MA31952B1 - Pyrrolopyrimidines et pyrrolopyridines - Google Patents
Pyrrolopyrimidines et pyrrolopyridinesInfo
- Publication number
- MA31952B1 MA31952B1 MA32971A MA32971A MA31952B1 MA 31952 B1 MA31952 B1 MA 31952B1 MA 32971 A MA32971 A MA 32971A MA 32971 A MA32971 A MA 32971A MA 31952 B1 MA31952 B1 MA 31952B1
- Authority
- MA
- Morocco
- Prior art keywords
- compounds
- pyroloperimidinis
- pyroloperidinis
- alk
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
L'invention concerne des composés de la formule (i) sous forme libre, de sel ou de solvate, dans laquelle x, t1, t2 et t4 ont les significations indiquées dans la description, qui sont utiles pour le traitement de maladies médiées par le récepteur alk-5 et/ou alk-4. L'invention concerne également des compositions pharmaceutiques qui contiennent les composés et des procédés pour la préparation des composés.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08150182 | 2008-01-11 | ||
PCT/EP2009/050225 WO2009087225A2 (fr) | 2008-01-11 | 2009-01-09 | Pyrrolopyrimidines et pyrrolopyridines |
Publications (1)
Publication Number | Publication Date |
---|---|
MA31952B1 true MA31952B1 (fr) | 2010-12-01 |
Family
ID=39445770
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA32971A MA31952B1 (fr) | 2008-01-11 | 2010-06-30 | Pyrrolopyrimidines et pyrrolopyridines |
Country Status (22)
Country | Link |
---|---|
US (1) | US8314112B2 (fr) |
EP (1) | EP2242756A2 (fr) |
JP (1) | JP5643110B2 (fr) |
KR (1) | KR20100116606A (fr) |
CN (1) | CN101970435B (fr) |
AR (1) | AR070127A1 (fr) |
AU (1) | AU2009203694B2 (fr) |
BR (1) | BRPI0907231A2 (fr) |
CA (1) | CA2711845A1 (fr) |
CL (1) | CL2009000028A1 (fr) |
CO (1) | CO6331340A2 (fr) |
CR (1) | CR11554A (fr) |
EA (1) | EA201001126A1 (fr) |
EC (1) | ECSP10010335A (fr) |
IL (1) | IL206819A0 (fr) |
MA (1) | MA31952B1 (fr) |
MX (1) | MX2010007605A (fr) |
PE (1) | PE20091306A1 (fr) |
TN (1) | TN2010000305A1 (fr) |
TW (1) | TW200934781A (fr) |
WO (1) | WO2009087225A2 (fr) |
ZA (1) | ZA201004602B (fr) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5211063B2 (ja) * | 2006-11-30 | 2013-06-12 | ジェネンテック, インコーポレイテッド | アザ−インドリル化合物及び使用方法 |
WO2009085185A1 (fr) | 2007-12-19 | 2009-07-09 | Amgen Inc. | Composés condensés de pyridine, de pyrimidine et de triazine en tant qu'inhibiteurs du cycle cellulaire |
WO2009126584A1 (fr) | 2008-04-07 | 2009-10-15 | Amgen Inc. | Pyridines/pyrimidines amino spirocycliques et disubstituées par gem en tant qu'inhibiteurs de cycle cellulaire |
US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
LT2300013T (lt) | 2008-05-21 | 2017-12-27 | Ariad Pharmaceuticals, Inc. | Fosforo dariniai kaip kinazių inhibitoriai |
CA2676946A1 (fr) | 2009-08-28 | 2011-02-28 | Lucie Peduto | Inhibiteurs de l'enzyme adam12 et leur utilisation contre la fibrose induite par l'inflammation |
EP2475666A2 (fr) | 2009-09-11 | 2012-07-18 | Trius Therapeutics, Inc. | Inhibiteurs de gyrase |
ES2667049T3 (es) | 2010-02-05 | 2018-05-09 | Merck Patent Gmbh | Derivados de heteroaril-[1,8]naftiridina |
ES2528441T3 (es) | 2010-02-22 | 2015-02-10 | Merck Patent Gmbh | Hetarilaminonaftiridinas |
WO2011104183A1 (fr) * | 2010-02-24 | 2011-09-01 | Syngenta Participations Ag | Nouveaux microbicides |
MX2012015023A (es) | 2010-06-30 | 2013-04-03 | Fujifilm Corp | Derivado novedoso de nicotinamida o sal del mismo. |
PL2624696T3 (pl) | 2010-10-06 | 2017-07-31 | Glaxosmithkline Llc | Pochodne benzimidazolu jako inhibitory kinazy PI3 |
MY161199A (en) | 2011-03-23 | 2017-04-14 | Amgen Inc | Fused tricyclic dual inhibitors of cdk 4/6 and flt3 |
WO2012151561A1 (fr) | 2011-05-04 | 2012-11-08 | Ariad Pharmaceuticals, Inc. | Composés permettant d'inhiber la prolifération cellulaire dans les cancers induits par l'egfr |
ES2676180T3 (es) | 2011-07-01 | 2018-07-17 | Novartis Ag | Terapia de combinación que comprende un inhibidor de CDK4/6 y un inhibidor de PI3K para el uso en el tratamiento de cáncer |
EP2573086A1 (fr) * | 2011-09-26 | 2013-03-27 | AiCuris GmbH & Co. KG | Monohydrate de mesylate acétamide N-[5-(Aminosulfonyl)-4-méthyl-1,3-thiazol-2-yl]-N-méthyl-2-[4-(2-pyridinyl)phényl] |
EP2573085A1 (fr) | 2011-09-26 | 2013-03-27 | AiCuris GmbH & Co. KG | Monohydrate de mesylate acétamide N-[5-(aminosulfonyl)-4méthyl-1,3-thiazol-2-yl]-N-méthyl-2-[4-(2-pyridinyl)phényl] disposant d'une gamme de distribution de taille de particules spécifiques et portée de surface spécifique |
JP6469567B2 (ja) | 2012-05-05 | 2019-02-13 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Egfr発動性がんの細胞増殖阻害用化合物 |
JO3407B1 (ar) | 2012-05-31 | 2019-10-20 | Eisai R&D Man Co Ltd | مركبات رباعي هيدرو بيرازولو بيريميدين |
RU2014151004A (ru) | 2012-06-07 | 2016-08-10 | Ф. Хоффманн-Ля Рош Аг | Пирролопиримидоновые и пирролопиридоновые ингибиторы танкиразы |
SG11201408816QA (en) * | 2012-07-03 | 2015-03-30 | Aurigene Discovery Tech Ltd | 3-(PYRAZOLYL)-1H-PYRROLO[2,3-b]PYRIDINE DERIVATIVES AS KINASE INHIBITORS |
WO2014160203A2 (fr) | 2013-03-14 | 2014-10-02 | The Brigham And Women's Hospital, Inc. | Inhibiteurs de bmp et leurs procédés d'utilisation |
US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
US9776997B2 (en) | 2013-06-04 | 2017-10-03 | Bayer Pharma Aktiengesellschaft | 3-aryl-substituted imidazo[1,2-A]pyridines and their use |
CN106459090A (zh) | 2014-02-19 | 2017-02-22 | 拜耳制药股份公司 | 3‑(嘧啶‑2‑基)咪唑并[1,2‑a]吡啶 |
WO2015148654A1 (fr) * | 2014-03-26 | 2015-10-01 | The Brigham And Women's Hospital, Inc. | Compositions et procédés d'inhibition de la bmp |
TW201613916A (en) | 2014-06-03 | 2016-04-16 | Gilead Sciences Inc | TANK-binding kinase inhibitor compounds |
WO2016011019A1 (fr) | 2014-07-15 | 2016-01-21 | The Brigham And Women's Hospital, Inc. | Compositions et procédés d'inhibition de la bmp |
MX2017003930A (es) | 2014-09-26 | 2017-06-30 | Gilead Sciences Inc | Derivados de aminotriazina utiles como compuestos inhibidores de la cinasa de union a tank. |
JP2017536396A (ja) | 2014-12-02 | 2017-12-07 | バイエル・ファルマ・アクティエンゲゼルシャフト | ヘテロアリール置換イミダゾ[1,2−a]ピリジンおよびその使用 |
WO2016172496A1 (fr) | 2015-04-23 | 2016-10-27 | Constellation Pharmaceuticals, Inc. | Inhibiteurs de lsd1 et leurs utilisations |
WO2016183071A1 (fr) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Composés hétéro-tricycliques substitués et utilisation de ces composés pour le traitement du cancer |
WO2017027717A1 (fr) | 2015-08-12 | 2017-02-16 | Incyte Corporation | Composés de pyrimidine fusionnés bicycliques utilisés en tant qu'inhibiteurs de tam |
US10053465B2 (en) | 2015-08-26 | 2018-08-21 | Incyte Corporation | Pyrrolopyrimidine derivatives as TAM inhibitors |
FR3041640B1 (fr) | 2015-09-30 | 2019-05-17 | Les Laboratoires Servier | NOUVEAUX DERIVES DE PYRROLO[2,3-d]PYRIMIDINE, LEUR PROCEDE DE PREPRATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT |
KR20180094976A (ko) | 2015-12-17 | 2018-08-24 | 길리애드 사이언시즈, 인코포레이티드 | Tank-결합 키나제 억제제 화합물 |
CA3008171A1 (fr) | 2015-12-22 | 2017-06-29 | SHY Therapeutics LLC | Composes pour le traitement du cancer et de maladies inflammatoires |
KR20230111268A (ko) | 2016-03-28 | 2023-07-25 | 인사이트 코포레이션 | Tam 억제제로서 피롤로트리아진 화합물 |
AU2017250302B2 (en) | 2016-04-15 | 2021-01-21 | Blueprint Medicines Corporation | Inhibitors of activin receptor-like kinase |
FI3532459T3 (fi) | 2016-10-26 | 2023-10-23 | Constellation Pharmaceuticals Inc | Lsd1-estäjiä ja niiden lääkinnällisiä käyttöjä |
CA3066939A1 (fr) | 2017-06-21 | 2018-12-27 | SHY Therapeutics LLC | Composes interagissant avec la superfamille ras destines a etre utilises dans le traitement de cancers, de maladies inflammatoires, de rasopathies et de maladies fibrotiques |
CN109384782A (zh) * | 2017-08-04 | 2019-02-26 | 厦门大学 | 取代五元并六元杂环类化合物、其制备方法、药物组合及其用途 |
EP3988552A1 (fr) | 2017-09-27 | 2022-04-27 | Incyte Corporation | Sels de dérivés de pyrrolotriazine utiles en tant qu'inhibiteurs de tam |
US11236086B2 (en) | 2017-10-18 | 2022-02-01 | Blueprint Medicines Corporation | Substituted pyrrolopyridines as inhibitors of activin receptor-like kinase |
MX2020006613A (es) * | 2017-12-22 | 2020-11-13 | Ravenna Pharmaceuticals Inc | Derivados de aril-bipiridina amina como inhibidores de fosfatidilinositol fosfato cinasa. |
JP2021517574A (ja) * | 2018-03-23 | 2021-07-26 | サイトーCytoo | 骨格筋肥大誘発剤としてのalk5阻害剤 |
AR117600A1 (es) | 2018-06-29 | 2021-08-18 | Incyte Corp | Formulaciones de un inhibidor de axl / mer |
US20200247812A1 (en) * | 2018-07-10 | 2020-08-06 | Integral Biosciences Private Limited | Heterocyclic compounds and methods of use |
CN111018858B (zh) * | 2018-10-10 | 2022-11-18 | 复旦大学 | 杂环类衍生物及其制备方法和用途 |
TWI827760B (zh) * | 2018-12-12 | 2024-01-01 | 加拿大商愛彼特生物製藥公司 | 經取代之芳基甲基脲類及雜芳基甲基脲類、其類似物及其使用方法 |
KR20200105246A (ko) * | 2019-02-28 | 2020-09-07 | 한미약품 주식회사 | 아데노신 수용체 길항제로서 신규 화합물 및 이를 포함하는 약학 조성물 |
US20230145793A1 (en) * | 2020-03-16 | 2023-05-11 | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | Substituted pyrimidine or pyridine amine derivative, composition thereof, and medical use thereof |
CN113698395B (zh) * | 2020-05-22 | 2023-12-08 | 赛诺哈勃药业(成都)有限公司 | 转化生长因子受体拮抗剂、其制备方法和应用 |
JP2023529867A (ja) | 2020-06-05 | 2023-07-12 | キネート バイオファーマ インク. | 線維芽細胞増殖因子受容体キナーゼの阻害剤 |
KR20230051500A (ko) | 2020-07-15 | 2023-04-18 | 키에시 파르마슈티시 엣스. 피. 에이. | Alk5 억제제로서 피리다진일 아미노 유도체 |
AU2021307560A1 (en) | 2020-07-15 | 2023-02-23 | Chiesi Farmaceutici S.P.A. | Pyrido oxazine amino derivatives as ALK5 inhibitors |
US20240116947A1 (en) | 2020-07-15 | 2024-04-11 | Chiesi Farmaceutici S.P.A. | Pyrido oxazine derivatives as alk5 inhibitors |
US20240116948A1 (en) | 2020-12-23 | 2024-04-11 | Chiesi Farmaceutici S.P.A. | Pyrido oxazine derivatives as alk5 inhibitors |
WO2023046698A1 (fr) | 2021-09-21 | 2023-03-30 | Chiesi Farmaceutici S.P.A. | Dérivés d'amino pyridazinyle en tant qu'inhibiteurs d'alk5 |
WO2023208986A1 (fr) | 2022-04-27 | 2023-11-02 | Chiesi Farmaceutici S.P.A. | Dérivés d'imidazole en tant qu'inhibiteurs d'alk5 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL175347B1 (pl) | 1992-04-03 | 1998-12-31 | Upjohn Co | Trójpierścieniowe heterocykliczne aminy aktywne farmaceutycznie |
US6686366B1 (en) * | 1998-06-02 | 2004-02-03 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
