FR3046792B1 - Nouveaux derives d'ammonium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents
Nouveaux derives d'ammonium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Download PDFInfo
- Publication number
- FR3046792B1 FR3046792B1 FR1650411A FR1650411A FR3046792B1 FR 3046792 B1 FR3046792 B1 FR 3046792B1 FR 1650411 A FR1650411 A FR 1650411A FR 1650411 A FR1650411 A FR 1650411A FR 3046792 B1 FR3046792 B1 FR 3046792B1
- Authority
- FR
- France
- Prior art keywords
- preparation
- pharmaceutical compositions
- compositions containing
- ammonium derivatives
- novel ammonium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000003863 ammonium salts Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cephalosporin Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (43)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1650411A FR3046792B1 (fr) | 2016-01-19 | 2016-01-19 | Nouveaux derives d'ammonium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CR20180363A CR20180363A (es) | 2016-01-19 | 2016-12-19 | Nuevos derivados de amonio, un proceso para su preparación y composiciones farmacéuticas que los contienen |
| KR1020187023819A KR20180098677A (ko) | 2016-01-19 | 2016-12-19 | 신규 암모늄 유도체, 이의 제조 방법 및 이를 함유하는 약학적 조성물 |
| CN201680080679.7A CN108602841B (zh) | 2016-01-19 | 2016-12-19 | 新的铵衍生物、它们的制备方法以及含有它们的药物组合物 |
| HUE16816667A HUE048449T2 (hu) | 2016-01-19 | 2016-12-19 | Új ammónium-származékok, eljárás azok elõállítására és azokat tartalmazó gyógyászati kompozíciók |
| PL16816667T PL3405471T3 (pl) | 2016-01-19 | 2016-12-19 | Nowe pochodne amoniowe, sposób ich wytwarzania oraz zawierające je kompozycje farmaceutyczne |
| AU2016387870A AU2016387870B2 (en) | 2016-01-19 | 2016-12-19 | New ammonium derivatives, a process for their preparation and pharmaceutical compositions containing them |
| BR112018014536-0A BR112018014536B1 (pt) | 2016-01-19 | 2016-12-19 | Derivados de amônio, processo para sua preparação, composição farmacêutica contendo os mesmos, combinação e seu uso |
| PT168166676T PT3405471T (pt) | 2016-01-19 | 2016-12-19 | Novos derivados de amónio, um processo para a sua preparação e composições faremacêuticas que os contêm |
| RS20191499A RS59622B1 (sr) | 2016-01-19 | 2016-12-19 | Novi amonijum derivati, postupak za njihovo dobijanje i farmaceutske kompozicije koje ih sadrže |
| MX2018008808A MX2018008808A (es) | 2016-01-19 | 2016-12-19 | Nuevos derivados de amonio, un proceso para su preparacion y composiciones farmaceuticas que los contienen. |
| US16/069,891 US10457689B2 (en) | 2016-01-19 | 2016-12-19 | Ammonium derivatives, a process for their preparation and pharmaceutical compositions containing them |
| MDE20181134T MD3405471T2 (ro) | 2016-01-19 | 2016-12-19 | Noi derivați de amoniu, procedeu pentru prepararea acestora și compoziții farmaceutice care îi conțin |
| SI201630558T SI3405471T1 (sl) | 2016-01-19 | 2016-12-19 | Novi derivati amonija, postopek za njihovo pripravo in farmacevtski sestavki, ki jih vsebujejo |
| EP16816667.6A EP3405471B1 (fr) | 2016-01-19 | 2016-12-19 | Nouveaux dérivés d'ammonium, procédé de préparation de ceux-ci et compositions pharmaceutiques les contenant |
| LT16816667T LT3405471T (lt) | 2016-01-19 | 2016-12-19 | Nauji amonio dariniai, jų gamybos būdas ir juos turinčios farmacinės kompozicijos |
| PCT/EP2016/081688 WO2017125224A1 (fr) | 2016-01-19 | 2016-12-19 | Nouveaux dérivés d'ammonium, procédé de préparation de ceux-ci et compositions pharmaceutiques les contenant |
