CR8546A - DERIVADOS DE 1H-TIENO [2,3c] PIRAZOL UTILES COMO INHIBIDORES DE QUINASA - Google Patents

DERIVADOS DE 1H-TIENO [2,3c] PIRAZOL UTILES COMO INHIBIDORES DE QUINASA

Info

Publication number
CR8546A
CR8546A CR8546A CR8546A CR8546A CR 8546 A CR8546 A CR 8546A CR 8546 A CR8546 A CR 8546A CR 8546 A CR8546 A CR 8546A CR 8546 A CR8546 A CR 8546A
Authority
CR
Costa Rica
Prior art keywords
useful
derivatives
tieno
pirazol
quinase
Prior art date
Application number
CR8546A
Other languages
English (en)
Inventor
Fancelli Daniele
Bindi Simona
Varasi Mario
Vianello Paola
Vioglio Sergio
Tesei Dania
Original Assignee
Pfizer Italia S R I
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Italia S R I filed Critical Pfizer Italia S R I
Publication of CR8546A publication Critical patent/CR8546A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41621,2-Diazoles condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se revelan derivados tieno(2,3-c)pirazol de formula (I) y sales de los mismos aceptables para uso farmaceutico, segun se definio en la memoria descriptiva, proceso para su preparacion y composiciones farmaceuticas que las comprenden; los compuestos de la invencion pueden ser utiles en terapia, en el tratamiento de enfermedades asociadas con una mala regulacion de la actividad proteina quinasa, como cancer.
CR8546A 2004-02-03 2006-08-03 DERIVADOS DE 1H-TIENO [2,3c] PIRAZOL UTILES COMO INHIBIDORES DE QUINASA CR8546A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54145204P 2004-02-03 2004-02-03

Publications (1)

Publication Number Publication Date
CR8546A true CR8546A (es) 2007-05-30

Family

ID=34837492

Family Applications (1)

Application Number Title Priority Date Filing Date
CR8546A CR8546A (es) 2004-02-03 2006-08-03 DERIVADOS DE 1H-TIENO [2,3c] PIRAZOL UTILES COMO INHIBIDORES DE QUINASA

Country Status (38)

Country Link
US (2) US8138217B2 (es)
EP (1) EP1711177B1 (es)
JP (1) JP4908233B2 (es)
KR (1) KR20060124734A (es)
CN (1) CN1946395B (es)
AP (1) AP2006003701A0 (es)
AR (1) AR047531A1 (es)
AT (1) ATE396724T1 (es)
AU (1) AU2005210114B2 (es)
BR (1) BRPI0507375A (es)
CA (1) CA2555262C (es)
CR (1) CR8546A (es)
CY (1) CY1108246T1 (es)
DE (1) DE602005007181D1 (es)
DK (1) DK1711177T3 (es)
DO (1) DOP2005000014A (es)
EA (1) EA011032B1 (es)
EC (1) ECSP066767A (es)
ES (1) ES2307144T3 (es)
GE (1) GEP20094633B (es)
GT (1) GT200500020A (es)
HK (1) HK1101343A1 (es)
IL (1) IL177141A0 (es)
MA (1) MA28429B1 (es)
MX (1) MXPA06008787A (es)
NO (1) NO20063768L (es)
NZ (1) NZ548896A (es)
PA (1) PA8622801A1 (es)
PE (1) PE20051095A1 (es)
PL (1) PL1711177T3 (es)
PT (1) PT1711177E (es)
SI (1) SI1711177T1 (es)
TN (1) TNSN06244A1 (es)
TW (1) TW200526204A (es)
UA (1) UA86223C2 (es)
UY (1) UY28738A1 (es)
WO (1) WO2005074922A1 (es)
ZA (1) ZA200606179B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004013146A1 (en) * 2002-07-25 2004-02-12 Pharmacia Italia S.P.A Condensed heterocyclic pyrazole derivatives as kinase inhibitors
WO2007009898A1 (en) * 2005-07-19 2007-01-25 Nerviano Medical Sciences S.R.L. 1h-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors
WO2007039773A1 (en) * 2005-10-06 2007-04-12 Merck Sharp & Dohme Limited Use of fused pyrrole carboxylic acids for the treatment of neurodegenerative and psychiatric diseases as d-amino acid oxidase inhibitors
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
EP2007380B1 (en) * 2006-03-30 2011-09-14 Nerviano Medical Sciences S.r.l. Use of a kinase inhibitor for the treatment of particular resistant tumors
ES2351366T3 (es) 2006-05-31 2011-02-03 Nerviano Medical Sciences S.R.L. Compuestos de 1h-furo[3,2-c]pirazol útiles como inhibidores de quinasas.
FR2904626B1 (fr) * 2006-08-03 2008-09-19 Sanofi Aventis Derives de pyrazolo[4,3]thiazole, leur preparation et leur application en therapeutique
SG175609A1 (en) 2006-10-09 2011-11-28 Takeda Pharmaceutical Kinase inhibitors
KR100923540B1 (ko) 2007-11-23 2009-10-27 한국과학기술연구원 5-아실하이드라진카르보닐-3,4-디치환 피라졸 유도체 및이의 제조방법
AR071780A1 (es) 2008-05-15 2010-07-14 Nerviano Medical Sciences Srl Derivados de carbamoilo de carbonilamino-pirazoles biciclicos como profarmacos
JP2012521429A (ja) * 2009-03-23 2012-09-13 メルク・シャープ・エンド・ドーム・コーポレイション 疼痛治療用のp2x3受容体アンタゴニスト
US9255072B2 (en) 2011-03-04 2016-02-09 National Health Rsearch Institutes Pyrazole compounds and thiazole compounds as protein kinases inhibitors
ES2755719T3 (es) * 2012-04-05 2020-04-23 Nerviano Medical Sciences Srl Nuevos agentes alquilantes
US11466024B2 (en) 2017-08-01 2022-10-11 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Bicylic compound acting as an inhibitor
MX2020005563A (es) * 2017-11-30 2020-10-28 Hanmi Pharm Ind Co Ltd Compuesto de tieno[3,2-d]pirimidina que tiene actividad inhibidora para proteina cinasa.
CN113072562B (zh) * 2021-04-06 2022-01-14 山东大学 一种GSK-3β抑制剂及其制备方法与应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0234622B1 (en) 1986-02-19 1990-06-27 Duphar International Research B.V New thio compounds having fungicidal activity
GB9911053D0 (en) 1999-05-12 1999-07-14 Pharmacia & Upjohn Spa 4,5,6,7-tetrahydroindazole derivatives process for their preparation and their use as antitumour agents
ES2249270T3 (es) 1999-08-12 2006-04-01 Pharmacia Italia S.P.A. Derivados de 3(5)-aminopirazol, procedimiento para su preparacion y su uso como agentes antitumorales.
US6387900B1 (en) 1999-08-12 2002-05-14 Pharmacia & Upjohn S.P.A. 3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents
JP4555547B2 (ja) * 2000-08-10 2010-10-06 ファイザー イタリア ソシエタ ア レスポンサビリタ リミタータ キナーゼ阻害剤としての二環式ピラゾール、それらを製造するための方法およびそれらを含む医薬組成物
JP2004517840A (ja) 2000-11-27 2004-06-17 フアルマシア・イタリア・エツセ・ピー・アー フェニルアセトアミド−ピラゾール誘導体およびそれの抗腫瘍薬としての使用
US20040116497A1 (en) 2001-01-26 2004-06-17 Gabriella Traquandi Chromane derivatives, process for their preparation and their use as antitumor agents
ES2357502T3 (es) 2001-09-26 2011-04-27 Pfizer Italia S.R.L. Derivados de aminoindazol activos como inhibidores de quinasa, procedimiento para su preparación y composiciones farmaceuticas que los contienen.
WO2003097610A1 (en) * 2002-05-17 2003-11-27 Pharmacia Italia S.P.A. Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
CA2492673A1 (en) * 2002-07-17 2004-01-22 Pharmacia Italia S.P.A. Heterobicyclic pyrazole derivatives as kinase inhibitors
WO2004013146A1 (en) * 2002-07-25 2004-02-12 Pharmacia Italia S.P.A Condensed heterocyclic pyrazole derivatives as kinase inhibitors
US20050026984A1 (en) * 2003-07-29 2005-02-03 Aventis Pharma S.A. Substituted thieno [2,3-c] pyrazoles and their use as medicinal products

