TNSN06244A1 - Derives de 1h-thieno [2,3-c] pyrazole utiles comme inhibiteurs de kinases - Google Patents

Derives de 1h-thieno [2,3-c] pyrazole utiles comme inhibiteurs de kinases

Info

Publication number
TNSN06244A1
TNSN06244A1 TNP2006000244A TNSN06244A TNSN06244A1 TN SN06244 A1 TNSN06244 A1 TN SN06244A1 TN P2006000244 A TNP2006000244 A TN P2006000244A TN SN06244 A TNSN06244 A TN SN06244A TN SN06244 A1 TNSN06244 A1 TN SN06244A1
Authority
TN
Tunisia
Prior art keywords
des
thieno
kinase inhibitors
pyrazole derivatives
derivatives useful
Prior art date
Application number
TNP2006000244A
Other languages
English (en)
Inventor
Simona Bindi
Mario Varasi
Paola Vianello
Sergio Vioglio
Dania Tesei
Daniele Fancelli
Original Assignee
Pfizer Italia Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Italia Srl filed Critical Pfizer Italia Srl
Publication of TNSN06244A1 publication Critical patent/TNSN06244A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

Des dérivés de thiéno [2,3-c] pyrazole de formule (I) et leurs sels pharmaceutiquement acceptables, tels que définis dans le présent mémoire, des procédés pour leur préparation et des compositions pharmaceutiques les contenant sont décrits ; les composés de l'invention peuvent être utiles en thérapeutique, dans le traitement de maladies associées à une activité de protéine-kinase dérégulée, telles que le cancer.
TNP2006000244A 2004-02-03 2006-08-03 Derives de 1h-thieno [2,3-c] pyrazole utiles comme inhibiteurs de kinases TNSN06244A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54145204P 2004-02-03 2004-02-03
PCT/EP2005/001021 WO2005074922A1 (fr) 2004-02-03 2005-02-02 Derives de 1h-thieno[2,3-c]pyrazole utilises en tant qu'inhibiteurs de kinases

Publications (1)

Publication Number Publication Date
TNSN06244A1 true TNSN06244A1 (fr) 2007-12-03

Family

ID=34837492

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2006000244A TNSN06244A1 (fr) 2004-02-03 2006-08-03 Derives de 1h-thieno [2,3-c] pyrazole utiles comme inhibiteurs de kinases

Country Status (38)