| GEAP201614858A GEP20207126B (en) | 2016-01-19 | 2016-12-19 | New ammonium derivatives, a process for their preparation and pharmaceutical compositions containing them |
| EA201891622A EA036932B1 (ru) | 2016-01-19 | 2016-12-19 | Производные аммония, способ их получения и фармацевтические композиции, содержащие их |
| UAA201808693A UA123508C2 (uk) | 2016-01-19 | 2016-12-19 | Похідні амонію, спосіб їхнього одержання та фармацевтичні композиції, які їх містять |
| SG11201805913QA SG11201805913QA (en) | 2016-01-19 | 2016-12-19 | New ammonium derivatives, a process for their preparation and pharmaceutical compositions containing them |
| MEP-2019-336A ME03555B (fr) | 2016-01-19 | 2016-12-19 | Nouveaux dérivés d'ammonium, procédé de préparation de ceux-ci et compositions pharmaceutiques les contenant |
| MYPI2018702472A MY196352A (en) | 2016-01-19 | 2016-12-19 | New Ammonium Derivatives, a Process for Their Preparation and Pharmaceutical Compositions Containing Them |
| MA43639A MA43639B1 (fr) | 2016-01-19 | 2016-12-19 | Nouveaux dérivés d'ammonium, procédé de préparation de ceux-ci et compositions pharmaceutiques les contenant |
| CA3011761A CA3011761C (fr) | 2016-01-19 | 2016-12-19 | Nouveaux derives d'ammonium, procede de preparation de ceux-ci et compositions pharmaceutiques les contenant |
| CU2018000073A CU20180073A7 (es) | 2016-01-19 | 2016-12-19 | Nuevos derivados de amonio, un proceso para su preparación y composiciones farmacéuticas que los contienen |
| ES16816667T ES2760545T3 (es) | 2016-01-19 | 2016-12-19 | Nuevos derivados de amonio, un proceso para su preparación y composiciones farmacéuticas que los contienen |
| JP2018555822A JP6871275B2 (ja) | 2016-01-19 | 2016-12-19 | 新規アンモニウム誘導体、それを調製するためのプロセス及びそれを含有する医薬組成物 |
| RU2018129308A RU2743098C2 (ru) | 2016-01-19 | 2016-12-19 | Новые производные аммония, способ их получения и фармацевтические композиции, содержащие их |
| PE2018001293A PE20190336A1 (es) | 2016-01-19 | 2016-12-19 | Nuevos derivados de amonio, un proceso para su preparacion y composiciones farmaceuticas que los contienen |
| TNP/2018/000239A TN2018000239A1 (en) | 2016-01-19 | 2016-12-19 | New ammonium derivatives, a process for their preparation and pharmaceutical compositions containing them |
| DK16816667.6T DK3405471T3 (da) | 2016-01-19 | 2016-12-19 | Nye ammoniumderivater, en fremgangsmåde til deres fremstilling og farmaceutiske sammensætninger som indeholder dem |
| SV2018005722A SV2018005722A (es) | 2016-01-19 | 2018-07-10 | Nuevos derivados de amonio, un proceso para su preparacion y composiciones farmaceuticas que los contienen |
| IL260550A IL260550B (en) | 2016-01-19 | 2018-07-11 | New faith histories, a process for their preparation and pharmaceutical preparations containing them |
| PH12018501506A PH12018501506A1 (en) | 2016-01-19 | 2018-07-12 | New ammonium derivatives, a process for their preparation and pharmaceutical compositions containing them |
| CL2018001908A CL2018001908A1 (es) | 2016-01-19 | 2018-07-13 | Nuevos derivados de amonio, un proceso para su preparación y composiciones farmacéuticas que los contienen. |
| CONC2018/0007443A CO2018007443A2 (es) | 2016-01-19 | 2018-07-16 | Nuevos derivados de amonio, un proceso para su preparación y composiciones farmacéuticas que los contienen |
| NI201800076A NI201800076A (es) | 2016-01-19 | 2018-07-17 | Nuevos derivados de amonio, un proceso para su preparación y composiciones farmacéuticas que los contienen |
| ZA2018/04770A ZA201804770B (en) | 2016-01-19 | 2018-07-17 | New ammonium derivatives, a process for their preparation and pharmaceutical compositions containing them |