Also Published As

Publication number Publication date
GEP20094633B (en) 2009-03-10
JP2007520513A (ja) 2007-07-26
CY1108246T1 (el) 2014-02-12
PT1711177E (pt) 2008-09-04
US20050187209A1 (en) 2005-08-25
TNSN06244A1 (fr) 2007-12-03
CN1946395B (zh) 2014-04-02
SI1711177T1 (sl) 2008-10-31
EP1711177A1 (en) 2006-10-18
HK1101343A1 (en) 2007-10-18
KR20060124734A (ko) 2006-12-05
MXPA06008787A (es) 2007-01-19
JP4908233B2 (ja) 2012-04-04
NZ548896A (en) 2010-05-28
UY28738A1 (es) 2005-09-30
AR047531A1 (es) 2006-01-25
AP2006003701A0 (en) 2006-08-31
ZA200606179B (en) 2008-02-27
ES2307144T3 (es) 2008-11-16
AU2005210114A1 (en) 2005-08-18
PA8622801A1 (es) 2005-11-25
DE602005007181D1 (de) 2008-07-10
AU2005210114B2 (en) 2011-07-14
DOP2005000014A (es) 2006-08-15
EA200601418A1 (ru) 2006-12-29
MA28429B1 (fr) 2007-02-01
CA2555262C (en) 2014-10-14
EP1711177B1 (en) 2008-05-28
TW200526204A (en) 2005-08-16
ECSP066767A (es) 2006-11-24
CA2555262A1 (en) 2005-08-18
ATE396724T1 (de) 2008-06-15
US8481584B2 (en) 2013-07-09
BRPI0507375A (pt) 2007-07-10
CN1946395A (zh) 2007-04-11
US8138217B2 (en) 2012-03-20
WO2005074922A1 (en) 2005-08-18
EA011032B1 (ru) 2008-12-30
GT200500020A (es) 2005-09-06
UA86223C2 (uk) 2009-04-10
IL177141A0 (en) 2006-12-10
PL1711177T3 (pl) 2008-11-28
DK1711177T3 (da) 2008-09-29
US20120165311A1 (en) 2012-06-28
NO20063768L (no) 2006-11-02
PE20051095A1 (es) 2005-12-31

Similar Documents

Publication Publication Date Title
CR8546A (es) DERIVADOS DE 1H-TIENO [2,3c] PIRAZOL UTILES COMO INHIBIDORES DE QUINASA
CR8171A (es) Derivados de pirrolo[3,4-c] pyrazol activos como inhibidores de quinasa
CR8102A (es) Derivados de pirazolo- quinazolina, procedimiento para preparacion y su uso como inhibidores de quinasa
BRPI0413427A (pt) derivados de piridilpirrol ativos como inibidores da cinase
MY143206A (en) 1h-thieno 2,3-c pyrazole derivatives useful as kinase i inhibitors
EA200970595A1 (ru) Производные замещенных индазолов, активные в качестве ингибиторов киназ
BRPI0416801A (pt) derivados de 1h-imidazoquinolina como inibidores de proteìna sinase
HK1136292A1 (en) Substituted pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors
ATE514699T1 (de) Substituierte pyrrolopyrazolderivate als kinaseinhibitoren
DK2324008T3 (da) Diarylpyrazol som protein kinase inhibitorer
MXPA06000302A (es) Derivados de pirazolil-indol activos como inhibidores de cinasa, procedimientos para su preparacion y composiciones farmaceuticas que los comprenden.
BRPI0413438A (pt) derivados de pirimidilpirrol ativos como inibidores de cinase
CU20060152A7 (es) Derivados 1h-tieno[2,3-c]pirazol útiles como inhibidores de quinasa
CU23566B7 (es) Derivados de pirrolo [3,4-c]pirazol activos como inhibidores de quinasa
UY28409A1 (es) Derivados de pirrolo (3,4-c) pirazol activos como inhibidores de quinasa, proceso para su preparación y composiciones farmaceuticas que los comprenden
CU23596A3 (es) Derivados de pirazol-quinazolina y proceso para su preparación
UY27309A1 (es) Derivados de quinazolina
UY27315A1 (es) Pirimidinas inhibidoras de cdk, su preparación y uso como medicamento.

Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)