FR2976284B1 - Nouveaux co-cristaux d'agomelatine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. - Google Patents

Nouveaux co-cristaux d'agomelatine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Info

Publication number
FR2976284B1
FR2976284B1 FR1101766A FR1101766A FR2976284B1 FR 2976284 B1 FR2976284 B1 FR 2976284B1 FR 1101766 A FR1101766 A FR 1101766A FR 1101766 A FR1101766 A FR 1101766A FR 2976284 B1 FR2976284 B1 FR 2976284B1
Authority
FR
France
Prior art keywords
agomelatin
crystals
novel
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR1101766A
Other languages
English (en)
Other versions
FR2976284A1 (fr
Inventor
Philippe Letellier
Michael Lynch
Jean Manuel Pean
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Servier SAS filed Critical Laboratoires Servier SAS
Priority to FR1101766A priority Critical patent/FR2976284B1/fr
Priority to PH12012000132A priority patent/PH12012000132A1/en
Priority to SG2012038949A priority patent/SG186548A1/en
Priority to TNP2012000266A priority patent/TN2012000266A1/fr
Priority to JOP/2012/0132A priority patent/JO3213B1/ar
Priority to PE2012000732A priority patent/PE20130047A1/es
Priority to CR20120287A priority patent/CR20120287A/es
Priority to IL220066A priority patent/IL220066A0/en
Priority to CA2778850A priority patent/CA2778850C/fr
Priority to AU2012203196A priority patent/AU2012203196C1/en
Priority to CU2012000086A priority patent/CU20120086A7/es
Priority to UY0001034111A priority patent/UY34111A/es
Priority to MYPI2012700327A priority patent/MY159816A/en
Priority to MA34936A priority patent/MA34498B1/fr
Priority to ECSP12011949 priority patent/ECSP12011949A/es
Priority to GEAP201212736A priority patent/GEP20156339B/en
Priority to UAA201206840A priority patent/UA112407C2/uk
Priority to CO12095643A priority patent/CO6580196A1/es
Priority to SA112330595A priority patent/SA112330595B1/ar
Priority to NZ600479A priority patent/NZ600479B/en
Priority to SV2012004235A priority patent/SV2012004235A/es
Priority to ARP120102011A priority patent/AR086849A1/es
Priority to CL2012001501A priority patent/CL2012001501A1/es
Priority to ZA2012/04184A priority patent/ZA201204184B/en
Priority to MDA20120050A priority patent/MD4308C1/ro
Priority to KR1020120061605A priority patent/KR20120138223A/ko
Priority to DK12171231.9T priority patent/DK2532647T3/en
Priority to ES12171231.9T priority patent/ES2608799T3/es
Priority to GT201200188A priority patent/GT201200188A/es
Priority to MX2012006577A priority patent/MX2012006577A/es
Priority to LTEP12171231.9T priority patent/LT2532647T/lt
Priority to JP2012130471A priority patent/JP5525011B2/ja
Priority to PT121712319T priority patent/PT2532647T/pt
Priority to MEP-2016-295A priority patent/ME02574B/fr
Priority to RS20161060A priority patent/RS55406B1/sr
Priority to PCT/FR2012/051291 priority patent/WO2012168665A1/fr
Priority to PL12171231T priority patent/PL2532647T3/pl
Priority to SI201230823A priority patent/SI2532647T1/sl
Priority to RU2013158816/04A priority patent/RU2593749C2/ru
Priority to US13/492,095 priority patent/US8710101B2/en
Priority to EP12171231.9A priority patent/EP2532647B1/fr
Priority to BR102012013816-6A priority patent/BR102012013816B1/pt
Priority to TW101120779A priority patent/TWI441803B/zh
Priority to HUE12171231A priority patent/HUE031266T2/en
Priority to NI201200101A priority patent/NI201200101A/es
Priority to EA201200728A priority patent/EA021386B1/ru
Priority to AP2012006308A priority patent/AP3198A/xx
Priority to CN201210191879.3A priority patent/CN102816079B/zh
Publication of FR2976284A1 publication Critical patent/FR2976284A1/fr
Application granted granted Critical
Publication of FR2976284B1 publication Critical patent/FR2976284B1/fr
Priority to HK13106486.3A priority patent/HK1178881A1/xx
Priority to HRP20161647TT priority patent/HRP20161647T1/hr
Priority to CY20161101298T priority patent/CY1118439T1/el
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
FR1101766A 2011-06-09 2011-06-09 Nouveaux co-cristaux d'agomelatine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. Active FR2976284B1 (fr)

Priority Applications (51)

Application Number Priority Date Filing Date Title
FR1101766A FR2976284B1 (fr) 2011-06-09 2011-06-09 Nouveaux co-cristaux d'agomelatine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
PH12012000132A PH12012000132A1 (en) 2011-06-09 2012-05-25 New co-crystals of agomelatine, a process for their preparation and pharmaceutical compositions containing them
SG2012038949A SG186548A1 (en) 2011-06-09 2012-05-28 New co-crystals of agomelatine, a process for their preparation and pharmaceutical compositions containing them
TNP2012000266A TN2012000266A1 (fr) 2011-06-09 2012-05-28 Nouveaux co-cristaux d'agomelatine, leur procede de preparation et les compositions pharmaceutiques qui les contiennet
JOP/2012/0132A JO3213B1 (ar) 2011-06-09 2012-05-28 بلورات مشتركة جديدة من أجوميلاتين
PE2012000732A PE20130047A1 (es) 2011-06-09 2012-05-29 Nuevos co-cristales de agomelatina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen
CR20120287A CR20120287A (es) 2011-06-09 2012-05-29 Nuevos co-cristales de agomelatina, su procedimiento de preparación y las composiciones farmacéuticas que los contienen
IL220066A IL220066A0 (en) 2011-06-09 2012-05-30 New co-crystals of agomelatine, a process for their preparation and pharmaceutical compositions containing them
CA2778850A CA2778850C (fr) 2011-06-09 2012-05-30 Nouveaux co-cristaux d'agomelatine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2012203196A AU2012203196C1 (en) 2011-06-09 2012-05-30 New Co-crystals of Agomelatine, a Process for Their Preparation and Pharmaceutical Compositions Containing Them
CU2012000086A CU20120086A7 (es) 2011-06-09 2012-05-31 Nuevos co-cristales de agomelatina, su procedimiento de preparación y las composiciones farmacéuticas que los contienen
UY0001034111A UY34111A (es) 2011-06-09 2012-05-31 Nuevos co-cristales de agomelatina, su procedimiento de preparación y las composiciones farmacéuticas que los contienen
MYPI2012700327A MY159816A (en) 2011-06-09 2012-05-31 New co-crystals of agomelatine, a process for their preparation and pharmaceutical compositions containing them
MA34936A MA34498B1 (fr) 2011-06-09 2012-06-04 Nouveaux co-cristaux d'agometaline leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ECSP12011949 ECSP12011949A (es) 2011-06-09 2012-06-04 Nuevos co-cristales de agomelatina, su procedimiento de preparación
GEAP201212736A GEP20156339B (en) 2011-06-09 2012-06-05 New co-crystals of agomelatine, process for their preparation and pharmaceutical compositions containing them
UAA201206840A UA112407C2 (uk) 2011-06-09 2012-06-05 Співкристали агомелатіну, спосіб їх виготовлення і фармацевтичні композиції, що їх містять
CO12095643A CO6580196A1 (es) 2011-06-09 2012-06-06 Nuevos co- cristales de agomelatina, su procedimiento de preparación y las composiciones farmacéuticas que los contienen
SA112330595A SA112330595B1 (ar) 2011-06-09 2012-06-06 بلورات مشتركة جديدة من أجوميلاتين، وعملية لتحضيرها وتركيبات صيدلانية تحتوي عليها
NZ600479A NZ600479B (en) 2011-06-09 2012-06-06 New co-crystals of agomelatine, a process for their preparation and pharmaceutical compositions containing them
SV2012004235A SV2012004235A (es) 2011-06-09 2012-06-06 Nuevos co-cristales de agomelatina, su procedimiento de preparación y las composiciones farmacéuticas que los contienen
ARP120102011A AR086849A1 (es) 2011-06-09 2012-06-07 Co-cristales de agomelatina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen
CL2012001501A CL2012001501A1 (es) 2011-06-09 2012-06-07 Co-cristal constituido por agomelatina y un acido organico que presenta un estado solido a temperatura ambiente; procedimientos de preparacion; composicion farmaceutica; y uso en el tratamiento de trastornos del sistema melatoninergico tales como estres, trastornos del sueño y trastornos de ansiedad generalizada, entre otros.
ZA2012/04184A ZA201204184B (en) 2011-06-09 2012-06-07 Co-crystals of agomelatine, a process for their preparation and pharmaceutical compositions containing them
MDA20120050A MD4308C1 (ro) 2011-06-09 2012-06-07 Cocristale noi ale agomelatinei, procedeu de obţinere a lor şi compoziţii farmaceutice care le conţin
KR1020120061605A KR20120138223A (ko) 2011-06-09 2012-06-08 아고멜라틴의 신규한 공동-결정, 이의 제조 공정 및 이를 함유하는 약학 조성물
DK12171231.9T DK2532647T3 (en) 2011-06-09 2012-06-08 Hitherto unknown CO-CRYSTALS OF AGOMELATIN
ES12171231.9T ES2608799T3 (es) 2011-06-09 2012-06-08 Nuevos cocristales de agomelatina
GT201200188A GT201200188A (es) 2011-06-09 2012-06-08 Nuevos co-cristales de agomelatina su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
MX2012006577A MX2012006577A (es) 2011-06-09 2012-06-08 Nuevos co-cristales de agomelatina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
LTEP12171231.9T LT2532647T (lt) 2011-06-09 2012-06-08 Aglometino ko-kristalai
JP2012130471A JP5525011B2 (ja) 2011-06-09 2012-06-08 アゴメラチンの新規な共結晶、その調製のための方法及びそれを含む医薬組成物
PT121712319T PT2532647T (pt) 2011-06-09 2012-06-08 Novos co-cristais de agomelatina
MEP-2016-295A ME02574B (fr) 2011-06-09 2012-06-08 Nouveaux co-cristaux d'agomelatin.
RS20161060A RS55406B1 (sr) 2011-06-09 2012-06-08 Novi ko-kristali agomelatina
PCT/FR2012/051291 WO2012168665A1 (fr) 2011-06-09 2012-06-08 Nouveaux co-cristaux d' agomelatine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PL12171231T PL2532647T3 (pl) 2011-06-09 2012-06-08 Nowe kokryształy agomelatyny
SI201230823A SI2532647T1 (sl) 2011-06-09 2012-06-08 Novi kokristali agomelatina
RU2013158816/04A RU2593749C2 (ru) 2011-06-09 2012-06-08 Новые сокристаллы агомелатина, способ их получения и фармацевтические композиции, которые их содержат
US13/492,095 US8710101B2 (en) 2011-06-09 2012-06-08 Co-crystals of agomelatine, a process for there preparation and pharmaceutical compositions containing them
EP12171231.9A EP2532647B1 (fr) 2011-06-09 2012-06-08 Nouveaux co-cristaux d'agomelatin.
BR102012013816-6A BR102012013816B1 (pt) 2011-06-09 2012-06-08 cocristal de agomelatina, processo de preparo do dito cocristal e composições farmacêuticas contendo o mesmo
TW101120779A TWI441803B (zh) 2011-06-09 2012-06-08 阿戈美拉汀（ａｇｏｍｅｌａｔｉｎｅ）之新共結晶，其製備方法及包含其之醫藥組合物
HUE12171231A HUE031266T2 (en) 2011-06-09 2012-06-08 New Cocrystals of Agomelatin
NI201200101A NI201200101A (es) 2011-06-09 2012-06-08 Nuevos co-cristales de agomelatina, su procedimiento de preparación y las composiciones farmacéuticas que los contienen
EA201200728A EA021386B1 (ru) 2011-06-09 2012-06-09 Новые сокристаллы агомелатина, способ их получения и фармацевтические композиции, которые их содержат
AP2012006308A AP3198A (en) 2011-06-09 2012-06-11 New co-crystals of agomelatine, a process for their preparation and pharmaceutical compositions containing them
CN201210191879.3A CN102816079B (zh) 2011-06-09 2012-06-11 阿戈美拉汀的新共晶、它们的制备方法和含有它们的药物组合物
HK13106486.3A HK1178881A1 (en) 2011-06-09 2013-06-03 New co-crystals of agomelatine, a process for their preparation and pharmaceutical compositions containing them
HRP20161647TT HRP20161647T1 (hr) 2011-06-09 2016-12-06 Novi sukristali agomelatina
CY20161101298T CY1118439T1 (el) 2011-06-09 2016-12-14 Νεοι συγκρυσταλλοι αγομελατινης

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1101766A FR2976284B1 (fr) 2011-06-09 2011-06-09 Nouveaux co-cristaux d'agomelatine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (2)

Publication Number Publication Date
FR2976284A1 FR2976284A1 (fr) 2012-12-14
FR2976284B1 true FR2976284B1 (fr) 2013-05-24

Family

ID=46690337

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1101766A Active FR2976284B1 (fr) 2011-06-09 2011-06-09 Nouveaux co-cristaux d'agomelatine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Country Status (6)

Country Link
CN (1) CN102816079B (fr)
AP (1) AP3198A (fr)
CU (1) CU20120086A7 (fr)
FR (1) FR2976284B1 (fr)
HK (1) HK1178881A1 (fr)
UA (1) UA112407C2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE036989T2 (hu) * 2013-06-06 2018-08-28 Zentiva Ks Agomelatin készítmény, amely agomelatint ko-kristály formájában tartalmaz
EP2810647A1 (fr) * 2013-06-06 2014-12-10 Zentiva, a.s. Formulations pharmaceutiques, comprenant l'agomélatine sous forme d'un co-cristal de l'agomélatine avec un acide organique
ES2959460T3 (es) * 2015-03-31 2024-02-26 Fis Fabbrica Italiana Sintetici Spa Forma sólida de agomelatina

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE457089B (sv) * 1986-02-05 1988-11-28 Sandvik Ab Saett att behandla en blandning av haardmetallkroppar foer att skilja dessa fraan varandra paa grundval av deras sammansaettningar och/eller strukturer
FR2866335B1 (fr) * 2004-02-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'agomelatine
PT2114924E (pt) * 2007-02-27 2012-04-03 Vertex Pharma Co-cristais e composições farmacêuticas que compreendem os mesmos

Also Published As

Publication number Publication date
CN102816079A (zh) 2012-12-12
CN102816079B (zh) 2015-04-08
FR2976284A1 (fr) 2012-12-14
HK1178881A1 (en) 2013-09-19
CU20120086A7 (es) 2014-01-29
AP2012006308A0 (en) 2012-06-30
UA112407C2 (uk) 2016-09-12
AP3198A (en) 2015-03-31

Similar Documents

Publication Publication Date Title
FR2986002B1 (fr) Nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3015483B1 (fr) Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3046792B1 (fr) Nouveaux derives d'ammonium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
MA37206B1 (fr) Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037956B1 (fr) Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
MA42231A (fr) Nouveaux dérivés d'hydroxyacide, leur procédé de préparation, et compositions pharmaceutiques les contenant
FR3037959B1 (fr) Nouveaux derives bicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2984355B1 (fr) Procede de preparation d'alliage polymere/entites biologiques
FR3008979B1 (fr) Nouveaux derives phosphates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2943342B1 (fr) Nouveaux derives de benzothiadiazepines,leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2920773B1 (fr) Derives de 1,2,4,5-tetrahydro-3h-benzazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GEP20156339B (en) New co-crystals of agomelatine, process for their preparation and pharmaceutical compositions containing them
EA201500112A1 (ru) 3-замещенные производные эстра-1,3,5(10),16-тетраена, способы их получения, фармацевтические средства, которые их содержат, и их использование для получения лекарственных средств
FR2993881B1 (fr) Procede de preparation d'alkoxyphenol et d'alkoxyhydroxybenzaldehyde
FR2912145B1 (fr) Nouveaux derives tricycliques,leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP2697238A4 (fr) Formes solides de composés antirétroviraux, procédé de préparation correspondant et composition pharmaceutique de ces composés
FR2976284B1 (fr) Nouveaux co-cristaux d'agomelatine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
MA35002B1 (fr) Forme cristalline delta du sel d'arginine du périndopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2896800B1 (fr) Nouveaux composes pyridinylaminoalkylene-et pyridinyloxyalkylene-cyclopropanamines polysubstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2992232B1 (fr) Materiau multicompartimente pour la delivrance thermostimulee de substances d'interet, procede de preparation, applications.
FR2940650B1 (fr) Nouveaux derives d'oxime du 3,5-seco-4-nor-cholestane, compositions pharmaceutiques les renfermant,et procede de preparation
FR2948372B1 (fr) Nouveaux derives chromeniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EA201400444A1 (ru) Производные 2-оксопиперидинила
FR2964969B1 (fr) Nouveaux derives dihydrobenzoxathiazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2972454B1 (fr) Nouveaux derives dihydro-oxazolobenzodiazepinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Legal Events

Date Code Title Description
PLFP Fee payment

Year of fee payment: 6

PLFP Fee payment

Year of fee payment: 7