AR082968A1 - Inhibidores biciclicos de notum pectinacetilesterasa y una composicion farmaceutica en base al compuesto - Google Patents
Inhibidores biciclicos de notum pectinacetilesterasa y una composicion farmaceutica en base al compuestoInfo
- Publication number
- AR082968A1 AR082968A1 ARP110103323A ARP110103323A AR082968A1 AR 082968 A1 AR082968 A1 AR 082968A1 AR P110103323 A ARP110103323 A AR P110103323A AR P110103323 A ARP110103323 A AR P110103323A AR 082968 A1 AR082968 A1 AR 082968A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- heterocycle
- aryl
- heteroalkyl
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se describen compuestos que se pueden utilizar para inhibir la Notum pectinacetilesterasa, como también composiciones que los comprenden. Estos compuestos son útiles para tratar las enfermedades y los trastornos que afectan a los huesos, en particular la osteoporosis.Reivindicación 1: Un compuesto de la fórmula (1) o una sal farmacéuticamente aceptable del mismo, en donde: R1B es hidrógeno o alquilo, arilo, heteroalquilo o heterociclo opcionalmente sustituidos; R2 es hidrógeno, halo, -CO2R2A, -C(O)N(R2A)2, -SR2A, -OR2A o -N(R2A)2, alquilo, arilo, heteroalquilo o heterociclo, opcionalmente sustituidos; cada R2A es, de manera independiente, hidrógeno o alquilo, arilo, heteroalquilo, o heterociclo, opcionalmente sustituidos; R3 es hidrógeno, halo, ciano, -CO2R3A, -C(O)N(R3A)2, -SR3A, -OR3A, -N(R3A)2, o alquilo, arilo, heteroalquilo o heterociclo, opcionalmente sustituidos; cada R3A es, de manera independiente, hidrógeno, alquilo, arilo, heteroalquilo o heterociclo, opcionalmente sustituidos; R4 es hidrógeno, halo o alquilo, arilo, heteroalquilo o heterociclo, opcionalmente sustituidos; R5 es hidrógeno, halo, -CO2R5A, -C(O)N(R5A)2, -SR5A, -OR5A, -N(R5A)2 o arilo, heteroalquilo, o heterociclo, opcionalmente sustituidos; cada R5A es, de manera independiente, hidrógeno, alquilo, arilo, heteroalquilo, o heterociclo, opcionalmente sustituidos; y n es 0, 1 ó 2; en donde “opcionalmente sustituido” significa opcionalmente sustituido con uno o más de alcoxi, alquilo, amino (incluyendo alquilamino, dialquilamino), arilo, ácido carboxílico, ciano, halo, heterociclo o hidroxilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38252610P | 2010-09-14 | 2010-09-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR082968A1 true AR082968A1 (es) | 2013-01-23 |
Family
ID=44678054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110103323A AR082968A1 (es) | 2010-09-14 | 2011-09-13 | Inhibidores biciclicos de notum pectinacetilesterasa y una composicion farmaceutica en base al compuesto |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US20120065200A1 (es) |
| EP (1) | EP2616471B1 (es) |
| JP (1) | JP2013537202A (es) |
| KR (1) | KR20130112888A (es) |
| CN (1) | CN103328481A (es) |
| AR (1) | AR082968A1 (es) |
| AU (1) | AU2011302225A1 (es) |
| BR (1) | BR112013006131A2 (es) |
| CA (1) | CA2811005A1 (es) |
| CL (1) | CL2013000682A1 (es) |
| CO (1) | CO6710916A2 (es) |
| DK (1) | DK2616471T3 (es) |
| ES (1) | ES2536078T3 (es) |
| MX (1) | MX2013002851A (es) |
| NZ (1) | NZ608031A (es) |
| PL (1) | PL2616471T3 (es) |
| PT (1) | PT2616471E (es) |
| RU (1) | RU2013116801A (es) |
| SG (1) | SG188530A1 (es) |
| TW (1) | TW201219401A (es) |
| WO (1) | WO2012037141A1 (es) |
| ZA (1) | ZA201301795B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2808432C (en) | 2010-07-23 | 2019-06-04 | President And Fellows Of Harvard College | Tricyclic proteasome activity enhancing compounds with thieno[2,3-d]pyrimidine core |
| AR090037A1 (es) * | 2011-11-15 | 2014-10-15 | Xention Ltd | Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio |
| WO2013112706A1 (en) | 2012-01-25 | 2013-08-01 | Proteostasis Therapeutics, Inc. | Proteasome activity modulating compounds |
| CN110337437B (zh) | 2016-12-28 | 2023-02-03 | 达特神经科学有限公司 | 作为pde2抑制剂的取代的吡唑并嘧啶酮化合物 |
| AU2018373258B2 (en) | 2017-11-27 | 2023-03-02 | Dart Neuroscience, Llc | Substituted furanopyrimidine compounds as PDE1 inhibitors |
| GB201814151D0 (en) | 2018-08-31 | 2018-10-17 | Ucl Business Plc | Compounds |
| CN111171044B (zh) * | 2018-11-13 | 2022-06-24 | 沈阳化工研究院有限公司 | 一种噻吩并嘧啶类化合物及其医药用途 |
| WO2020132384A1 (en) | 2018-12-21 | 2020-06-25 | Celgene Corporation | Thienopyridine inhibitors of ripk2 |
| PE20220281A1 (es) | 2019-03-19 | 2022-02-25 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos de aza-benzotiofeno y aza-benzofurano como antihelminticos |
| JP2023528822A (ja) | 2020-05-29 | 2023-07-06 | ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド | 駆虫性複素環式化合物 |
| WO2022251343A2 (en) * | 2021-05-27 | 2022-12-01 | National Health Research Institutes | Cdgsh iron sulfur domain 2 activators and use thereof |
| WO2023073641A1 (en) | 2021-11-01 | 2023-05-04 | Boehringer Ingelheim Vetmedica Gmbh | Anthelmintic pyrrolopyridazine compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4008726A1 (de) | 1990-03-19 | 1991-09-26 | Basf Ag | Thieno(2,3-d)pyrimidinderivate |
| US6080576A (en) | 1998-03-27 | 2000-06-27 | Lexicon Genetics Incorporated | Vectors for gene trapping and gene activation |
| US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| WO2007146284A2 (en) * | 2006-06-12 | 2007-12-21 | Vertex Pharmaceuticals Incorporated | Thienopyrimidines useful as modulators of ion channels |
| WO2009001214A2 (en) * | 2007-06-28 | 2008-12-31 | Pfizer Products Inc. | Thieno[2,3-d]pyrimidin-4(3h)-one, isoxazolo[5,4-d]pyrimidin-4(5h)-one and isothiazolo[5,4-d]pyrimidin-4(5h)-one derivatives as calcium receptor antagonists |
-
2011
- 2011-09-08 TW TW100132460A patent/TW201219401A/zh unknown
- 2011-09-13 BR BR112013006131A patent/BR112013006131A2/pt not_active IP Right Cessation
- 2011-09-13 JP JP2013528388A patent/JP2013537202A/ja not_active Withdrawn
- 2011-09-13 SG SG2013018700A patent/SG188530A1/en unknown
- 2011-09-13 ES ES11761206.9T patent/ES2536078T3/es active Active
- 2011-09-13 PT PT117612069T patent/PT2616471E/pt unknown
- 2011-09-13 CA CA2811005A patent/CA2811005A1/en not_active Abandoned
- 2011-09-13 MX MX2013002851A patent/MX2013002851A/es not_active Application Discontinuation
- 2011-09-13 DK DK11761206.9T patent/DK2616471T3/en active
- 2011-09-13 AR ARP110103323A patent/AR082968A1/es unknown
- 2011-09-13 CN CN2011800442957A patent/CN103328481A/zh active Pending
- 2011-09-13 RU RU2013116801/04A patent/RU2013116801A/ru not_active Application Discontinuation
- 2011-09-13 US US13/231,653 patent/US20120065200A1/en not_active Abandoned
- 2011-09-13 EP EP11761206.9A patent/EP2616471B1/en not_active Not-in-force
- 2011-09-13 NZ NZ608031A patent/NZ608031A/en not_active IP Right Cessation
- 2011-09-13 WO PCT/US2011/051421 patent/WO2012037141A1/en active Application Filing
- 2011-09-13 PL PL11761206T patent/PL2616471T3/pl unknown
- 2011-09-13 AU AU2011302225A patent/AU2011302225A1/en not_active Abandoned
- 2011-09-13 KR KR1020137009332A patent/KR20130112888A/ko not_active Application Discontinuation
-
2013
- 2013-03-08 ZA ZA2013/01795A patent/ZA201301795B/en unknown
- 2013-03-13 CL CL2013000682A patent/CL2013000682A1/es unknown
- 2013-04-12 CO CO13094694A patent/CO6710916A2/es not_active Application Discontinuation
-
2014
- 2014-06-10 US US14/300,281 patent/US20140288071A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CO6710916A2 (es) | 2013-07-15 |
| PL2616471T3 (pl) | 2015-07-31 |
| JP2013537202A (ja) | 2013-09-30 |
| PT2616471E (pt) | 2015-04-20 |
| WO2012037141A1 (en) | 2012-03-22 |
| CA2811005A1 (en) | 2012-03-22 |
| BR112013006131A2 (pt) | 2016-06-07 |
| CL2013000682A1 (es) | 2013-11-08 |
| ZA201301795B (en) | 2014-05-28 |
| EP2616471A1 (en) | 2013-07-24 |
| CN103328481A (zh) | 2013-09-25 |
| NZ608031A (en) | 2015-01-30 |
| US20120065200A1 (en) | 2012-03-15 |
| SG188530A1 (en) | 2013-04-30 |
| TW201219401A (en) | 2012-05-16 |
| AU2011302225A1 (en) | 2013-03-21 |
| DK2616471T3 (en) | 2015-04-07 |
| MX2013002851A (es) | 2013-05-28 |
| ES2536078T3 (es) | 2015-05-20 |
| EP2616471B1 (en) | 2014-12-31 |
| KR20130112888A (ko) | 2013-10-14 |
| RU2013116801A (ru) | 2014-10-20 |
| US20140288071A1 (en) | 2014-09-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |