CR20110075A - Agentes antifúngicos - Google Patents

Agentes antifúngicos

Info

Publication number
CR20110075A
CR20110075A CR20110075A CR20110075A CR20110075A CR 20110075 A CR20110075 A CR 20110075A CR 20110075 A CR20110075 A CR 20110075A CR 20110075 A CR20110075 A CR 20110075A CR 20110075 A CR20110075 A CR 20110075A
Authority
CR
Costa Rica
Prior art keywords
antifungal agents
compounds
methods
enfumafungin
prodrugs
Prior art date
Application number
CR20110075A
Other languages
English (en)
Inventor
Mark L Greenlee
Robert WILKENING
James Apgar
Kenneth James Wildonger
Dongfang Meng
Dann L Parker
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41669132&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20110075(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of CR20110075A publication Critical patent/CR20110075A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describen novedosos derivados de enfumafungina, junto con sus sales, hidratos y prodrogas farmacéuticamente aceptables. También se describen composiciones que comprenden dichos compuestos, métodos para preparar dichos compuestos y métodos para usar dichos compuestos como agentes antifúngicos y/o inhibidores de (1,3) ? D glucan sintasa.
CR20110075A 2008-08-12 2011-02-08 Agentes antifúngicos CR20110075A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13610608P 2008-08-12 2008-08-12
PCT/US2009/004557 WO2010019203A1 (en) 2008-08-12 2009-08-07 Antifungal agents

Publications (1)

Publication Number Publication Date
CR20110075A true CR20110075A (es) 2011-06-03

Family

ID=41669132

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20110075A CR20110075A (es) 2008-08-12 2011-02-08 Agentes antifúngicos

Country Status (31)

Country Link
EP (1) EP2326172B1 (es)
KR (1) KR101686075B1 (es)
AR (1) AR073037A1 (es)
BR (1) BRPI0912074B1 (es)
CL (1) CL2011000292A1 (es)
CO (1) CO6351686A2 (es)
CR (1) CR20110075A (es)
DK (1) DK2326172T3 (es)
DO (1) DOP2011000053A (es)
EA (1) EA018337B1 (es)
ES (1) ES2526652T3 (es)
GT (1) GT201100039A (es)
HK (1) HK1158017A1 (es)
HN (1) HN2011000404A (es)
HR (1) HRP20150009T1 (es)
IL (2) IL210975A (es)
MA (1) MA32628B1 (es)
MX (1) MX2011001656A (es)
MY (1) MY156955A (es)
NI (1) NI201100035A (es)
NZ (1) NZ590914A (es)
PE (1) PE20110676A1 (es)
PL (1) PL2326172T3 (es)
PT (1) PT2326172E (es)
RS (1) RS53731B1 (es)
SI (1) SI2326172T1 (es)
SV (1) SV2011003839A (es)
TW (1) TWI439458B (es)
UA (1) UA105639C2 (es)
WO (1) WO2010019203A1 (es)
ZA (1) ZA201100788B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016118396A1 (en) * 2015-01-19 2016-07-28 Scynexis, Inc. Novel salts and polymorphs of scy-078
MX2019012116A (es) 2017-04-10 2019-11-21 Scynexis Inc Agentes antifungicos utilizados en combinacion.
AU2018309718A1 (en) * 2017-08-04 2020-02-27 Scynexis, Inc. Antifungal agents with enhanced activity in acidic pH
MA54866A (fr) * 2019-01-30 2022-05-04 Scynexis Inc Antifongiques triterpénoïdes pour le traitement d'infections ostéoarticulaires fongiques
CA3140637A1 (en) * 2019-05-16 2020-11-19 Scynexis, Inc. Antifungal agents, like ibrexafungerp for candida auris decolonization
WO2021239992A1 (en) 2020-05-29 2021-12-02 Centre National De La Recherche Scientifique Antifungal prodrugs

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756472A (en) 1996-01-31 1998-05-26 Merck & Co., Inc. Antifungal agent obtained from hormonema
DE69718141T2 (de) * 1996-01-31 2003-08-21 Merck & Co Inc Fungizid
US20050131041A1 (en) * 2002-04-17 2005-06-16 Mohammad Salman Azole derivatives as antifungal agents
CA2649432C (en) * 2006-04-03 2014-06-03 Merck & Co., Inc. Antifungal agents