CA2365401A1 (fr) * | 1999-03-11 | 2000-10-05 | Neurogen Corporation | Pyridines 2,4-disubstituees fusionnees avec un aryle: ligands du recepteur nk-3 |
AU784878B2 (en) | 1999-12-02 | 2006-07-13 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 A2A and A3 receptors and uses thereof |
US6680322B2 (en) | 1999-12-02 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
US7160890B2 (en) | 1999-12-02 | 2007-01-09 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
US6673802B2 (en) | 2000-12-01 | 2004-01-06 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
BR0115847A (pt) | 2000-12-01 | 2004-02-25 | Osi Pharm Inc | Compostos especìficos para receptor para adenosina a1, a2a, e a3 e usos dos mesmos |
US6680324B2 (en) | 2000-12-01 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
GB0100622D0 (en) | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical compounds V111 |
JP2005529062A (ja) | 2001-11-30 | 2005-09-29 | オーエスアイ・ファーマスーティカルズ・インコーポレーテッド | アデノシンa1及びa3受容体に特異的な化合物とその使用 |
US20030139427A1 (en) | 2002-08-23 | 2003-07-24 | Osi Pharmaceuticals Inc. | Bicyclic pyrimidinyl derivatives and methods of use thereof |
WO2004065392A1 (fr) * | 2003-01-24 | 2004-08-05 | Smithkline Beecham Corporation | Pyridines et pyrimidines condensees et leur utilisation en tant que ligands du recepteur alk-5 |
ES2305744T3 (es) * | 2003-03-12 | 2008-11-01 | Millennium Pharmaceuticals, Inc. | Derivados de quinazolina como inhibidores e tgf-beta. |
US20050205625A1 (en) * | 2004-03-16 | 2005-09-22 | House Arthur G | Container support device, system, and method |
PL1853270T3 (pl) | 2005-02-18 | 2010-09-30 | Solvay Pharm Gmbh | Kompozycje farmaceutyczne zawierające inhibitory - NEP, inhibitory układu wytwarzającego endogenną endotelinę i diuretyki |
US20060205625A1 (en) | 2005-02-18 | 2006-09-14 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and diuretics |
US20070014956A1 (en) * | 2005-07-14 | 2007-01-18 | Mccarthy Dillon P | Adhesive tape device |
PL1962830T3 (pl) * | 2005-12-23 | 2013-08-30 | Glaxosmithkline Llc | Azaindolowe inhibitory kinaz aurora |
-
2009
- 2009-01-08 AR ARP090100050A patent/AR070127A1/es not_active Application Discontinuation
- 2009-01-09 TW TW098100815A patent/TW200934781A/zh unknown
- 2009-01-09 MX MX2010007605A patent/MX2010007605A/es active IP Right Grant
- 2009-01-09 PE PE2009000024A patent/PE20091306A1/es not_active Application Discontinuation
- 2009-01-09 CA CA2711845A patent/CA2711845A1/fr not_active Abandoned
- 2009-01-09 BR BRPI0907231A patent/BRPI0907231A2/pt not_active IP Right Cessation
- 2009-01-09 US US12/351,438 patent/US8314112B2/en not_active Expired - Fee Related
- 2009-01-09 WO PCT/EP2009/050225 patent/WO2009087225A2/fr active Application Filing
- 2009-01-09 KR KR1020107017744A patent/KR20100116606A/ko not_active Application Discontinuation
- 2009-01-09 CL CL2009000028A patent/CL2009000028A1/es unknown
- 2009-01-09 CN CN200980108446.3A patent/CN101970435B/zh not_active Expired - Fee Related
- 2009-01-09 AU AU2009203694A patent/AU2009203694B2/en not_active Ceased
- 2009-01-09 EP EP20090700871 patent/EP2242756A2/fr not_active Withdrawn
- 2009-01-09 JP JP2010541794A patent/JP5643110B2/ja not_active Expired - Fee Related
- 2009-01-09 EA EA201001126A patent/EA201001126A1/ru unknown
-
2010
- 2010-06-30 MA MA32971A patent/MA31952B1/fr unknown
- 2010-06-30 TN TN2010000305A patent/TN2010000305A1/fr unknown
- 2010-06-30 ZA ZA2010/04602A patent/ZA201004602B/en unknown
- 2010-07-02 CR CR11554A patent/CR11554A/es not_active Application Discontinuation
- 2010-07-05 IL IL206819A patent/IL206819A0/en unknown
- 2010-07-09 EC EC2010010335A patent/ECSP10010335A/es unknown
- 2010-07-12 CO CO10084491A patent/CO6331340A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EA201001126A1 (ru) | 2011-02-28 |
CR11554A (es) | 2010-08-11 |
JP2011509279A (ja) | 2011-03-24 |
CL2009000028A1 (es) | 2009-07-17 |
BRPI0907231A2 (pt) | 2019-09-24 |
CN101970435A (zh) | 2011-02-09 |
AR070127A1 (es) | 2010-03-17 |
WO2009087225A3 (fr) | 2009-11-05 |
ZA201004602B (en) | 2011-03-30 |
US20090181941A1 (en) | 2009-07-16 |
TN2010000305A1 (en) | 2011-11-11 |
WO2009087225A2 (fr) | 2009-07-16 |
AU2009203694A1 (en) | 2009-07-16 |
ECSP10010335A (es) | 2010-08-31 |
IL206819A0 (en) | 2010-12-30 |
TW200934781A (en) | 2009-08-16 |
MX2010007605A (es) | 2010-08-02 |
JP5643110B2 (ja) | 2014-12-17 |
AU2009203694B2 (en) | 2012-04-26 |
EP2242756A2 (fr) | 2010-10-27 |
CN101970435B (zh) | 2014-07-02 |
KR20100116606A (ko) | 2010-11-01 |
US8314112B2 (en) | 2012-11-20 |
CA2711845A1 (fr) | 2009-07-16 |
PE20091306A1 (es) | 2009-09-24 |
CO6331340A2 (es) | 2011-10-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA31952B1 (fr) | Pyrrolopyrimidines et pyrrolopyridines | |
MA31766B1 (fr) | Composés organiques | |
MA38380A1 (fr) | Inhibiteurs quinazoline de l'activation des formes mutantes du récepteur de croissance épidermique (egfr) | |
MA33450B1 (fr) | Dérivés d'oxazine et leur utilisation en tant qu'inhibiteurs de bace pour le traitement de troubles neurologiques | |
TNSN07022A1 (fr) | Derives de pyridine | |
MA27775A1 (fr) | Composes organiques | |
MA34397B1 (fr) | Dérivés d'acide napht-2-ylacétique dans le traitement du sida | |
MA31683B1 (fr) | Composes et procedes pour moduler fxr | |
MA47447A (fr) | 2-hétéroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamides pour le traitement du cancer | |
MA32070B1 (fr) | Dérivés hétérocycliques réunis par fusion et procédés d'utilisation associés | |
TN2009000450A1 (fr) | Derives de pyridine | |
MA29926B1 (fr) | Derives de pyrazine | |
MA30063B1 (fr) | Derives pyrimidinyl-aryluree constituant des inhibiteurs des facteurs de croissance des fibroblastes (fcg) | |
TW200728305A (en) | Spiropiperidine beta-sectetase inhibitors for the treatment of alzheimer's disease | |
MA27560A1 (fr) | Nouveaux derives de fluorglycoside heterocycliques, produits pharmaceutiques contenant ces composes et leur utilisation | |
MA31754B1 (fr) | Cis-imidazolines chirales | |
MA31158B1 (fr) | Composes tricycliques et leur utilisation comme modulateurs du recepteur de glucocorticoïdes | |
TNSN05250A1 (fr) | Pyrimidinones substituees | |
EP1673078A4 (fr) | Inhibiteurs de type benzylether et benzylamino de beta-secretase pour le traitement de la maladie d'alzheimer | |
MA27559A1 (fr) | Nouveaux derives de fluorglycoside aromatiques, produits pharmaceutiques contenant ces composes et leur utilisation | |
MA29791B1 (fr) | Composes therapeutiques. | |
MA29377B1 (fr) | Derives de la pyrimidine pour traitement de troubles a caractere hyperproliferatif | |
IL176546A0 (en) | Imidazoline derivatives having cb1-antagonistic activity | |
EP1689713A4 (fr) | Inhibiteurs de benzylether et benzylamino de beta-secretase pour traiter la maladie d'alzheimer | |
MY147677A (en) | Piperazinyl derivatives useful in the treatment of gpr38 receptor mediated diseases |