 6-cycloamino-3-(1h-pyrrolo°2,3-b!pyridin-4-yl) imidazo°1,2-b!-pyridazine, leur preparation et leur application en therapeutique |
TWI520989B (zh) * | 2015-03-02 | 2016-02-11 | 國立交通大學 | 製備高分子球的方法 |
-
2008
- 2008-03-13 UA UAA200909484A patent/UA100684C2/uk unknown
- 2008-03-13 EA EA200901170A patent/EA016564B1/ru not_active IP Right Cessation
- 2008-03-13 BR BRPI0809193-5A patent/BRPI0809193A2/pt active Search and Examination
- 2008-03-13 CN CN2008800121920A patent/CN101657430B/zh not_active Expired - Fee Related
- 2008-03-13 MX MX2009009873A patent/MX2009009873A/es active IP Right Grant
- 2008-03-13 AR ARP080101030A patent/AR065718A1/es unknown
- 2008-03-13 US US12/531,341 patent/US8536168B2/en active Active
- 2008-03-13 JP JP2009553152A patent/JP5550352B2/ja not_active Expired - Fee Related
- 2008-03-13 AU AU2008225766A patent/AU2008225766B2/en not_active Ceased
- 2008-03-13 EP EP08717784.6A patent/EP2137162B1/fr active Active
- 2008-03-13 WO PCT/EP2008/053040 patent/WO2008110611A1/fr active Application Filing
- 2008-03-13 PE PE2008000477A patent/PE20090188A1/es not_active Application Discontinuation
- 2008-03-13 NZ NZ579402A patent/NZ579402A/en not_active IP Right Cessation
- 2008-03-13 MY MYPI20093757A patent/MY156814A/en unknown
- 2008-03-13 GE GEAP200811474A patent/GEP20125487B/en unknown
- 2008-03-13 CA CA2681162A patent/CA2681162C/fr not_active Expired - Fee Related
- 2008-03-13 DK DK08717784.6T patent/DK2137162T3/en active
- 2008-03-13 KR KR1020097021399A patent/KR101473504B1/ko active IP Right Grant
- 2008-03-13 SG SG2012044004A patent/SG182205A1/en unknown
- 2008-03-14 CL CL200800754A patent/CL2008000754A1/es unknown
- 2008-03-14 TW TW097109177A patent/TWI406857B/zh not_active IP Right Cessation
-
2009
- 2009-08-27 ZA ZA200905949A patent/ZA200905949B/xx unknown
- 2009-08-31 IL IL200654A patent/IL200654A/en not_active IP Right Cessation
- 2009-09-08 CR CR11016A patent/CR11016A/es unknown
- 2009-09-11 TN TNP2009000373A patent/TN2009000373A1/fr unknown
- 2009-09-11 NI NI200900168A patent/NI200900168A/es unknown
- 2009-09-14 GT GT200900244A patent/GT200900244A/es unknown
- 2009-09-14 DO DO2009000217A patent/DOP2009000217A/es unknown
- 2009-09-14 CO CO09098892A patent/CO6220967A2/es active IP Right Grant
- 2009-09-15 EC EC2009009636A patent/ECSP099636A/es unknown
- 2009-09-15 CU CU20090159A patent/CU23769B7/es active IP Right Grant
- 2009-09-24 MA MA32227A patent/MA31258B1/fr unknown
- 2009-10-15 SM SM200900082T patent/SMP200900082B/it unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA31258B1 (fr) | Composes organiques et leurs utilisations | |
MA34361B1 (fr) | Dérivés de tétrahydro-pyrido-pyrimidine | |
TN2015000547A1 (fr) | Composes heteroaromatiques et leur utilisation comme ligands de dopamine d1 | |
MA32904B1 (fr) | Composes de purine | |
MA31158B1 (fr) | Composes tricycliques et leur utilisation comme modulateurs du recepteur de glucocorticoïdes | |
BRPI0408251A (pt) | compostos de pirazina como inibidores do fator de crescimento transformante (tgf) | |
MA32466B1 (fr) | Derives de triazole utiles pour le traitement de maladies | |
MA34235B1 (fr) | Composes chimiques | |
MA33509B1 (fr) | Dérivés de l'oxazine et leur utilisation dans le traitement de troubles neurologiques | |
MA34331B1 (fr) | Composés pyrazole comme inhibiteurs du récepteur sigma | |
JO2686B1 (en) | Vehicles | |
MA31906B1 (fr) | Inhibiteurs de la replication du virus de limmunodeficience humaine | |
JO2843B1 (en) | Organic compounds as SMO inhibitors | |
MA30514B1 (fr) | Nouveaux composes. | |
RS52823B (en) | NEW UNITS USEFUL FOR TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | |
MA33428B1 (fr) | Agonistes du gpr119 | |
MXPA05009595A (es) | Compuestos 7-amino-isoindolilo y sus usos farmaceuticos. | |
UA99132C2 (ru) | Производные дикарбоновых кислот как агонисты рецепторов s1p1 | |
MA27769A1 (fr) | Dérivées de 2-acylamino-4-phenylthiazole, leur préparation et leur application en thérapeutique | |
MA29377B1 (fr) | Derives de la pyrimidine pour traitement de troubles a caractere hyperproliferatif | |
MX2011013016A (es) | Derivados de aminopirrolidinona y usos de los mismos. | |
MA27661A1 (fr) | Indolone-oxazolidinones antibacteriennes, intermediaires pour leur preparation et compositions pharmaceutiques les contenant | |
MA31623B1 (fr) | Nouveaux herbicides | |
MA32506B1 (fr) | Nouveaux composes | |
ATE473965T1 (de) | Radioaktiv markierte liganden auf chinolinbasis für die 5-ht6-rezeptorfunktionalität |