Also Published As

Publication number Publication date
GT201100039A (es) 2013-08-21
ES2526652T3 (es) 2015-01-14
CO6351686A2 (es) 2011-12-20
HN2011000404A (es) 2013-09-23
IL242031A0 (en) 2015-11-30
WO2010019203A8 (en) 2011-03-17
SI2326172T1 (sl) 2015-02-27
EA201100350A1 (ru) 2011-08-30
MY156955A (en) 2016-04-15
EA018337B1 (ru) 2013-07-30
RS53731B1 (en) 2015-06-30
TW201011004A (en) 2010-03-16
IL210975A0 (en) 2011-04-28
DOP2011000053A (es) 2011-04-30
EP2326172B1 (en) 2014-10-22
EP2326172A1 (en) 2011-06-01
HK1158017A1 (en) 2012-07-13
KR20110045054A (ko) 2011-05-03
NI201100035A (es) 2011-09-20
HRP20150009T1 (hr) 2015-02-27
MX2011001656A (es) 2011-05-25
BRPI0912074B1 (pt) 2021-08-03
EP2326172A4 (en) 2012-06-06
TWI439458B (zh) 2014-06-01
AR073037A1 (es) 2010-10-06
PL2326172T3 (pl) 2015-03-31
BRPI0912074A2 (pt) 2018-10-02
NZ590914A (en) 2011-11-25
PT2326172E (pt) 2015-02-04
IL210975A (en) 2015-10-29
KR101686075B1 (ko) 2016-12-13
MA32628B1 (fr) 2011-09-01
WO2010019203A1 (en) 2010-02-18
PE20110676A1 (es) 2011-09-23
CL2011000292A1 (es) 2011-11-04
UA105639C2 (uk) 2014-06-10
SV2011003839A (es) 2011-07-06
ZA201100788B (en) 2012-05-01
DK2326172T3 (da) 2015-01-26

Similar Documents

Publication Publication Date Title
CL2012003104A1 (es) Compuestos derivados de multiheteroarilos, inhibidores de prostaglandina d sintasa hematopoyetica (h-pgds); y composicion farmaceutica que los comprende.
DOP2015000014A (es) Derivados de azaadamantano y metodos de uso de los mismos
ECSP099721A (es) Inhibidores de cinasa p70 s6
CR11433A (es) Inhibidores de quinasa c-fms
NO20084334L (no) Farmasoytiske sammensetninger
CR20150045A (es) Inhibidores de hepatitis c
CR11370A (es) Inhibidores de quinasas simil polo
CR11427A (es) 2-fluoro-2 - desoxitetrahidrouridinas como inhibidores de citidina desaminasa
CO6321282A2 (es) Derivados de piperidinilindol como inhibidores de aldosterona sintasa
CR11488A (es) 4-fenilpiran 3,5-dionas, 4-feniltiopiran-3,5-dionas y 2-fenilciclohexan-1,3,5-trionas como herbicidas
GT200600117A (es) Nuevos compuestos farmaceuticos
CR20110028A (es) Derivados de pirimidina como inhibidores de cinasa
CR11803A (es) Pirrolopiridinas como inhibidores de cinasa
UY32049A (es) Inhibidores de cmet
CR11518A (es) Compuestos de carbamoilo como inhibidores de dgat1 190
CR20110240A (es) Inhibidores de cinasa akt y p70 s6
DOP2014000033A (es) Aminoquinazolinas como inhibidores de quinasa
CR20110075A (es) Agentes antifúngicos
GT200800251A (es) Nitrilos espirociclicos como inhibidores de proteasa
UA106880C2 (uk) Нові гербіциди
CR11629A (es) INHIBIDORES HETEROCICLICOS DE ESTEAROIL-CoA- DESATURASA.
SV2009003429A (es) Derivados de 7-alquinil-1,8-naftiridonas, su preparacion y su aplicacion en terapeutica
UY32635A (es) Derivados de bis-(sulfonilamino) en terapia 735
CO6440548A2 (es) 1-/arilsulfonil)-4-(piperazin-1-il)-1h-benzimidazoles como ligandos de 5-hidroxitriptamina-6.
CR11860A (es) Derivados de dibenzotiazepina y sus usos - 424