EA202193146A1 - Противогрибковые агенты для деколонизации candida auris - Google Patents

Противогрибковые агенты для деколонизации candida auris

Info

Publication number
EA202193146A1
EA202193146A1 EA202193146A EA202193146A EA202193146A1 EA 202193146 A1 EA202193146 A1 EA 202193146A1 EA 202193146 A EA202193146 A EA 202193146A EA 202193146 A EA202193146 A EA 202193146A EA 202193146 A1 EA202193146 A1 EA 202193146A1
Authority
EA
Eurasian Patent Office
Prior art keywords
candida auris
decolonization
enfumafungin
decolonize
subjects
Prior art date
Application number
EA202193146A
Other languages
English (en)
Inventor
Давид А. Ангуло Гонсалес
Стефен Эндрю Барат
Original Assignee
Сайнексис, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сайнексис, Инк. filed Critical Сайнексис, Инк.
Publication of EA202193146A1 publication Critical patent/EA202193146A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Тритерпеноидные противогрибковые соединения, являющиеся производными энфумафунгина, применяют для деколонизации грибков из анатомических областей субъектов, колонизированных грибками. Тритерпеноидные производные энфумафунгина (или их фармацевтически приемлемые соли или гидраты) являются ингибиторами синтеза (1,3)--D-глюкана и могут деколонизировать Candida auris с таких участков тела, как кожа и слизистые оболочки. Субъекты, которым будет полезна данная деколонизация, включают людей, колонизированных Candida auris, которые ранее перенесли инфекцию Candida auris и склонны к рецидиву и/или могут передавать грибок другим индивидам, которые могут быть восприимчивыми.
EA202193146A 2019-05-16 2020-05-12 Противогрибковые агенты для деколонизации candida auris EA202193146A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962849019P 2019-05-16 2019-05-16
PCT/US2020/032547 WO2020232037A1 (en) 2019-05-16 2020-05-12 Antifungal agents, like ibrexafungerp for candida auris decolonization

Publications (1)

Publication Number Publication Date
EA202193146A1 true EA202193146A1 (ru) 2022-02-11

Family

ID=70861571

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202193146A EA202193146A1 (ru) 2019-05-16 2020-05-12 Противогрибковые агенты для деколонизации candida auris

Country Status (14)

Country Link
US (1) US20220211684A1 (ru)
EP (1) EP3968986A1 (ru)
JP (1) JP2022532734A (ru)
KR (1) KR20220009416A (ru)
CN (1) CN113905733A (ru)
AU (1) AU2020276595A1 (ru)
BR (1) BR112021022876A2 (ru)
CA (1) CA3140637A1 (ru)
EA (1) EA202193146A1 (ru)
IL (1) IL288165A (ru)
MA (1) MA55958A (ru)
MX (1) MX2021013899A (ru)
TW (1) TW202110441A (ru)
WO (1) WO2020232037A1 (ru)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756472A (en) 1996-01-31 1998-05-26 Merck & Co., Inc. Antifungal agent obtained from hormonema
WO2007127012A1 (en) 2006-04-03 2007-11-08 Merck & Co., Inc. Antifungal agents
RS53731B1 (en) * 2008-08-12 2015-06-30 Scynexis, Inc. ANTIGLIVIC AGENTS
CN102176827B (zh) 2008-08-12 2015-05-20 西尼克斯公司 抗真菌制剂
MA43825A (fr) * 2016-03-16 2021-04-07 Cidara Therapeutics Inc Schémas posologiques pour le traitement d'infections fongiques
JP7263313B2 (ja) * 2017-04-10 2023-04-24 サイネクシス，インコーポレーテッド 併用される抗真菌剤
US20200291488A1 (en) * 2017-05-17 2020-09-17 T2 Biosystems, Inc. Nmr methods and systems for the rapid detection of candida species
WO2019028034A1 (en) * 2017-08-04 2019-02-07 Scynexis, Inc. ANTIFUNGAL AGENTS WITH IMPROVED PH ACID ACTIVITY
EA202192107A1 (ru) * 2019-01-30 2021-10-21 Сайнексис, Инк. Тритерпеноидные фунгициды для лечения грибковых костно-суставных инфекций

Also Published As

Publication number Publication date
KR20220009416A (ko) 2022-01-24
MA55958A (fr) 2022-03-23
TW202110441A (zh) 2021-03-16
AU2020276595A1 (en) 2021-12-09
BR112021022876A2 (pt) 2022-04-12
EP3968986A1 (en) 2022-03-23
CN113905733A (zh) 2022-01-07
US20220211684A1 (en) 2022-07-07
MX2021013899A (es) 2022-02-10
CA3140637A1 (en) 2020-11-19
IL288165A (en) 2022-01-01
WO2020232037A1 (en) 2020-11-19
JP2022532734A (ja) 2022-07-19

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