| ECSENADI201853634A ECSP18053634A (es) | 2016-01-19 | 2018-07-17 | Nuevos derivados de amonio, un proceso para su preparación y composiciones farmacéuticas que los contienen |
| SA518392049A SA518392049B1 (ar) | 2016-01-19 | 2018-07-19 | مشتقات أمونيوم جديدة، عملية لتحضيرها وتركيبات صيدلانية تحتوي عليها |
| HRP20192073TT HRP20192073T1 (hr) | 2016-01-19 | 2019-11-19 | Novi derivati amonija, postupak za njihovu pripravu te farmaceutski pripravci koji ih sadrže |
| CY20201100072T CY1122560T1 (el) | 2016-01-19 | 2020-01-27 | Νεα παραγωγα αμμωνιου, μεθοδος για παρασκευη αυτων και φαρμακευτικες συνθεσεις που περιεχουναυτα |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1650411 | 2016-01-19 | ||
| FR1650411A FR3046792B1 (fr) | 2016-01-19 | 2016-01-19 | Nouveaux derives d'ammonium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR3046792A1 FR3046792A1 (fr) | 2017-07-21 |
| FR3046792B1 true FR3046792B1 (fr) | 2018-02-02 |
Family
ID=55752504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR1650411A Expired - Fee Related FR3046792B1 (fr) | 2016-01-19 | 2016-01-19 | Nouveaux derives d'ammonium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Country Status (43)
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3037956B1 (fr) * | 2015-06-23 | 2017-08-04 | Servier Lab | Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3037958B1 (fr) * | 2015-06-23 | 2019-01-25 | Les Laboratoires Servier | Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| UY37560A (es) | 2017-01-06 | 2018-07-31 | Servier Lab | Combinación de un inhibidor de mcl-1 y un compuesto taxano, usos y composiciones farmacéuticas de ésta |
| JOP20190159B1 (ar) * | 2017-01-06 | 2023-09-17 | Servier Lab | توليفة من مثبط mcl-1 ومركب تاكسان، استخداماتها وتركيباتها الصيدلانية |
| BR112019026959A2 (pt) | 2017-06-22 | 2020-07-07 | Les Laboratoires Servier | combinação de um inibidor de mcl-1 e um tratamento com padrão de atendimento para cânceres hematológicos, seus usos e composições farmacêuticas |
| CN111818916A (zh) * | 2017-08-15 | 2020-10-23 | 艾伯维公司 | 大环mcl-1抑制剂和使用方法 |
| JP2020531436A (ja) * | 2017-08-15 | 2020-11-05 | アッヴィ・インコーポレイテッド | 大環状ｍｃｌ−１阻害剤及び使用の方法 |
| BR112020003180A2 (pt) | 2017-08-15 | 2020-09-15 | AbbVie Deutschland GmbH & Co. KG | inibidores macrocíclicos de mcl-1 e métodos de uso |
| CN108424417B (zh) * | 2017-12-21 | 2019-09-20 | 河南真实生物科技有限公司 | 噻吩并嘧啶衍生物、其制备方法及在制备抗肿瘤药物中的应用 |
| AR116635A1 (es) | 2018-10-15 | 2021-05-26 | Servier Lab | Proceso para la síntesis de derivados de piperazinil-etoxi-bromofenilo y su aplicación en la producción de compuestos que los contienen |
| TW202038960A (zh) | 2018-11-14 | 2020-11-01 | 法商施維雅藥廠 | Mcl-1抑制劑及米哚妥林(midostaurin)之組合，其用途及醫藥組合物 |
| US20220017533A1 (en) * | 2018-12-06 | 2022-01-20 | Les Laboratoires Servier | Crystalline forms of a mcl-1 inhibitor, a process for their preparation and pharmaceutical compositions containing them |
| JP2022532918A (ja) | 2019-05-20 | 2022-07-20 | ノバルティス アーゲー | Ｍｃｌ－１阻害剤抗体－薬物コンジュゲートおよび使用方法 |
| TW202114682A (zh) | 2019-06-17 | 2021-04-16 | 法商施維雅藥廠 | Mcl-1抑制劑與乳癌標準療法之組合，其用途及醫藥組合物 |
| JP2022551083A (ja) * | 2019-10-03 | 2022-12-07 | カリフォルニア インスティチュート オブ テクノロジー | Ｍｃｌ１インヒビター及びその使用 |
| JP2023553808A (ja) | 2020-11-24 | 2023-12-26 | ノバルティス アーゲー | Ｍｃｌ－１阻害剤抗体－薬物コンジュゲートおよび使用方法 |
| WO2022216946A1 (fr) * | 2021-04-07 | 2022-10-13 | California Institute Of Technology | Inhibiteurs de mcl1 et leurs utilisations |
| CA3222269A1 (fr) | 2021-06-11 | 2022-12-15 | Gilead Sciences, Inc. | Inhibiteurs de mcl-1 en combinaison avec des agents anticancereux |
