AR073037A1 - Derivados de enfumafungina, utiles en la inhibicionde (1,3)-beta-d-glucano sintasa - Google Patents
Derivados de enfumafungina, utiles en la inhibicionde (1,3)-beta-d-glucano sintasaInfo
- Publication number
- AR073037A1 AR073037A1 ARP090103123A ARP090103123A AR073037A1 AR 073037 A1 AR073037 A1 AR 073037A1 AR P090103123 A ARP090103123 A AR P090103123A AR P090103123 A ARP090103123 A AR P090103123A AR 073037 A1 AR073037 A1 AR 073037A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- prodrugs
- hydrates
- pharmaceutically acceptable
- beta
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pest Control & Pesticides (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cosmetics (AREA)
Abstract
Se describen derivados de enfumafungina, junto con sus sales, hidratos y prodrogas farmacéuticamente aceptables. También se describen composiciones que comprenden dichos compuestos, métodos para preparar dichos compuestos y métodos para usar dichos compuestos como agentes antifungicos y/o inhibidores de (1,3)-beta-D-glucan sintasa. Los compuestos descriptos, sus sales, hidratos y prodrogas farmacéuticamente aceptables, así corno las composiciones que comprenden dichas sales, hidratos y prodrogas, son utiles para tratar y/o prevenir infecciones fungicas y enfermedades y afecciones asociadas. Reivindicacion 1: Un compuesto de la formula (1); o una sal farmacéuticamente aceptable del mismo, caracterizado porque: X es O o H, H; Rc es C(O)NRfRg o un grupo de heteroarilo anular de 6 miembros que contiene 1 o 2 átomos de nitrogeno, en donde el grupo heteroarilo es, opcionalmente, mono-sustituido en un carbono del anillo con fluoro o cloro o en un nitrogeno del anillo con oxígeno; Rf, Rg, R6 y R7 son cada uno, independientemente, hidrogeno o alquilo C1-3; R8 es alquilo C1-4, cicloalquilo C3-4, o cicloalquilo-alquilo C4-5; R9 es metilo o etilo; y R8 y R9, opcionalmente, son tomados juntos para formar un anillo saturado de 6 miembros que contiene 1 átomo de oxígeno.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13610608P | 2008-08-12 | 2008-08-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR073037A1 true AR073037A1 (es) | 2010-10-06 |
Family
ID=41669132
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090103123A AR073037A1 (es) | 2008-08-12 | 2009-08-12 | Derivados de enfumafungina, utiles en la inhibicionde (1,3)-beta-d-glucano sintasa |
Country Status (31)
| Country | Link |
|---|---|
| EP (1) | EP2326172B1 (es) |
| KR (1) | KR101686075B1 (es) |
| AR (1) | AR073037A1 (es) |
| BR (1) | BRPI0912074B1 (es) |
| CL (1) | CL2011000292A1 (es) |
| CO (1) | CO6351686A2 (es) |
| CR (1) | CR20110075A (es) |
| DK (1) | DK2326172T3 (es) |
| DO (1) | DOP2011000053A (es) |
| EA (1) | EA018337B1 (es) |
| ES (1) | ES2526652T3 (es) |
| GT (1) | GT201100039A (es) |
| HK (1) | HK1158017A1 (es) |
| HN (1) | HN2011000404A (es) |
| HR (1) | HRP20150009T1 (es) |
| IL (2) | IL210975A (es) |
| MA (1) | MA32628B1 (es) |
| MX (1) | MX2011001656A (es) |
| MY (1) | MY156955A (es) |
| NI (1) | NI201100035A (es) |
| NZ (1) | NZ590914A (es) |
| PE (1) | PE20110676A1 (es) |
| PL (1) | PL2326172T3 (es) |
| PT (1) | PT2326172E (es) |
| RS (1) | RS53731B1 (es) |
| SI (1) | SI2326172T1 (es) |
| SV (1) | SV2011003839A (es) |
| TW (1) | TWI439458B (es) |
| UA (1) | UA105639C2 (es) |
| WO (1) | WO2010019203A1 (es) |