Country Link
US (2) US8138217B2 (fr)
EP (1) EP1711177B1 (fr)
JP (1) JP4908233B2 (fr)
KR (1) KR20060124734A (fr)
CN (1) CN1946395B (fr)
AP (1) AP2006003701A0 (fr)
AR (1) AR047531A1 (fr)
AT (1) ATE396724T1 (fr)
AU (1) AU2005210114B2 (fr)
BR (1) BRPI0507375A (fr)
CA (1) CA2555262C (fr)
CR (1) CR8546A (fr)
CY (1) CY1108246T1 (fr)
DE (1) DE602005007181D1 (fr)
DK (1) DK1711177T3 (fr)
DO (1) DOP2005000014A (fr)
EA (1) EA011032B1 (fr)
EC (1) ECSP066767A (fr)
ES (1) ES2307144T3 (fr)
GE (1) GEP20094633B (fr)
GT (1) GT200500020A (fr)
HK (1) HK1101343A1 (fr)
IL (1) IL177141A0 (fr)
MA (1) MA28429B1 (fr)
MX (1) MXPA06008787A (fr)
NO (1) NO20063768L (fr)
NZ (1) NZ548896A (fr)
PA (1) PA8622801A1 (fr)
PE (1) PE20051095A1 (fr)
PL (1) PL1711177T3 (fr)
PT (1) PT1711177E (fr)
SI (1) SI1711177T1 (fr)
TN (1) TNSN06244A1 (fr)
TW (1) TW200526204A (fr)
UA (1) UA86223C2 (fr)
UY (1) UY28738A1 (fr)
WO (1) WO2005074922A1 (fr)
ZA (1) ZA200606179B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7541378B2 (en) * 2002-07-25 2009-06-02 Pfizer Italia S.R.L. Condensed heterocyclic pyrazole derivatives as kinase inhibitors
WO2007009898A1 (fr) * 2005-07-19 2007-01-25 Nerviano Medical Sciences S.R.L. Composes 1h-thieno[2,3-c]pyrazole servant d'inhibiteurs de kinase
AU2006298563A1 (en) * 2005-10-06 2007-04-12 Merck & Co., Inc. Use of fused pyrrole carboxylic acids for the treatment of neurodegenerative and psychiatric diseases as D-amino acid oxidase inhibitors
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
EP2007380B1 (fr) * 2006-03-30 2011-09-14 Nerviano Medical Sciences S.r.l. Utilisation d'un inhibiteur de la kinase pour traiter des tumeurs résistantes spécifiques
WO2007138017A1 (fr) * 2006-05-31 2007-12-06 Nerviano Medical Sciences S.R.L. COMPOSÉS DE 1H-FURO[3,2-c]PYRAZOLE UTILES EN TANT QU'INHIBITEURS DE KINASES
FR2904626B1 (fr) 2006-08-03 2008-09-19 Sanofi Aventis Derives de pyrazolo[4,3]thiazole, leur preparation et leur application en therapeutique
JP2010505962A (ja) 2006-10-09 2010-02-25 武田薬品工業株式会社 キナーゼ阻害剤
KR100923540B1 (ko) 2007-11-23 2009-10-27 한국과학기술연구원 5-아실하이드라진카르보닐-3,4-디치환 피라졸 유도체 및이의 제조방법
AR071780A1 (es) 2008-05-15 2010-07-14 Nerviano Medical Sciences Srl Derivados de carbamoilo de carbonilamino-pirazoles biciclicos como profarmacos
CA2755768A1 (fr) * 2009-03-23 2010-09-30 Merck Sharp & Dohme Corp. Antagonistes du recepteur p2x3 pour le traitement de la douleur
US9255072B2 (en) 2011-03-04 2016-02-09 National Health Rsearch Institutes Pyrazole compounds and thiazole compounds as protein kinases inhibitors
ES2929759T3 (es) * 2012-04-05 2022-12-01 Nerviano Medical Sciences Srl Nuevos agentes alquilantes
WO2019024809A1 (fr) * 2017-08-01 2019-02-07 正大天晴药业集团股份有限公司 Composé bicyclique agissant en tant qu'inhibiteur de rorγ
EP3717492B1 (fr) * 2017-11-30 2023-05-24 Hanmi Pharm. Co., Ltd. Composé de thiéno[3,2-d]pyrimidine ayant une activité inhibitrice pour des protéines kinases
CN113072562B (zh) * 2021-04-06 2022-01-14 山东大学 一种GSK-3β抑制剂及其制备方法与应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3763409D1 (de) 1986-02-19 1990-08-02 Duphar Int Res Thio-verbindungen und ihre wirkung als fungizide.
GB9911053D0 (en) 1999-05-12 1999-07-14 Pharmacia & Upjohn Spa 4,5,6,7-tetrahydroindazole derivatives process for their preparation and their use as antitumour agents
US6387900B1 (en) 1999-08-12 2002-05-14 Pharmacia & Upjohn S.P.A. 3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents
BR0013143A (pt) 1999-08-12 2002-06-11 Pharmacia Italia Spa Derivados de 3 (5) amino pirazol, processo para sua preparação e uso dos mesmos como agentes antitumorais
CA2416527C (fr) * 2000-08-10 2009-12-22 Pharmacia Italia S.P.A. Bicyclo-pyrazoles actifs en tant qu'inhibiteurs de kinase, leur procede de preparation et compositions pharmaceutiques les contenant
CA2430151A1 (fr) 2000-11-27 2002-06-20 Pharmacia Italia S.P.A. Derives phenylacetamido-pyrazole et leur utilisation comme agents antitumoraux
EP1379524A2 (fr) 2001-01-26 2004-01-14 Pharmacia Italia S.p.A. Derives de chromane, procede de preparation et d'utilisation de ces derives en tant qu'agents antitumoraux
EA007430B1 (ru) 2001-09-26 2006-10-27 Фармация Италия С.П.А. Производные аминоиндазола, активные в качестве ингибиторов киназ, способ их получения и содержащая их фармацевтическая композиция
ES2411655T3 (es) * 2002-05-17 2013-07-08 Pfizer Italia S.R.L. Derivados de aminoindazol activos como inhibidores de quinasas, procedimiento para su preparación y composiciones farmacéuticas que los comprenden
JP2006501191A (ja) * 2002-07-17 2006-01-12 ファルマシア・イタリア・エス・ピー・エー キナーゼ阻害剤としてのヘテロ二環式ピラゾール誘導体
US7541378B2 (en) * 2002-07-25 2009-06-02 Pfizer Italia S.R.L. Condensed heterocyclic pyrazole derivatives as kinase inhibitors
US20050026984A1 (en) * 2003-07-29 2005-02-03 Aventis Pharma S.A. Substituted thieno [2,3-c] pyrazoles and their use as medicinal products

Also Published As

Publication number Publication date
CA2555262C (fr) 2014-10-14
CN1946395A (zh) 2007-04-11
EA200601418A1 (ru) 2006-12-29
NO20063768L (no) 2006-11-02
PE20051095A1 (es) 2005-12-31
UA86223C2 (uk) 2009-04-10
JP2007520513A (ja) 2007-07-26
DOP2005000014A (es) 2006-08-15
MA28429B1 (fr) 2007-02-01
KR20060124734A (ko) 2006-12-05
UY28738A1 (es) 2005-09-30
DE602005007181D1 (de) 2008-07-10
ECSP066767A (es) 2006-11-24
AR047531A1 (es) 2006-01-25
ZA200606179B (en) 2008-02-27
BRPI0507375A (pt) 2007-07-10
PT1711177E (pt) 2008-09-04
US20120165311A1 (en) 2012-06-28
HK1101343A1 (en) 2007-10-18
AU2005210114B2 (en) 2011-07-14
EP1711177B1 (fr) 2008-05-28
GEP20094633B (en) 2009-03-10
TW200526204A (en) 2005-08-16
AP2006003701A0 (en) 2006-08-31
EA011032B1 (ru) 2008-12-30
PA8622801A1 (es) 2005-11-25
SI1711177T1 (sl) 2008-10-31
DK1711177T3 (da) 2008-09-29
NZ548896A (en) 2010-05-28
CA2555262A1 (fr) 2005-08-18
CN1946395B (zh) 2014-04-02
US20050187209A1 (en) 2005-08-25
WO2005074922A1 (fr) 2005-08-18
MXPA06008787A (es) 2007-01-19
JP4908233B2 (ja) 2012-04-04
EP1711177A1 (fr) 2006-10-18
CY1108246T1 (el) 2014-02-12
ATE396724T1 (de) 2008-06-15
GT200500020A (es) 2005-09-06
US8481584B2 (en) 2013-07-09
IL177141A0 (en) 2006-12-10
CR8546A (es) 2007-05-30
US8138217B2 (en) 2012-03-20
AU2005210114A1 (en) 2005-08-18
ES2307144T3 (es) 2008-11-16
PL1711177T3 (pl) 2008-11-28

Similar Documents

Publication Publication Date Title
TNSN06244A1 (fr) Derives de 1h-thieno [2,3-c] pyrazole utiles comme inhibiteurs de kinases
TNSN06009A1 (fr) Derives de pyrrolo [3,4-c] pyrazole actifs comme inhibiteurs de kinases
TNSN05298A1 (fr) Derives de pyrazolo-quinazoline, procede pour leur preparation et leur utilisation comme inhibiteurs de kinases
TNSN06038A1 (fr) Derives d'indazole 3,5-disubstitues, compositions pharmaceutiques, et methodes de mediation ou d'inhibition de la proliferation cellulaire
TN2010000171A1 (fr) Derives de thienopyrimidine et pyrazolopyrimidine et leur utilisation comme inhibiteurs de la kinase mtor te de la kinase k13
MA31655B1 (fr) Pyrimidines cyclopenta [d] hydroxylés et méthoxylés utilisés en tant qu'inhibiteurs de la protéine kinase akt.
MA30952B1 (fr) Cyclopenta [d] pyrimidines utiles en tant qu'inhibiteurs de la proteine kinase akt
TNSN01095A1 (fr) DERIVES DE PYRROLO [2,3-d] PYRIMIDINE NOUVEAUX ET COMPOSITIONS LES CONTENANT
MA31766B1 (fr) Composés organiques
MA29713B1 (fr) Derives de tetrahydroindolone et de tetrahydroindazolone
MA27703A1 (fr) Derives de diazepino-indole servant d'inhibiteurs de kinases
MA32306B1 (fr) Derives de quinoleines et de quinoxalines en tant qu'inhibiteurs de proteine tyrosine kinases
MA31763B1 (fr) Inhibiteurs de kinase de type polo
TNSN06186A1 (fr) Pyrido [2,3-d] pyrimidine -2, 4-diamines servant d'inhibiteurs de pde 2
ATE536353T1 (de) 2-(4-amino-1,2,5-oxadiazol-4-yl)-imidazol- verbindungen als protein kinase inhibitoren
MY139355A (en) Compounds and methods for inhibiting mitotic progression by inhibition of aurora kinase
MA26997A1 (fr) Derives de 3-(4-amidopyrrole-2-ylmethylidene)-2-indolinone utilisables comme inhibiteurs de proteine-kinases
MA29160B1 (fr) Derives de triazole substitues, servant d'antagonistes d'ocytocine
MA30557B1 (fr) Composés de pyrrolopyrimidine et leurs utilisations.
MA31952B1 (fr) Pyrrolopyrimidines et pyrrolopyridines
TNSN07476A1 (fr) Derives de n-(pyridine -2- yl) - sulfonamide
MA31949B1 (fr) Dérivés d'aminotriazole comme agonistes d'alx
ATE339418T1 (de) Thiazolverbindungen, die sich als inhibitoren von proteinkinasen eignen
ATE451376T1 (de) Zusammensetzungen, die sich als inhibitoren von proteinkinasen eignen
DE60332433D1 (de) Azolylaminoazine als proteinkinasehemmer