| WO2022261310A1 (fr) | 2021-06-11 | 2022-12-15 | Gilead Sciences, Inc. | Inhibiteurs de mcl-1 en combinaison avec des conjugués anti-corps-médicament |
| WO2023225359A1 (fr) | 2022-05-20 | 2023-11-23 | Novartis Ag | Conjugués anticorps-médicament de composés anti-cancéreux et procédés d'utilisation |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5650425A (en) * | 1994-04-04 | 1997-07-22 | Pharmos Corporation | Permanently ionic derivatives of steroid hormones and their antagonists |
| JP2001511182A (ja) * | 1997-02-09 | 2001-08-07 | ファーモス コーポレイション | ステロイドホルモンの永久に荷電された誘導体の増進された抗血管形成誘導活性 |
| JP2008505084A (ja) * | 2004-06-29 | 2008-02-21 | アムゲン インコーポレイティッド | フラノピリミジン |
| MX2010004260A (es) * | 2007-10-16 | 2010-04-30 | Wyeth Llc | Compuestos de tienopirimidina y pirazolopirimidina y su uso como inhibidores de mtor cinasa y pi3 cinasa. |
| CN102014627B (zh) * | 2008-04-30 | 2014-10-29 | 国家卫生研究院 | 作为极光激酶抑制剂的稠合双环嘧啶化合物 |
| WO2010054285A2 (fr) * | 2008-11-10 | 2010-05-14 | National Health Research Institutes | Composés de pyrimidine bicycliques et tricycliques condensés à titre d'inhibiteurs de tyrosine kinase |
| CN102464667B (zh) * | 2010-11-03 | 2014-06-04 | 中国科学院上海药物研究所 | 一类五元杂环并嘧啶类化合物及其制备方法和用途 |
| RU2015118985A (ru) * | 2012-11-14 | 2017-01-10 | Ф. Хоффманн-Ля Рош Аг | Производные имидазопиридина |
| KR102330794B1 (ko) * | 2013-05-02 | 2021-11-26 | 에프. 호프만-라 로슈 아게 | Cb2 수용체 작용제로서의 퓨린 유도체 |
| FR3015483B1 (fr) * | 2013-12-23 | 2016-01-01 | Servier Lab | Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2016
- 2016-01-19 FR FR1650411A patent/FR3046792B1/fr not_active Expired - Fee Related
- 2016-12-19 JP JP2018555822A patent/JP6871275B2/ja active Active
- 2016-12-19 SG SG11201805913QA patent/SG11201805913QA/en unknown
- 2016-12-19 ME MEP-2019-336A patent/ME03555B/fr unknown
- 2016-12-19 EP EP16816667.6A patent/EP3405471B1/fr active Active
- 2016-12-19 BR BR112018014536-0A patent/BR112018014536B1/pt active IP Right Grant
- 2016-12-19 RU RU2018129308A patent/RU2743098C2/ru active
- 2016-12-19 MX MX2018008808A patent/MX2018008808A/es active IP Right Grant
- 2016-12-19 US US16/069,891 patent/US10457689B2/en active Active
- 2016-12-19 CA CA3011761A patent/CA3011761C/fr active Active
- 2016-12-19 TN TNP/2018/000239A patent/TN2018000239A1/en unknown
- 2016-12-19 CN CN201680080679.7A patent/CN108602841B/zh active Active
- 2016-12-19 RS RS20191499A patent/RS59622B1/sr unknown
- 2016-12-19 SI SI201630558T patent/SI3405471T1/sl unknown
- 2016-12-19 CR CR20180363A patent/CR20180363A/es unknown
- 2016-12-19 MA MA43639A patent/MA43639B1/fr unknown
- 2016-12-19 KR KR1020187023819A patent/KR20180098677A/ko unknown
- 2016-12-19 PT PT168166676T patent/PT3405471T/pt unknown
- 2016-12-19 DK DK16816667.6T patent/DK3405471T3/da active
- 2016-12-19 LT LT16816667T patent/LT3405471T/lt unknown
- 2016-12-19 CU CU2018000073A patent/CU20180073A7/es unknown
- 2016-12-19 WO PCT/EP2016/081688 patent/WO2017125224A1/fr active Application Filing
- 2016-12-19 PE PE2018001293A patent/PE20190336A1/es unknown
- 2016-12-19 MD MDE20181134T patent/MD3405471T2/ro unknown
- 2016-12-19 UA UAA201808693A patent/UA123508C2/uk unknown
- 2016-12-19 PL PL16816667T patent/PL3405471T3/pl unknown
- 2016-12-19 MY MYPI2018702472A patent/MY196352A/en unknown
- 2016-12-19 EA EA201891622A patent/EA036932B1/ru unknown
- 2016-12-19 HU HUE16816667A patent/HUE048449T2/hu unknown
- 2016-12-19 GE GEAP201614858A patent/GEP20207126B/en unknown
- 2016-12-19 AU AU2016387870A patent/AU2016387870B2/en active Active