| ZA (1) | ZA201100788B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10174074B2 (en) | 2015-01-19 | 2019-01-08 | Scynexis, Inc. | Salts and polymorphs of SCY-078 |
| BR112019021138A2 (pt) * | 2017-04-10 | 2020-05-12 | Scynexis, Inc. | Combinação farmacêutica, métodos para tratar uma infecção micótica, para prevenir uma infecção micótica, para tratar aspergilose pulmonar invasiva e para reduzir os níveis de galactomanana, preparação de um medicamento, e, uso da combinação farmacêutica. |
| KR20200044823A (ko) * | 2017-08-04 | 2020-04-29 | 싸이넥시스, 인크. | 산성 pH에서 증진된 활성을 갖는 항진균제 |
| EA202192107A1 (ru) * | 2019-01-30 | 2021-10-21 | Сайнексис, Инк. | Тритерпеноидные фунгициды для лечения грибковых костно-суставных инфекций |
| EA202193146A1 (ru) * | 2019-05-16 | 2022-02-11 | Сайнексис, Инк. | Противогрибковые агенты для деколонизации candida auris |
| CN115811989A (zh) | 2020-05-29 | 2023-03-17 | 法国国家科学研究中心 | 抗真菌前体药物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5756472A (en) | 1996-01-31 | 1998-05-26 | Merck & Co., Inc. | Antifungal agent obtained from hormonema |
| DE69718141T2 (de) * | 1996-01-31 | 2003-08-21 | Merck & Co., Inc. | Fungizid |
| WO2003086271A2 (en) * | 2002-04-17 | 2003-10-23 | Ranbaxy Laboratories Limited | Azole derivatives as antifungal agents |
| JP5245057B2 (ja) * | 2006-04-03 | 2013-07-24 | メルク・シャープ・アンド・ドーム・コーポレーション | 抗真菌剤 |
-
2009
- 2009-08-07 PT PT98069446T patent/PT2326172E/pt unknown
- 2009-08-07 EP EP09806944.6A patent/EP2326172B1/en active Active
- 2009-08-07 KR KR1020117005837A patent/KR101686075B1/ko active IP Right Grant
- 2009-08-07 UA UAA201102860A patent/UA105639C2/uk unknown
- 2009-08-07 RS RS20150006A patent/RS53731B1/en unknown
- 2009-08-07 NZ NZ590914A patent/NZ590914A/en unknown
- 2009-08-07 WO PCT/US2009/004557 patent/WO2010019203A1/en active Application Filing
- 2009-08-07 PE PE2011000156A patent/PE20110676A1/es active IP Right Grant
- 2009-08-07 DK DK09806944.6T patent/DK2326172T3/da active
- 2009-08-07 PL PL09806944T patent/PL2326172T3/pl unknown
- 2009-08-07 BR BRPI0912074-2A patent/BRPI0912074B1/pt active IP Right Grant
- 2009-08-07 EA EA201100350A patent/EA018337B1/ru unknown
- 2009-08-07 MX MX2011001656A patent/MX2011001656A/es active IP Right Grant
- 2009-08-07 ES ES09806944.6T patent/ES2526652T3/es active Active
- 2009-08-07 MY MYPI2011000483A patent/MY156955A/en unknown
- 2009-08-07 SI SI200931102T patent/SI2326172T1/sl unknown
- 2009-08-10 TW TW098126822A patent/TWI439458B/zh active
- 2009-08-12 AR ARP090103123A patent/AR073037A1/es active IP Right Grant
-
2011
- 2011-01-31 ZA ZA2011/00788A patent/ZA201100788B/en unknown
- 2011-01-31 IL IL210975A patent/IL210975A/en active IP Right Grant
- 2011-02-08 CR CR20110075A patent/CR20110075A/es unknown
- 2011-02-10 NI NI201100035A patent/NI201100035A/es unknown
- 2011-02-11 GT GT201100039A patent/GT201100039A/es unknown
- 2011-02-11 DO DO2011000053A patent/DOP2011000053A/es unknown
- 2011-02-11 CL CL2011000292A patent/CL2011000292A1/es unknown
- 2011-02-11 CO CO11016262A patent/CO6351686A2/es active IP Right Grant
- 2011-02-11 HN HN2011000404A patent/HN2011000404A/es unknown
- 2011-02-11 SV SV2011003839A patent/SV2011003839A/es active IP Right Grant
- 2011-03-11 MA MA33691A patent/MA32628B1/fr unknown
- 2011-11-23 HK HK11112674.5A patent/HK1158017A1/xx unknown
-
2015
- 2015-01-07 HR HRP20150009AT patent/HRP20150009T1/hr unknown
- 2015-10-12 IL IL242031A patent/IL242031A0/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |