CO5080791A1 - Derivados de la piperidina que tienen efectos sobre sistemas con serotonina - Google Patents

Derivados de la piperidina que tienen efectos sobre sistemas con serotonina

Info

Publication number
CO5080791A1
CO5080791A1 CO99040500A CO99040500A CO5080791A1 CO 5080791 A1 CO5080791 A1 CO 5080791A1 CO 99040500 A CO99040500 A CO 99040500A CO 99040500 A CO99040500 A CO 99040500A CO 5080791 A1 CO5080791 A1 CO 5080791A1
Authority
CO
Colombia
Prior art keywords
alkyl
alkoxy
phenyl
alkylthio
halo
Prior art date
Application number
CO99040500A
Other languages
English (en)
Inventor
Kohlman Daniel Timothy
Xi Liang Sidney
Xu Yao-Chang
Larry Wayne Hertel
Wong David Taiwai
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CO5080791A1 publication Critical patent/CO5080791A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Un compuesto de la fórmula :<EMI FILE="99040500_1" ID="1" IMF=JPEG >En la que X es O, S, NR, S(=O) o S(=O)2;Y es -C(=O)-, -CH(OH)-, CH2 , -C(=NOR), CHNR7R, S, SO o SO2 ;--------- representa un enlace sencillo o doble;n es 1, 2, 3 ó 4;R es H o alquilo C1-C6;cada uno de R1a, R1b, R1c, y R2 es, independientemente, H, F, Cl, Br, I OH, alquilo C1-C6, alcoxi C1-C6, halo-alquilo (C1-C6), alquiltio (C1-C6), fenilo, NO2, -NR7R8, -C(=O)NR7-R8, -NR7C(=O)R8, CN o fenilo sustituido con 1 a 3 sustituyentes seleccionados entre el grupo compuesto por F, CL, Br, I, OH, alquilo C1-C6, alcoxi C1-C6, halo-alquilo (C1-C6), alquiltio (C1-C6), fenilo, NO2 , NH2 o CN;R3 es H, OH, hidroxi-alquilo(C1-C6), alquilo C1-C6, alcoxi C1-C6 o alquiltio (C1-C6);R4 es arilo, heterociclo, cicloalquilo C3-C8, arilo sustituido con 1 a 3 sustituyentes seleccionados entre el grupo compuesto por F, Cl, Br, I, OH, alquilo C1-C6, alcoxi C1-C6, halo-alquilo (C1-C6) alquiltio (C1-C6 ), fenilo, NO2, NH2 o CN; o heterociclo sustituido con 1 a 3 sustituyentes seleccionados entre el grupo compuesto por F, Cl, Br, I, OH, alquilo C1-C6, alcoxi, C1-C6, halo-alquilo (C1-C6), alquiltio (C1-C6)fenilo, NO2 , NH2 , o CN;R5 es arilo, heterociclo, cicloalquilo C3-C8, arilo sustituido con 1 a 3 sustituyentes seleccionados entre el grupo compuesto por F, Cl, Br, I, OH, alquilo C1-C6, alcoxi C1-C6, hidroxi-alquilo(C1-C6), halo-alquilo (C1-C6), alquiltio (C1-C6), fenilo, NO2, NH2, o CN; o heterociclo sustituido con 1 a 3 sustituyentes seleccionados entre el grupo compuesto por F, Cl, Br, I, OH, alquilo C1-C6, alcoxi C1-C6, hidroxi-alquilo (C1-C6), halo-alquilo (C1-C6), alquiltio (C1-C6 fenilo, NO2, NH2, o CN;cada uno de R6a y R6b es, independientemente, H o alquilo C1-C3;Cada uno de R7 y R8 es, independientemente, H o alquilo C1-C6; arilo o arilo sustituido con 1 a 3 sustituyentes seleccionados entre el grupo compuesto por F, Cl, Br, I, OH, alquilo C1-C6, alcoxi C1-C6, halo-alquilo (C1-C6), fenilo, NO2, NH2 o CN; o heterociclo sustituido con 1 a 3 sustituyentes seleccionados entre el grupo compuesto por F, Cl, Br, I, OH, alquilo C1-C6, alcoxi C1-C6, halo-alquilo (C1-C6), alquiltio (C1-C6) fenilo, NO2, NH2 o CN; y las sales farmacéuticas del mismo.
CO99040500A 1998-06-30 1999-06-29 Derivados de la piperidina que tienen efectos sobre sistemas con serotonina CO5080791A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9124198P 1998-06-30 1998-06-30

Publications (1)

Publication Number Publication Date
CO5080791A1 true CO5080791A1 (es) 2001-09-25

Family

ID=22226762

Family Applications (1)

Application Number Title Priority Date Filing Date
CO99040500A CO5080791A1 (es) 1998-06-30 1999-06-29 Derivados de la piperidina que tienen efectos sobre sistemas con serotonina

Country Status (12)

Country Link
US (1) US6436964B1 (es)
EP (1) EP0982304B1 (es)
JP (1) JP2002519323A (es)
AR (1) AR019178A1 (es)
AT (1) ATE225345T1 (es)
AU (1) AU4726699A (es)
CA (1) CA2336117A1 (es)
CO (1) CO5080791A1 (es)
DE (1) DE69903239T2 (es)
ES (1) ES2181366T3 (es)
PE (1) PE20000763A1 (es)
WO (1) WO2000000198A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002519326A (ja) 1998-06-30 2002-07-02 イーライ・リリー・アンド・カンパニー セロトニン関連系に効果を有するアゼピン誘導体
EP1196382A2 (en) * 1999-06-29 2002-04-17 Eli Lilly And Company Preparation of substituted piperidin-4-ones
AU5866500A (en) * 1999-06-29 2001-01-31 Eli Lilly And Company Preparation of 7-substituted benzothiophenes
CA2380608A1 (en) * 1999-07-29 2001-02-08 Cynthia Darshini Jesudason Serotonergic benzofurans
US6881733B1 (en) 1999-07-29 2005-04-19 Eli Lilly And Company Serotonergic benzofurans
JP2003506371A (ja) * 1999-07-29 2003-02-18 イーライ・リリー・アンド・カンパニー セロトニン作動性ベンゾチオフェン
JP2003510321A (ja) * 1999-09-29 2003-03-18 イーライ・リリー・アンド・カンパニー セロトニン再取込み抑制薬としてのピペリジン誘導体
MXPA02001994A (es) * 1999-09-29 2002-09-18 Lilly Co Eli Derivados de piperidina como inhibidores de la reabsorcion.
ITMI20021329A1 (it) * 2002-06-14 2003-12-15 Recordati Chem Pharm Nuove ossialchilammine sostituite
US20040058962A1 (en) * 2002-06-14 2004-03-25 Amedeo Leonardi Phenylalkylamines and pyridylalkylamines
AU2003268361A1 (en) * 2002-08-30 2004-03-19 Watson Pharmaceuticals, Inc. Drug delivery system for treating urinary incontinence
MXPA05002696A (es) 2002-09-17 2005-05-05 Hoffmann La Roche Indoles 2,7-sustituidos y su uso como moduladores de 5-hidroxitriptamina 6 (5-ht6).
JP4267573B2 (ja) 2002-09-17 2009-05-27 エフ．ホフマン−ラ ロシュ アーゲー ２，４−置換インドールおよびそれらの５−ｈｔ６モジュレーターとしての使用
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
MX2009001875A (es) 2006-08-21 2009-03-02 Genentech Inc Compuestos de aza-benzotiofenilo y metodos de uso de los mismos.
WO2016134684A1 (de) 2015-02-24 2016-09-01 Mso Messtechnik Und Ortung Gmbh Verfahren zur messung des erntegutmassestroms am feldhäcksler
NL1041393B1 (en) 2015-07-07 2017-01-30 Kessener B V Method and device providing a liquid display.
DE102016002899B4 (de) 2016-03-09 2020-03-12 Johannes Kraus Feuerraum mit verbessertem Ausbrand
DE202016005695U1 (de) 2016-09-12 2016-10-04 Jürgen Raudis Seifenabstandhalter zum Trocknen fester Seifen mit Seifenabtropfbehälter

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0006524A1 (de) * 1978-06-22 1980-01-09 Ciba-Geigy Ag Neue Tetrahydropyridin- und Piperidinderivate und deren Säureadditionssalze, Verfahren zu deren Herstellung und solche enthaltende pharmazeutische Zusammensetzungen
GB2056435A (en) * 1979-06-26 1981-03-18 Ciba Geigy Ag Novel Tetrahydropyridine and Piperidine Substituted Benzofuranes and Related Compounds
FR2670491B1 (fr) * 1990-12-14 1993-02-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les renfermant.
NZ240863A (en) * 1991-09-11 1995-04-27 Mcneilab Inc Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof
KR950702978A (ko) * 1992-08-05 1995-08-23 폴 에이. 리처 아미드 유도체(Amide derivatives)
DK148392D0 (da) * 1992-12-09 1992-12-09 Lundbeck & Co As H Heterocykliske forbindelser
GB9300195D0 (en) * 1993-01-06 1993-03-03 Wyeth John & Brother Ltd Piperazine derivatives
US5576321A (en) * 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems
BRPI9708389B8 (pt) * 1996-03-29 2015-12-08 Duphar Int Res compostos de piperazina e piperidina, composições farmacêuticas.
AU736596B2 (en) 1997-07-25 2001-08-02 H. Lundbeck A/S Indole and 2,3-dihydroindole derivatives, their preparation and use
FR2769312B1 (fr) * 1997-10-03 1999-12-03 Adir Nouveaux composes de l'indanol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
AR019178A1 (es) 2001-12-26
CA2336117A1 (en) 2000-01-06
WO2000000198A1 (en) 2000-01-06
ES2181366T3 (es) 2003-02-16
AU4726699A (en) 2000-01-17
EP0982304B1 (en) 2002-10-02
US6436964B1 (en) 2002-08-20
DE69903239D1 (de) 2002-11-07
JP2002519323A (ja) 2002-07-02
ATE225345T1 (de) 2002-10-15
WO2000000198A8 (en) 2000-03-23
DE69903239T2 (de) 2003-09-11
EP0982304A1 (en) 2000-03-01
PE20000763A1 (es) 2000-08-30

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