- 2016-12-19 ES ES16816667T patent/ES2760545T3/es active Active
-
2018
- 2018-07-10 SV SV2018005722A patent/SV2018005722A/es unknown
- 2018-07-11 IL IL260550A patent/IL260550B/en active IP Right Grant
- 2018-07-12 PH PH12018501506A patent/PH12018501506A1/en unknown
- 2018-07-13 CL CL2018001908A patent/CL2018001908A1/es unknown
- 2018-07-16 CO CONC2018/0007443A patent/CO2018007443A2/es unknown
- 2018-07-17 ZA ZA2018/04770A patent/ZA201804770B/en unknown
- 2018-07-17 EC ECSENADI201853634A patent/ECSP18053634A/es unknown
- 2018-07-17 NI NI201800076A patent/NI201800076A/es unknown
- 2018-07-19 SA SA518392049A patent/SA518392049B1/ar unknown
-
2019
- 2019-11-19 HR HRP20192073TT patent/HRP20192073T1/hr unknown
-
2020
- 2020-01-27 CY CY20201100072T patent/CY1122560T1/el unknown
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| FR3046792B1 (fr) | Nouveaux derives d'ammonium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| FR3052452B1 (fr) | Nouveaux derives de piperidinyle, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| FR3037959B1 (fr) | Nouveaux derives bicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| FR3037956B1 (fr) | Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| MA42231A (fr) | Nouveaux dérivés d'hydroxyacide, leur procédé de préparation, et compositions pharmaceutiques les contenant | |
| FR3015483B1 (fr) | Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| FR2986002B1 (fr) | Nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| MA46240A (fr) | Compositions d'arn de haute pureté et procédés pour leur préparation | |
| FR3008979B1 (fr) | Nouveaux derives phosphates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| LT3453707T (lt) | Benzazepino darinys, gamybos būdas, farmacinė kompozicija ir jos naudojimas | |
| FR3037957B1 (fr) | Nouveaux derives d'hydroxyester, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| MA37206B1 (fr) | Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| FR2943342B1 (fr) | Nouveaux derives de benzothiadiazepines,leur procede de preparation et les compositions pharmaceutiques qui les contiennent. | |
| IL250022B (en) | 1-(pyrimidin-2-yl)-6-(heterocyclyl-carbonyl)-(indoline/2,3-dihydroazaindole) derivatives, process for their preparation and pharmaceutical compositions comprising them | |
| MA29725B1 (fr) | Nouveaux derives tricycliques, leur procede de prepapation et les compositions pharmaceutiques qui les contiennent | |
| MA50450A (fr) | Nouveaux derives macrocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| FR3041644B1 (fr) | Polypeptides cycliques, leur procede d'obtention et leur application en therapeutique | |
| EP3308801A4 (fr) | Conjugué anticorps-médicament, intermédiaire, procédé de préparation, compositions pharmaceutique et leurs utilisations | |
| MA42264A (fr) | Procédé de préparation d'oltipraz | |
| MA53900A (fr) | Nouveaux dérivés d'amino-pyrimidonyl-pipéridinyl, leur procédé de préparation et compositions pharmaceutiques les contenant | |
| FR3046793B1 (fr) | Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| FR2976284B1 (fr) | Nouveaux co-cristaux d'agomelatine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. | |
| FR3052451B1 (fr) | Nouveaux derives de piperidinyle hetero(aryl)-substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| FR2948372B1 (fr) | Nouveaux derives chromeniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| FR2972454B1 (fr) | Nouveaux derives dihydro-oxazolobenzodiazepinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
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